Articles tagged with Academic Journals
A study found 161 differentially expressed genes in individuals with opioid dependence, including genes involved in immune and inflammatory processes. The researchers also developed a transcriptomic aging clock that predicts chronological age from gene expression patterns.
A pilot study by Bayes Business School found that shoppers using digital screens on their supermarket trolleys spent up to 32% more than those without. The study recorded significant spikes in spending and consumption among 'superusers' who engaged with the technology most.
Taylor & Francis is sharing standardized metadata for all new journal articles, including funding information and author details. Participating institutions will receive automated real-time notifications when their researchers publish in Taylor & Francis journals.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
Taylor & Francis introduces Plain Language Reviews to make technical information accessible to non-specialists. These open-access articles summarize multiple peer-reviewed articles on a single topic, empowering readers with complete understanding.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
Kirsten Bibbins-Domingo has extended her contract as JAMA and JAMA Network Editor in Chief through 2031. She brings fresh perspective and intellectual rigor to the prestigious journal, strengthening its influence worldwide. The JAMA Network has launched initiatives to expand engagement and support medical researchers.
Researchers find that targeting Trk and IGF1R pathways can delay Ewing sarcoma tumor growth, but effect is temporary. NTRK gene expression associations with patient OS were found, indicating potential biomarker value.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
Qassim University researchers can now publish their work openly in hundreds of top journals, increasing international collaboration and knowledge exchange. The partnership supports the university's values of transparency, innovation, and collaboration, and aims to amplify its growing research influence.
A new combination therapy selectively targets cancer cells and senescent cells by exploiting metabolic vulnerabilities, improving physical performance and extending lifespan. The treatment eliminates senescent cells, reduces cancer cell viability and improves metabolic profiles in aged mice.
The article proposes a healthspan-focused framework for Italy's National Health Service to promote healthy aging, prevent chronic diseases, and improve functional independence. The framework emphasizes prevention-oriented approaches, personalized healthcare, and multidisciplinary research.
A review highlights the role of culturally rooted practices in oral squamous cell carcinoma (OSCC) risk across global populations. Culturally sensitive prevention strategies combining education, harm reduction, and community engagement are crucial in reducing OSCC incidence and disparities. Dermatologists can play a key role in early c...
Researchers found that long-term systemic treatment with senolytic PROTAC 753b slowed several features of age-related intervertebral disc degeneration in male mice, preserving extracellular matrix protein aggrecan and reducing inflammatory markers. However, female mice showed little improvement, suggesting a sex-specific response.
Two interconnected signaling pathways, MAPK and PI3K/AKT, drive papillary thyroid carcinoma development and progression. Molecular diagnostics and targeted therapies are transforming treatment approaches.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
The Bulgarian Association of Clinical Immunology (BACI) has joined forces with Pensoft Publishers to host its official journal, Immunology in Medicine, which now operates under the open-access platform ARPHA. The journal aims to bridge basic immunological science with clinical applications, inviting researchers and clinicians to submit...
A new precision oncology paper presents a case of a 48-year-old woman with multiple primary cancers, including breast cancer, basal cell carcinoma, ovarian carcinoma, colon cancer, and small bowel adenocarcinoma. The study demonstrates how an international molecular tumor board developed personalized treatment recommendations based on ...
Researchers found that preserving peroxisomes preserves mitochondrial health during aging by maintaining long, interconnected mitochondrial networks and reducing oxidative stress. The study identifies peroxisome homeostasis as a promising area for future aging research.
Researchers discovered that senescent cells accumulate high levels of triacylglycerols and increase glycolytic activity, leading to increased lipid droplet accumulation. This finding suggests that lipid droplets may contribute to the harmful effects of senescent microglia in Alzheimer’s disease.
A rare case report highlights the challenges of diagnosing cervical angioleiomyoma, a benign tumor presenting symptoms similar to those of common gynecological conditions. The study describes a successful surgical excision and excellent clinical outcome for a young woman with persistent heavy menstrual bleeding and pelvic pain.
The proposed OMB rule change would fundamentally alter how federal research funding is allocated in the US, compromising research independence and restricting international collaboration. PLOS argues that costs linked to making research available should be assessed against public and economic value, rather than being unallowable.
The Japan Institutional Gateway platform is now available to researchers across Japan, enabling the publication of Japanese-language research at world-class speed and reliability. This expansion aims to support the acceleration of the open research movement promoted by the Japanese government.
Sarcopenia affects over 60% of individuals above age 80 and is influenced by distinct biological mechanisms in women and men. Hormones like apelin, insulin, and oxytocin play a crucial role in maintaining healthy skeletal muscle, with sex-specific differences affecting muscle aging and disease progression.
Cellular senescence is a stable form of cell-cycle arrest induced by intrinsic and extrinsic stimuli. The review highlights the importance of understanding how different initiating events shape distinct senescent cell phenotypes, contributing to chronic inflammation, tissue dysfunction, cancer, and age-related diseases.
A new review reveals adaptor proteins play a crucial role in regulating the behavior of tumor-associated macrophages in cancer. These molecular scaffolds coordinate signaling pathways that determine whether macrophages adopt anti-tumor or pro-tumor phenotypes, influencing immune responses within the tumor microenvironment.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
The American Journal of Occupational Therapy (AJOT) will move to the Sage Journals digital platform, strengthening reader experience and expanding visibility of occupational therapy scholarship. AJOT's mission remains unchanged, publishing peer-reviewed research supporting practitioners, educators, students, and researchers.
