Articles tagged with Neural Mechanisms
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that the prefrontal cortex sends customized signals to visual and motor regions, influencing their activity based on arousal levels and movement. The study reveals distinct roles of prefrontal subregions in shaping visual processing, with one region enhancing stimuli detection and another dampening irrelevant stimuli.
Research found that high-fat and high-carbohydrate diets are controlled by separate neural pathways in the brain. Neuropeptide Y neurons activate AMPK-regulated corticotropin-releasing hormone neurons to promote high-carb intake, while inhibiting melanocortin 4 receptor neurons to increase high-fat intake.
Researchers discovered that neurons in the brain's auditory cortex show large bursts of activity tied to specific moments in a task, suggesting a deep connection between behavior and sound processing. This 'tuning' mechanism enables the brain to produce smaller but more distinctive responses to sounds guiding task performance.
Scientists at RIKEN Center for Brain Science found that fruit flies use separate circuits to compute pleasant and unpleasant odors, challenging the idea that 'good' is the opposite of 'bad'. The discovery may contribute to a better understanding of human brain's flavor appreciation mechanisms.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
Researchers discovered that proprioceptive nerve cells for sensing leg motion are deactivated during active movement in fruit flies. This selective suppression may enable the insect to quickly respond to sudden external events. The study advances basic scientific knowledge of sensory feedback and its application to clinical treatments
A new brain training game has shown promise in treating nerve pain, with participants experiencing significant reductions in pain and comparable relief to opioids. The PainWaive technology uses EEG headsets to track brain activity and respond in real time, providing a potential non-invasive alternative for chronic pain management.
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Researchers identified CLU protein as a potential strategy to protect against Alzheimer's disease by increasing clusterin protein. Increased CLU protects the brain from amyloid plaques and loss of synapses, while identifying individuals most likely to respond based on their genetics.
A study by Helmholtz Munich researchers found that GIPR agonism and antagonism decrease body weight and food intake via different mechanisms. GIPR agonists use GABAergic neurons to exert their effect, while antagonists rely on the GLP-1 receptor signal.
A harmful form of tau protein directly damages blood vessels in the brain, leading to inflammation and weakening the brain's protective shield. The discovery highlights the importance of focusing on early neurovascular changes mediated by tau to prevent or slow down damage to the blood-brain barrier.
Capsule eliminates I/O overhead and optimizes performance by designing a subgraph loading mechanism and pipelined parallel strategy for large-scale graph neural network training, providing 22.24% memory usage and up to 12.02x performance improvement over existing systems
Researchers at UT Arlington's CIHI are developing innovative solutions to address complex health needs in children with disabilities, behavioral health issues, and medical conditions. The projects aim to improve healthcare services, enhance quality of life, and promote healthier aging through cutting-edge research and model organisms.
Two brain proteins, Imp and Sdc, play a crucial role in preventing seizures by regulating neuronal growth and brain circuit development. Reducing either protein can lead to seizure-prone behavior in flies, highlighting their importance in seizure regulation.
Researchers developed a novel 2D phase-transition memristor leveraging intrinsic ion migration to overcome existing device limitations. The device achieves record-low power consumption, ultrafast switching speed, and exceptional endurance, making it suitable for high-speed computing applications.
Researchers propose a novel machine memory structure and the M2I framework to address excessive data consumption, catastrophic forgetting, and logical reasoning capabilities in large models. The study has potential to revolutionize AI development by mimicking human brain's memory mechanisms.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
Researchers have found that people with cannabis use disorder have elevated dopamine levels in a brain region associated with psychosis. This could explain why frequent cannabis use increases the risk of hallucinations and delusions. The study's findings may help doctors educate patients about the potential risks of frequent cannabis u...
A new study by researchers at Tufts University suggests that a lack of vitamin K may increase inflammation and hamper proliferation of neural cells in the hippocampus, a key region for learning and memory. Vitamin K deficiency was also associated with increased neuroinflammation and reduced neurogenesis, leading to noticeable cognitive...
A study found that brain activity can predict a person's political affiliation with 80% accuracy when making food purchases. Researchers used fMRI to measure brain activity in Republicans and Democrats, finding distinct neural patterns for each group.
