Researchers from Regenstrief Institute and Indiana University have found that machine learning algorithms can detect cancer cases from free-text pathology reports with similar accuracy to human reviewers. The computerized approach is faster and less resource-intensive, facilitating timely health department action.
Scientists at the University of Wisconsin-Madison have created a mouse model to study Zika virus, allowing researchers to test vaccines and antivirals while understanding the virus's effects on human brains. The model, lacking key immune system defenses, shows the virus causes severe pathology in brain tissue.
A new publication by the Association for Molecular Pathology provides cost and value analysis of gene panels, including non-small cell lung cancer and hearing loss. The study demonstrates economic value in optimizing care for patients with hereditary diseases and cancer through targeted gene panels.
New research finds that chemical weathering can weaken rock structures in river beds, making them more susceptible to erosion. The study reveals a positive feedback loop where high precipitation rates maintain high erosion rates despite continuously exposing 'fresh rock'.
A new study combines optical coherence tomography (OCT) with near-infrared autofluorescence (NIRAF) imaging to identify fibroatheromas, advanced lesions prone to rupture. The technique provided more accurate information on molecular composition and inflammation in arterial plaques.
A study in the American Journal of Pathology finds that serotonin deficiency is associated with worse rheumatoid arthritis (RA) symptoms and pathology in mice. Serotonin or its agonists can reduce RA effects, suggesting a new therapeutic target for this debilitating disease.
Researchers at Massachusetts General Hospital found that inducing the hypoxia response, the body's reaction to low oxygen levels, may relieve symptoms of mitochondrial diseases. Activation of this response alleviated mitochondrial pathology and extended survival in animal models.
The locus coeruleus is a critical brain region that releases norepinephrine, regulating heart rate, attention, memory, and cognition. It is vulnerable to toxins and infection, making it the first place affected by late-onset Alzheimer's disease.
The Association for Molecular Pathology (AMP) has updated its pathology residency curriculum recommendations, focusing on 10 major molecular pathology topics. The new report aims to equip pathologists with the latest scientific breakthroughs and technological innovations in molecular pathology.
Adverse Outcome Pathways (AOPs) are a framework for improving chemical hazard assessment by prioritizing modern test methods that reduce animal use. Scientists can identify specific Key Events that lead to adverse outcomes, allowing them to choose the most needed tests.
Researchers discovered a distinctive odor signature in mouse models of Alzheimer's disease that appears before significant brain pathology development, suggesting a non-invasive tool for early diagnosis. The odor profile may be related to the presence of an underlying gene rather than actual brain changes.
Researchers found elevated concentrations of synaptic soluble amyloid-β (Aβ) oligomers in early-stage AD patients compared to controls. The study suggests that therapies targeting synaptic Aβ oligomers may be more effective than anti-amyloid therapies in preventing or delaying AD-related dementia.
Researchers developed a detailed chemical zonation model for oxygen-deficient oceans prior to 520 million years ago. The model suggests that early life was influenced by the heterogeneous and dynamic chemical conditions of these ancient oceans.
Researchers at Mayo Clinic found significant evidence of chronic traumatic encephalopathy (CTE) in males who participated in amateur contact sports, including football, wrestling, and rugby. The study suggests that these sports may increase the risk of developing CTE, a progressive degenerative disease caused by repetitive brain trauma.
A study by UPMC and KingMed Diagnostics researchers found that international telepathology consultations significantly improved patient care in China, altering treatment plans for over half of cases. The consultation service expanded access to pathology expertise, facilitating the diagnosis of rare malignancies.
A special issue of Future Medicinal Chemistry explores the diverse field of chemical biology, highlighting its expanding scope and sub-disciplines. The issue features reviews, opinion pieces, and primary research papers on topics such as protein-protein interactions, epigenetic modulators, and tissue regeneration.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
Researchers have developed new compounds that target three ways to interrupt the disease's pathology in cells, showing promise against myotonic dystrophy type 1. The compounds reduce levels of mutant RNA and reverse symptoms in a fruit fly model.
Researchers used genetically-modified mice to study hereditary deafness caused by mitochondrial dysfunction. Reducing enzyme activity in mice showed promise for preventing or delaying deafness, according to new research.
A study published in Human Pathology found that lung cancer patients without the retinoblastoma tumor suppressor protein (pRB) experience significantly improved survival rates when undergoing chemotherapy. The absence of pRB was detected in 15% of patients, with a 92% 5-year survival rate compared to 49% for those with the protein.
