Scientists have developed a method to synthesize Neosrangcicin A, a complex molecule with potential as a reserve antibiotic. The successful synthesis provides a foundation for altering the natural substance and developing more stable variants.
Researchers at Science Tokyo develop a Ramsey-based magnetometer that overcomes thermal limitations, enabling close-proximity detection of weak biomagnetic signals. The sensor achieves high sensitivity and safe operation near biological tissue.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
The review explores various propulsion strategies, navigation algorithms, and on-demand release mechanisms for autonomous microrobots. The authors propose a four-tier hierarchy based on barrier traversal capability, enabling local, systemic, deep tissue, and immune-privileged delivery.
A study identifies curcumin as the natural compound with the most balanced combination of anticancer activity and safety against fibrosarcoma cells. Curcumin, along with berberine, disrupts mitochondrial function and energy metabolism in cancer cells, leading to cellular senescence and death.
A new study reveals that p53 mutations in cancer cells can limit the effectiveness of immunotherapy by manipulating cellular metabolism, specifically through autophagy. Removing these mutant forms of p53 restores mTORC1 activity and reduces autophagy, making tumors more vulnerable to immune attack.
Insilico Medicine has nominated an AI-driven novel compound ISM9528 for pain management, addressing the $100 billion market challenge. The compound targets Target Z and offers a non-opioid treatment approach with superior efficacy and safety profile.
Scientists at UVA have developed a new method to target glioblastoma, the most common and deadly brain cancer, by delivering microRNAs through the brain's natural barrier. The approach shows promise in slowing tumor growth and extending survival in animal models.
A new randomized clinical trial suggests that singing therapy provides greater short-term symptom relief and improved quality of life compared to diaphragmatic breathing exercises for people with supragastric belching. Structured singing therapy also resulted in higher response rates and more enjoyable experiences among patients.
A new study has found that exposure to glyphosate, a widely used herbicide, may increase the chance of giving birth too early. Women with higher levels of glyphosate in their urine samples were more likely to go into spontaneous labor before 37 weeks.
Researchers found that bee venom can improve motor function and cognitive decline in a mouse model of Parkinson's disease when used alongside conventional therapy. The study suggests promising benefits for developing adjunct therapies to improve treatment outcomes.
Researchers at ISTA develop two modeling approaches to represent extremely deformable surfaces more realistically while cutting computational costs. They take inspiration from natural systems like volcanic lava and cake batter to create a wave-based approach, which tackles long-standing graphics problems from a new angle.
A novel cross-modal fusion framework integrates low-altitude drone RSI with ground robot LiDAR-inertial measurement unit (IMU) odometry to create accurate digital models of orchards. The system achieved localization accuracy on the order of a few centimeters, demonstrating robustness to seasonal variations and long-term drift.
Researchers found that brain fluid circulation depends on blood flow in the venous sinuses, and impaired lymphatic vessels lead to accumulated fluids causing pressure buildup. The study opens new avenues for refining diagnosis and improving patient care for patients with IIH.
A new study reveals that despite improvements in access to services through Jordan's Principle, First Nations children still face long-standing inequalities in healthcare. The review highlights the critical role of allied health professionals in navigating the system and calls for improved training and awareness among healthcare workers.
A recent study by the University of Bonn and international partners found that land degradation significantly impacts crop yields worldwide. Reversing 10% of human-made soil damage could increase arable land's food supply by 70 million people.
A groundbreaking study quantified CO2 emissions from acid mine drainage neutralization in metal mining, finding it releases a similar amount of CO2 as conventional copper production. The long-term impact is concerning, as the process can continue for centuries, making it a significant challenge for decarbonizing the industry.
A team of international researchers has successfully demonstrated a breakthrough in detecting satellites and space debris in orbit using repurposed radio telescopes. This technology can increase sensitivity by more than tenfold, enabling the detection of smaller objects at greater distances.
A randomized clinical trial found that ingesting fecal microbes from healthy donors improved sleep efficiency and reduced wake after sleep onset in participants with chronic insomnia. Sleep quality scores also showed significant improvement over two months.
Scientists have developed a method to encapsulate enzymes in a protective molecular cage, enabling efficient and recyclable reactions at high temperatures. This breakthrough has far-reaching implications for sustainable chemical manufacturing and could lead to the creation of new products in industries such as cosmetics.
Research in New Phytologist shows that plant spininess is shaped by browsing mammals past and present, as well as environmental conditions like dry-season length, soil pH, and temperature. Current and extinct large herbivores are key predictors of spiny species prevalence.