A study using cryo-electron microscopy revealed that autoantibodies in myasthenia gravis disrupt acetylcholine receptor function by blocking or activating the immune system's complement pathway. This knowledge helps explain treatment variability and offers a foundation for personalized therapies targeting specific antibody interactions.
Princeton neuroscientists pinpoint the central amygdala as the brain region responsible for forming lasting memories of food poisoning, which may shed light on PTSD and inform future clinical treatments. The study found that novel flavors can 'tag' specific brain cells to remain sensitive to illness signals.
A research group has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. CD11c-positive microglia, crucial for myelination, play a key role in this process.
Researchers develop a powerful model to study TDP-43 pathology, which accumulates in the cytoplasm and depletes from the nucleus, leading to neuronal death. The 'seeded' protein aggregates recapitulate key features of ALS and frontotemporal dementia.
Researchers discovered that dopamine levels in a specific brain region are closely linked to male sexual behavior transitions. The study found rhythmic dopamine input during intromission was regulated by acetylcholine innervation, directly triggering ejaculation.
A study published in Biological Psychiatry identified the Shisa7 gene as a key driver of heroin addiction. The research team used machine learning to analyze brain tissue from human opioid users and found that modulating this gene's expression influenced heroin-seeking behavior and cognitive flexibility.
Researchers discover Dscamb protein regulates spacing between color-detecting cells, ensuring perfect arrangement for optimal vision. The protein acts as a 'self-avoidance enforcer' to maintain proper distances between cone cells.
Researchers found that perceiving prices significantly different from expectations triggers a strong N400 signal in the brain, engaging regions involved in evaluating rewards and learning. This suggests that consumers' perceptions of value are part of automatic cognitive mechanisms activated long before conscious decision-making.
Researchers identified a conserved splicing mechanism controlling the production of different proteins from the same gene, crucial for neuronal function and development. The study sheds light on how neuronal identity is established and maintained through alternative splicing.
A study by the University of the Basque Country has detected potential biomarkers in the blood that could help predict the risk of developing schizophrenia due to cannabis use. The researchers found significant differences in fatty acid content between cannabis users, individuals with schizophrenia, and those with dual diagnoses.
The review explores the pathophysiological mechanisms linking obstructive sleep apnea syndrome and metabolic syndrome, highlighting recent advancements in therapeutic strategies. Treatment approaches aim to break the harmful cycle between OSA and MetS, which affects approximately 14% of the global population.
Researchers at Ruhr-University Bochum discovered that the rubber hand illusion reduces perceived pain intensity when a heat stimulus is applied to one hand while simultaneously illuminating a rubber hand. This phenomenon, known as visual analgesia, could potentially be used in treating complex regional pain syndrome.
Researchers at Baylor College of Medicine have identified new variants of CDKL2 and CDKL1 genes associated with developmental disorders, including epilepsy. The study proposes a mechanism by which defective variants cause neurological symptoms in affected individuals.
This study found that electroacupuncture (EA) improved gastric emptying in rats with burn-induced dysmotility by down-regulating cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. EA also normalized sympathetic hyperactivity and enhanced vagal activity, suggesting a potential therapeutic benefit for burn-induced gastric dysmotility.
Research highlights the interconnected relationship between aging, circadian rhythms, and cancer, with shared mechanisms including genomic instability, cellular senescence, and chronic inflammation. Modulating circadian rhythms may serve as a novel strategy to intervene in age-related functional decline and treat cancer.
Researchers from Kyoto University and Cambridge University developed a fluorescent dopamine sensor to monitor dopamine signals in primate brains. The study found that dopamine signals varied depending on the location in the striatum, with distinct patterns observed in the anterior putamen and caudate head.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
A study by Dr. Keum Sehoon's team identified key neural ensembles in the anterior cingulate cortex that encode empathic freezing, a behavioral response to witnessing distress in others. The researchers found that observing another's pain triggers activation in the ACC as if the observer were experiencing pain themselves.
Coyotes exhibit genetic monogamy, forming long-lasting social attachments. USU neuroscientist Sara Freeman studies the behavioral, hormonal, and neural basis of coyote pair-bonding behavior.
A study led by Dr. Rodrigo Quian Quiroga has confirmed that individual neurons represent concepts learned in any context, enabling abstract relationships and human intelligence. This finding contradicts previous research on animals, where memories were thought to be stored in different groups of neurons.
