Articles tagged with Blood Brain Barrier
A team of researchers found that losartan, a commonly used hypertension drug, prevents post-traumatic seizures in a rodent model of the disease. The study suggests that blocking the TGF-beta receptor with losartan stops the cascade of steps that lead to localized inflammation and permanent brain damage.
A USF study found that compromised blood-brain barrier integrity in cerebral areas distant from initial ischemic insult can lead to chronic post-stroke deficits. Restoring endothelial and/or astrocytic integrity towards BBB repair is proposed as a potential therapeutic strategy.
A neurotensin conjugate has shown effective transportation across the blood brain barrier and dose-dependent pain relief in animal models. In contrast, hematopoietic stem cell transplantation has been found to impact T cell repertoire in multiple sclerosis patients, with diverse repertoires associated with better treatment responses.
Researchers at University of Pennsylvania develop method to deliver protein across blood-brain barrier, degrading Alzheimer's plaques by up to 70% in mice brains and human brain tissue. The approach uses cholera toxin B as carrier and myelin basic protein to break down amyloid beta chains.
Researchers found that injected methamphetamine significantly enhanced colonization of the lungs by Cryptococcus neoformans and accelerated progression of the disease. The fungus can cause a deadly brain infection when it crosses the blood-brain barrier, which is more susceptible due to drug-induced changes in the blood-brain barrier.
A team of researchers has successfully developed a method to breach the blood-brain barrier using the nasal lining, allowing for higher molecular weight drug delivery to the central nervous system. This breakthrough opens up new treatment options for neurodegenerative and CNS diseases affecting millions of people worldwide.
Researchers found that even routine hits can impact the blood-brain barrier and lead to an immune response. The study suggests a possible vaccine or drug therapy to prevent head trauma, offering new insights into concussions and their long-term consequences.
Researchers have developed an experimental molecular therapy that crosses the blood-brain barrier to reverse neurological lysosomal storage disease in mice. The therapy uses a modified enzyme called IDUAe1, which penetrates the blood-brain barrier and delivers large-molecule therapeutic agents to treat brain diseases.
A new Notre Dame study examines the dual-use aspect of nanotechnology research, exploring both its benefits and threats. The report discusses the potential for nano-sized particles to breach the blood-brain barrier and deliver targeted medicines, while also posing a serious threat in combat situations.
Researchers at Johns Hopkins Medicine have developed a new way of analyzing standard MRI scans to accurately measure blood-brain barrier damage in stroke victims. This could lead to better treatment outcomes and reduced risk of complications from clot-dissolving drugs, known as tPA.
A protein pair called Norrin/Frizzled-4 plays a crucial role in managing the blood vessel network that serves the brain and retina. The study reveals a dual role for the protein pair, with one job forming the network's proper architecture during fetal development and another maintaining the blood-brain barrier after birth.
Researchers found a new class of antibody in camelids that can cross the blood-brain barrier, diffusing into brain tissue to reach specific targets. This breakthrough may lead to enhanced imaging and improved drug delivery for people with brain diseases like Alzheimer's.
Research indicates diets high in saturated fat and refined sugar may impair brain function in obese individuals, leading to increased overconsumption of high-calorie foods. Obesity-related changes may also lead to permanent cognitive decline, making it a lifelong battle to maintain weight loss.
Scientists at the University of Wisconsin-Madison have created cells that mimic the blood-brain barrier, a filter that separates the brain from circulating blood. These cells hold promise for streamline drug discovery and modeling neurological diseases.
Researchers have identified several South African daffodil plant compounds that can potentially bypass the blood-brain barrier, a key challenge in developing new antidepressant drugs. The study's findings, published in the Journal of Pharmacy and Pharmacology, offer hope for the development of novel treatments for depression.
A new technique published in JoVE uses MRI-guided microbubbles and focused ultrasound to disrupt the blood-brain barrier, potentially opening new treatment avenues for devastating conditions like Alzheimer's and brain cancers. The method is safer than current methods, which can leave large areas of the barrier exposed to toxins.
Researchers at University of Copenhagen mapped a previously unknown biological mechanism in the brain's blood-brain barrier, revealing its vital role in maintaining glutamate balance. The discovery has enormous potential for future drug development and could lead to new treatments for neurological diseases.
Researchers at Whitehead Institute found that brain glia cells increase their DNA content through polyploidization to maintain the blood-brain barrier. This process allows for growth while keeping the barrier intact, as seen in other tissues like the placenta and skin.
Columbia University researchers developed a technique to reach neurons through the blood-brain barrier using short ultrasound pulses, enabling safe and noninvasive drug delivery. The study aims to improve treatment options for devastating neurological disorders.
Researchers found that adenosine can modulate the entry of large molecules into the brain, establishing a gateway into the blood-brain barrier. They successfully transported large dextrans and antibodies into the brain using an FDA-approved drug, Lexiscan.
A recent study found that HIV infection in astrocytes breaks down the blood-brain barrier, leading to cognitive impairment and other neurological complications. The researchers suggest that minute numbers of infected astrocytes can trigger a cascade of signals that open the brain to toxic influences.
University of South Florida researchers have found that the blood-brain barrier is structurally and functionally damaged in mice with Sanfilippo syndrome type B. This damage may lead to destruction of the central nervous system equilibrium and accelerate neuropathological changes in the disease.
Researchers at Karolinska Institutet have found a potential solution to the blood-brain barrier problem, allowing for the transport of molecules into the brain while preserving basic functions. The discovery, led by Professor Christer Betsholtz, could lead to new therapies for Alzheimer's and stroke.
