Articles tagged with Liver
Researchers investigated 56,000 participants and found daily drinking significantly increases the risk of alcoholic cirrhosis. Recent alcohol consumption, not lifetime consumption, is the strongest predictor of this condition.
A new preservation system that uses machine perfusion keeps livers healthier for up to nine hours before transplantation, leading to better liver function and increased survival rates. The system has shown promising results in animal studies, with 100% of pigs surviving after receiving perfused livers.
Scientists have developed a breakthrough culturing system for human liver stem cells and pancreatic cancer stem cells, allowing for the growth of mini-organisms in the lab. This technology has the potential to revolutionize liver transplantation and aid in the fight against pancreatic cancer, with applications in personalized medicine.
A novel nomogram was developed by UCLA researchers to accurately calculate the risk of disease recurrence in liver cancer patients after a liver transplant. The tool uses pre-transplant radiologic information, blood biomarkers, and pathological characteristics to predict recurrence rates.
Experts argue that widespread hepatitis C screening may not lead to net clinical benefit, citing potential harms and a lack of strong evidence. Many patients infected with hepatitis C will not develop end-stage liver disease, rendering unnecessary treatment.
Researchers at the University of Michigan have identified how a promising drug, amlexanox, improves sugar metabolism by generating a new signal between fat cells and the liver. The findings suggest a new pathway for future treatments for obesity, diabetes, and fatty liver disease.
A 24-week course of sofosbuvir and ribavirin prevents HCV recurrence after liver transplantation, with positive outcomes for short- and long-term health. The therapy is effective in 70% of patients, including those with advanced disease.
A recent study published in the Journal of Clinical Gastroenterology found that liver cirrhosis is more common than previously thought, affecting approximately 633,000 adults in the US yearly. The study also revealed that 69% of these individuals may not be aware they have the disease.
Researchers discovered that triglyceride production in the liver is independent of insulin action, contributing to health risks in type 2 diabetics. The study's findings provide new insights into non-alcoholic liver disease and potential treatments.
A 30-year study found that neonatal HBV vaccination significantly reduced the risk of primary liver cancer and other liver diseases in young adults. The study's results show that vaccination led to a 84% reduction in liver cancer incidence, highlighting the importance of early intervention.
Researchers found that blocking excessive mitochondrial fission reduced reactive oxygen species production and liver cell death in cholestasis. The study suggests novel therapies targeting this process could prevent liver damage.
Penn researchers developed mathematical models of collagen matrix stiffness, providing insights into fibrosis, cirrhosis, and certain cancers. The models show that nonlinear elasticity can arise from the ECM's fibrous structure, allowing for long-range force transmission and bridging formation.
Many HCV patients are lost in healthcare due to inadequate screening, testing, and treatment. A new study found that up to 70% of those with acute infection have no symptoms until years later.
Researchers have identified a compound in Korean mistletoe that can help treat nonalcoholic fatty liver disease. Viscothionin, the key ingredient, has been shown to reduce body and liver weights in obese mice, suggesting its potential as a therapeutic agent.
A team of researchers found that inhibiting the intestinal farnesoid X receptor with drugs like tempol and antibiotics can prevent nonalcoholic fatty liver disease in mice. This discovery highlights the complex role of gut microbes in human health and potential targets for treating metabolic disorders.
Researchers develop a propionate supplement that targets gut hormone release, leading to reduced food intake and fat distribution. The study shows significant weight loss and fat reduction in participants taking the supplement, with minimal side effects.
A study published in Liver Transplantation found that liver transplant recipients with limited literacy struggle to understand and adhere to their medication regimens, resulting in higher rates of organ rejection and graft loss. The study suggests that improving treatment knowledge and regimen use can reduce post-transplant re-hospital...
Scientists have developed a method to transmute living cells into more permanent materials that defy rot and can endure high-powered probes. This technique is widening research opportunities for biologists developing cancer treatments and materials scientists creating commercially useful shapes.
Indiana University researchers are developing a computational model to predict acetaminophen-induced liver failure, using advanced microscopic and computational technologies. The model aims to reduce the use of animals in toxicity studies while enabling realistic scientific predictions for environmental and human health problems.
Medical experts call for radical improvements in UK liver disease treatment and detection, citing a 'postcode lottery' for patients. The commission recommends increasing specialist centers and improving primary care services to address excessive alcohol use and obesity.
Researchers are developing a new type of cell therapy to treat liver cirrhosis, which claims 4000 lives in the UK each year. The therapy aims to reduce scarring and rebuild the damaged organ from within using macrophages.
