Articles tagged with Peer Review
Researchers found that fisetin reduces calcium buildup and protects blood vessels from hardening in vascular smooth muscle cells. Fisetin's anti-calcification activity depends on the phosphatase DUSP1, which inhibits p38 MAPK.
Impact Journals will exhibit its publications, including Aging-US, Oncotarget, and Genes & Cancer, at the SSP 47th Annual Meeting. The event aims to reimagine the future of scholarly publishing and aligns with Impact Journals' mission to foster open and impactful scientific communication.
Aging-US invites submissions for a Special Collection on cellular senescence, focusing on its mechanisms, physiological and pathological functions, and clinical applications. The collection honors Dr. Judith Campisi's groundbreaking work on senescence in aging, cancer, and tissue homeostasis.
Researchers discovered compromised NAD+ metabolism in WS cells and found that boosting NAD+ levels using nicotinamide riboside decreased senescence in both stem cells and primary fibroblasts. The study suggests targeting NAD+ metabolism for age-related and genetic diseases.
Researchers have discovered that inhibiting the metalloprotease ADAM19 can reduce gut inflammation and cell aging markers across species. The study found that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells, offering a promising path for creating treatments to maintain healthy tissues.
Researchers found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of immune-related markers PD-L1 and FOXP3. These findings suggest that HPV may begin avoiding the immune system early in infection, allowing infected cells to grow and potentially leading to cancer.
A study on captive olive baboons found that about a quarter exhibited accelerated aging, while another quarter showed signs of slower aging. The researchers investigated physical indicators such as walking speed and fine motor skills, but found that these changes were more closely related to chronological age than epigenetic age.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
The American Physical Society has received the leading score among publishers participating in SCOAP3 for its investment in open science practices. The Society earned high marks in elements like data availability, article metadata, and persistent identifiers.
Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
A new study finds that a specific genetic variation in the PTGS2 gene is associated with an increased risk of benign prostate hyperplasia (BPH) in Lebanese men. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it.
Researchers discovered that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium, a vital layer of cells in the eye. This study provides a clearer understanding of why aging leads to eye disease and introduces a reliable laboratory model for testing new therapies.
Researchers found that GSK3β becomes increasingly active in melanoma cells during treatment, helping them survive and adapt despite BRAF inhibitors. Treating resistant cancer cells with a GSK3β inhibitor significantly reduced their growth, suggesting blocking this protein could restore sensitivity to treatment.
A study found that smaller embryos already hatching are more likely to be chromosomally normal. This insight helps fertility clinics select better embryos during IVF, particularly for women over 35 or those undergoing PGT-A.
A new editorial in Oncotarget discusses how artificial intelligence can improve liver imaging by recognizing when it might be wrong. The approach, called 'uncertainty quantification,' helps clinicians better detect liver cancer and other diseases by pointing out areas in medical scans that need a second look.
Researchers investigated why bones become less responsive to exercise with age, finding increased mtROS or decreased Atg7-dependent autophagy in osteoblastic cells do not contribute to reduced mechanoresponsiveness. Damage to the bone's osteocyte network also does not prevent a healthy bone-building response.
Researchers found that combining imipridones with radiation therapy and temozolomide slowed glioblastoma growth and prolonged survival in mice. The treatment also boosted immune responses and suppressed MGMT protein expression, making it more effective.
A new case report presents a highly unusual combination of two benign ovarian tumors: serous cystadenofibroma and collision lesions. Accurate preoperative diagnosis is critical for effective treatment planning, and this case emphasizes the need for personalized evaluation of each ovarian mass.
Aging (Aging-US) journal announces a commemorative collection honoring Dr. Mikhail Blagosklonny, a pioneer in aging biology. The special issue will explore key themes central to his scientific contributions, including mechanistic insights and translational approaches.
Researchers found that NSD2 helps maintain MM cell identity by reorganizing DNA and influencing gene activity. This discovery could shape future treatment approaches for patients with t(4;14) myeloma.
Researchers at Cornell University discovered that the FGR protein can induce cell differentiation in leukemia cells similar to retinoic acid treatment. The presence of FGR alone was enough to make these cells mature, producing well-known markers of maturation and expressing inhibitor of the cell cycle p27.
The MIT Press has funded the open publication of 320 books through its Direct to Open framework, which shifts from market-based purchase models to collaborative library-supported open access. This approach has shown significant usage and citation increases for Humanities and STEAM books, with a notable impact on global readership.
A study using NHANES data found that inflammation, rather than diet and exercise, has the strongest association with telomere shortening. Managing chronic inflammation may be key to preserving telomere length and promoting healthy aging.
A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.
A new study found that treating aged mice with montelukast improved retinal health by reducing inflammation and boosting proteasome activity. This approach may offer a promising new way to slow age-related vision loss and protect eye health in older adults.
Biology Open's Fast & Fair peer review pilot has successfully reduced publication delays by recruiting contracted reviewers who are paid per manuscript. The innovative system, launched in July 2024, ensures high-quality reviews within 7 business days, often faster.
IOP Publishing awards Outstanding Reviewer Awards to recognize reviewers who provided exceptional peer review reports over the past year. Over 5,000 reviewers have boosted their competency through IOPP's Peer Review Excellence certification program.
A new editorial highlights a growing concern in cancer care: radiotherapy may leave behind residual disease that can lead to worse long-term outcomes. Studies have shown that patients with residual disease are more likely to experience cancer recurrence and shorter survival, emphasizing the need for regular biopsy-based tests.
This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
Breast cancer survivors experience accelerated aging due to detrimental effects of BC and its treatments, particularly systemic therapies. The study highlights the need for ongoing monitoring and potential strategies to slow down aging in cancer survivors.
