Researchers found that a vitamin D analog reduced fibroblast activation and increased T cell infiltration in pancreatic tumors, improving chemotherapy responses and progression-free survival. Patients with high vitamin D receptor expression also had longer overall survival.
Lurie Children's Hospital of Chicago has successfully eliminated months of postoperative pain for microtia patients through a minimally invasive nerve freezing procedure. The method, which lasts only 20 minutes, allows patients to enjoy natural ear sensation and appearance without prolonged pain or opioid use.
Researchers identified a potential new way to relieve chronic pain linked to neurofibromatosis type 1 (NF1). Blocking MAPK signaling with a MEK inhibitor lowered GDNF levels in Schwann cells and reduced pain-like responses in mice.
Researchers at Umeå University have created the first complete 3D map of an entire pancreas from a donor with late-onset type 1 diabetes. The analysis revealed hundreds of thousands of insulin-producing cells outside traditional islet structures, challenging traditional understanding of β-cell loss in type 1 diabetes.
A UCalgary study found that Engleman and white spruce trees use the same genetic tool kit to survive in variable climates across the Canadian Rockies. The research provides insight into species adaptation and evolution, shedding light on how trees thrive in different environments.
Researchers at St. Jude Children's Research Hospital discovered that cells use two pathways to silence invading transposons: RNA interference and heterochromatin. These pathways are triggered by abnormal RNA patterns produced by the transposon, allowing cells to detect and defend against invasive DNA sequences.
A new study published in the British Journal of Sports Medicine found that children who received early, tailored care experienced significant improvements in recovery from concussion. The intervention combined education, physiotherapy, and psychological support, resulting in a 62.5% full recovery rate compared to 37% for those receivin...
Researchers at MUSC Hollings Cancer Center have identified a potential way to reduce relapse in medulloblastoma by targeting tumor cells most likely to survive treatment and drive regrowth. The dual-pathway approach, focusing on CK1α, shows promise in preclinical models.
Monta Vista High School and Sierra Vista Middle School won the championships in Division C and B, respectively. The tournament featured rigorous hands-on events covering various STEM topics.
Researchers at Southwest Research Institute (SwRI) and Texas Biomedical have identified nearly two dozen antiviral compounds that could potentially treat Bundibugyo Ebolavirus. The project utilizes AI and machine learning tools to quickly identify drug candidates, with Texas Biomed set to screen the compounds in the coming weeks.
A Dartmouth Cancer Center study reveals that the location of immune cells within a tumor can determine whether they aid or hinder the anti-cancer response. Macrophages, often seen as helpful in clearing debris, have been found to play complex roles depending on their location and signals produced.
A new study from the Wilmot Cancer Institute highlights the benefits of yoga in improving four domains of physical and psychological side effects experienced by cancer patients. Yoga was found to have a significant positive effect on overall mood disturbances, anxiety, and fatigue among survivors.
Researchers found that hydroxychloroquine use was associated with better cardiovascular and cardiometabolic health outcomes in patients with discoid lupus erythematosus. The study also found a lower risk of hypertension, hyperlipidemia, type 2 diabetes, stroke, and coronary artery disease among hydroxychloroquine users.
A new study has identified a group of blood proteins that can flag multiple sclerosis risk years before diagnosis. Researchers found that these proteins are altered in people who develop MS, potentially leading to early intervention and prevention.
A Boston University researcher found that most hikers and trail runners are not carrying the necessary emergency gear, despite being in remote areas. The study suggests targeted educational outreach can help alleviate this problem and recommends more awareness about preparedness.
Researchers developed targeted platinum-antibody conjugates that effectively enhance tumor immunogenicity and promote anti-tumor immunity. The low-dose platinum delivery strategy showed strong synergy with anti-PD-1 therapy, achieving tumor suppression superior to monotherapy or simple combination treatment.
A collaborative team developed an AI-assisted pipeline to identify promising gp130 inhibitors from a library of natural products. Evodiamine was identified as a starting scaffold, and Compound 8a was selected as the optimal candidate with high affinity for the gp130 D1 domain.
Researchers discovered acteoside alleviates hepatic ischemia-reperfusion injury through two mechanisms: inhibiting IRF1 nuclear translocation and promoting CMPK2 degradation. Acteoside reduces liver injury, serum ALT/AST, inflammatory infiltration, oxidative stress, and mtDNA release.
The University of Manchester is developing new technologies to recover valuable materials from hard-to-recycle waste, including disposable vapes and cars. The project aims to break down these materials at a molecular level and recover valuable components that can be reused.