A rare benign kidney tumor, renal oncocytoma, is diagnosed through biopsy and histopathology, guiding individualized treatment decisions. Minimally invasive approaches like percutaneous cryoablation provide effective disease control while preserving kidney function.
A new review investigates the impact of aging, stress, and behavior on endocrine dysfunctions in nonhuman primates. The study finds that older monkeys with depression-like behavior exhibit impaired regulation of stress responses and thyroid function, leading to increased disease risk.
Recent research suggests that senescence often limits stem cell activity in normal tissues but can also promote tumor progression in cancer. Understanding the dynamic interplay between these two biological processes is crucial for developing safer regenerative therapies and more effective cancer treatments.
The journal addresses ethical challenges, best practices, and scientific integrity issues through metascience and evidence-based research standards. Emerging technologies like AI are transforming how researchers conduct, communicate, and disseminate their work.
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
Researchers found frequent silencing of TRAIL-R2 in breast tumors through promoter hypermethylation, associated with invasive ductal carcinoma and advanced tumor stage. Lower TRAIL-R2 expression was linked to more aggressive disease and reduced overall survival.
JMIR Publications and Jisc have expanded their Flat-Fee Unlimited Open Access Partnership, making APCs free for researchers affiliated with participating institutions. The agreement allows researchers to prioritize open access publishing without financial burdens.
The Indonesian Academy of Sciences has launched an open access journal, Journal of the Indonesian Academy of Sciences, with Taylor & Francis to bridge research and policy. The multidisciplinary journal features original research, opinion pieces, and a policy forum, making it an authoritative source for policymakers and practitioners.
JMIR Publications has extended its agreement with Eindhoven University of Technology for two years, providing researchers with unlimited APC-free publishing in all JMIR's Gold Open Access journals. The partnership eliminates individual Article Processing Charges (APCs) and ensures equity for TU/e researchers.
A new study reveals that p38MAP kinase plays a central role in regulating senescence-related changes in human muscle cells. The researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to drive aging in mature muscle fibers.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
The Journal of Dental Research and JDR Clinical & Translational Research have announced their 2025 journal impact factors, showing significant growth for JDR. The JDR climbed to #5 in the 'Dentistry, Oral Surgery & Medicine' category with a 2-year impact factor of 6.6.
A new study found that childhood adversity, especially forced childhood migration, is associated with higher cardiometabolic risk and accelerated biological aging in later life. Forced migration was linked to elevated diabetes risk, cardiovascular disease, and hypertension, as well as signs of accelerated biological aging.
A hospital-based study in India found that higher coffee consumption and meat intake were associated with lower odds of prostate cancer. The researchers identified potential biological mechanisms behind these findings, but note that the relationship between diet and prostate cancer is complex and warrants further investigation.
Researchers found that eliminating a protein called DHHC3 in melanoma cells led to increased oxidative stress, cellular senescence, and activation of anti-tumor immune cells. This suggests that DHHC3 plays an immunoregulatory role in melanoma growth.
A nationwide population-based study found that individuals with neovascular age-related macular degeneration had a modest but statistically significant increase in overall cancer risk. However, the increased risk was only observed for specific malignancies, including thyroid, kidney, and prostate cancers.
Dimensions Citation Check API detects self-citation, evaluates instances in context, and provides risk ratings for journal editors' decision-making. The tool aims to safeguard research integrity by addressing the challenge of excessive or gratuitous self-citation.
Taylor & Francis has published the world's first Plain Language Summary of Publication (PLSP) in veterinary research, making complex findings more accessible to a broader audience. The PLSP bridges the gap between scientific complexity and practical understanding, offering a new way to present veterinary science.
A Phase I/II clinical trial of the HPV therapeutic vaccine PepCan found it to be well-tolerated, with mild injection-site reactions being the most common adverse events. However, the study did not demonstrate a reduction in head and neck cancer recurrence rates, likely due to its small sample size.
The Journal of Research on Research aims to support evidence-informed change in research systems through a unique dual role as both a publisher and researcher. It will occupy a dual role: publish and conduct research on research, providing access to data on publishing processes across its portfolio.
JMIR Publications has partnered with MetaROR to advance open science, elevate peer review quality, and recognize reviewers' contributions. The partnership integrates MetaROR's publish-review-curate platform with JMIRx overlay journals.
VeriXiv's trust marker badges showcase rigorous verification checks, setting new standards for preprint integrity. The badges provide clear confirmation of the extensive checks each preprint undergoes before being made available on the site.
The Global Conference on Gerophysics brought together researchers from various disciplines to develop predictive models of aging. Key findings include the application of physical principles, such as thermodynamics and network theory, to biological systems. The conference highlighted the importance of collaboration between theory and ex...
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
A 28-year-old woman was misdiagnosed with intussusception due to imaging similarities, but surgical removal revealed a rare ileal leiomyoma. Histopathology and immunohistochemistry confirmed the diagnosis, emphasizing the importance of combining imaging, histopathology, and immunohistochemistry for accurate diagnosis.
A new study published in Genes & Cancer identifies activated beta-catenin as a key driver of aggressive pediatric osteosarcoma progression. The researchers found that cells expressing active beta-catenin exhibited enhanced invasive capacity and cancer-associated traits, suggesting a potential therapeutic target for this aggressive cancer.
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.