The WIN Consortium is transforming cancer care through personalized medicine, leveraging AI, molecular profiling, and clinical trials. The organization's innovations, including N-of-1 clinical trials and WINTHER and WINGPO trials, are helping clinicians make more precise treatment decisions and improving outcomes for cancer patients.
Impact Journals is proud to exhibit at the AACR Annual Meeting 2025, featuring its esteemed journals Aging-US, Oncotarget, Oncoscience, and Genes & Cancer. The meeting highlights significant advancements in cancer research, aligning with Impact Journals' mission to disseminate impactful scientific research.
Research from the Long Life Family Study found individuals from long-lived families have significantly better vascular health than the general population. The study identified key risk factors and four genomic regions linked to PAD risk, providing novel insight into underlying mechanisms.
Recent research suggests that some invasive cancers diagnosed in early-stage breast cancer may not need immediate surgery, highlighting the importance of more precise screening methods for DCIS. The COMET trial found that at least half of invasive breast cancers take years to progress or may never progress at all.
Genetic changes triggered by environmental factors like pollution, diet, and stress can increase cancer risk. Nearly everyone is exposed to cancer risk factors daily, highlighting the need for public awareness and policy action to reduce exposure.
Researchers found that PRP treatment increased gene expression related to metabolism, cell survival, and communication between cells in cumulus cells. This suggests that PRP may help support egg development and fertility in women with poor ovarian response.
The American Society of Plant Biologists is searching for a new Editor-in-Chief to drive the editorial direction of Plant Physiology. The successful candidate will have a vision for the journal's future and be responsible for elevating its profile within the community.
A study published in Aging (Aging-US) found associations between several environmental exposures and epigenetic aging in a large sample of US adults. Cadmium, lead, and cotinine were linked to faster biological aging, increasing the risk of age-related diseases such as heart disease and cancer.
Researchers discover engineered TIMP molecules can block cancer cell migration and invasion, offering a targeted approach to treating GBM. The findings also suggest the potential for safe treatment with minimal side effects.
A new study reveals that radiotherapy has opposite effects on glioblastoma multiforme (GBM) and low-grade gliomas (LGG), with GBM patients living longer after treatment. The study highlights the need for personalized treatment approaches based on genetic and molecular characteristics to improve survival outcomes.
Researchers have discovered several novel downstream p53 targets that could lead to improved cancer therapies. The study highlights the critical role of p53 in preventing cancer and identifies two new genes, ALDH3A1 and NECTIN4, as potential targets for cancer treatment.
A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.
A new classification system for SJS/TEN divides the disorder into five types based on causative factors and diagnostic algorithms. This typology aims to bring clarity to diagnosis and treatment by providing consistent criteria for identifying underlying causes.
A rare case of adenomyosis in an 81-year-old postmenopausal woman closely resembles invasive endometrial cancer, emphasizing the challenges of diagnosing this condition. Further studies are needed to refine diagnostic protocols and determine risk factors for postmenopausal patients.
A study found that pro-inflammatory molecules contribute to benign prostatic hyperplasia (BPH) in aging men, especially those with metabolic syndrome. Men with BPH had higher levels of pro-inflammatory markers and lower anti-inflammatory substances, suggesting a link between inflammation and prostate conditions.
ABT-263 eliminates harmful aging cells in the gut, reducing inflammation and lowering cancer risk in a mouse model of GI cancer. The study suggests that removing senescent cells could help prevent radiation-related GI cancer, highlighting the potential of senolytic drugs as a preventive treatment.
Researchers found that a combination of Panitumumab and low-dose Capecitabine is an effective and well-tolerated maintenance regimen for patients with wild-type KRAS metastatic colorectal cancer. The treatment delayed disease progression while managing side effects, improving patients' quality of life.
Osteosarcoma cells often have extra copies of the SETDB1 gene, making the cancer more aggressive and harder to treat. Blocking SETDB1 may help the immune system recognize and attack osteosarcoma cells, offering a promising new way to treat this type of bone cancer.
A study found that DNA methylation clocks used in forensic science and epigenetics are less reliable when applied to non-blood tissues, such as lungs, colon, and kidneys. The researchers suggest that organ-specific epigenetic clocks may be needed to improve biological age prediction.
A new research paper found that physical activity (PA) is associated with better sleep quality in older adults during social isolation. Reduced levels of PA had a negative association with the quality of sleep in four studies, while one study found improved sleep patterns among active individuals.
A new case report reveals a rare and aggressive form of leukemia developing from donor cells nine years after a stem cell transplant. The disease, driven by genetic mutations in key genes, progresses despite intensive treatment and ultimately proves fatal.
A new genetic mutation, RUFY1-RET fusion, was discovered in a patient with stage IV CD-74-ROS1 fusion NSCLC who developed resistance to lorlatinib. The finding highlights the importance of ongoing genetic testing to guide therapy decisions.
A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.
A study found clear differences in brain health between Hispanic and non-Hispanic White older adults, with Hispanic participants scoring lower on tests of memory, attention, and problem-solving despite similar mental health. Researchers emphasize the importance of considering social, economic, and cultural factors when developing progr...
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
Aging cats with chronic kidney disease (CKD) have lower levels of key kidney transporter genes, leading to impaired waste removal. Monitoring these transporters and toxin buildup may help detect CKD early and improve treatment options.
Researchers tracked cfDNA levels before, during, and after colorectal cancer surgery, revealing significant increases associated with age, comorbidities, and surgical manipulation. The study suggests that cfDNA could serve as a non-invasive biomarker to monitor patient outcomes and evaluate surgical effectiveness.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
Researchers explore HER2-low breast cancer, a new clinical subtype that benefits from novel treatments and personalized care. Current testing methods are not always accurate, calling for better detection methods to correctly identify patients who can benefit from these new therapies.