The Restore-1 clinical trial aims to modify the small intestine's lining with steam energy to restore natural blood-sugar control in patients with type 2 diabetes. The procedure, if successful, could prevent patients from advancing to insulin-dependent diabetes.
A new study finds that investing in cleaner alternatives for the steel sector before 2030 can prevent 73 gigatonnes of CO2 emissions by 2070. This would be more cost-efficient than reducing emissions through other sectors or carbon removals.
Researchers found that atoms on certain gold surfaces naturally rearrange themselves into protective patterns that suppress reactions with oxygen. This discovery helps explain why gold jewelry and objects can remain untarnished for centuries.
Researchers identified a key protein called PERM1 that is restored in patients whose hearts recover after left ventricular assist device (LVAD) support. PERM1 regulates energy production and contractile function in heart cells, and its normalization is associated with improved cardiac function.
Professor Hannah Cloke's appointment as Regius Professor of Meteorology and Climate highlights the importance of human imagination in understanding and mitigating extreme weather. Her research has already helped communities prepare for floods and extreme weather, and she aims to empower people to take charge of their own futures.
A new study of over 1 million young Swedish men found that the risk of atrial fibrillation is less than previously calculated, and the benefits of high fitness levels outweigh the risks. After age 40, the balance shifts in favor of higher fitness levels, suggesting that the benefits of exercise may be more significant.
Researchers have created a gene expression map of seed development in Arabidopsis thaliana, revealing the role of specific genes and cell types in shaping seed traits. The study identifies key regions where hormones regulate growth and nutrient storage, providing insights into how seeds develop and can be improved for crop productivity.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
A new study highlights the potential of AI tools in soil science, enabling researchers to better understand soil ecosystems and adapt to climate change. The system successfully generated hypotheses on how soils store carbon and what controls their storage limits, with outputs aligning with expert research.
New AI tools can accelerate soil science by speeding up early-stage work, improving predictions to support decisions on land-use, carbon, and climate adaptation. The system successfully mimicked key parts of the scientific process, with outputs beyond what's currently being used that strongly align with expert research.
Researchers from EPFL have developed a new holographic approach to volumetric 3D printing, enabling cell-compatible, high-resolution printing at near-clinical scales. The method uses phase control to produce higher-fidelity objects in light-scattering media, such as those containing living cells.
A new study found irisin reduces clinical symptoms and neuron loss in a mouse model of MS. Irisin also protects neurons from inflammation-driven neurodegeneration.
Researchers developed an AI system called CMR-CLIP that can interpret complex heart scans without manual labels, outperforming existing models by up to 35%. The system learned from over a million images and hundreds of thousands of motion sequences collected from Cleveland Clinic.
A team from Graz University of Technology has developed a prefabricated brick wall system that can be dismantled and re-used without being destroyed. The system reduces CO2 emissions by up to 60% compared to conventional construction methods, offering significant environmental benefits.
Researchers at ISTA uncovered why keratin plays an essential part in embryonic cell movement and organization. Without keratin, the process slows dramatically, leading to tissue collapse and loss of cellular alignment. Keratin helps maintain the structural integrity and cohesion of cells during early development.
Europe's bacterial STI cases reached record highs in 2024, driven by gonorrhoea and syphilis, with men who have sex with men disproportionately affected. The near doubling of congenital syphilis cases highlights the need for improved antenatal screening protocols to prevent transmission to newborns.
A study analyzed over 300,000 citizen science observations to identify patterns influencing participation rates. Regional data from the Hungarian Central Statistical Office was combined with citizen science data to examine the relationship between socio-economic and environmental factors on observation density.
Researchers from OIST have reported the first full structural characterization of a doubly ring-slipped reaction intermediate in metallocene formation. This discovery provides new evidence on how metallocenes form and react, presenting opportunities for designing tunable structures for applications such as drug delivery systems, cataly...
A lower CA19-9 cutoff of 7 units/mL can identify patients with pancreatic cancer who have high-risk disease despite low biomarker levels. This dual-threshold model helps distinguish between true low tumor burden and Lewis antigen-negative status, improving prognostic assessment.
Researchers at Cornell University have developed a robotic collective that exhibits coordinated motion and adaptability without centralized control. The Cross-Link Collective consists of small robots that can entangle and move collectively, self-organizing into shifting configurations.
A new study found that air pollution can disrupt insect communication by chemically altering pheromones. Ozone pollution degrades pheromone signals in moths, reducing mating success and threatening pheromone-based pest control strategies.