Researchers found that when damselfish release chemical alarm cues on coral reefs, additional predators are attracted, allowing prey a greater chance of escape. This mechanism boosts the sender's survival rate by about 40 percent.
A new method of predicting the path of weaponized chemical agents has been developed by UTSA associate professor Kiran Bhaganagar, with a focus on tracking environmental conditions that affect the direction and movement of released chemical agents. The project aims to enable faster evacuation and response to chemical terrorist attacks.
Researchers found that a humanized mouse model of gluten sensitivity showed increased immune responses and gut damage when exposed to gluten, but protection was seen in mice with a balanced microbiome. The study suggests that microbial imbalance may contribute to the development of celiac disease.
The new 2015 WHO Classification of Lung Tumors provides standard criteria for pathology diagnosis and clinical practice. The updated classification focuses on histologic subtyping and classification according to predominant subtype, leading to multiple new discoveries in lung adenocarcinoma.
Foreign chemical and pharmaceutical companies face challenges in China due to economic downturn, overcapacity, and tightening regulations. Despite uncertainty, company heads remain confident in their long-term success in the country, which represents 50% of the Asian chemical market.
Researchers at UGA's Savannah River Ecology Laboratory found toxic chemical Aroclor 1268 in egg and tissue samples of least terns across coastal Georgia, causing adverse effects. The contaminant has spread beyond the Superfund site via the food web, posing a risk to bird populations.
Research suggests retinal changes can serve as measures of brain pathology in schizophrenia, predicting disease risk and progression. The findings may help guide future treatment adjustments.
Researchers found that repeated exposure to stimuli can lead to recurring mast cell degranulation and long-term pathological eye changes. Inhibiting this release with substances like disodium cromoglycate may offer new ways to treat serous retinal detachment.
Researchers have recreated firefly bioluminescence in the lab using a chemical reaction between luciferin and oxygen. The discovery could lead to new applications in medicine, such as more efficient light therapy for patients with certain diseases.
A new website, the Chemical Probes Portal, aims to guide researchers in selecting better-quality chemical probes, reducing errors and wasting time and money. The platform crowdsources knowledge from leading researchers, providing up-to-date comparative information to help users choose the best probe for their needs.
A study published by the American Academy of Neurology found that Alzheimer's disease causes different changes in the brain, or pathologies, in African-Americans compared to white Americans of European descent. African-Americans were more likely to have mixed pathologies and blood vessel disease in their brains.
The American Chemical Society is featuring 'The Talented 12' - a group of young researchers using chemistry to address global issues like climate change and disease. These innovators are developing more environmentally friendly methods for synthesizing molecules and investigating biochemical underpinnings of diseases.
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.
A study of 197 patients with breast cancer found that more selective use of biomarker testing could save up to $117 million annually. Testing larger excisional biopsies instead of reflexively testing smaller core biopsies would help pick up tumors eligible for targeted therapy, reducing unnecessary costs.
Rice University researchers have developed a new method to create valuable graphene nanoribbons by grinding carbon nanotubes, eliminating the need for harsh chemical solutions. This solid-state process enables strong chemical coupling between nanostructures and produces novel forms of nanostructured products with specific properties.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
Two studies analyze amyloid prevalence among adults of varying ages and its association with cognitive impairment. The findings indicate that key risk factors for Alzheimer's disease are also risk factors for amyloid positivity in cognitively normal persons.
Researchers used chemical signatures on otoliths to track Alaska's Bristol Bay salmon, revealing birthplaces and life histories. The technique can help scientists understand freshwater habitats and conservation efforts for Chinook salmon populations.
The Association for Molecular Pathology compiles current research on liquid biopsy approaches for cancer diagnostics. The review supports the notion that these minimally invasive tests allow for earlier diagnosis, faster and more targeted treatment, reduced costs, and increased quality of life.
The BMC protocol provides a set of predetermined guidelines for processing and preserving forensic evidence in surgical specimens after a terrorist attack. Key findings include the importance of identifying a team to handle all surgical specimens, obtaining labeled photographs and x-rays, and storing forensic evidence securely.
Research highlights the need for collaboration between the chemical industry and DHS to ensure US chemical facilities' safety and security. The team suggests that communities should develop preparedness plans in anticipation of possible chemical disasters.
