Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
A University of Houston researcher has developed a new method to detect cancer using PANORAMA imaging and fluorescent imaging, achieving a 98.7% accuracy rate. The method analyzes the number and cargo of small EVs in patients' blood samples, allowing for early detection and improved treatment efficacy.
A clinical trial led by Mount Sinai researchers shows zodasiran, an RNA inhibitor targeting ANGPTL3, significantly reduces various types of cholesterol and triglycerides. The therapy also lowers apolipoprotein B, a lipid-transporting protein linked to heart disease.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Researchers at the State University of Campinas found that daily consumption of jaboticaba peel improved glucose metabolism even after meals. The study showed lower post-prandial glycemia and less inflammation in volunteers with obesity and metabolic syndrome.
A team of researchers led by Dr. Ahmed discovered that two FDA-approved antibiotics can induce heart regeneration in mammals, showing promise for treating heart failure. The study found that the antibiotics improved cardiac output and reduced fibrotic scar tissue, suggesting a potential new therapy.
A study published in JAMA Surgery found that bariatric surgery significantly reduces the risk of breast cancer in women with obesity, particularly those with high blood insulin levels. The results show a 32% lower risk overall and a 52% lower risk for women with high insulin levels at the start of the study.
Researchers at UC Santa Cruz discovered a secondary population of platelets that appears with aging, exhibiting hyperreactive behavior and unique molecular properties. This 'shortcut' pathway bypasses normal differentiation processes, producing problematic cells that can cause blood clotting diseases.
A University of Saskatchewan researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer's disease. These 'mini-brains' more accurately reflect a fully-fledged adult human brain, allowing for closer examination of neurological conditions.
Researchers at Duke University have developed a synthetic molecule that mimics the effects of compounds in the saliva of blood-sucking critters, providing a dual-action anti-clotting function. The new molecule can be swiftly reversed, enabling clotting to resume when needed after treatment.
Researchers developed a synthetic biomarker technology that can differentiate between prior Zika and dengue virus infections. The technology, using epitope surrogates, correctly identified people previously infected with Zika virus 85.3% of the time.
A new study suggests that countries should prioritize tuberculosis treatment for exposed individuals with evidence of TB infection, regardless of age—except in high-burden settings, where all exposed individuals should be considered for treatment. Preventive treatment can stop latent TB infections from developing into deadly TB disease.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers developed a non-invasive imaging technique to visualize cardiac micro-vessels in high resolution, enabling better understanding of cardiovascular diseases. The study improves diagnosis and treatment of conditions like microvascular coronary disease and cardiomyopathies.
A new screening algorithm combining maternal history, ultrasound data and several tests for blood markers may predict most preeclampsia cases in the first trimester of pregnancy. The study found that personalized risk-based treatment decisions may improve adherence to preventative measures.
Researchers at UCLA Health have developed a potential biomarker for stroke risk using a network of inflammatory molecules in the blood. The study, published in the journal Stroke, found that patients with higher concentrations of these molecules had an 84% chance of experiencing a stroke during their lifetime.
Scientists have identified a shared gene module in people with depression and cardiovascular disease, providing new markers for both conditions. The study found that genes involved in inflammation are associated with both diseases, explaining why they often occur together.
Adults with type 1 diabetes who use modern hybrid insulin pumps experience significant improvements in blood sugar levels, reducing the risk of organ damage by up to three hours per day. The treatment also reduces the time spent with low blood sugar levels and is associated with high patient satisfaction.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
Researchers at Gladstone Institutes have identified a blood coagulation protein, fibrin, as the culprit behind toxic inflammation and neuron loss after a major head injury. This finding can inform new treatment strategies for traumatic brain injuries, which often lead to dementia, depression, and difficulty concentrating.
Researchers found that individuals from certain racial and ethnic groups are less likely to be eligible for Alzheimer's disease clinical trials due to lower amyloid levels at early stages of the disease. Amyloid buildup in the brain varies across different populations, contributing to underrepresentation in clinical trials.