Researchers discovered specific microRNAs, including miR-16 and miR-140, which may help detect cancer-related muscle wasting in dogs. The study's findings have implications for human medicine, suggesting a potential new approach for earlier diagnosis and monitoring of cancer-related cachexia.
A US county-level analysis reveals a significant association between high levels of household debt and increased suicide rates during the Great Recession. Suicide rates doubled for men and tripled for adults aged 40–64 years in high-debt counties, highlighting the need for policy interventions targeting mental health impacts.
Research suggests that sports-based interventions may improve motor skills in children with autism spectrum disorder. Martial arts and aquatic training demonstrated the most consistent benefits, particularly in balance and total motor skills. Larger studies are needed to confirm these findings.
Researchers at Japan Advanced Institute of Science and Technology developed a new computational method combining neural networks with Bayesian localization, achieving accurate predictions while reducing computational cost. This breakthrough enables the high-precision analysis of large-scale materials and complex chemical reaction systems.
Researchers developed an AI that navigates ships using human-like decision-making, handling complex situations such as narrow channels and multiple vessels. The AI achieved compliance with maritime traffic rules and demonstrated unexpected behavior like local navigation customs.
A new study in the Canadian Journal of Cardiology predicts that generic semaglutide will dramatically increase cost-effectiveness and health system affordability for patients with type 2 diabetes and high cardiorenal risk. The estimated annual cost of providing GLP-1RAs to all indicated patients would be $3.35 to $5.31 billion at pre-g...
According to new research from the West Health-Gallup Center on Healthcare in America, nearly one in four U.S. workers are currently in a job they want to quit but stay due to health insurance coverage. Women and people with chronic conditions experience higher rates of job lock.
Indigenous Australians gathered whole grasses from the landscape and burned them in a cave for ritual practices dating back 25,000 years. The study found that people selectively targeted specific types of grasses for burning, with over 97% coming from temperate or cool-climate grasses.
A study reveals a contrast in decision-making pathways between fuel vehicle and EV owners, highlighting pragmatic benefits for FV owners and habit-driven loyalty among EV owners. The research suggests segment-specific strategies to convert fuel-to-EV owners and retain existing EV users.
Researchers introduced CogDrive, a cognition-driven framework for autonomous vehicles to think ahead and make structured reasoning about multiple possible future behaviors. The framework achieves state-of-the-art performance in trajectory prediction and demonstrates smoother maneuvers in dense urban environments.
Researchers use periodic driving to transform optical lattice into accurate SYK model simulator, reproducing strong quantum chaos and information scrambling. This method opens door to studying complex quantum phenomena in strongly interacting systems.
The Robotic Servicing of Geosynchronous Satellite (RSGS) payload successfully launched from Space Launch Complex 40 at Cape Canaveral U.S. Space Force Station. The mission aims to extend the life and resilience of satellites in geosynchronous orbit through on-orbit servicing.
Researchers constructed yeast strain SYNE27α with all 300 spliceosomal introns removed, demonstrating intron non-essentiality. The strain showed slow growth but heterozygous cells grew normally, supporting recessive fitness defects.
A major international review finds that exercise addiction is marked by a loss of control and can lead to physical harm, emotional distress, and strained connections. Researchers caution against alarm and emphasize the importance of exercising smarter, building in rest and recovery days, and seeking support early.
A new 'Hydrology–Environment–Ecology' framework bridges aquatic and terrestrial ecological risk assessment for lake conservation. The framework reveals significant increasing trends in both aquatic and terrestrial ecological risks from 2000 to 2019, with habitat quality identified as the key risk indicator.
A new model, PSIDMViT, combines anatomy, physics, and machine learning to predict accurate dose distributions for CyberKnife radiation therapy. The study shows improved agreement with Monte Carlo reference doses and reduced computation time, suggesting a promising strategy for improving radiotherapy dose prediction.
A research group at Tohoku University has overturned the long-standing assumption that smoother surfaces produce less aerodynamic drag. By applying Distributed Micro-Roughness, they achieved a world-first experimental demonstration of up to 43.6% drag reduction.
Researchers found that traditional inerting methods are ineffective in preventing explosions from nano-aluminum powder in additive manufacturing. The study suggests that only certain types of inert powders can suppress combustion without promoting it. This research provides critical evidence and theoretical basis for developing targete...
A study by Kumamoto University researchers reveals a hidden communication network between the skin and bone marrow that drives psoriatic inflammation. This pathway highlights a crucial role for neutrophils in fueling psoriatic flare-ups, suggesting a promising new target for future therapies.
A new computational approach extends the Particle-in-Cell method with condensed-matter physics, enabling researchers to simulate a broader range of light–matter interactions in metals, semiconductors, and emerging quantum materials. This allows for more realistic predictions and optimizations in next-generation semiconductor and photon...
