Research on the causes and treatment of heart disease. Covers light exposure and heart health, sex differences, heart-in-a-dish models, and cardiac risk.
A new study by the European Society of Cardiology found that giving birth is associated with a 14% higher risk of heart disease and stroke. Pregnant women are advised to keep weight gain under control and adopt healthy lifestyle habits after pregnancy to reduce the risk of cardiovascular disease.
Connexin43 is a widely distributed gap junction protein involved in myocardium disease and tumor migration. Understanding its role in these processes can provide insight into new therapeutic options for cancer and myocardial disease diagnosis and therapy.
A team from GW is investigating the causes of cardiovascular disease in HIV-infected patients and testing a potential therapeutic strategy to reduce heart disease risk.
The Wayne State University team will address hypertension, hyperlipidemia, and obesity through innovative approaches to comprehensive population health initiatives. They will explore the use of community health workers, telehealth smartphone applications, and bi-directional referrals to promote better management of these conditions.
A study analyzing 6,000 people found that tracking a patient's weight history from young adulthood can provide valuable insights into their future risk of heart failure. The investigation showed that maintaining a normal weight over the lifespan is ideal, while obesity at specific ages significantly increases the risk of heart disease.
Researchers found that people who eat a diet rich in red meat have triple the TMAO levels of those who eat a diet rich in either white meat or mostly plant-based proteins. However, discontinuation of red meat eventually lowers these TMAO levels, suggesting a promising new strategy for individualizing diets and preventing heart disease.
Research reveals a strong association between workplace exposure to metals and pesticides and an increased risk of coronary heart disease and atrial fibrillation. The study suggests that cumulative exposure may be more harmful, particularly for Hispanic/Latino workers who may face language barriers and limited resources.
Researchers found a diet rich in red meat increases TMAO levels, linked to heart disease. A study also revealed the kidneys can change how effectively they expel compounds depending on dietary choices.
A team led by Kiran Musunuru used a stem-cell-based assay to determine the impact of a TNNT2 gene variant on a patient's health. The test successfully identified the variant as benign, allowing the patient and her family to avoid unnecessary genetic screening.
A new study found that flu vaccination is associated with a reduced risk of premature death and cardiovascular death in heart failure patients. The study analyzed data on 134,048 patients with newly diagnosed heart failure over a 12-year period.
Researchers at Ohio State University found that mice exposed to polluted air before conception had heart problems and impaired function in their offspring. The study suggests that pollution-related cardiovascular disease may start even before conception.
A study found that Indiana firefighters had a 30.4% death rate from malignant cancers, 20% higher than non-firefighters between 1985-2013. Heart disease was the second leading cause of firefighter deaths, with no difference in odds compared to non-firefighters.
Research reveals an increased risk of ill health in people with evening preference, including erratic eating patterns and consumption of unhealthy foods. The study also found that glucose levels increase when night owls eat shortly before bed, negatively affecting metabolism.
Researchers at the University of Arizona have identified multiple subpopulations of cardiomyocytes expressing specific transcription factors, which could lead to better repair of heart muscle injuries. The study uses a systems-based approach encompassing single-cell transcriptomics, single-cell proteomics and CRISPR gene-editing.
A new research published in the Journal of the American Heart Association found that a healthy lifestyle during menopause may offset the acceleration of atherosclerosis. Women who adhered to a 'Healthy Lifestyle Score' had significantly wider arteries, less arterial thickening and buildup of fatty plaque compared to those with lower sc...
A study published in the European Heart Journal found that greater cardiorespiratory fitness was linked to a lower risk of cardiovascular disease, including heart attacks. The researchers discovered that even small increases in fitness could have a significant impact on health.
Researchers have determined the structure of an enzyme that helps remove excess cholesterol from the body. A small molecule stimulates LCAT enzyme action, showing promise for treating heart and kidney disease. The study paves the way for potential new therapeutics.
Early treatment of high blood pressure as advised by US guidelines does not reduce the risk of deadly heart disease and may negatively affect mental health. In contrast, patients with 'Stage 2 Hypertension' face a greater risk of dying from heart disease despite medication recommendations.
The life expectancy gap between rich and poor in England is increasing, with the poorest women's life expectancy falling since 2011. The study reveals that the richest live up to 9 years longer than the poorest men and women.
Research reveals that a genetic mutation in Filamin A protein impairs cellular force transmission, leading to valvular heart disease. The study provides new insights into the molecular mechanisms of the disease and paves the way for developing new treatments.
Research found that static activities, such as strength training, were more strongly associated with reducing heart disease risks than dynamic activities like walking and cycling. Both types of physical activity appeared to be heart healthy, even in small amounts, at the population level.