Researchers discovered that certain bacteria, including Salmonella enterica and Escherichia coli, are attracted to human serum, which contains the amino acid serine. This phenomenon, known as bacterial vampirism, allows the bacteria to navigate towards the source of blood in under a minute.
Researchers analyzed blood stem cells in mice with prior sepsis and found they were fully recovered but failed to respond to a second inflammatory stimulus, leading to inefficient immune cell production.
Researchers mapped the distribution of lone star ticks, a dominant tick species in Georgia, to identify areas with high prevalence. The study found that these regions contain sweet spots for lone star ticks, including forested areas of mid-elevation and soils retaining moisture but not swampy.
A new study has identified alpha-1-antichymotrypsin as a blood protein marker that can predict delayed recovery of concussion in children. The study found that children with low levels of alpha-1-antichymotrypsin were more likely to experience delayed recovery, highlighting the potential for early diagnosis and targeted treatment.
Studies at the University of Gothenburg found a clear shift in arterial disease risks in diabetes, with decreases in central organ diseases like heart attack and stroke, but increases in peripheral vessel complications. Closer monitoring of long-term blood sugar levels can reduce peripheral arterial disease risk by 30-50%.
New data suggest that blood-based colorectal cancer screening tests could lead to more cases and deaths than established methods, despite improving outcomes for unscreened individuals. The tests are predicted to be less effective and more costly, making them unsuitable replacements for current screening programs.
Scientists have discovered six proteins that can accurately diagnose tuberculosis (TB). The breakthrough study paves the way for a simple blood test to detect the bacteria, which could prevent millions of cases annually. TB is the world's deadliest infectious disease, killing over one million people each year.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
Researchers found that daily cranberry extract consumption for 28 days improved running speeds by 1.5% and reduced post-exercise blood lactate levels. The study also showed increased muscle oxygenation rates and slower deoxygenation.
A new study finds that e-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers. The researchers also found that some smoking-related epigenetic changes remain more stable after giving up smoking, suggesting that e-cigarettes may not be completely safe.
Researchers at Rensselaer Polytechnic Institute have developed a patented process to produce heparin in the lab, offering a consistent and safe supply of the essential medicine. The discovery has the potential to revolutionize the production of heparin, reducing reliance on animal-derived sources and addressing global supply chain issues.
Tulane University researchers have developed a CRISPR-based platform for diagnosing nontuberculous mycobacteria (NTM) infections, allowing for accurate results in as little as two hours. The blood test can identify over 93% of patients with an NTM infection, enabling rapid treatment plans and reducing the risk of complications.
Researchers analyzed molecular data from brain tissue and blood of individuals who committed suicide, identifying risk markers for novel therapeutic targets. The study found alterations in the prefrontal cortex and inhibitory neurotransmitters, highlighting potential new approaches for preventing suicidal behavior.
Researchers found associations between prenatal vitamin and metal exposures and epigenetic aging biomarkers in early life. A one standard deviation increase in essential metals was associated with lower Horvath EAA at birth, while arsenic was linked to greater EAA at birth and in childhood.
Researchers at Staffordshire University and the University of Hull studied bloodstain patterns in microgravity, revealing unique challenges for forensic investigators. The study found that amplified surface tension and cohesion cause blood droplets to stick to surfaces, leading to slower spread rates and altered shapes.
A new study has revealed a molecular fingerprint of biological aging, shedding light on why people age differently. The researchers identified 25 metabolites that can reflect biological age, known as the Healthy Aging Metabolic (HAM) Index, which was found to be more accurate than other aging metrics.
Researchers at the University of Virginia Health System are developing a technique to 'paint' tiny nanoparticles on transplanted veins to prevent blockages, potentially sparing patients from repeated surgeries. This approach could significantly reduce the number of vascular reconstructions performed annually in the US.
Research from UCSF found COVID antigens lingering in blood up to 14 months and tissue samples for over two years after infection. The persistence of these fragments may drive long COVID symptoms and associated risks.
A U.S.-Canadian research collaboration identified common blood changes as a risk factor for acute kidney injury (AKI) in over 1 in 5 hospitalized adults. The discovery may lead to new, more effective treatments for AKI and prevent its progression to end-stage renal disease.