Two UT microbiology researchers, Steven Wilhelm and Brittany N. Zepernick, received the 2026 Daylight Award for their research on phytoplankton thriving under ice. Their work provides novel mechanistic insights into how diatoms respond to ice loss and has major implications for planetary health and biodiversity.
A team of researchers led by Michigan State University has been tracking tree seedlings for 25 years to understand their impact on forest resilience. They found that some species are better suited to the changing climate than others, while tree canopy cover can help shelter certain species from extreme weather conditions.
Researchers developed HerbSyner_Finder to identify synergistic herb pairs for cough variant asthma. The model showed strong synergy between berberine and luteolin, reducing symptoms and inflammation in rat models.
A recent study found that homing pigeons use simple route averaging to improve their navigation when flying together. This strategy allows the birds to generate social routes from solitary ones, providing evidence for a simpler mechanism of social learning than previously thought.
Dual-comb spectroscopy enables precise, rapid, and broadband measurements using two optical frequency combs with slightly different repetition frequencies. This technique has been implemented across the electromagnetic spectrum, from terahertz to visible range, with ongoing efforts towards ultraviolet range.
A 2021 dog daycare outbreak in LA County revealed critical gaps in vaccinations and animal-to-human transmission. Leptospirosis, a bacterial disease, can cause severe illness in dogs and flu-like symptoms in humans.
The collaboration aims to jointly develop a super-intelligence AI foundation model to predict disease risk, diagnose conditions, and discover novel therapeutics. By integrating advanced algorithms with deep biological insights, the models are expected to drive breakthroughs in early detection and personalized interventions for age-rela...
Researchers found that tropical butterflies in the Peruvian Amazon undergo 'seasonal reproductive plasticity', changing their traits in response to seasonal changes. Two species reduced egg production during dry seasons, with one undergoing a reproductive diapause and others continuing to mate at a reduced rate.
A recent study using whole-genome data reveals the complex history of South American Indigenous peoples, with genetic diversity higher in Central America and the Southern Cone. The research also identifies a third wave of migration from Mesoamerica around 1,300 years ago, which challenges previous views about Indigenous groups.
Researchers developed a Pt–CuOx interfacial catalyst that converts HMF to FDCA at significantly lower voltages, achieving 99.1% FDCA selectivity and 93.8% yield. The optimized catalyst demonstrated excellent durability, maintaining over 90% selectivity for more than 110 hours.
A novel DNA aptamer, NP14, targets the N-terminal domain of the SARS-CoV-2 N protein for highly sensitive and mutation-resistant viral detection. A dual-mode biosensing platform combines visual and quantitative readouts to achieve ultrasensitive and reliable diagnosis.
A novel therapeutic paradigm combines electroacupuncture with regenerative tissue engineering to enhance nerve regeneration and functional recovery in spinal cord injury. The study found that electroacupuncture stimulation improved neural signal transmission, suppressed neuroinflammation, and promoted myelin regeneration.
Researchers developed a new model showing that supply chain disruptions exacerbate systemic risk in the banking sector. The model reveals that supply chain contagion can amplify losses on the interbank market by 70%, posing a major threat to financial stability.
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Research by Göttingen University found that colourful Nutri-Score labels on the shelf and price tag are more noticeable and influencing consumer choices. The study suggests that companies should display multi-coloured labels to support consumers in making health-conscious choices.
Researchers identify Sanguinarine as a potent agent that synchronously induces apoptosis and ferroptosis in lung squamous cell carcinoma by hijacking the ER chaperone protein BiP. This 'switch' triggers Endoplasmic Reticulum Stress, leading to catastrophic cell death.
A new study by researchers at the University of Toronto identified a specific brain pathway through which cholecystokinin (CCK) acts to amplify pain in response to negative expectations. This pathway, traveling from the anterior cingulate cortex to the lateral periaqueductal gray, increases pain sensitivity and worsens symptoms.
A large-scale study reveals that obesity rates have slowed and even reversed in many high-income countries, while continuing to rise in developing nations. The analysis, involving over 1,900 researchers and 232 million people across 200 countries, suggests that previous claims of a global obesity epidemic may be an oversimplification.
Advincula received the Frank Tiller Award for his pioneering work on new materials, 3D printed membranes and smart separation surfaces. His research at ORNL focuses on polymer design, synthesis and characterization.
Research explores the impact of donor-acceptor ratio on buried interface optimization in perovskite solar cells. The study reveals that an EDG-rich modification leads to efficient defect passivation and high-quality film growth, resulting in improved stability and performance.
A novel biogel solves hair-related issues with EEG systems, maintaining stable performance across different hair types for multiple days. The biogel enables objective measurements of brain responses to touch, potentially revolutionizing virtual reality and human-computer interfaces.
