Articles tagged with Academic Journals
Researchers found potentially beneficial molecular changes in the liver and kidneys of aged mice, alongside signals in the spleen that raise concerns about long-term safety. However, larger controlled studies are needed to assess functional outcomes and safety in humans.
The Taylor & Francis Ebola resource offers free access to curated medical and social science research, supporting the global response to the current outbreak. The collection features seven sections, covering transmission, diagnosis, vaccine strategy, treatment, and international relations.
Reducing DUSP4 activity slows cancer cell proliferation, but related protein DUSP5 helps compensate and restore cell growth. Adaptive feedback mechanisms limit the therapeutic potential of DUSP4 in treating colorectal cancer.
A new framework proposes that communication between cells and organs plays a central role in amplifying age-related changes, shifting focus from cellular damage to systemic signaling. The framework suggests that restoring healthier systemic communication could be important for coordinated late-life rejuvenation.
Tracking hCG levels over time helps clinicians assess disease risk, guide treatment decisions, and detect possible relapse. Regular monitoring also supports early detection and timely intervention, even after treatment.
Extracellular vesicles, including exosomes, play critical roles in intercellular communication, influencing aging and cancer progression. Research highlights similarities in molecular signals between aging and cancerous cells, suggesting potential links between the two conditions.
Dr. Joseph L. Wright has been selected as the 2027 David G. Nichols Health Equity Award recipient for his significant contributions to advancing child and adolescent health, well-being, and equity. The award recognizes his decades-long commitment to improving health equity and his transformative contributions to pediatric health.
A new study identifies three genes associated with ferroptosis and immune infiltration in Duchenne muscular dystrophy, suggesting a connection to age-related muscle degeneration. The findings may reveal new approaches to preserving muscle function and guiding future research into molecular biomarkers.
A new study found associations between coagulation-related genes and lung cancer survival, with varying prognostic significance depending on mutation status and tumor location. The research identified four genes, F2, F5, PROS1, and SERPINC1, which may provide additional information for understanding lung cancer prognosis.
Early-career researchers recognized for their outstanding and innovative work across seven disciplines; selected from 382 applicants across 52 countries. The winners receive a $1,000 research prize and amplification through Advanced Science's global platform.
A new review proposes the Polycentric Aging Framework, which suggests that epigenetic regulation is a dominant factor limiting human lifespan. The framework identifies three major constraint layers, including epigenetic regulation, irreversible genetic and physical damage, and the accumulation of damaged proteins and organelles.
Researchers found that small extracellular vesicles released by senescent cells can induce senescence in neighboring cells, promoting a stable growth-arrested state without activating classical inflammatory pathways. These findings reveal a key mechanism of intercellular communication and tissue aging.
Research highlights the interconnected regulatory network of programmed cell death pathways in cervical cancer, influenced by HPV-related signaling and the tumor microenvironment. This review proposes targeting multiple pathways, including ferroptosis, to restore cancer-cell susceptibility to destruction and improve treatment responses.
A study found that body composition, particularly fat-free mass percentage and body fat distribution, is associated with inflammation and growth hormone levels in middle-aged men. However, these associations disappeared after adjusting for body fat, suggesting that body fat may help explain the observed relationships.
The Research Ideas and Outcomes journal has joined the Publish, Review, Curate Alliance as a founding member, adopting an open-science model that promotes timely publication and open peer review. This transition aims to increase the visibility and discoverability of research outputs, aligning with the Alliance's goals.
Francis Peyton Rous identifies transmissible cancer agent in chickens, challenging established ideas about cancer. His discovery leads to the development of viral oncology and modern understanding of cancer as a genetic disease.
JMIRx journals have joined the Publish, Review, Curate (PRC) Alliance as a founding member to help advance more open and transparent approaches to scholarly publishing. This move reflects the commitment of JMIRx journals to the PRC approach, which prioritizes openness, equity, interoperability, and stakeholder governance.
The case report highlights the challenges of monitoring residual disease in stage IIIc colon cancer, where conventional imaging shows no measurable tumor but circulating tumor DNA and DNA methylation patterns suggest molecular residual disease. Molecular profiling and international collaboration may help guide treatment decisions in su...
