Dr. James George is recognized for his pioneering work on platelet glycoproteins, diagnosis and clinical management of idiopathic thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP). He has also made significant contributions to education, research, and practice through various initiatives.
Eileen Crimmins, PhD, receives the Robert W. Kleemeier Award for her research on socioeconomic factors and life expectancy. She is recognized as an internationally acclaimed expert on aging, focusing on genetic influences, trends in mortality, morbidity, and disability
The newly established Therapeutic Innovation Australia Queensland Node will provide a testing model to speed up the movement of inventions from laboratory to therapeutic products. The Node will focus on four initial projects, including migraine prevention and diabetes management, aiming to deliver tangible commercial returns within fiv...
New lipid screening guidelines for children are overly aggressive, according to UCSF researchers. The recommendations fail to weigh health benefits against costs and have the potential to label millions of healthy children with so-called dyslipidemia.
A new study estimates that contraceptive use prevents more than 272,000 maternal deaths from childbirth each year. The researchers found that satisfying the global unmet need for contraception could reduce maternal deaths by an additional 30%. Effective contraception also averts nearly 230 million unintended births annually.
The Lifespan/Tufts/Brown Center for AIDS Research has received a $8.5 million, five-year renewal grant from the National Institutes of Health to support interdisciplinary collaboration and shared resources among over 60 investigators from various fields.
A study suggests that women can reduce their breast cancer risk by avoiding unnecessary medical imaging. According to the UCSF analysis of IOM report, radiation exposure from medical imaging is a known risk factor for breast cancer.
The Cleveland Clinic will participate in a six-institution MDS Clinical Research Consortium, supported by the Aplastic Anemia & MDS International Foundation. The five-year initiative aims to improve outcomes for patients with myelodysplastic syndrome through clinical trials and research.
A simple blood test can identify people at high risk of dying within a month after non-cardiac surgery. The test called Troponin T measures protein markers of heart injury and is strongly associated with 30-day mortality.
A study reevaluating the long-term effects of alendronate on bone fractures found that patients with low bone density at high risk of spine fractures can benefit from continuing therapy. However, for other types of fractures, there is limited data on continued treatment benefits.
Research suggests that lifelong depression increases the risk of developing vascular dementia, while late-life depression may be an early symptom of Alzheimer's disease. A study of over 13,000 participants found a significant association between depressive symptoms in midlife and late life with increased risk of dementia.
A new study by Michigan State University researchers found that the peak risk for misusing prescription pain relievers occurs in mid-adolescence, specifically around 16 years old. The results suggest that prevention programs may need to be introduced earlier, in childhood and early adolescence.
A new UCSF study questions the previous analysis of varenicline's safety, finding no clinically or statistically significant increase in serious adverse cardiovascular events. The researchers analyzed data from 22 trials with over 9,200 participants, concluding that the risk difference is only 0.27 percent.
Researchers confirm that Avastin and Lucentis yield similar improvements in vision for patients receiving monthly or as-needed treatment. The year-two results of the Comparison of AMD Treatment Trials (CATT) support the findings from the first year of the study.
A new biostatistical tool, prediction-based classification (PBC), can help allocate resources to patients who need them most by linking CD-4 T-cell levels to other patient data. The study found that PBC could reduce the number of CD-4 tests needed during the first year of ART by nearly 57 percent.
Researchers found that EKG abnormalities in healthy elderly individuals increased the risk of heart attack. The study, which followed 2,192 adults aged 70 and older for eight years, suggests that EKGs could be used to detect heart disease earlier in patients without chest pain or symptoms.
A new study finds that more than 60% of breast cancer survivors experience treatment-related complications even six years after their diagnosis. The study provides a comprehensive snapshot of the physical late effects of breast cancer treatment and outlines a model for monitoring and preventing these conditions.
Researchers found that corneal thickening occurs in FECD patients before swelling is observed, necessitating regular monitoring and potential surgical intervention. The study's findings have the potential to improve patient care for Fuchs corneal dystrophy.
A new study published in Annals of Emergency Medicine found that early administration of systemic corticosteroids can reduce hospital admissions for children with moderate or severe asthma attacks. By prioritizing treatment within 75 minutes of triage, patients are more likely to avoid admission and stay reduced by almost 45 minutes.
A new study from the University of Cincinnati found that children exposed to high levels of secondhand smoke who also had allergic sensitizations during early childhood are at greater risk for decreased lung function. Lung function among girls was six times worse than in boys who were exposed to similar levels of both secondhand smoke ...