Researchers argue that reflective practice has lost its ancient meaning under neoliberal governance, advocating for a return to phronesis as virtue. They propose teacher flourishing as the core of pedagogical tact, emphasizing the importance of habituation of virtue in daily practice.
Researchers at Memorial Sloan Kettering Cancer Center have uncovered promising combination therapies for a rare childhood brain tumor by analyzing patient samples, cell models, and laboratory data. The study found that cancer cells can develop workarounds to evade targeted RAS therapies, highlighting the need for new treatment strategies.
The Bulgarian Society of Endocrinology's open-access journal, Endocrinologia, has moved to the ARPHA publishing platform developed by Pensoft. The platform provides a fast-track system for authors, reviewers, and editors, improving management and increasing international integration.
The study shows that Finnish support for NATO is linked to current perceived threats, increasing rapidly after Russia's invasion of Ukraine in 2022. Material factors like assets and emotional attachment to Europe also influence people's willingness to defend the nation.
Researchers identify MARK2 as a unique upregulator of mutant p53 in triple-negative breast cancer, linked to poor survival. Disrupting the MARK2-mutp53 interaction through dominant-negative mutants may restore mutp53 degradation and inhibit TNBC growth.
A new study reveals that worker bumble bees play a crucial role in determining the sex of baby bees, with juvenile hormone being the key trigger. The researchers found that when workers were treated with the hormone, they passed it to larvae through food, making them more likely to become queens.
Researchers at Lund University developed a blood test that can detect early signs of breast cancer recurrence, providing information on how the disease responds to chemotherapy. The method, called Pathlight, measures small fragments of tumor DNA in blood samples and detected recurrence up to four years before current methods.
A daily glass of 100% fruit juice could help people reach the UK's 5-a-day fruit and vegetable targets, potentially supporting mental wellbeing. The study found that participants who consumed fruit juice in addition to whole fruit had lower depression scores compared to those who only ate whole fruit.
The University of North Carolina at Chapel Hill has been ranked 18th among US universities in the inaugural Cure Innovation Index. The Index evaluates institutions nationwide based on research output, entrepreneurial readiness, and market translation.
Researchers identified chipericumin D as a potent inhibitor of human aortic valve interstitial cell calcification, halting the disease progression by silencing the EGFR/PI3K/AKT signaling pathway. This natural compound offers a new therapeutic strategy for calcific aortic valve disease.
Researchers found that after five exposures, users' impressions stabilize and shape their response to future information. The study challenges the common assumption that people evaluate information accuracy before forming opinions.
Research identifies HMGB3 as a critical driver of malignancy in ESCC, enhancing cell proliferation, migration, and invasion. TGIF2-mediated HMGB3 overexpression drives the oncogenic cascade through the TLR3/TGF-β axis, promoting tumor progression and metastasis.
A new study by UC3M researchers reveals how extracellular acidosis destabilizes microtubules, the 'avenues' that organize internal cellular traffic, leading to disruptions in cellular function. This finding holds significant implications for understanding pathologies like cancer, diabetes, and certain infectious processes.
Researchers investigate MDK's role in bone remodeling and inflammation, finding its inhibition enhances osteogenesis while suppressing inflammatory response. Inhibition also restores PI3K/Akt pathway activity, promoting osteogenic gene expression and enhancing bone formation.
A mobile app is being developed to identify disease-carrying insects from their wing patterns using machine learning, aiming to reduce the risk of disease transmission in low-income communities. The technology will enable rapid and accurate identification of vectors, tracing disease clusters and responding effectively to outbreaks.
A hybrid Ti3C2Tx/Bi2Se3 material exhibits high-efficiency photothermal conversion and gradually conceals targets in environmental simulations. This work constructs a thermal protection strategy via enhanced photothermal conversion, providing a promising approach for developing advanced stealth technologies.
West Virginia University is launching the WVU Rare Earth Elements Initiative to explore U.S. feedstocks and commercialize AMDREE technology for extracting rare earths from acid mine drainage. The initiative aims to enhance national security interests and economic innovation by securing a domestic supply of critical materials.
A new study identifies distinct gut microbiome 'cluster types' associated with disease severity and progression risk in IBD. These clusters reflect higher-order microbial community organization, suggesting a more integrated view of host-microbe interactions in IBD.
Researchers at KAIST have developed an AI system that supports the initial psychiatric interview process, helping patients organize their symptoms and condition in advance. The system effectively obtained key clinical information within 30 minutes of conversation.
The LIGO-Virgo-KAGRA Collaboration has released a new catalog of gravitational-wave detections, revealing distinct sub-populations of merging black holes. These sub-populations are thought to arise from different formation pathways, including the collapse of gas clouds and hierarchical mergers between black holes.