Researchers at the University of Guelph developed a faster way to identify potential drug targets against Candida albicans using CRISPR interference. The new system reduced the time from laboratory discoveries to clinical applications by years, focusing on hundreds or thousands of genes simultaneously.
Tahiyat Rahman, a physics Ph.D. holder, will work on policy investing in workforce and training for quantum technologies and materials manufacturing. As a Congressional Fellow, they aim to build public consensus around science policy.
Research shows that intrinsic motivations, such as enjoying physical activity and feeling healthy, consistently matter most in predicting aerobic fitness. Teenagers who value these factors are significantly fitter at 17 than those motivated primarily by winning or external rewards.
New research from the University of Otago has uncovered a specific biomarker in blood plasma associated with Alzheimer's disease. The study found that elevated levels of ptau181 were linked to subjective cognitive concerns, but not objective decline or structural brain integrity measures.
Researchers used cryo-EM to investigate the molecular basis of functional diversity in alcohol oxidase isozymes. The study found structural differences in cofactor binding and amino acid residues that affect enzyme stability and catalytic performance, ultimately resulting in distinct roles among the variants.
Researchers developed Cel-T plastic, a novel cellulose-based supramolecular plastic with high mechanical strength, thermal stability, and versatile shapeability. The material combines the strengths of polylactic acid, polymethyl methacrylate, acrylonitrile-butadiene-styrene, and polyethylene terephthalate.
CURE SYNGAP1 partners with RARE-X to accelerate ProMMiS study's Patient-Reported Outcome measure data collection. This investment enables the centralized collection of high-quality PROs, essential for regulatory approval and therapy development.
The Lancet MedZero platform offers product-level carbon data for hospitals and health systems worldwide, enabling evidence-based decision-making and supporting climate action. With over 14,000 entries launched, the platform aims to help healthcare institutions reduce waste, improve patient care, and tackle climate change.
Researchers identified CREP1, a pectinase-like effector protein from Fusarium lateritium, as a key regulator of plant immunity. CREP1 interacts with receptor protein NbEIX2 to activate immune responses, including ROS burst and cell death.
Research identifies a novel narnavirus, TmNV1, as a potent virulence attenuator in Talaromyces marneffei. Coinfection with TmPV1 amplifies hypovirulent phenotypes, reducing fungal burden and inflammation.
Researchers from The University of Osaka discovered that only a small proportion of CD8 T cells undergo sustained clonal expansion in multiple myeloma immunotherapy, leading to the strongest anti-tumor response. Early immune activity could help predict which cells will become effective cancer fighters.
Recent advancements in microwave dielectric ceramics research focus on property characterization, theoretical mechanisms, sample preparation, applications, and data-driven discovery. Key findings include the development of standardized resonant methods for evaluating low-loss materials and advanced cold sintering processes enabling co-...
A new study from Edith Cowan University found that music listening habits vary greatly among university students. For some, music boosts motivation and enhances focus, while others find it distracting. The research highlights the importance of individual differences in music engagement in studying.
Research in regional Australia found nearly a third of rural siblings experience low wellbeing due to insufficient access to formal mental health services. Resilience, community support, and understanding from local communities are critical for improving sibling outcomes and addressing emotional strain.
Researchers at SKKU have created a highly efficient water-splitting catalyst that activates 'lattice oxygen' to break the oxygen evolution reaction bottleneck. By controlling atomic spacing, they enabled robust metal-oxygen interactions, achieving lower energy levels than precious metal catalysts.
Researchers have developed engineered peptide binders called CRABs that can selectively interfere with calcium signaling pathways, potentially leading to more effective and safer immunotherapies. The study's findings offer new hope for treating disorders linked to excessive CRAC-channel activity.
The coalition aims to accelerate validation and qualification of human-relevant methodologies, such as complex in vitro models and microphysiological systems, for drug discovery and development. By aligning developers around shared qualification standards, the coalition reduces duplicative validation efforts and helps regulators evalua...
Researchers discovered a new gene expression signature linked to prolonged overall survival in patients with metastatic castration-resistant prostate cancer who responded to combined immune checkpoint inhibitors. The biomarker has the potential to help identify patients most likely to benefit from this treatment combination.
Researchers at La Jolla Institute for Immunology have discovered that combining key vaccine ingredients could give the body the tools it needs to fight the entire family of arenaviruses with a single vaccine. This approach may protect against life-threatening infections from Lassa virus, Junin virus, and many other arenaviruses.
Researchers found that small-scale thunderstorms strengthen over cities, while cold frontal storms weaken their rainfall intensity. Urban heat and roughness disrupt the lower part of storm systems, leading to varying effects on different types of storms.