The A.J. Drexel Autism Institute will focus on research strategies that address the impact of autism throughout an individual's lifespan, including prevention, intervention, and community approaches. The institute aims to develop effective solutions to reduce morbidity and disability associated with autism.
A study led by UCSF researchers found that women with mild retinopathy are more likely to experience cognitive decline and related brain changes. The findings suggest retinopathy could serve as a simple eye screening tool for detecting early stages of vascular disease.
Between 1975-2000, US lung cancer mortality declined significantly due to reduced smoking rates. Tobacco control measures such as increased taxes and smoke-free laws contributed to this decrease.
African Americans in Georgia have poorer survival rates from cancer compared to national averages, with racial disparities widening rural areas. The study found that MIRs were higher for African Americans than whites across all cancer sites, particularly prostate, cervical, and oral cancers.
Researchers identified five distinct dietary patterns among US adults based on demographic factors such as age, race, region, gender, income, and education. These patterns include the Southern, Traditional, Healthy, Sweets, and Alcohol diets, which have clear differences in food choices across demographic groups.
Two studies found that CYP2D6 genotypes associated with reduced enzyme activity do not predict clinical responsiveness to adjuvant tamoxifen therapy among postmenopausal women. This challenges the conventional hypothesis that poor metabolizers experience fewer side effects and may receive less benefit from tamoxifen.
A meta-analysis of 159 studies found rapid influenza diagnostic tests (RIDTs) can confirm the flu, but not rule it out; RIDTs are more accurate in children than adults and better at detecting influenza A virus; this suggests routine implementation of RIDTs during flu season could improve patient care.
Researchers say anti-clotting effect of heparin is well established but its impact on cancer patients remains unclear. The SAVE-ONCO study found semuloparin reduced thromboembolism incidence but had no significant effect on major bleeding and death.
A recent study published in the Journal of Autism and Developmental Disorders found a joint association between maternal and paternal age and autism risk. Mothers with autistic children were on average 6.5 years older than non-autistic women, while fathers had an average age difference of 5.9 years.
A study by researchers at Hospital for Special Surgery found that surgeons who have performed less than 60 ACL reconstructions are roughly four to five times more likely to undergo a subsequent ACL reconstruction. The learning curve for ACL surgery is complex, and training programs may not be adequate to prepare young surgeons.
A study of 64,659 women found that only 173 received recommended breast screening MRI despite being at high enough risk. The researchers aim to understand the disconnect and assess the value, feasibility, and implementation of breast MRI screening.
Researchers identified a genetic variation in the RBMS3 gene that increases the risk of osteonecrosis of the jaw (ONJ) in patients taking bisphosphonates. A genetic screening test could help determine safe treatment options, reducing the need for medication discontinuation or invasive dental procedures.
A new study from Boston University has discovered 13 genetic loci associated with the age of menopause onset, providing insight into hormonal regulation and DNA repair. The research team found that genes related to immune function and auto-immune disease are also linked to menopause timing.
Researchers have identified a rare genetic mutation linked to a significantly higher risk of developing prostate cancer, particularly in men with a family history of early-onset disease. The mutation, called HOXB13, is associated with a 10-20 times higher risk of developing prostate cancer.
A nationwide tax on sugary drinks could prevent nearly 100,000 cases of heart disease and 26,000 deaths annually. The tax would also generate $13 billion in direct revenue and save the public an additional $17 billion per year in healthcare costs.
Researchers found that a brief adherence program improves blood sugar test results and depression symptoms in patients with Type 2 diabetes and depression. The study showed that 60.9% of patients with integrated care had improved blood sugar test results, compared to 35.7% with usual primary care.
A malignancy-risk gene signature developed for breast cancer has been found to have predictive and prognostic value for patients with early stage non-small cell lung cancer. The signature was able to distinguish between low and high malignancy risk groups, correlating with good or poor overall survival rates.
Researchers analyzed the whole-genome sequences of two supercentenarians, aged over 114 years, and found a mix of common and rare genetic variants. Despite carrying many disease-associated genes, they lived exceptionally long lives, suggesting other protective mechanisms are at work.
A recent study by researchers at the University at Buffalo found that framing effects have a minimal influence on consumer behavior when making health decisions. This contradicts the widely held medical premise that framing affects health behaviors, suggesting language and other factors play a more significant role.
A comprehensive training program for healthcare staff significantly reduced adverse events, including birth trauma, by more than half. The two-year study also showed improved staff perceptions of safety, patient satisfaction, and documentation rates.
