Articles tagged with Memory Disorders
A protein fragment derived from soybeans has been shown to improve working and long-term memory in mice with simulated Alzheimer's disease. The dipeptide, named Tyr-Pro, is the first known molecule to enter the brain intact after ingestion.
Researchers from Florida State University have uncovered new information about how Alzheimer's disease affects the brain during sleep. The study found that the interaction between two brain regions may contribute to symptoms experienced by patients, such as impaired memory and cognition. This discovery could lead to a better understand...
Researchers at the University of Edinburgh discovered that synapse type shifts with age in unique patterns across different brain areas. This shift helps explain why genes cause synapse damage at set ages and in set brain areas.
Research at DZNE reveals that experience encoding neurons interfere with memory containing neurons, disturbing recall of memories. Healthy mice and those with Alzheimer-like pathology were used to explore novel environments, showing a difference in brain activity.
Researchers discovered that memory recall processes in older adults resemble those in younger populations, but for those who struggle to remember, brain activity patterns are diminished. Stronger hippocampal activity and replay in the cortex were linked to better memory performance, regardless of age.
A new study reveals that the brain can update poorly formed memories with incorrect information, leading to inaccurate recall. The research suggests targeting updating mechanisms therapeutically to treat memory and anxiety disorders.
Researchers found that immune receptor TLR4 suppresses neuronal activity in the normal brain to improve signal-to-noise ratio, while increasing excitability after injury. Inhibiting TLR4 signaling reduces long-term working memory deficits and improves memory function weeks to a month after brain injury.
A study of 161 Japanese adults with Alzheimer's disease found that day service users experienced significant improvements in cognitive function over six months. The Mini-Mental State Examination scores showed notable enhancements in orientation, attention, memory, language, and visual-spatial skills.
A team of researchers has discovered that neural networks relevant to memory and learning are over-activated and connectivity is poor in mice with Down syndrome. Chronic treatment with epigallocatechin gallate improves memory deficits. The study identifies biomarkers in brain rhythms that can predict memory deficits.
A new study reveals how APOE4 triggers leaks in the brain's plumbing system, allowing toxic substances to seep into areas responsible for memory encoding and cognitive functions. The damage is linked to future problems in learning and memory, even when Alzheimer's signature sticky plaques have not appeared.
A study found that age-related hearing loss damages the brain's hippocampus, a key memory organ. The findings suggest that progressive hearing impairment impairs memory formation by altering neurotransmitter receptors.
Yale researchers identified a critical molecule in prefrontal cortex circuits that enables working memory. Activating this receptor may offer potential treatments for neurocognitive disorders like schizophrenia and Alzheimer's disease.
Scientists at Tokyo Metropolitan University have discovered that traumatic memories can be erased in Drosophila flies when exposed to environmental light. The team identified the molecular mechanism responsible for this effect, which involves the regulation of proteins in the brain.
Researchers discovered that resolvins, specialized lipids, can reduce inflammation and prevent memory loss in a preclinical model of Down syndrome. This finding has the potential to lead to new therapies for Alzheimer's disease, targeting inflammation as a key mechanism in healthy aging.
Researchers have identified a link between L-serine and memory problems in Alzheimer's disease. Supplying this amino acid as a nutritional supplement restored spatial memory affected early in mouse models.
A blood test measuring phosphorylated tau 181 (pTau181) shows promise in detecting Alzheimer's disease and mild cognitive impairment. The test's accuracy surpasses existing methods, offering a potential solution for early diagnosis and treatment.
A new epidemiological study found that women consuming at least two servings of walnuts per week had a greater likelihood of healthy aging compared to those who did not eat walnuts. The study, supported by the California Walnut Commission, suggests that adopting simple habits like snacking on walnuts can help slow down the effects of a...
A new study published in JAMA Network Open found that declines in both memory and gait speed are associated with an increased risk of dementia in adults 60 and older. The observational meta-analysis included six studies with over 8,700 participants from the US and Europe.
Scientists from Tokyo University of Science discovered that an opioid compound called KNT-127 can help mask fear memory, reducing anxiety in individuals with PTSD. The study suggests that combining KNT-127 with cognitive behavioral therapy may enhance treatment efficacy for anxiety disorders.
A study of 139,000 older Australians found strong links between certain food groups, such as fruit, vegetables, and protein-rich foods, and reduced memory loss and comorbid heart disease. Age-specific dietary guidelines may be necessary to prevent cognitive impairment in older populations.