A recent study found that consuming common preservative food additives increases the risk of high blood pressure and cardiovascular disease. Non-antioxidant preservatives, in particular, were linked to a higher risk of hypertension.
A study from Michigan State University found that people consistently underestimate their friends' cynicism and overestimate their benevolence. This biases can impact friendship maintenance and may be more pronounced in newer friendships.
Odylia Therapeutics is advancing a gene therapy treatment for Usher Syndrome Type 1C (USH1C)-associated vision loss, a rare autosomal recessive disorder. The grant will support the development of an investigational USH1C gene therapy designed to restore or preserve vision.
A new Cochrane review finds planned early birth for pregnant women with high blood pressure cuts maternal complications by nearly half and reduces the risk of stillbirth. The practice is found to be safe across both high- and low-income settings, without increasing the likelihood of caesarean section.
A new study by the University of Southampton has found that reusable catheters are just as safe for patients as single-use ones and do not increase the risk of urinary tract infections. The study followed hundreds of patients for a year and discovered that those who tested reusable catheters used 35 per cent fewer antibiotics.
The BMJ argues that healthcare has lost its human, moral, and relational foundations. Experts say reconnecting with these values is crucial for improving patient outcomes and staff well-being. By prioritizing kindness, compassion, and leadership, healthcare can rebalance its focus from technical power to individualized care.
A systematic review of 69 trials involving over 153,000 adults found that calcium, vitamin D, or combined supplements have little to no effect on fracture prevention. The findings suggest that routine supplementation may not be necessary, and instead focus should be on interventions like balance and resistance exercise.
The ISSCR Consortium supports the FDA's draft guidance on using new approach methodologies (NAMs) in drug development, emphasizing the need for a flexible and science-driven framework. The consortium recommends clarifying biological complexity alignment with context of use and expanding recognition of computational modeling and hybrid ...
Researchers at UC Riverside have identified a key neural circuit, the locus coeruleus, which plays a central role in cognitive flexibility and adapting to new rules. Disrupting this circuit impairs the brain's ability to reorganize neural networks during complex decision-making.
Researchers use NASA's James Webb Space Telescope to analyze light passing through a distant, temperate gas giant planet's atmosphere, revealing methane and potentially other gases. The study provides insights into planetary formation and evolution, and could improve understanding of Earth's atmosphere.
The University of Texas MD Anderson Cancer Center has been awarded $19 million by CPRIT to support young cancer survivors, groundbreaking research, and faculty recruitment programs. The funding will enable UT MD Anderson to recruit world-class scientists and clinicians, pursue new discoveries, and accelerate cancer treatment advancements.
A recent study reveals that Atlantic herring rewired its reproduction to survive in the Baltic Sea's low-salinity waters through four key genetic adaptations. These adaptations enabled the species to reproduce successfully despite the challenging environmental conditions, highlighting the importance of gene function and regulation in e...
Primary care practices acquired by private equity firms tend to see more patients, provide more services, and complete annual wellness visits. They also hire more physicians and advanced practice providers, suggesting a spread of extra work across larger teams rather than individual doctors.
Researchers at the University of Texas at Arlington are developing a new technology to enable clear, detailed imaging of biological structures far beneath the skin's surface. This innovation has the potential to improve disease detection and diagnosis, particularly in areas such as cancer and vascular diseases.
Researchers at Texas Tech will develop wide/ultrawide bandgap semiconductor materials and devices with a $4.5M grant. The project aims to improve performance and reliability in harsh environments for aerospace, defense, and other industries.
A study published in Neurology found that quitting smoking is associated with a lower risk of dementia, especially for those who maintain a stable weight. The research followed 32,802 middle-aged and older individuals without dementia at the start of the study, finding a sustained lower risk of dementia with time since quitting.
Migraine with aura is linked to a 73% increased risk of ischemic stroke in middle-aged and older adults. The study found no association between migraine without aura and an increased risk of stroke. Men under age 72 with migraine also face a significantly higher risk of stroke, contradicting previous research in younger individuals.
A new report from Brookings Institution highlights the federal government's growing use of AI, but also notes significant disparities and bottlenecks to widespread adoption. Large agencies lead the way, while smaller agencies struggle with workforce capacity and trust issues.
A Simon Fraser University study found over 200 contaminants in juvenile Chinook salmon in the Lower Fraser River estuary, including priority contaminants like pharmaceuticals and pesticides. This exposure adds stress to already vulnerable fish populations.