Researchers identified 90 genetic points associated with increased risk for both cardiovascular disease and Alzheimer's, including genes involved in lipid metabolism. The study found that targeting these genes may help lower Alzheimer's risk by managing cholesterol and triglyceride levels.
The Dapagliflozin Effect on CardiovascuLAR Events - Thrombolysis in Myocardial Infarction 58 trial found that dapagliflozin markedly reduced the risk of hospitalization for heart failure and progression of renal disease, with benefits seen across the study population.
Researchers at NYIT are investigating the process of molecular calcification to develop a new therapy for vascular calcification. The study will validate theories on phosphatase enzyme activity and test a compound known as SBI-425 as a potential treatment.
A new study from Northwestern University finds that grieving spouses with sleep problems have a two-to-three times higher risk of chronic immune activation and increased inflammation, making them more susceptible to heart disease or cancer. Cognitive behavioral therapy is highly effective in treating sleep disturbances, and physicians ...
A study of 12,708 participants found that consuming more than 30% of daily calories after 6pm was associated with a 23% higher risk of developing high blood pressure and a 19% higher risk of becoming pre-diabetic. Eating earlier in the day may be an important strategy to help lower heart disease risk.
A systematic review and meta-analysis of 19 studies found that people with the highest anthocyanin intake were 9% less likely to suffer from coronary heart disease. Anthocyanins have also been linked to improved risk factors for heart disease, such as cholesterol levels and blood pressure.
The Tsimane's high-carbohydrate and protein-rich diet with low fat intake is associated with low cardiovascular disease risk. Despite the lack of dietary diversity, their daily food intake provides a balanced nutrient profile, highlighting the importance of adopting similar eating habits to mitigate the effects of Western diets.
Researchers at Baker Heart and Diabetes Institute found that specific brain signaling promotes heart disease by altering bone marrow stem cells, leading to atherosclerosis. The study highlights the importance of managing stress, anxiety, and pain in controlling this form of hypertension.
A Finnish study found that consuming high amounts of fermented dairy products can lower the risk of coronary heart disease by 26%. Fermented dairy products, such as cheese and yoghurt, were associated with improved blood lipid profiles and reduced heart disease risk.
Scientists at Newcastle University have found that metformin can reduce the presence of microRNAs that contribute to heart disease in patients with Type 1 diabetes. By decreasing these microRNAs, metformin improves glucose levels and promotes blood vessel repair, opening up new treatment options for this vulnerable patient group.
A large-scale study found that bariatric surgery significantly reduces the risk of heart attacks, strokes, and deaths in individuals with type 2 diabetes and severe obesity. The study involved over 5,000 patients who underwent bariatric surgery compared to nearly 15,000 patients receiving usual medical care.
A new study from The University of Texas at Dallas analyzes the impact of terrorism injuries, estimating that victims lost an average of 12,628 years of healthy life due to injuries. The study puts the annual toll of terrorist attacks in context with other causes of death, highlighting the devastating human cost of these events.
A new study examines the potential effects of Brexit on the UK's Sugar Tax and coronary heart disease mortality. The research suggests that the SSB levy would increase prices by approximately 38%, leading to a 26% decrease in SSB intake, and prevent around 370 CHD deaths.
Researchers identified a gene mutation linked to lower risk of diabetes, obesity, heart failure, and death. Selectively blocking the SGLT-1 receptor could slow down glucose uptake to prevent or treat cardiometabolic disease.
Research suggests statins may benefit people with certain non-heart diseases, such as kidney disease and cancer progression, but the evidence is inconclusive. The study found a modest link between statin use and diabetes, highlighting the importance of lifestyle advice for patients at risk.
Researchers sequenced RNA in 20,000 cardiac cells, uncovering a broad variety of cell types in healthy and diseased hearts. The study found great diversity among each cell type, as well as indications of functional changes during normal and diseased conditions.
A recent study identified three genetic mutations that improve cholesterol profiles and reduce the risk of heart disease, abdominal aortic aneurysms, or diabetes. The PDE3B mutation has shown significant benefits, with a lower risk of heart disease and improved triglyceride levels.
A team of researchers, led by Professor Davide Calebiro, will investigate the function of G protein coupled receptors (GPCRs) to develop new therapies for diseases like heart failure and diabetes. They will use innovative microscopy methods to directly visualize individual receptors in living cells.
A study published in the Journal of Endodontics found that smoking damages the pulp inside teeth, reducing their ability to fight illness and disease. This increases the risk of gum disease and delayed healing, with smokers nearly twice as likely to require a root canal as non-smokers.