A study by DZNE researchers found that a good blood supply to the hippocampus is crucial for healthy memory performance. Participants with doubly supplied hippocampi showed improved cognitive scores compared to those with single-supplied hippocampi or microbleeding, suggesting better oxygen delivery may be key.
Researchers at RMIT University found that microglia cells can be activated to boost memory performance in rats by up to 50%, reversing damage caused by neuroinflammation. This discovery could lead to the development of new treatments for cognitive decline and dementia.
A study by Kloft et al. found that cannabis use increases susceptibility to false memories and misinformation in mock crime scenarios. This research has significant implications for the questioning of cannabis-intoxicated eyewitnesses and suspects during investigative interviews.
Researchers found that neurons in the hippocampus become more synchronized when a memory is formed, enabling animals to form and retrieve episodic knowledge. This finding provides clues for the development of future therapies for diseases like dementia, autism, and PTSD.
A larger hippocampus may not guarantee better memory in older adults, with a new study highlighting the significance of its white matter connectivity. The research analyzed over 330 participants and found that faster learning was only seen in those with both a larger hippocampus and uniform white matter structure.
Researchers at HRL Laboratories found that targeted transcranial electrical stimulation during slow-wave sleep can improve metamemories of specific episodes by nearly 20% after just one viewing. This non-invasive approach may benefit patients with learning and memory deficits, as well as those with PTSD.
A physically and mentally active lifestyle can slow FTD symptoms by providing cognitive resilience to brain degeneration. Research participants with dominant genetic mutations showed slower functional decline in the most active group compared to the least active group.
A new study by Cedars-Sinai researchers found that abnormal electrical pulses from specific brain cells cause temporary memory disruptions in epilepsy patients. The study's findings could lead to better treatments for cognitive impairment in epilepsy patients, with the potential to improve their quality of life.
Experiments in rodents reveal engrams exist as multiscale networks of neurons, forming complex networks for memory storage. Engram cells can be manipulated through synaptic plasticity and dendritic spine formation, allowing for the retrieval and persistence of memories.
Researchers found people with subtle thinking and memory differences had faster amyloid accumulation and thinner brain regions compared to those with normal skills. The study challenges the long-held theory that beta-amyloid is the first sign of Alzheimer's disease.
Researchers discovered a way to encode specific physical properties in materials by utilizing their 'memory' of past stresses. This approach allows for the creation of auxetic materials with enhanced mechanical properties, such as improved energy absorption and fracture resistance.
A team at RIKEN Center for Brain Science analyzed mouse brain activity using machine-learning algorithms, identifying distinct brain waves for recent and remote memories. They found a strong link between the frontal brain region and hippocampus, suggesting a possible mechanism to track memory age.
Dr. Frost's team identified targets that can mitigate the spread of toxic proteins in the brain, aiming to intervene at the earliest stages of the disease. By preventing tau protein activation, her research holds promise for preventing memory loss and cognitive decline in Alzheimer's patients.
A study of over 1000 people aged 70 found that those who played non-digital games scored better on memory and thinking tests. Increasing game playing during their 70s also predicted maintaining certain thinking skills as they grew older.
A nationwide study published in Brain found that higher exposure to fine particle pollution, or PM 2.5, was associated with greater declines in memory performance and more Alzheimer's-like brain changes in older women. The researchers used data from 998 women aged 73-87 and adjusted for other factors.
A new study by Gladstone Institutes reveals that specific patterns of brain activity can predict Alzheimer's symptoms in young mice. By analyzing sharp-wave ripples and short gamma power, researchers found that deficits in these activities at an early age can predict memory problems decades later.
A new study published in the Journal of the American College of Cardiology found no association between statin use and memory or cognitive decline in elderly patients. Statin users showed similar cognitive performance to never-users, suggesting potential protective effects in this population.
Researchers found that inhibiting the integrated stress response (ISR) reversed memory deficits in a mouse model of Down syndrome. The study suggests that modulating ISR networks may help treat Down syndrome and other disorders resulting from disruption of this network.
A study published in Thorax confirms that ICU patients experience delayed return-to-work and joblessness, with 20-27% requiring disability benefits at one year. Survivors incur substantial lost earnings, impacting quality of life.
A new gene, NPSR1, has been discovered that promotes natural short sleep and prevents memory deficits associated with sleep deprivation. The researchers found that the mutant version of NPSR1 is easier to activate and better at switching on other proteins involved in wakefulness.
