Articles tagged with Arteries
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A study found that colchicine significantly improved survival rates for patients hospitalized with worsening heart failure. Colchicine may also reduce the risk of heart attack and stroke in patients with a buildup of cholesterol in their arteries.
A new study has shown that Transcatheter Aortic Valve Implantation (TAVI) is just as effective as conventional open-heart surgery in treating severe symptomatic aortic stenosis. The procedure offers a safer and faster recovery for patients, with improved symptoms, functional capacity, and quality of life at 6 weeks.
A new study found that artery stiffness is a better predictor of future Type 2 diabetes risk than blood pressure or other standard risk factors. People with high blood pressure and stiffer arteries had the highest risk of developing diabetes, highlighting the importance of early detection and treatment.
A new device, consisting of a smart stent and printed soft sensors, can wirelessly monitor hemodynamics in real-time, detecting various vascular conditions. The system uses inductive coupling for wireless energy transfer and has the potential to replace existing clinical devices and angiograms.
Researchers at UC San Diego describe the underlying signaling pathway that causes PAH and a novel monoclonal antibody therapy that blocks abnormal blood vessel formation. The study reveals two opposing roles of NOTCH ligands and opens a door to a potentially new treatment for PAH.
Research published in Science Advances discovers the importance of pressure sensing combined with stiffness sensing in determining vascular smooth muscle cell behavior. The study identifies molecular pathways related to mechanical sensing in cells and tissues, shedding light on potential new strategies for targeting atherosclerosis.
A team of scientists has found that nerve signals are exchanged between arteries with plaques and the brain in atherosclerosis. This discovery sheds light on the chronic inflammatory disease of the entire artery, revealing an electrical circuit between the arteries and brain.
A retrospective study found high sensitivity and specificity for diagnosing coronary artery calcium on contrast-enhanced and non-contrast chest CT. The visual ordinal assessment of CAC has prognostic utility, identifying patients at higher risk of cardiovascular events.
Researchers found that cancer patients who underwent elective AAA repair were associated with longer hospital stays, renal failure, respiratory problems, and infection. However, a cancer diagnosis did not increase the risk of in-hospital mortality or cardiac complications.
A recent study published in JAMA Ophthalmology analyzed the incidence of vision loss caused by retinal vein or artery blockage in 430,000 patients after a COVID-19 infection diagnosis. The research suggests that COVID-19 may be associated with an increased risk of this condition.
A retrospective study found that higher coronary artery calcium score, higher pulmonary artery-to-aorta ratio, and lower thoracic skeletal muscle index independently predicted worse overall survival. The PA-to-aorta ratio was the most important predictor of overall survival.
A new study found the second-generation Chocolate Touch paclitaxel-coated balloon catheter to be superior for opening blocked leg arteries. The trial showed improved patency rates and lower mortality rates compared to the commercially available Lutonix device.
Researchers found a significant decline in in-hospital mortality and secondary endpoints for STEMI patients with COVID-19 in 2021 compared to 2020. Vaccination status showed zero hospital deaths among vaccinated patients, while unvaccinated patients experienced high death rates.
A randomized clinical trial comparing FFR-guided and IVUS-guided PCI found similar outcomes for patients with intermediate coronary artery stenosis. Patients evaluated by FFR underwent fewer stents but had similar rates of adverse events and improved quality of life.
The study found a twofold regression of coronary atherosclerosis and stabilization of high-risk plaques in patients who received alirocumab, compared to those who received a placebo. Patients treated with alirocumab also needed significantly fewer repeat stenting procedures.
A study has discovered that using a strategically-timed pull from a waist belt can help individuals walk more efficiently, reducing metabolic cost by as much as half. This approach uses biomechanical testing to optimize the timing of assistance, which was found to be most effective during a brief window between steps.
Researchers at UConn Health found that deleting TRPM2 from macrophages in mice reduced atherosclerosis by inhibiting the TRPM2–CD36 inflammatory axis. This approach prevented foamy macrophages and alleviated inflammation in arteries.
A prospective study found that the 3-T Dixon gradient-recalled echo (GRE) sequence performed better than the current standard of 1.5-T SSFP for unenhanced coronary MRA, particularly in distal and branch segments. The technique demonstrated higher image quality, visible segments, sensitivity, and specificity for significant stenoses.