A systematic review of 25 studies found physical activity significantly reduces heart disease risk by 40%, with moderate-intensity exercise lowering systolic blood pressure by up to 15mmHg. Replacing sedentary behaviors with daily activities can also lower all-cause mortality.
A study published in Circulation Journal found that increased height increases the risk of developing varicose veins, as well as genes that determine height influencing the development of the condition. Researchers also discovered a strong genetic correlation between deep vein thrombosis and varicose veins.
A global analysis reveals that most countries, including the US and UK, are falling short of reducing premature deaths from chronic diseases. The study suggests that a faster decline in deaths would require investments in policies such as treatment of hypertension and controlling tobacco and alcohol use.
Researchers at Penn State are developing a new generation of blood pumps that use computational methods to predict clot formation and design safer devices. This could enable earlier intervention for patients with congestive heart failure, reducing recovery time and improving outcomes.
Researchers discovered that mitochondrial DNA (mtDNA) variants interact with nuclear DNA mutations to determine the severity of heart disease in mice. Different mtDNA variants conferred either worsened or protected heart damage, suggesting a key role for mtDNA in cardiomyopathy progression.
Researchers at Northwestern University developed a simple blood test called TimeSignature that can identify the body's precise internal time clock. The test measures gene expression markers and can be taken any time of day, allowing for more accurate diagnosis and treatment of diseases such as heart disease, diabetes, and Alzheimer's.
Scientists at Baker Heart and Diabetes Institute have identified plasma lipid biomarkers that improve upon traditional risk factors in predicting heart disease and stroke. The new blood test will use up to ten lipid markers to better diagnose heart disease, reclassifying patient risk and guiding treatment.
Researchers from the University of Bradford analyzed Anglo Saxon children's milk teeth to identify modern children at risk for conditions like diabetes and heart disease. The study found that teeth provide a more reliable indicator of diet and health than bones, revealing biomarkers for stress in early life.
Dr. Mandeep R. Mehra proposes a novel explanation for the Mona Lisa's smile and facial features, attributing them to clinical hypothyroidism. The theory is supported by visible signs of thyroid dysfunction in the painting, including thinning hair and yellow skin.
Researchers at MUSC and Ohio State University have discovered an unexpected mechanism that underlies cardiomyopathy in DMD. Inhibiting NF-κB normalizes calcium handling and significantly increases calcium gene expression, leading to improved heart function.
A new rapid imaging protocol has been developed and tested in Peru, quickly and cheaply diagnosing heart ailments in patients. The technique, which took 18 minutes and cost $150 per patient, revealed important changes in patient care and satisfied all imaging needs in 89% of patients.
A systematic review and meta-analysis found exposure to arsenic, lead, cadmium, and copper increases the risk of coronary heart disease and cardiovascular disease. The study suggests that even low doses of toxic chemicals pose a significant risk to cardiovascular health, highlighting the need for policymakers to take action to reduce p...
A comprehensive analysis of the evidence found exposure to toxic metals like arsenic, lead, copper, and cadmium to be associated with an increased risk of cardiovascular disease. The study suggests that these metals may be an independent risk factor for cardiovascular disease, even at relatively low levels of exposure.
A comprehensive analysis found associations between exposure to toxic metals and increased risk of cardiovascular disease and coronary heart disease. The study's authors call for attention to metals as a significant source of cardiovascular risk, highlighting the need for population-wide strategies to minimize exposure.
Research suggests that dairy products can protect against total mortality and cerebrovascular causes, but milk consumption increases the risk of CHD. Public health officials should revise guidelines on dairy consumption, recommending fat-free or low-fat milk.
A large study of Australian adults found that psychological distress was linked to a higher risk of heart attack and stroke. The researchers estimated that among women, high/very high psychological distress was associated with a 44 percent increased risk of stroke.
Researchers analyzed data from over 5,700 pregnant women with heart disease and found that fewer deaths occurred during pregnancy compared to previous years. However, nearly one in ten women with pulmonary arterial hypertension died during pregnancy or early post-partum. Pre-pregnancy counseling is crucial to identify high-risk patients.
A large study found that low-carbohydrate diets were associated with a 32% higher risk of all-cause death over an average 6.4-year follow-up. Risks were also increased for coronary heart disease, stroke, and cancer.
A large study found that care coordination strategies significantly reduce symptoms of depression and improve health in seniors with multiple chronic diseases. The review included 25 studies and 12,579 older adults, highlighting the potential benefits of managing co-existing chronic illnesses in a coordinated manner.
A new analysis of the LEADER trial suggests liraglutide treatment reduces the risk of death from heart attack and nonfatal stroke in people with Type 2 diabetes, regardless of their cholesterol levels. The study found that liraglutide also lowers LDL-C levels, an important marker of developing heart disease.