Researchers discovered distinct neuronal populations in the ACC process pain and itch information separately, with stimulus-specific neurons receiving differentiated synaptic inputs from the mediodorsal thalamus. Suppressing these neurons reduced corresponding sensations without affecting the other.
Researchers at Kyoto University investigated the effects of two-hit stress on mouse behavior, revealing significant changes in the cerebellum. The study found increased microglia turnover, neuronal loss, and decreased brain connectivity, correlating with anxiety-like behaviors and mental disorders.
Researchers found that brain connectivity related to cognitive control predicted substance use initiation, while cognitive control behavior did not. Stronger connectivity between the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex was associated with delayed substance use onset.
Scientists have identified a new target to prevent cold sores by understanding how the herpes virus triggers its own immune response. The discovery has important implications for genital herpes caused by the same virus, with potential treatments in development.
Researchers from the University of Konstanz challenged long-held hypotheses on collective motion in locust swarms, finding that sensory input and neural representations drive movement decisions. Contrary to previous assumptions, alignment with others is not responsible for coordinating collective motion.
Researchers at Johannes Gutenberg University Mainz have discovered that histone deacetylase 8 (HDCA8) inhibits the conversion of Schwann cells into their repair phenotype, slowing down peripheral nervous system recovery. Removing HDAC8 accelerates regeneration and restores sensory function.
Researchers at Karolinska Institutet discovered a fundamental mechanism linking breathing to pupil size, which affects vision. The study shows that the pupil is smallest during inhalation and largest during exhalation, impacting visual perception.
A new study found that voluntary exercise restores Stat3 levels in the amygdala, a region involved in emotional responses and blood pressure regulation. This restoration prevents stress-induced hypertension, highlighting a previously unknown brain-based mechanism behind exercise's ability to combat high blood pressure.
Ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant depression, often within hours of administration. However, the long-term efficacy and safety of ketamine therapy remain uncertain, with potential risks including cognitive impairment and cardiovascular effects.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
Scientists at Brown University and Cincinnati Children's found that suppressing opsin 3 in the brain of mice makes them eat less. The study suggests that opsin 3 plays an important role in regulating food consumption via the melanocortin 4 receptor MC4R.
Researchers at Penn State developed a new method to analyze bird songs, revealing context dependence and underlying neurobiology. The study suggests that auditory feedback plays a key role in creating context dependence, and may hold insights into the neural mechanisms of human language.
Researchers discovered that mismatch repair genes are critical in eliciting damages to neurons vulnerable to Huntington's disease, triggering downstream pathologies and motor impairment. Targeting these genes may offer novel therapeutic approaches, including improving locomotor and gait deficits and reducing neuronal cell death.
Researchers mapped the precise brain mechanisms that enable animals to overcome instinctive fears, revealing two key components in this learning process. The study found that a brain structure called the ventrolateral geniculate nucleus (vLGN) stores learning-induced memories and is triggered by the release of endocannabinoids.
Researchers developed a next-generation technology, MycoBCP, using artificial intelligence to screen for antimicrobial compound candidates. This method has already vastly accelerated the team's TB research capabilities and helped identify optimal candidate compounds for drug development.
Marshall University researcher Brandon Henderson has secured a $1.85 million NIH grant to study the impact of synthetic coolants in vaping products on nicotine addiction. The five-year research project will explore how synthetic coolants influence addiction-related behaviors, particularly among adolescents.
Scientists from DZNE found that preventing brain inflammation may help treat Alzheimer's disease. The study, published in Immunity, suggests that inhibiting the NLRP3 inflammasome can reduce neuroinflammation and help microglia clear harmful amyloid-beta deposits.
New research suggests lycopene treatment reverses depressive-like traits in mice by promoting synaptic plasticity via the BDNF-TrkB pathway. Lycopene also increases brain-derived neurotrophic factor (BDNF) expression, a protein essential for brain function.
Studies using a rodent model found sustained increase in neural activity in the paraventricular thalamus (PVT) after exposure to a strongly stressful event. This persistent activity is linked to altered behavior, including restlessness and disturbed sleep patterns. The findings suggest a new therapeutic target for stress-related issues.