A new study published in PLoS ONE found that cooperative interactions between reviewers and authors increase reviewing accuracy, with a 13% rise in accuracy under open review models. Reviewers and authors who participated in these interactions had an 11% higher accuracy rate.
A recent study by the National Institutes of Health has discovered a correlation between high blood pressure and stroke risk factors with cognitive impairment. The research, which followed over 30,000 participants, found that age, left ventricular hypertrophy, and high blood pressure were independent predictors of cognitive decline.
The Arizona State University-led initiative aims to identify molecular markers for type 2 diabetes and cardiovascular disease risk, with the goal of predicting heart attack risk and assessing potential new treatments. The project will use proteomics and mass spectrometry technology to discover and validate biomarkers.
Researchers chart gene expression in human brain from fetal development to aging, revealing coordinated changes that shape brain structure and function. The study found reversible gene expression changes after birth and during Alzheimer's disease, with distinct patterns of change at different life stages.
A University of North Carolina at Chapel Hill researcher is leading a collaborative network to study the genetic determinants of Barrett's esophagus and esophageal adenocarcinoma. The network aims to develop new methods for identifying individuals at risk, early detection, and monitoring Barrett's esophagus progression.
A large study found that daughters of women given diethylstilbestrol during pregnancy face an increased risk of reproductive problems and certain cancers. The study also found a twofold higher risk of infertility and a fivefold increased risk of preterm delivery among DES-exposed women.
A study of over 1,100 healthy Indiana school children found that being overweight or obese nearly triples the risk of developing high blood pressure. Leptin, a protein hormone involved in body weight regulation, is also positively associated with increased blood pressure in these children.
A team of researchers, led by Michael Levy, have traced the spread of Chagas disease in Peru using advanced mathematical methods and door-to-door surveys. They found that the parasite was introduced into the region around 20 years ago, with most infections occurring over the last decade.
Researchers from Boston University Schools of Medicine and Public Health are part of a $10 million grant to examine the consequences of alcohol on HIV disease. The study aims to understand how alcohol affects HIV clinical manifestations and develop more effective treatments.
A large study led by Stanford urologist Michael Eisenberg found that childless men are more likely to die from cardiovascular disease than fathers. The study tracked over 135,000 male members and found a 17% increase in mortality risk among childless men compared to fathers.
Researchers suggest that smaller, faster trials with relaxed evidence criteria could lead to improved cancer patient survival and quicker access to new treatments. This approach would allow for the testing of more treatments and potentially reduce the time it takes to bring new therapies to patients.
Researchers will evaluate the impact and cost-effectiveness of a unique combination of HIV prevention strategies in Botswana, aiming to reduce infections by at least 50%. The study will analyze viral gene signatures and examine the effectiveness of targeting individuals with high viral loads.
Research reveals a strong association between stress and tumor aggressiveness in black and Hispanic breast cancer patients, compared to white patients. The study found that higher levels of psychosocial stress were linked to more aggressive tumors, suggesting potential impact on treatment outcomes.
Researchers mapped the global spread of drug-resistant influenza, revealing that genetic mutations and human migration through air travel can lead to rapid transmission. The study suggests that a combination of factors, including overuse of antiviral drugs and human movement, contribute to the emergence of resistant strains.
The National Institutes of Health has awarded Dartmouth Medical School a $11 million grant to establish a network of institutions in northern New England for quantitative biologists. The Center of Biomedical Research Excellence will recruit, train, and support young scientists to investigate the interaction between genes and environment.
The university is supporting pre- and post-doctoral training programs in dental public health to address the gap between those with and without dental care. The funding will support efforts to provide access to dental care for underserved communities.
Robert Binstock, a professor at Case Western Reserve University, has made a significant impact on policies regarding aging. His research has improved the targeting of services to economically and socially disadvantaged older persons.
A new study has identified possible genetic variations that could influence a patient's recovery from an eating disorder. The findings suggest that certain genetic traits, including those associated with anxiety and concerns over mistakes, may be linked to chronic eating disorders.
A randomized trial found that standard triple therapy was more effective than newer four-drug regimens in Latin America, justifying population-wide eradication trials to prevent gastric cancers. However, comment authors disagree, citing potential risks and complications associated with mass eradication programmes.
A study found that changes in family history of cancer can significantly alter screening recommendations, particularly for colorectal, breast, and prostate cancers. For patients aged 30-50, the risk of increased cancer risk more than tripled for colorectal cancer and increased by 60% for breast cancer.