A 32-year-old man presented with a persistent, painless lip ulcer that failed to heal. Blood tests ruled out HIV and herpes, but syphilis serology confirmed the diagnosis. Treatment with benzathine penicillin G led to complete healing within two weeks.
Skin, a new international dermatology journal, has launched in Beijing to provide a high-quality platform for Chinese researchers to publish original studies on skin and venereology. The journal will adhere to rigorous academic standards and prioritize rapid global dissemination.
This study explored the association between mental health, dermatology-related quality of life, and probiotic intake in 305 Brazilian adults. Women showed higher anxiety, depression, and stress scores compared to men, with strong positive correlations among these conditions.
Researchers discovered a molecular seesaw that regulates healthy skin development. Modulating this balance with topical drugs could aid wound healing and slow skin cancer growth. The study found ubiquitin-like proteins trigger progenitor cells to mature or self-renew, leading to changes in immune cell populations.
Researchers developed a data standardization pipeline to transform heterogeneous clinical records into analyzable research resources for psoriasis. The approach enables the creation of integrated specialty databases and AI-assisted clinical decision support tools.
A new AI paradigm, Dermatology AI 2.0, enhances rare skin disease diagnosis by up to 32.9% through causal algorithms, while predicting eczema flares with over 90% accuracy. This technology frees dermatologists to focus on complex cases and patient care, potentially cutting diagnosis delays.
This Brazilian adult study explores the association between mental health, dermatology-related quality of life, and probiotic intake. Women were found to have higher anxiety, depression, and stress levels than men, with strong positive correlations among these conditions.
A recent study found that AI-powered chatbots can provide accurate information in 76.2% of healthcare-related questions, with specialties like obstetrics and gynecology performing best. However, internal medicine, neurology, and dermatology saw lower accuracy rates, with risks of harm associated with incorrect responses.
Researchers found that Demodex mite overgrowth and heightened innate immune activity are hallmark drivers of rosacea but not sensitive skin syndrome. Sensitive skin syndrome has its own unique mechanisms, characterized by distinct biomarkers such as reduced cathelicidin and dermcidin levels.
A study found that AI models trained on large amounts of registry data can identify individuals at higher risk of melanoma. The most advanced model distinguished individuals with a 33% probability of developing melanoma in about 73% of cases.
Researchers discovered that mutations in a key protein make yeast found in dogs with common outer ear infections more resistant to topical antifungals. The team recommends using shorter-tailed azoles as initial therapy for dogs with yeast ear infections, reserving longer-tailed azoles for recurrent or non-responsive cases.
Researchers used AI to analyze skin lesion changes in mastocytosis patients treated with avapritinib, finding a 36.6% reduction in lesion area and normalized skin color. AI can aid dermatologists in assessing small lesions, but human expertise remains essential.
The CU Anschutz School of Medicine has achieved the best ranking in NIH funding in 20 years, moving to No. 21 among all medical schools. This is attributed to the growth in NIH funding from $314 million, with nine clinical departments ranked in the top 15.
A study of US veterans has identified a possible link between exposure to Agent Orange and acral melanoma, a rare form of skin cancer. The researchers found that veterans exposed to the herbicide had a 30% higher odds of developing this type of melanoma.
A study published in PLOS One found that women authors comprise just 16.5% of first authors in a dataset of 878 retracted medical papers, despite accounting for at least 41% of first authors across biomedical publications. Women were also underrepresented among last authors and had fewer multiple retractions.
A major study has found that people with eczema can bathe either daily or weekly without affecting their symptoms. The study, published in the British Journal of Dermatology, involved 438 participants and showed no significant difference in eczema symptoms between the two groups.
The congress will focus on key mechanisms of skin ageing, including cellular senescence, mitochondrial dysfunction, and microbiome-skin interactions. Top experts in dermatology and longevity science will present new strategies for enhancing skin vitality and combating age-related decline.
Researchers have identified a new genetic marker, HLA-A*34:02, which can predict severe gout drug reactions in US patients when combined with HLA-B*58:01. This discovery could improve the safety of allopurinol for millions by expanding genetic screening.