Two new treatments for liver diseases are being explored. A probiotic, VSL#3, has been shown to improve liver function and reduce the risk of hospitalization in patients with cirrhosis. Meanwhile, a fatty acid conjugate called Aramchol has been found to significantly reduce liver fat content in patients with nonalcoholic fatty liver di...
Researchers at University of California, San Diego School of Medicine found that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms relevant in humans. Long-term exposure to the chemical may lead to liver toxicity, particularly when combined with other compounds.
A position paper by ESPGHAN Hepatology Committee outlines recommendations and a checklist for liver biopsy in infants and children. Liver biopsy is still necessary in follow-up after liver transplantation and for monitoring disease activity.
Researchers at the University of Georgia discovered that chlorogenic acid significantly reduced insulin resistance and fat accumulation in mice fed a high-fat diet. The compound also maintained normal blood sugar levels and healthy liver composition.
Researchers found that mice eat less when their liver stores high levels of glucose, suggesting a link between the liver and brain in regulating appetite. The study's findings could lead to new therapeutic targets for improving diabetes and obesity.
A new oral interferon-free therapy has produced significantly fewer side effects and is prescribed for 24 weeks. Cirrhosis caused by hepatitis C is the leading reason for liver transplantation in the U.S., with patients having lower survival rates than those transplanted for other causes of cirrhosis.
Researchers at Mayo Clinic found that a new oral medication combination therapy is safe and beneficial for liver transplant patients, requiring only 12 weeks of treatment. The study showed excellent eradication of the virus with much fewer side effects compared to traditional interferon-based therapies.
A new experimental drug, obeticholic acid, has improved liver health in people with nonalcoholic steatohepatitis (NASH) by reducing inflammation and fat. However, the treatment was associated with increased total cholesterol levels, a potential risk factor for cardiovascular disease.
The rate of hospitalization due to hepatitis A virus infection has declined significantly in the US, with a decrease from 0.72 to 0.29 per 100,000 cases between 2002 and 2011. Vaccination of adults with chronic liver disease may help prevent HAV infection and hospitalization.
Researchers found that bald and golden eagles in North America have dangerously high levels of polybrominated diphenyl ethers (PBDEs) in their livers, with concentrations highest near urban areas. The study suggests a range of exposure to these toxic chemicals, with more research needed to understand trends and accumulation patterns.
Newborn rats showed increased uptake of vitamin A in tissues beyond the liver after supplementation, providing insight into neonatal nutritional needs. This research could inform evidence-based dietary recommendations to reduce infant mortality in developing countries.
Researchers will investigate how the Western diet increases the risk of developing liver and gastrointestinal cancers. They also aim to determine if specific bifidobacteria species can mitigate the negative effects of a high-fat, high-sugar diet.
A new preservation technique, sequential subnormothermic ex vivo liver perfusion (SNEVLP), has been shown to prevent ischemic type biliary stricture following liver transplantation using grafts from donations after cardiac death (DCD). SNEVLP reduces bile duct and endothelial cell injury post-transplantation compared to cold storage.
Researchers found that dietary iron plays a crucial role in regulating the liver's circadian clock, which can disrupt blood glucose levels. Eating high-iron foods at night may exacerbate this issue for shift workers, increasing the risk of metabolic disorders. More research is needed to determine optimal iron intake for shift workers.
A team of scientists led by Prof. Mathias Heikenwälder found that immune cells, particularly CD8+ T cells and NK T cells, play a crucial role in the development of fatty liver disease, non-alcoholic steatohepatitis (NASH), and liver cancer. The study suggests that an existing metabolic imbalance triggers the activation and migration of...
A Mount Sinai-led research team has discovered a new kind of stem cell that can become either a liver cell or a blood vessel cell, contradicting current theory on organ development. This discovery may hold clues to the origins of and future treatment for liver cancer.
Researchers discovered that high levels of the inhibitor TIMP-1 induce local inflammation in liver tissue, allowing tumor cells to form metastases. By understanding this mechanism, scientists can develop new treatments to prevent cancer progression and metastasis formation.
Researchers used an epigenetic clock to measure the biological age of liver tissues in obese subjects, finding a significant acceleration of liver aging. The study suggests that obesity may contribute to the premature development of age-related diseases such as liver cancer and insulin resistance.
Researchers found that decaf coffee consumption was linked to lower levels of abnormal liver enzymes in a study of over 27,000 participants. The study suggests that chemical compounds in coffee other than caffeine may help protect the liver.
