Articles tagged with Peer Review
A recent study published in Oncoscience found that lifestyle choices and hormonal imbalances significantly impact male fertility in Indian men. The research discovered a strong association between poor habits such as tobacco and alcohol use, heat exposure, and body weight with lower semen quality and higher DNA damage.
This study found that aged rats living in socially enriched environments retained better memory and cognitive flexibility than those housed alone. Socially housed rats showed increased activity in the hippocampus and reduced overactivity in the anterior cingulate cortex, suggesting a more balanced and efficient neural response.
ACTM-838, a novel bacterial immunotherapy, enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity. The therapy shows durable anti-tumor efficacy and synergizes with anti-PD1 drugs, improving outcomes in treatment-resistant tumor models.
A new study found that miR-145-5p and miRNA-27b-3p interfere with fat cell formation in children with Hutchinson-Gilford progeria syndrome, a rare and fatal premature aging disorder. These microRNAs silence genes required for fat cell growth and function, suggesting they could be a promising therapeutic strategy to restore fat tissue.
A new study calls for standardized, transparent, and reproducible methods to evaluate frailty in preclinical aging studies. The researchers analyzed 18 rodent studies and found substantial variation in how frailty is defined and measured.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
A new study found no clear clinical evidence that rapamycin can extend healthspan or delay aging in healthy adults, despite promising results in animal studies. The review suggests that off-label use of rapamycin should be approached with caution due to limited evidence and potential side effects.
The loss of Trp53 leads to more aggressive tumor growth and weaker immune responses in ovarian cancer. Researchers developed a mouse model that mimics human HGSC, showing how the disease progresses and evades the immune system.
A 71-year-old man was diagnosed with advanced colorectal cancer after suffering from multiple unexplained strokes and blood clots. The cancer remained undetected until widespread clot complications appeared, highlighting the need for comprehensive oncologic evaluation in patients with unexplained hypercoagulable states.
Researchers found that cells exiting the cell cycle show stronger signs of senescence and are more sensitive to senolytic drugs. DNA content plays a crucial role in how aging cells function and respond to treatment.
JMIR Publications has launched a new 'News & Perspectives' section, providing in-depth analysis on the implications of increased political oversight in US research. The section aims to bring rigor and integrity to digital health news, empowering researchers, policymakers, and health professionals to stay ahead of the curve.
The Flat-Fee Unlimited Open Access Partnership between JMIR Publications and Jisc has expanded to cover 22 UK research institutions. Participating authors can publish in JMIR's Gold Open Access journals without APCs, simplifying the publication process.
Researchers discovered that FGF21, a muscle hormone released during exercise, is elevated in people with ALS and may play a protective role. Higher levels of FGF21 were associated with slower disease progression and longer survival in patients.
The JAMA Network has selected 13 early-career researchers from around the world to participate in the 2025–2026 Peer Review Academy. The program aims to cultivate excellence in peer reviewing and deepen understanding of editorial decision-making.
A study found that older adults with Parkinson's disease have a higher rate of brain amyloid positivity compared to younger patients, even without dementia. The researchers suggest this may indicate an accelerated transition from healthy cognition to dementia in PD patients.
These rare tumors often present with aggressive behavior, early metastasis, and resistance to chemotherapy and radiotherapy. Early detection and disease staging are key factors associated with improved survival.
A growing divide among reviewers in physical sciences regarding the use of generative AI in peer review has been revealed. Women tend to be less positive about AI's potential compared to men, while junior researchers are more optimistic.
Researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy. The study found that IPF is not simply accelerated aging, but a unique biological condition shaped by age-related dysfunction.
Renowned environmental scientist Prof. Willie Peijnenburg shares insider tips on how to write and present research that makes it into top-tier journals like Nature. Key strategies include presenting novelty, clarity, and conciseness to increase manuscript success.
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
Researchers propose idiopathic pulmonary fibrosis as a disease-specific treatment to test general geroprotector therapies, leveraging its high overlap with aging biology. This approach could accelerate drug development and reduce costs by targeting shared biological pathways.
Researchers associated with a fictitious network have collectively netted millions of dollars in funding from the US, Japan, Ireland, and other nations. The investigation highlights weaknesses in research and publishing systems that can be exploited for personal gain.
A Taylor & Francis journal has found high levels of author satisfaction with the quality, speed, and decision-making under a transparent peer review model. Authors valued constructive feedback, and most reported they would submit or review again due to the journal's support for transparency.
The TARGET statement aims to improve reporting transparency and peer review in observational studies, enabling better interpretation and application of results. By following the guideline recommendations, researchers can provide more reliable information for clinicians and readers.
Researchers found that exosomes from senescent cells and circulatory exosomes carry molecular signatures associated with biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs linked to inflammation, oxidative stress, and tissue remodeling.
Researchers discovered that disrupting protein quality control slows tumor growth in rhabdomyosarcoma, a rare and aggressive cancer primarily affecting children. The treatment, which targets the proteostasis network, significantly slowed or stopped tumor growth in mice implanted with human RMS tumors.