A novel therapeutic candidate has been developed to treat severe cutaneous adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The compound suppresses disease-specific keratinocyte death, demonstrating its efficacy in preclinical studies.
Longitudinal research found that severe stress caused by family structure changes like divorce or separation during infancy triples the risk of developing psoriasis. The study, published in Journal of Investigative Dermatology, emphasizes the need to protect young children from stressful life factors.
A novel gene therapy targets and kills cancer cells infected with the Kaposi's sarcoma-associated herpesvirus (KSHV), while leaving healthy cells unharmed. The treatment uses a harmless virus to deliver a genetic 'Trojan horse' into infected cells, converting an anti-herpesvirus drug into a cancer-killing agent.
A new study published in JAMA Dermatology found that nicotinamide reduced the risk of skin cancer by 14%, particularly among patients taking the treatment after a first skin cancer diagnosis. The benefits were more pronounced for squamous cell carcinoma, suggesting earlier intervention may be beneficial.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
A recent study has found that people with psoriasis are at a significantly higher risk of developing AMD, including both exudative and non-exudative forms. The study suggests that biologic therapies may offer protective benefits for individuals with psoriasis.
A national review by Northwestern University identifies top dermatologist-recommended skin care ingredients for seven common complaints. Mineral sunscreen and retinoids are among the most effective ingredients, while too many products can irritate skin and worsen concerns.
Researchers found that central body fat, especially around the abdomen, is a stronger link to psoriasis risk than total body fat. This association remained consistent regardless of genetic predisposition, suggesting abdominal fat as an independent risk factor.
Researchers found that residual inflammation in psoriasis patients is linked to obesity, metabolic dysfunction, and increased systemic inflammation. This study suggests that despite good skin response to biologics, patients may still exhibit broader health implications, such as cardiovascular disease and fatty liver disease.
A topical BRAF-inhibiting gel, LUT014, improved acneiform rash in 69% of patients with grade 2 or 3 rash and received an EGFR-targeted antibody. The treatment also showed a 33% success rate for the placebo arm, but was associated with similar adverse events.
SKINdeep, a new international journal on translational dermatology and clinical studies, is now available online. The journal features original articles, reviews, and perspectives on skin diseases and their therapeutic relevance.
Researchers found basal cell carcinomas (BCCs) have an immune-excluded phenotype with minimal HLA-I expression, even in early development. A stem-like quiescent program suppressed APM genes, which could be reversed to enable BCC immunotherapy.
Medical students at UC San Diego provide free laser tattoo removal services to justice-impacted adults, gaining hands-on experience in dermatology. The initiative, which has been well-received, enhances medical education, social justice engagement, and patient care in underserved communities.
A Stanford Medicine study reveals glucose plays a crucial role in tissue regeneration by binding to proteins that control gene expression. Researchers found that glucose levels increase significantly as cells differentiate, supporting the growth of specialized cells in various tissues.
Dermatology researchers have identified a novel skin disease in a male patient with erythroderma, a rare and severe inflammation that causes widespread redness and scaling. Targeted treatment with biologic inhibitors reversed symptoms, providing a promising diagnostic tool for precision-medicine.
A large-scale screen of single nucleotide variants has identified 380 variants controlling cancer-associated genes. These variants regulate biological pathways such as DNA repair, energy production, and cell microenvironment interaction. The findings suggest new therapeutic targets for preventing or stopping cancer growth.
Researchers found a rare genetic interaction between ERAP1 and ERAP2 genes that increases the risk of frontal fibrosing alopecia (FFA). The study sheds light on the autoimmune basis of FFA and may lead to new treatments, including predictive genetic tests.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
A natural compound derived from gut-friendly bacteria significantly slows vitiligo progression and may restore pigmentation in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences.
A new study from Mass General Brigham found that approximately 1-in-5 patients experience acne recurrence after isotretinoin treatment. The researchers identified factors that increase the risk of recurrence, including female gender and lower cumulative dosages.