Researchers at MU School of Medicine identified epigenetic protein changes caused by binge drinking, which can amplify liver damage and lead to chronic liver failure. The study suggests that excessive alcohol consumption with a binge drinking pattern is a major public health concern globally.
Researchers found compounds in Camelina sativa seed that increase liver detoxification enzymes fivefold, showcasing its potential as a nutritional supplement and anti-cancer agent. The bioactive ingredients work synergistically when combined, similar to sulforaphane in broccoli.
Researchers at the University of Pittsburgh School of Medicine are developing a state-of-the-art 3D liver model to better predict organ physiology, assess drug toxicity and build disease models. The project aims to improve ways of predicting drug safety and effectiveness through collaboration with researchers from 11 institutions.
Scientists have developed a method to inject tonsil-derived stem cells into damaged livers, potentially treating liver disease without surgery. The technique uses a heat-sensitive liquid to grow liver cells on a 3-D scaffold, showing promise as an injectable tissue engineering approach.
Researchers have developed a magnetic resonance technique to detect and quantify fat in the liver, improving upon traditional hepatic biopsy methods. The study uses magnetic resonance imaging (MRI) to measure liver fat content with high accuracy, providing valuable insights for diagnosing and monitoring liver diseases.
Researchers have found that ATF4 levels are elevated in livers of mice exposed to interventions increasing longevity. The protein is shared across diets, drugs, genes, and developmental alterations extending lifespan.
The Mayo Clinic has developed a scoring system to identify patients who can safely bypass the intensive care unit (ICU) after liver transplantation. The study found that 54.3% of patients can be fast-tracked, with better survival rates compared to those sent to the ICU.
A new study found that living liver donor candidates often experience ambivalence regarding donation, which is linked to physical, psychosocial, and financial concerns. Providing social support can help mitigate these concerns and reduce ambivalence among living liver donors.
A recent study found a significant increase in liver injury caused by herbals and dietary supplements in the US population over a ten-year period. Non-bodybuilding supplements were more likely to result in death or liver transplantation compared to conventional medications.
Using Extracorporeal Membrane Oxygenation (ECMO) has increased the number of organs available for transplant after circulatory death by 20%. This technology improves organ viability, particularly for kidneys, livers, and pancreases, making more life-saving organs available for patients waiting for transplants.
New research reveals that broader organ sharing for liver transplants will not negatively impact Cold Ischemia Time (CIT) but will increase the percentage of organs transported by flying, according to findings published in Liver Transplantation.
A novel complement inhibitor has been found to reduce liver cell death and stimulate post-surgery liver regrowth in mice. The treatment increased survival rates from 0% to 70% even after removing up to 90% of the liver. This breakthrough could represent a new treatment strategy for various liver injuries in humans.
Researchers at UCI found that two circadian-linked proteins, SIRT1 and SIRT6, manage separate and distinct metabolic processes in the liver. This discovery sheds new light on how the body's internal clock influences metabolic functions and could lead to more targeted treatments for liver disease and related disorders.
A new study finds that a Minimum Unit Price (MUP) policy would have a significant impact on heavy drinkers with cirrhosis, while leaving low-risk moderate drinkers unaffected. The policy targets the cheapest booze and heaviest drinkers, reducing their risk of liver deaths by 200 times.
Researchers have identified a combination of pills that cures 9 out of 10 hepatitis C patients, achieving a 93% cure rate in 12 weeks. The treatment was well-tolerated by patients and offers a higher cure rate than previous standard care.
A global prevalence study reveals that HCV genotype 1 accounts for over 46% of all cases, followed by genotypes 3 and 2. The study emphasizes the importance of understanding viral genotype to develop new treatments for HCV.
Two new pill-only antiviral drug regimens have shown promise in treating the most difficult-to-cure form of hepatitis C, with high cure rates and minimal side effects. The treatments offer a more effective, safer, and shorter option for patients with cirrhosis or those who have failed existing therapies.
A six-month treatment with tesamorelin lowered liver fat modestly but significantly in HIV patients. The drug's impact on glucose metabolism was temporary, and reduced liver inflammation may result from lower fat levels.
A study found that HIV-infected patients with excess abdominal fat experienced modest reductions in liver fat after receiving tesamorelin, a growth hormone-releasing hormone analog. The treatment also led to significant decreases in abdominal fat accumulation.
A new study by University of Granada researchers shows that consuming probiotics for 30 days can significantly reduce liver fat accumulation in obese rats. This finding is a promising step forward in the fight against Non-Alcoholic Fatty Liver Disease, which is closely linked to obesity and diabetes.