This study examines the impact of financial penalties on US airlines' behavior during lengthy tarmac delays. Despite improvements in some cases, changes are generally modest and short-lived, with unintended effects like increased flight cancellations.
A recent study using high-resolution modeling suggests that Hawaiian corals may be able to adapt to increasing temperatures, even under a high emissions scenario. However, the rate of adaptation varies across different coastal locations, with those around Hawaiʻi Island projected to experience higher heat stress.
A comprehensive study has consolidated knowledge on the production of green hydrogen for jet fuel, highlighting its potential to transform the sector. To make it commercially viable, significant research is needed on hydrogen infrastructure needs, refuelling systems, and policy frameworks.
Research at Oregon State University found that frequent cannabis users wake up with more cortisol in their system, indicating a possible dysregulation of the body's daily stress response. This could lead to impairments in daily stress rhythms and a cycle of more cannabis use.
Researchers have successfully controlled individual molecule spins using electrical signals, opening up new prospects for fast and compact quantum components. This approach enables precise control of quantum-mechanical states without the limitations of magnetic fields.
A team at TUM has developed a process to produce crucial amino acids from carbon dioxide, hydrogen, and renewable energy. The approach converts solar energy into electricity, generating hydrogen that is then converted into methanol and eventually into amino acids.
A new study led by Durham University suggests that reassuring body contact can improve social tolerance and promote peaceful resource sharing. The research analyzed behaviours of bonobos and chimpanzees and found that individuals who engaged in pre-feeding reassurance spent more time co-feeding alongside others.
A joint KAIST research team developed a new framework for analyzing networks of circulating amino acids, reflecting the body's metabolic state. They showed that this approach can predict recurrence or metastasis in patients with colorectal cancer more accurately than current methods.
Use of newer GLP-1 receptor agonists like semaglutide and tirzepatide was associated with a significant reduction in alcohol-related hospital admissions among adults with type 2 diabetes and obesity. The findings suggest a potential role for these medications in treating alcohol-use disorder.
A study published in RMD Open found that specific oral microbiome imbalances may contribute to the development of hand osteoarthritis by influencing systemic inflammation and gut microbiome dysbiosis. The research suggests a potential role for the oral-gut microbiome axis in symptomatic hand arthritis pathogenesis.
Astronomers discovered high-speed 'bullets' of oxygen-rich gas shooting out of the only known helium nova in Milky Way, confirming binary system responsible for rare stellar explosion. The discovery provides unprecedented opportunity to study one of universe's rarest types of stellar explosions.
A KAIST research team has developed a new molecular system that can selectively switch the pathway through which electrons are transferred during oxygen activation. The findings provide a fundamental design principle for next-generation catalysts and energy-conversion technologies.
A new Global Burden of Disease study found that people are spending more years living with chronic disease and disability as global life expectancy increases. The analysis revealed that high-income countries face the widest morbidity gaps, while women consistently live longer but spend more years in poor health.
A new study has developed a high-resolution inventory of veterinary antibiotic emissions across China, tracking emissions from livestock and aquaculture into soil, freshwater, and seawater. The inventory estimated that approximately 23,110 tonnes of veterinary antibiotics were released into China's environment in 2020.
A new study introduces a standardized method for measuring greenhouse gas and air pollutant emissions generated across the entire retail journey. The protocol covers online and traditional in-store shopping and provides nationwide parameters for China from 1990 to 2023, identifying opportunities for meaningful reductions.
John Scully, a renowned materials scientist, has been recognized with the SURA Distinguished Scientist Award for his groundbreaking work on corrosion research. His contributions have led to significant advancements in understanding materials degradation in harsh environments, impacting human health and national defense.
Researchers have discovered a key breeding ground for endangered sand tiger sharks off the coast of São Paulo, Brazil. The Alcatrazes Archipelago Wildlife Refuge provides a vital sanctuary for the critically endangered species, allowing them to complete their reproductive cycle in Brazilian waters.
Homa Alemzadeh's groundbreaking 2016 paper identified the security risks of teleoperated surgical robots, demonstrating that they can be vulnerable to cyberattacks. Her research proposed a real-time safety engine to mitigate these threats and has had a sustained impact on the field of dependable systems.
Craig Meyer, a UVA professor of biomedical engineering and radiology, received the ISMRM Gold Medal for his pioneering work in advancing MRI technology. His research focuses on refining fast acquisition methods, including spiral-based approaches, to capture high-quality images in challenging conditions like imaging the lungs. The awar...