Researchers found that hypomagnetic fields extend survival in a fly model of Parkinson's disease, but reduce mobility. The study suggests that magnetic field strength may be a potential therapeutic strategy, particularly in the context of ageing and neurodegenerative disease.
A 55-year-old man with glioblastoma exhibiting amplifications in MDM2 and EGFR genes underwent comprehensive genomic profiling and an international molecular tumor board. The case highlights the potential for precision oncology to identify potential treatment strategies for aggressive brain cancer.
A case report describes a patient who developed toxic epidermal necrolysis after combination therapy with pembrolizumab and enfortumab vedotin for metastatic urothelial carcinoma. The patient's high-grade urothelial carcinoma and recent radiotherapy may have contributed to the severe skin reaction.
The mTOR signaling pathway is a central regulator of cellular metabolism, stress adaptation and tissue maintenance. Carefully controlled modulation of mTOR signaling could support future strategies for healthy aging.
Taylor & Francis has announced a new open access partnership with CRUI, the largest university association in Italy, supporting OA publishing of over 2,100 journals across various disciplines. The agreement enables researchers at CRUI-affiliated institutions to choose OA without paying a charge, with articles becoming OA immediately up...
A new study found that adding 3D goggles to deep-inspiratory breath-hold radiotherapy did not significantly reduce treatment time. However, setup time was longer when goggles were used, and treatment efficiency improved with repeated sessions.
A new control theory framework introduces a mathematical framework for understanding aging and guiding the development of therapies. The framework prioritizes maintaining or recovering acceptable physiological function, rather than targeting every molecular feature to a youthful state.
The Tree of Life programme aims to sequence the genome of every findable species in the UK and Ireland. The programme has introduced a new semi-automated process to publish and review genome notes, expanding access to research that supports advances in agriculture, conservation, and medicine.
Researchers identified fagopyrine, a naturally occurring compound in buckwheat, as a potential starting point for developing new AKT1-targeting drugs. The analysis revealed substantial variation in AKT1 expression across 33 cancer types, with increased expression linked to poorer outcomes in certain malignancies.
The study found that disrupting PLA2G15 reduced stress-induced cellular senescence in mouse kidney cells while altering the composition of phospholipids involved in lysosomal function. This suggests a possible connection between lipid metabolism, mitochondrial pathways, and kidney aging.
A rare case of high-grade serous ovarian carcinoma diagnosed during early gestation at 10 weeks of pregnancy was reported, highlighting the challenges of identifying ovarian malignancy during early pregnancy. The patient underwent surgical management and received adjuvant chemotherapy, and remained disease-free at one-year follow-up.
A new commentary proposes expanding gerophysics to include behavioral complexity, which may complement molecular and biological markers of aging. Measuring changes in movement, physiological rhythms, and other behavioral patterns could help identify declining resilience and the transition to frailty. The concept of complexity reserve m...
Researchers investigated the effects of mini-GRID radiotherapy on glioma cells, finding it reduced senescence and preserved growth inhibition, whereas conventional radiotherapy induced senescence. The study suggests that mini-GRID's spatial dose distribution may be responsible for this difference.
The 11th International Cell Senescence Association Conference brings together researchers worldwide to advance understanding of cellular senescence and its roles in aging, cancer, and disease. Aging supports the conference through a $200 cash poster prize recognizing outstanding scientific research.
Digital Science has appointed Charlesworth as its strategic sales partner for Altmetric and Dimensions in China's scholarly publishing sector. The partnership aims to support the growing demand for research data and information, enabling publishers to access high-quality research insights and understand the reach and attention generate...
A new study found a higher prevalence of prior breast cancer in patients with gallbladder cancer compared to patients with other biliary tract cancers. The association was observed in two independent cohorts, with 25.7% of patients with gallbladder cancer having a history of breast cancer.
Research found that unfavorable social determinants of health are associated with a higher risk of dementia in adults with and without type 2 diabetes, with particularly strong associations observed among women with T2D. The study also found that diabetes-related dementia risk varies across social environments.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
Wiley has launched two new research journals, Advanced Medicine and Advanced Healthy Aging, as part of its expanding Advanced Portfolio. The new journals aim to elevate breakthrough science that impacts lives, reflecting Wiley's commitment to accelerating science that addresses humanity's most pressing challenges. Led by expert editori...