Researchers at Rensselaer Polytechnic Institute are developing new technology to push drugs through the blood-brain barrier, directly targeting brain tumors. The goal is to deliver treatments for diffuse malignant glioma, a lethal type of brain cancer with no cure.
A University of South Florida-led study finds that mannitol boosts the therapeutic effectiveness of human umbilical cord blood cells in treating cerebral palsy. Mannitol helps open the blood-brain barrier to facilitate entry of beneficial cells and promote neurotrophic factor effects.
A team of researchers from Ben-Gurion University and UC Berkeley have identified a TGF Beta Blocker that prevents epilepsy in rats after brain damage. The blocker blocks hyper-excitability and gene expression changes that lead to epilepsy.
A study published at Experimental Biology 2009 found that regular exercise prevents the disruption of the blood-brain barrier caused by methamphetamine use. The study showed that exercising mice were protected from increased oxidative stress and permeability in the brain, while sedentary mice experienced damage.
Researchers at Virginia Tech will explore the development of novel methods for delivering chemical antidotes that can mitigate the devastating effect of organophosphate-based neurotoxicants. The team aims to use nanoparticles called fullerenes to enhance their water solubility and catalytic properties, which could potentially protect a...
Researchers explore approaches to preserve BBB function and permit effective medicine passage. One technology involves targeting endogenous nutrient transporters, such as SLCs, to facilitate small molecule transport across the BBB.
Researchers have developed a novel drug delivery system that can cross the blood-brain barrier to reach and kill cancer cells in the brain. The technology has shown promise in preclinical trials, with increased survival rates and reduced tumor growth in mice and rats.
A new study published in Nature Medicine reveals why tPA, the most effective emergency stroke treatment, carries risks of brain bleeding. Researchers found that the leukemia drug Gleevec inhibits a protein receptor involved in this effect, suggesting it could prevent problems and improve treatment outcomes.
A daily dose of caffeine has been shown to protect the blood-brain barrier from damage caused by high cholesterol, a risk factor for Alzheimer's disease. Caffeine maintains tight junction protein expression, preventing unwanted molecule entry into the central nervous system.
Researchers outline the blood-brain barrier's role in neurological disorders, calling for more studies and resources to overcome delivery obstacles. They propose interdisciplinary collaborations to develop new therapies for diseases like Alzheimer's and multiple sclerosis.
An international team of scientists proposes strategies to overcome obstacles posed by the blood-brain barrier, a gate-keeping system protecting the brain from toxins and letting in nutrients. The review article highlights the importance of understanding the blood-brain barrier in treating brain diseases such as Alzheimer's, multiple s...
Researchers at Saint Louis University have discovered a way to deliver medicine to the brain for treating Sly Syndrome, a rare genetic disorder. The breakthrough uses epinephrine to induce the enzyme beta-glucuronidase, which is missing in patients with Sly Syndrome.
Immunology researchers at Jefferson University have found that blood-brain barrier damage correlates with multiple sclerosis (MS) severity. The study used mice models and found that permeability changes are critical in disease development, with even mice lacking immune system components able to develop disease.
Researchers delivered antisense oligonucleotides through cerebrospinal fluid to treat neurodegenerative diseases like ALS. The therapy effectively modulated protein levels and slowed disease progression in rats.
The American Institute of Ultrasound in Medicine has awarded a New Investigator Award to Dr. Elisa Konofagou for her groundbreaking work on treating neurodegenerative diseases using ultrasound-induced blood-brain barrier opening. Seven nominees presented their research, showcasing the diverse applications of ultrasound technology.
A new study reveals that targeting the brain chemical methionine enkephalin (Met-Enk) with antisense molecules can alter brain function and increase alcohol consumption in mice. This breakthrough could lead to a new class of drugs for treating Alzheimer's disease and possibly even alcoholism.
Researchers have found a way to get drugs past the blood-brain barrier to treat brain cancer. The compound JV-1-36, an antagonist of the hypothalamic growth hormone-releasing hormone, has shown promising results in treating malignant glioblastomas.
Saint Louis University researchers discovered that the blood-brain barrier has a transport system for enzymes that is lost with aging. This discovery opens up new possibilities for treating lysosomal storage diseases by targeting the blood-brain barrier's delivery mechanism.
Researchers identified 80 genes in the blood-brain barrier activated by Group B Streptococcus, a leading cause of bacterial meningitis. These genes triggered an immune response by mobilizing neutrophils to combat infection.
Researchers discover that Alzheimer's protein amyloid beta is transported into the brain by riding piggyback on a larger molecule called RAGE. This discovery opens up new possibilities for treating the disease. By blocking RAGE, blood flow to the brain can be restored and amyloid plaques reduced.
OHSU researchers successfully delivered chemotherapy across the blood-brain barrier for patients with primary central nervous system lymphomas. The study showed that 93% of treated patients achieved a complete response and participating centers outperformed OHSU in blood-brain barrier disruptions.
A study published in Neurosurgery found that 42% of patients survived five years or more after receiving enhanced chemotherapy through blood-brain barrier disruption. The treatment also showed no cognitive loss or impairment in 36 patients, contrary to previous studies.
Researchers at University of Maryland School of Medicine identified zonulin and zot proteins in human brain that regulate the blood-brain barrier. This discovery could lead to new treatments for brain disorders such as Multiple Sclerosis, Alzheimer's disease, and HIV infection.
Researchers have found a secondary barrier in the brain that prevents certain drugs from reaching tumors and neurological disorders. The barrier is called the basement membrane and traps stealth agents while allowing others to pass through, highlighting challenges for gene therapy and drug delivery.