A new AI tool has identified over 1,000 'questionable' scientific journals, including those that charge hundreds or thousands of dollars to publish research without proper vetting. The AI system uses six criteria to evaluate journals, including editorial board composition and website quality.
A study published in Oncoscience found that over 60% of oncology healthcare professionals in Morocco showed signs of severe burnout, with emotional exhaustion being the key factor. The study highlights the need for urgent institutional changes to support healthcare workers and improve work environments.
Researchers found that AUF1 helps prevent aging by breaking down enzymes involved in glucose metabolism. The study's findings improve our understanding of how metabolism affects the aging process.
Researchers found that faster biological aging is associated with lower scores on digital cognitive tests, particularly among older adults. DNA methylation patterns were used to estimate biological age acceleration, and protein markers PAI1 and ADM showed strong associations with lower cognitive scores.
The 10th International Congress on Peer Review and Scientific Publication will focus on artificial intelligence, highlighting its impact on the scientific publishing process. The event aims to improve conduct, reporting, and dissemination of scientific research.
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.
Researchers found that cancer does not typically affect forensic age estimation accuracy, except for very aggressive forms of cancer. In contrast, blood cancers led to large errors, with ages overestimated by up to 50 years.
A new study found a strong association between accelerated epigenetic aging and increased risk of colorectal cancer in postmenopausal women. Lifestyle factors like diet significantly influenced this risk, with healthy diets potentially reducing cancer risk associated with biological aging.
Researchers found that combining aramchol with regorafenib killed liver and colorectal cancer cells more effectively than either drug alone, triggering stress responses and disrupting survival pathways. The combination was especially effective in cells with a genetic variant called ATG16L1 T300.
A new paper warns that the world's reliance on submarine cables poses significant risks to global communication, commerce, and security. The study highlights growing vulnerabilities to natural disasters and deliberate sabotage, sparking calls for diversification of global communications infrastructure beyond the ocean floor. Experts pr...
The FDA-approved MI Cancer Seek test is a comprehensive molecular profiling assay that delivers accurate and reliable results from minimal tissue input. It identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers.
A new study published in Aging-US found that frailty is associated with increased respiratory exacerbations and mortality in individuals with a history of cigarette smoking. Frail participants had a three- to five-fold higher chance of developing serious or frequent respiratory attacks, even if they had normal lung function.
PLOS Biology joins forces with MetaROR to enhance the peer-review process, utilizing pre-existing reviewer reports to streamline publication practices. This collaboration aims to promote open science and accelerate meaningful change in research publishing.
A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
A new study suggests that regular exercise can influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan. Physical fitness is closely associated with slower epigenetic aging, and sedentary behavior may have detrimental effects on the body's internal aging process.
Researchers found that RSPO2 amplification is associated with poor outcomes in PC patients and promotes genes and signaling pathways associated with aggressive PC. The study highlights RSPO2 as a key driver of disease progression and opens new possibilities for treatment strategies.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
A new research paper found that epigenetic aging is linked to cognitive decline in midlife, with twins experiencing a larger drop in IQ scores if they had grown up in families with lower socioeconomic status. This study provides new evidence for the impact of childhood adversity on brain aging.
Researchers analyzed data from over 10,000 solid tumor samples and found that more than 90 percent contained genetic changes that could guide treatment. The study identified biomarkers associated with approved therapies and rare mutations missed by simpler tests.
Researchers developed TraMA, an RNA-based measure of biological aging that predicts health risks and mortality. It captures distinct aspects of aging and health decline, including inflammation, immune function, and kidney and brain health.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
A study reveals that epigenetic changes associated with aging in adults do not occur before sexual maturity. In fact, rDNA copy numbers and methylation increase during childhood and adolescence, suggesting cells actively maintain a youthful state to ensure efficient protein production.
Researchers discovered that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, leading to lower levels of tumor-promoting proteins and cancer-suppressing cellular behaviors. Statins downregulate SATB1 while increasing SATB2, making cancer cells less able to grow and spread.
Researchers evaluated the Stem Cell Regenera treatment in 145 women with ovarian failure, showing nearly 70% oocyte activation and 14% conception through IVF after treatment. The therapy stimulates ovarian activity, increasing conception chances in selected patients.
A new case report documents a rare instance of lipoleiomyoma, a benign uterine tumor with characteristics similar to malignant liposarcoma. The diagnosis was confirmed through histopathological evaluation and imaging techniques, emphasizing the importance of careful assessment in elderly patients.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Researchers discovered a new monoclonal antibody, 2B010, that selectively targets regulatory T cells (Tregs) in tumors, boosting the activity of CD8+ T cells and improving anti-tumor immune responses. This unique mechanism could complement existing cancer therapies and lead to more effective treatments.
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
Researchers found that spermidine supplementation improves memory and preserves physical activity, while reducing protein intake boosts mitochondrial activity and extends lifespan. Combining the two interventions offers additive benefits, suggesting potential for synergistic effects.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.