Researchers developed an AI algorithm that can measure coronary plaque buildup in five seconds, predicting heart attack risk within five years. The tool was trained on images from 921 people and matched results with invasive tests considered highly accurate.
The American Academy of Neurology recommends using medications such as aspirin and clopidogrel, alongside statins and regular physical activity, to prevent a second stroke in people with intracranial atherosclerosis. This approach is more beneficial than placing a stent in the blood vessel.
Researchers have created a groundbreaking dataset of ultrasonography scans of three major arteries supplying blood to the brain in children. The dataset consists of 821 participants, allowing for the development of machine learning models that can accurately predict a child's age and cognitive abilities based on their ultrasounds.
Researchers at Massachusetts General Hospital identified genetic variants in fibrillar collagen genes that increase the risk of spontaneous coronary artery dissection (SCAD), a common cause of fatal heart attacks in young women. The study's findings provide a potential new target for therapies to prevent SCAD.
Researchers have made a significant breakthrough in predicting heart attacks and strokes by developing a non-invasive method using super-resolution ultrasound imaging. The technology aims to detect high-risk atherosclerotic plaques that are prone to rupture, allowing doctors to prescribe life-saving interventions.
A meta-analysis found that bridging therapy, combining intravenous thrombolysis and mechanical thrombectomy, is associated with better chances of survival, functional independence, and robust blood flow returning to the brain after stroke. Researchers suggest this approach may be more effective than physical clot removal alone for peop...
Patients with severe coronary artery calcium have a significantly increased risk of major adverse cardiovascular events during thoracic radiation therapy for non-small cell lung cancer. The study found that patients with severe coronary artery calcium had a 21.4 times increased risk compared to those with no coronary artery calcium.
Researchers have discovered a new method to predict heart attacks by analyzing the gene expression of foamy macrophages, revealing a person's cardiovascular health. The study found that foamy cells can be both beneficial and detrimental depending on their behavior in individuals with certain conditions.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
Researchers at La Jolla Institute for Immunology found that macrophages in artery walls can sense octanal, leading to inflammation and atherosclerosis. By blocking this detection, they reversed disease progression. Further research is needed to explore the role of olfactory receptors in cardiovascular diseases.
A new issue of the CVIA journal has been published, featuring research on the clinical significance of angiographically detectable neovascularity in patients with cardiac myxoma. Studies found that ADN was present in 42.4% of patients and was associated with higher levels of eosinophils and low-density lipoprotein cholesterol.
Researchers have developed a custom finger clip device that measures blood pressure and other vital signs like heart rate, oxygen saturation, body temperature, and respiratory rate. The device uses photoplethysmography sensors and achieves an accuracy rate of about 90% for systolic blood pressure.
A study by Indiana University School of Medicine researchers suggests that reperfusion therapy may not be as effective in halting muscle damage during heart attacks as previously thought. The team's findings indicate that internal bleeding within the heart muscle can continue to cause damage even after the blocked coronary artery is op...
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
A new study from the University of Georgia found that overweight youth are developing signs of artery stiffness, a significant risk factor for cardiovascular disease. Researchers measured visceral fat levels and arterial stiffness in over 600 children, adolescents, and young adults, revealing higher levels of visceral fat and arterial ...
A study found that arterial stiffness increases with age, but hormonal fluctuations also play a role. Women's hormone levels, particularly estradiol and follicle-stimulating hormone, were associated with stiffer arteries, while older women had stiffer vessels regardless of hormone status.
The new guideline recommends a patient-centric approach to managing patients with coronary artery disease, incorporating clinical indications and multidisciplinary team decision-making. The guideline aims to improve quality of care and reduce disparities in treatment, particularly among women and underrepresented racial or ethnic groups.
A recent study published in Hypertension suggests that adolescent arterial stiffness may increase the risk of systolic and diastolic hypertension by 20% and 2-fold, respectively, seven years later. Higher arterial stiffness levels were also associated with an increased risk of abdominal and whole-body obesity.
A recent study published in Circulation found that patients receiving a combination of antiplatelet drugs for many months (up to 2.5 years) after stent procedures may not receive the full benefit of treatment. The researchers compared characteristics of 8,864 patients from an older trial to 568,540 contemporary patients and determined ...
A new risk score developed by Mount Sinai researchers can help predict possible contrast-associated acute kidney injury among patients undergoing PCI. The 'Mehran-2 CA-AKI Risk Score' enhances management of high-risk patients before, during, and after the procedure.