A new study by Mass General Brigham researchers reveals that a novel immunotherapy can eliminate precancerous spots and prevent skin cancer through the activation of specific immune cells. The therapy successfully cleared over 95% of facial lesions and showed long-term efficacy, with benefits lasting up to five years after treatment.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
The digital age is transforming cosmetic dermatology, with technologies like AI and telehealth pushing boundaries. However, challenges arise from social media's influence on skin advice and the need for in-person exams to ensure patient safety.
A geospatial analysis found that areas with more tanning bed facilities experience higher rates of melanoma. The study identified six high-risk clusters and seven low-risk clusters, suggesting a significant association between access to tanning beds and increased melanoma incidence.
Researchers at Weill Cornell Medicine identified a unique enzyme called FTSJ1 that enables melanoma cells to escape oxidative stress and spread. By targeting this enzyme, therapies may prevent or treat metastasis with minimal side effects.
Researchers are creating microphysiological systems to simulate infection and treatment in vitro, linking human lung and brain tissue models. This project aims to explore the relationship between respiratory diseases and neurological symptoms, potentially leading to new treatments.
A new study found that benzoyl peroxide acne treatments lack stability and degrade into carcinogenic benzene when exposed to heat, UV light, or stored at room temperature. Refrigeration may be a practical solution to minimize unnecessary exposure until safer formulations are developed.
A randomized clinical trial found home-based phototherapy to be as effective as office-based treatment for plaque and guttate psoriasis, while reducing patient burden. The study suggests that this approach could become a viable option for everyday clinical practice.
A new study demonstrates the potential of semaglutide in treating hidradenitis suppurative (HS) in people with obesity. The results show marked improvements in patient outcomes across several key measures, including reduced flare frequency, improved quality of life, and better glycaemic control.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
Researchers have identified lower levels of certain amino acids in the blood plasma of patients with unexplainable chronic itch, offering a potential breakthrough in treating this debilitating condition. These findings may pave the way for new targeted therapies.
A study comprehensively evaluated occurrence patterns of immune-related adverse events, including those affecting single organs and multiple organs. Researchers found that most events tend to co-occur and identified seven patient clusters with different development patterns, which were associated with improved or worsened survival outc...
Following a Mediterranean diet and taking omega-3 fatty acid supplements, participants experienced significant reductions in inflammatory and non-inflammatory skin lesions. Those who reached target omega-3 levels showed the most substantial improvement in acne severity.
A scientific team has identified pentamidine as an active substance that can prevent chlamydial infections, even at low concentrations. The compound suppresses the growth of intracellular bacteria by inhibiting host cell metabolism, offering a promising alternative to existing treatments.
The study uses the Dermatological Vision Dataset and compares vision transformers with traditional CNNs, achieving an impressive 97.8% accuracy on validation sets. Integrating ViTs into dermatology represents a promising step toward more accurate diagnostics.
A clinical trial discovered that the drug abrocitinib, approved for eczema treatment, significantly reduced symptoms of patients with severe itching diseases. Abrocitinib improved symptoms in both prurigo nodularis and chronic pruritus of unknown origin by 78% and 54%, respectively.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
A new Northwestern Medicine study reveals that 73% of children with skin diseases face stigma and bullying, leading to impaired relationships and mental health issues such as depression and anxiety. The study suggests that clinicians should aggressively treat skin disorders in children and consider referral to evaluation and counseling.
Researchers at Boston University School of Medicine created a new scale for hyperpigmentation, the Post-inflammatory Dyspigmentation Area and Severity Index (PIDASI), which performs well in patients with varying skin tones.
Researchers developed a scoring system to distinguish between two serious skin diseases with similar symptoms. The study analyzed data from 117 patients and found the scoring system could help medical professionals quickly diagnose and choose appropriate treatment.
Researchers warn of a growing problem with severe fungal infections, resulting in over 150 million cases annually and 1.7 million fatalities globally. The emergence of multidrug-resistant fungal species, such as Candida auris and Trichophyton indotineae, poses a significant threat to patient outcomes.
Current AI dermatology mobile apps can improve access to care, but their efficacy, safety, and transparency are concerns. Regulating these apps is essential to minimize risks and maximize benefits.