Researchers at XPANCEO and Nobel laureate Konstantin S. Novoselov unveil new properties of rhenium diselenide and rhenium disulfide, enabling novel light-matter interaction. This breakthrough has huge potential for integrated photonics, healthcare and AR applications.
Researchers at Aarhus University have developed a new cell-based assay to measure total cortisol levels accurately, improving diagnosis and treatment of stress-related illnesses and chronic conditions. This method has the potential to reduce misdiagnoses and side effects, enabling more precise treatment.
The new guidelines recognize the aorta as an independent organ, bundling its treatment with other specialties. This holistic approach improves treatment outcomes for patients with aortic rupture and other serious diseases.
A study of routine fecal occult blood testing found a significant decrease in colorectal cancer mortality in Sweden. The association between screening and reduced mortality is expected to be higher due to co-existing testing and delayed diagnoses.
Researchers at the University of Waterloo have developed a rapid blood testing method that can detect fentanyl and other opioids in under three minutes, making it twice as quick as traditional approaches. This new technique has the potential to save lives by quickly identifying overdoses.
Researchers found that pulse oximeters underestimate blood pumping and overestimate resistance, affecting treatment decisions. Direct blood oxygen measurement is crucial for accurate guidance, especially for Black patients already at higher risk.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
Researchers developed a test to predict which heart attack patients are likely to experience dysfunction after receiving mechanical pumps. The test measures pulmonary vascular compliance and its adaptability, helping doctors prevent right ventricle failure.
Researchers identify a promising prognostic biomarker for lung cancer using circulating tumor DNA-based minimal residual disease detection. The study found that this method can effectively guide treatment decisions and predict recurrence risk, potentially modifying the lung cancer treatment paradigm.
Researchers from Brigham and Women's Hospital propose innovative solutions to address the global blood crisis, including civilian walking blood banks and intraoperative auto-transfusion. These short-term strategies aim to increase access to blood transfusion in rural settings, where millions of people lack basic medical care.
Researchers at Uppsala University have developed a tool that uses standard blood test results to identify individuals at increased risk of having a heart attack within six months. The study analyzed data from 169,053 individuals and identified 90 molecules linked to a first heart attack.
Researchers found that injecting a substance to block an artery and combining it with surgery significantly reduced the risk of repeat surgery for patients with subdural hematomas. The study, published at the American Stroke Association's International Stroke Conference, showed a nearly 3-fold reduction in re-operation rates.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
A new blood test developed by Indiana University School of Medicine has identified biomarkers that can objectively measure schizophrenia severity and predict future risk. The test enables personalized treatment matching, reducing uncertainty and improving patient outcomes.
Researchers found that adding blood thinners to clot-busting medications for ischemic strokes did not improve physical function at 90 days post-stroke. The study, MOST, enrolled 514 patients and analyzed the effectiveness of two blood-thinning medications.
Researchers found that positioning stroke patients with large vessel ischemic strokes at 0-degrees resulted in significant improvements in neurological function compared to those with 30-degree head positioning. This approach optimized blood flow through the narrowed artery and improved collateral arteries, leading to better outcomes.
Johns Hopkins researchers have made progress toward developing a blood test to identify disease-associated changes in the brain linked to postpartum depression and other psychiatric disorders. They identified 26 placental mRNAs present in maternal blood only during pregnancy, which reflected changes occurring inside the tissues.
Researchers found a four-fold increase in immune response when people alternate arms during two-dose vaccinations. The study showed improved immunity to the original and omicron variants after three weeks and persisted beyond 13 months.
Researchers discovered a new role for Mfsd7c in exporting excessive choline from the brain. The study suggests that targeting this protein could lead to therapeutic interventions for Alzheimer's disease and other neurological disorders.
A study of over 1,700 adult patients found that gastric bypass and sleeve surgeries have few short-term complications and are equivalent in terms of risk. The results suggest that patients and doctors can choose between the two procedures without worrying about short-term surgical risks.
Researchers developed an AI algorithm to monitor patient variables and predict sepsis before symptom onset. The tool resulted in a 17% reduction in mortality rates.