Researchers developed a new imaging technique that enables fast and broad diagnostic assessments using infrared light, eliminating the need for chemical stains. This allows pathologists to obtain precise information from tissue samples without damaging them.
The Explosive Destruction System (EDS) has begun destroying chemical munitions at the US Army Pueblo Chemical Depot, preparing for a larger operation to destroy 780,000 munitions containing 2,600 tons of mustard agent. The new system is designed to process stockpile munitions more efficiently than previous versions.
The European technical report presents aquatic effect-based monitoring tools to address chemical pollution in surface waters, including bioassays and biomarkers for detecting toxic effects. These tools support the Water Framework Directive's goal of achieving a 'good status' for all Europe's surface waters by 2015.
Researchers found that in muscular dystrophy, abdominal muscles take over more of the respiratory function as diaphragm muscle damage progresses. This study highlights the importance of supporting cardiopulmonary function in neuromuscular disease.
A new thin-film material rapidly changes color in response to chemical nerve agents, offering a potential solution for real-time detection of deadly CWAs. This innovation is based on a distinct color change, a technique that could help save lives and hold aggressors accountable.
A new analysis has identified over 58,000 long non-coding RNA genes that may play a role in cancer. The study also found that one lncRNA, SChLAP1, is a potential biomarker for aggressive prostate cancer.
A new use of an existing antibody cocktail has been confirmed to provide key information about tumor recurrence in head and neck cancer patients. The ProExC cocktail allows pathologists to differentiate between true pre-neoplasia and reactive biopsies, enabling surgeons to make informed decisions about therapeutic interventions.
The year saw major advances in solar cells and treatments for Ebola, as well as efforts to label GMO products and restrict neonicotinoid use. The American Chemical Society highlighted its impact on research, policy, and industry through various initiatives.
A study of over 3,000 women in Michigan found that nearly 40% did not receive alternative treatment before their hysterectomy. Nearly two in five women under 40 had unsupportive pathology, suggesting that treatment guidelines are often not followed.
A new study published in the American Journal of Pathology suggests that HLA class I hyperexpression on pancreatic islet cells may not be a crucial step in developing type 1 diabetes. The study found discrepancies between results from immunohistochemistry and quantitative molecular techniques.
Researchers developed a predictive model associating chemical fragments with positive or negative effects in 20% of human diseases. The analysis of 10,000 chemical molecules revealed new knowledge on safer drug design and potential uses for current drugs.
A pathology specialist, Dr. Glenn Palomaki, contributes to the debate on breast cancer gene screening, citing concerns about population characteristics and feasibility. He suggests pilot trials for high-risk populations like Ashkenazi Jewish women before considering widespread screening.
A study in the Journal of Marketing found that chemical farmers resist converting to organic methods because it challenges their belief systems. Organic farmers, on the other hand, report a sense of joy and renewal through their practice.
Scientists have developed micromotors that use water as fuel to rapidly neutralize chemical and biological warfare agents. The micromotors propelled titanium dioxide to accelerate the decontamination process, showing promise in combating these dangerous agents.
Schizophrenia and bipolar disorder are associated with dendritic spine loss, suggesting shared pathophysiological features. Individuals with these disorders have reduced average spine density and number of spines per dendrite compared to control group individuals.
For the first time, a chemical bond was established between seaborgium and a carbon atom, opening perspectives for detailed investigations of chemical behavior at the end of the periodic table. The study focused on gaseous properties and adsorption to a silicon dioxide surface, comparing with similar compounds of neighboring elements.
Biochemists at City College of New York find a way to detect common class of odors using water's ability to undergo chemical reactions with aldehydes. Researchers propose that some odorant receptors recognize aldehydes by their reactivity, rather than structure, enabling the nose to distinguish them from similar chemicals.
Isabell Thomann's research focuses on improving photocatalysis, a process that uses light to drive chemical reactions, with a goal of reducing carbon dioxide using sunlight. She will use an ultrafast laser spectroscopy system to study short-lived chemical intermediates and optimize the efficiency and selectivity of chemical reactions.
A team of researchers from the University of Pennsylvania School of Medicine has developed new cell culture and mouse models to test immunotherapy for Parkinson's disease. By targeting distorted alpha-synuclein proteins, they prevented pathology development and reversed some effects of existing disease.