A new UCL study has found that a period of rest following a traumatic event can reduce the development of involuntary 'memory intrusions' in post-traumatic stress disorder (PTSD). The study suggests that increasing memory consolidation, which involves storing and contextualizing memories, may help prevent these disturbances.
Using sex-specific scores on memory tests may change who gets diagnosed with mild cognitive impairment (MCI) by 20 percent, with possibly more women and fewer men being diagnosed. The study found that using the sex-specific scores resulted in a higher diagnosis rate for women, while lower rates for men.
Researchers restored normal working memory to a mouse model of schizophrenia, eliminating a core symptom that has proven virtually impossible to treat. The findings, published in Neuron, hold immense promise for treating over 21 million people diagnosed with schizophrenia.
Researchers developed new diagnostic criteria that consider a woman's sex when evaluating verbal memory performance, leading to improved diagnosis accuracy and potentially detecting cognitive impairment earlier. This could result in better study designs for clinical trials and more accurate studies on disease progression.
A new study by MIT neuroscientists pinpointed the earliest emergence of amyloid protein plaques in the human brain, finding they correlate strongly with disease progression. The research uses a mouse model to track plaque development and shows that these regions eventually spread throughout the brain.
A study by the University of Waterloo found that anticipating performance at work or school can hinder memory recall. The presence of an audience may also contribute to this effect. Researchers suggest strategies like presenting first to avoid pre-performance anxiety.
A study published in Nature Communications elucidated transcription factors and enzymes controlling brain processes through DNA methylation, shedding light on long-term memory storage. This research has significant implications for understanding Alzheimer's disease and potentially enhancing learning.
Calcium channel blockers reduced calcium ion flow into brain cells, restoring normal function and improving memory in diseased flies. The study suggests targeting L-type channels could be effective in treating Alzheimer's memory loss.
A stepwise approach to assessing dementia risk in primary care uses a single question on subjective memory loss, followed by cognitive function tests. This method predicts incident dementia over seven years with high accuracy.
Researchers found that Zika virus replicates in adult human brain tissue and impairs synapse function and memory in infected mice. The study showed that the virus causes a strong inflammatory response, leading to microglia activation and synapse damage, resulting in memory loss.
Researchers found that resistance to ghrelin hormone is linked to cognitive impairments and memory loss in Alzheimer's disease. Activating both ghrelin and dopamine receptors simultaneously may help restore brain function and reduce lesions.
Researchers found that viewing memories in the third person reduces vividness and emotion, while recalling experiences in the first person strengthens memory. Virtual reality technology is being used to explore how perspective influences memory formation.
Rutgers University studies reveal higher rates of cognitive impairment among older Chinese American women, linked to depression, chronic conditions, and lower education levels. The research emphasizes the need for policy interventions to address linguistic, cultural, and socioeconomic barriers.
Researchers at Caltech have discovered that strong memories are formed when multiple neurons fire in sync, providing redundancy for long-term retention. This finding has implications for understanding memory loss due to brain damage or aging.
Scientists have developed a theory on how the brain stores and recalls the order of events, shedding light on memory dysfunctions. This new understanding has significant implications for treating mental health conditions like depression and schizophrenia.
A recent study in mouse neurons reveals how the protein CPEB3 primes neurons to store long-term memories. P bodies, specialized isolation chambers within neurons, contain dormant CPEB3 and transfer it to synapses, where it strengthens connections and stabilizes memories.
Research found that mice exposed to low-dose radiation for six months experienced impaired cellular signaling, leading to learning and memory problems and increased anxiety behaviors. The study highlights the need for safety measures to protect astronauts' brains during deep space missions.
Researchers at the University of Texas Southwestern Medical Center found that stimulating the cingulate cortex worsened memory recall in epilepsy patients. However, deep brain stimulation also modified hippocampal brain waves and demonstrated a direct role for the cingulate cortex in memory encoding.
A study in mice identified parvalbumin interneurons as key brain cells involved in social memory retrieval. Deficits in these cells may contribute to social memory deficits in schizophrenia and Alzheimer's disease.
A $1,825,742 NIH grant will fund a randomized controlled trial of strategy-based cognitive training in individuals with multiple sclerosis. The study aims to develop a treatment that improves everyday functioning and neuropsychological performance in those affected by the condition.