A new trial shows that the novel surgical device venous external support (VEST) may improve outcomes of coronary bypass grafting using leg veins by preventing intimal hyperplasia, a key factor in vein graft failure.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
Researchers at CNIC have identified the essential role of GPR126 in placental development, revealing its critical function in fetal growth and viability. The study also highlights a possible link between GPR126 dysfunction and pregnancy complications such as preeclampsia.
A study found that Hispanic adults with peripheral artery disease are 80% more likely to access inpatient care through the emergency room, leading to longer and more costly hospitalizations. This disparity highlights the need for improved outpatient care and education among this population to manage PAD effectively.
A new study found that QFR-guided PCI resulted in lower one-year rates of heart attack and a lesser chance of needing additional PCI, with a 35% reduction in mortality. The technology helped eliminate unnecessary stents and identified more obstructive lesions.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
A new study found that main renal artery plus branch ablation improves blood pressure in patients with resistant hypertension, a condition where traditional treatments fail. The procedure, which involves denervating the kidney's sympathetic nerves, showed promising results with no significant long-term benefits.
A study evaluated the clinical efficacy of a drug-eluting stent combined with a drug-coated balloon in treating left main coronary artery bifurcation lesions. The treatment resulted in low restenosis rates and no serious clinical events, making it a safe and effective option.
A new study found that women whose menstrual cycle length increased two years before menopause had better vascular health than those with stable cycles. Changes in cycle length may predict cardiovascular disease risk, allowing clinicians to recommend preventive strategies.
Researchers at Karolinska Institutet studied long-term outcomes of patients with pacemakers after transcatheter aortic valve replacement and found no significant difference in mortality. The study included over 3,400 patients, with 481 receiving permanent pacemakers within 30 days of surgery.
A study published in BMJ Open found a significant link between asymmetric brain arteries and the likelihood of developing a cerebral aneurysm. The research suggests that MRI and CT angiograms can be used to screen people with asymmetrical brain arteries for cerebral aneurysms, providing a new tool for monitoring those at risk.
A new study found that nearly 40% of Swedish adults aged 50-64 without known heart disease have some degree of atherosclerosis, according to researchers. This risk factor is often overlooked as having a zero calcification score, but can increase the likelihood of a heart attack, stroke or dying.
Researchers found that using the 'no-touch' technique to remove leg veins during coronary artery bypass surgery resulted in fewer blocked grafts and a lower incidence of recurrent chest pain. However, the technique was associated with more wound complications, particularly in female patients with type 2 diabetes or hypertension.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
Researchers develop novel models to investigate the impact of drug-eluting stents on arterial tissue permeability and blood flow. The study identifies key factors contributing to restenosis near stent edges, highlighting potential avenues for design improvements.
A study published in the Journal of the American Heart Association found that people with peripheral artery disease (PAD) living in poor or Black metropolitan areas have higher amputation rates. The analysis also noted significant disparities in healthcare access and quality among different racial and socioeconomic groups.
Researchers have developed a special polymer to coat blood vessels on transplanted organs, reducing rejection rates in mice by substantially diminishing immune system response. The breakthrough has the potential to eliminate the need for drugs that prevent organ rejection and improve transplant outcomes.
Researchers developed a new imaging technique that uses light and sound to detect plaques in arteries, potentially preventing strokes and heart attacks. The technique uses nanoparticles that absorb light and emit sound waves, allowing doctors to visualize the plaques in a non-invasive way.
A new study found that 44% of micro-arteries from patients had abnormal myogenic tone, associated with excessive caldesmon presence and poor cell alignment. This abnormality affects blood supply within the heart and other organs, impacting quality of life and life expectancy.
Researchers found that a mobile interventional stroke team treated patients faster and with better outcomes than standard care. Patients treated by the MIST team were more likely to be functionally independent at 90 days post-stroke.
A study found that women with severe large vessel occlusion ischemic strokes are approximately 11% less likely to be sent to comprehensive stroke centers compared to men. Stroke severity, travel distances, and comorbidities were similar between genders.
A recent study by the AIDS Clinical Trials Group found that nearly half of participants had atherosclerotic plaque in their coronary arteries, despite being considered at low-to-moderate risk. The study also revealed an association between plaque presence and higher levels of inflammation independent of traditional risk scores.