JMIR Publications earned a spot on the 2026 Report on Business magazine ranking of Canada's Top Growing Companies, driven by the value it delivers to the scientific community. The company's sustained growth is attributed to its open science work, innovative practices, and global network of talented staff and authors.
Researchers are exploring biomarker-guided patient selection and combination therapies to overcome glioblastoma's biological barriers. Agents targeting tumor metabolism, immunotherapies, and oncolytic viruses are being investigated.
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
ORPHO is a collaborative scientific writing platform that streamlines writing and publishing processes. Key features include real-time collaboration, automatic semantic enrichment, and machine-readable content for discoverability and interoperability.
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
A new commentary calls for consistent evaluation of potential links between COVID-19, vaccination, and cancer, highlighting potential associations and biological mechanisms. The author argues that similar mechanisms reported in connection with COVID-19 vaccination warrant consideration and further study.
A new study published in Aging reveals that a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, showing improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The findings separate liver inflammation and fibrosis from insulin resistance, obesity and lipi...
The study validated the Cancer Stigma Scale (CASS) in the Greek context, examining its relationship with attitudes toward mental illness. The Greek CASS demonstrated high internal consistency and construct validity, with moderate correlations between cancer stigma and attitudes toward mental illness.
Editage and European Association of Science Editors (EASE) will discuss peer review capacity, volume, speed, and quality during Peer Review Week 2026. The event aims to balance volume and speed with quality and integrity in the peer review process.
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
JMIR Publications and ZB MED extend their Flat-Fee Unlimited Open Access Publishing Agreement for two years, covering over 30 Gold Open Access journals with zero Article Processing Charges (APCs) for participating German research institutions. The new agreement provides predictable and sustainable funding for open access publishing.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
A new case report describes a 68-year-old woman with stage IV lung adenocarcinoma who developed severe hemolysis after receiving pembrolizumab, despite a negative Coombs test. The patient's hemoglobin declined from 11-12 g/dL to 6.4 g/dL, and laboratory markers of hemolysis improved with corticosteroid treatment. The case highlights th...
Researchers explored strategies to restore MHC-I expression in CNS cancers to make them more visible to the immune system. Approaches include epigenetic therapies, AAV vectors, PCSK9 inhibition, and modifying the tumor microenvironment. However, efficient delivery, antigen processing, and a limited neoantigen repertoire remain signific...
Researchers found three herbal extracts protect mitochondrial function in a cellular model of Parkinson’s disease, suggesting a potential treatment. The extracts, including Uncaria rhynchophylla, Gardenia jasminoides, and Scutellaria baicalensis, improved cell viability and mitochondrial function in cells with reduced VPS13C expression.
The 2027 APE Award for Innovation in Scholarly Communication honors innovators improving scholarly communication. The award, presented at the 22nd Academic Publishing in Europe APE Conference, recognizes individuals who bring innovation to research and the academic publishing community.
The WIN 2026 Symposium will bring together experts to explore advances in precision oncology and strategies for improving personalized cancer care. The symposium, themed Precision Oncology: Innovation and Equity Across the Globe, will feature an international lineup of distinguished oncology and biomedical research leaders.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
MRI revealed rare cervical cancer spread into the uterine corpus, which was confirmed by histopathology. The unusual pattern created diagnostic challenges and required careful individual assessment. The study highlights the importance of recognizing less typical imaging features in evaluating suspected cervical malignancy.
Tumor-derived extracellular vesicles exhibit intrinsic organotropism and participate in establishing premetastatic niches, making them promising vehicles for targeted imaging probe delivery. However, current imaging approaches have limitations, including difficulty distinguishing between tumor-derived EVs and normal host cell-derived EVs.
Six UK universities have renewed their unlimited OA publishing agreement with JMIR Publications, allowing corresponding authors to publish APC-free in all JMIR journals. This sustainable model establishes a more predictable and equitable publishing environment.
Tumor-infiltrating lymphocyte therapy has shown potential in several types of solid tumors, including metastatic melanoma, breast cancer, and ovarian cancer. Despite challenges, the approach has favorable clinical outcomes, and researchers are exploring combination strategies and advanced technologies to improve treatment durability.