Research on the causes and treatment of heart disease. Covers light exposure and heart health, sex differences, heart-in-a-dish models, and cardiac risk.
A recent study analyzing data from the Mexican National Health and Nutrition Surveys (2016-2023) found that cardiovascular disease risk increased in Mexico between 2016 and 2023. The average 10-year CVD risk was estimated at 9.5% using region-specific tools, highlighting the need for accurate models to predict local disease burden.
A randomised trial found that regular exercise reduced inflammation and improved endothelial function, leading to lower risk of heart attack and strokes. Exercise maintained weight loss without GLP-1 receptor agonist liraglutide.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
Researchers developed a novel biomaterial called elastin domain-derived protein (EDDP) that overcomes natural elastin limitations. EDDP promotes cell adhesion and growth, aiding tissue regeneration in damaged tissues like heart valves, blood vessels, or torn ligaments.
The American Heart Association and American Medical Association recognize 2,307 health care organizations for their efforts in tackling high blood pressure through the Target: BP initiative. This effort has impacted over 10 million adults with hypertension.
The TCT AI Lab equips clinicians with skills to integrate AI into clinical practice, advancing precision, efficiency, and patient outcomes. The initiative is made possible by a generous grant from the Jon DeHaan Foundation.
Dr. Collet joins CRF to accelerate integration of cutting-edge research into clinical practice and expand global leadership in cardiovascular education. He will lead efforts to unify translational science, technological innovation, and education.
Golden retrievers are at risk of a fatal heart condition due to a genetic mutation in the Cardiac Troponin-I gene. The study, published in Circulation: Genomic and Precision Medicine, identified a single genetic variant that causes hypertrophic cardiomyopathy (HCM) and sudden death in dogs.
New research from the American Heart Association reveals that most people with atrial fibrillation (AFib) are unaware of the condition before being diagnosed. The study found that AFib patients reported experiencing an average of three symptoms before receiving a diagnosis, highlighting the importance of recognizing early warning signs...
A University of Oklahoma study found that acute normovolemic hemodilution (ANH) lowered the likelihood of a transfusion by 27%, reducing blood use and costs. The technique preserved platelet functionality, allowing patients to recover more effectively after surgery.
Augsburg researchers identify reticulated platelets as key players in blood clot formation, providing promising therapeutic approaches. The study's findings could lead to personalized platelet inhibition and tailored therapies.
Researchers found that diabetes directly affects the heart's structure and energy production in humans for the first time. Diabetes causes distinct molecular changes to heart cells and structural changes to the muscle, particularly in patients with ischaemic cardiomyopathy.
Researchers have successfully treated damage caused by heart attacks in non-human primates using gene therapy, restoring both strength and rhythm of the damaged hearts. The treatment improved heart function in pathological conditions with no adverse effects observed.
The system uses magnetoelectric power-transfer technology to deliver precise electrical stimulation to organs like the heart and spinal cord. The more devices in the network, the more efficient it is, offering a less invasive alternative to traditional implantable medical devices. This technology has potential for treating conditions s...
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
A case series of 19 patients has successfully undergone partial heart transplant, enabling valve growth and representing a novel approach to congenital heart disease treatment. Careful follow-up and monitoring are crucial for the continued expansion of this procedure.
New research reveals that older age and low aerobic fitness levels are strong and independent risk factors for heartbeat irregularities, or arrhythmias, in healthy adults. Regular exercise can help reduce the risk of frequent and complex atrial arrhythmias.
The American Heart Association has extended its Rural Health Care Outcomes Accelerator program until 2028, expanding access to cardiovascular care and quality improvement resources for over 1,000 rural hospitals. This extension aims to address the significant disparities in health outcomes between urban and rural communities.
The American College of Cardiology has established a digital registry for hypertrophic cardiomyopathy (HCM) to broaden understanding and provide equitable access to treatment. The registry will capture data on HCM symptoms, diagnostic images, treatment plans, and outcomes to improve diagnosis and management.
A new study published in The Annals of Thoracic Surgery found that over 6% of patients experienced early hemodynamic valve deterioration just one year after undergoing TAVI. Smaller implanted valve sizes were significantly associated with the development of HVD, while larger valves appeared to be protective.
Researchers from the University of South Australia have identified a potential early warning system for Takotsubo syndrome in ICU patients using electrocardiogram patterns and blood markers. Critical care nurses with advanced ECG skills can play a key role in recognising early signs of the condition.
A study found that large community heart health checks can identify people with uncontrolled cardiovascular risk factors, such as elevated blood pressure and obesity. The screenings were conducted at community pharmacies and sporting events, and identified modifiable risk factors in over half of participants.
Researchers at the University of Sydney have discovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing blood clots. A protein called SEC61B was found to disrupt calcium balance inside platelets, making them more likely to form clots.
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
A recent study has found that women who experienced stalking or obtained restraining orders are more likely to develop heart disease and stroke than those who did not. Researchers analyzed data from over 66,000 women and found a strong association between stalking and cardiovascular disease.
Researchers found that individuals with a mutation in the TTN gene are 21 times more likely to develop dilated cardiomyopathy than those without. Lifestyle factors such as being overweight or having high alcohol consumption contribute to an earlier diagnosis, and men with the mutation are more likely to develop DCM at a younger age.
A multi-center study identified critical risk factors for children with single-ventricle heart defects, including low oxygen levels, which significantly increased the risk of death. The study also found improved survival rates for patients with single ventricle physiology and those who had undergone a Fontan procedure.
A new study published in JACC found that using portable HEPA air filters at home can significantly lower systolic blood pressure in adults with elevated readings. The study found an average 2.8 mmHg reduction in SBP after one month of HEPA filtration.
A new study from University of California San Diego found that frequent standing breaks can lower diastolic blood pressure in postmenopausal women. Women who increased daily sit-to-stand movements saw measurable improvements in blood pressure, with an average decrease of 2.24 mmHg within three months.
A personalized approach to recommending CPAP machines for patients with obstructive sleep apnea (OSA) may decrease adverse cardiovascular events. However, CPAP use can also increase cardiovascular risk for those with low-risk OSA markers.
Research finds CPAP lowers cardiovascular risk by 17% in patients with high-risk OSA, but may increase risk by 22% in those without high-risk OSA. The study suggests a more personalized approach to treating OSA, focusing on patients with high-risk features.
A landmark study found that adopting five healthy lifestyle habits—healthy weight, no smoking, regular physical activity, high-quality diet, and moderate alcohol intake—can reduce cardiovascular disease risk by up to 86% in women with a history of gestational diabetes. Women who followed all these habits had no cardiovascular events ov...
Researchers found that high rates of coronary heart disease were linked to poverty, limited healthcare provider availability, and low broadband access. However, some counties with similar challenges reported lower-than-expected cardiovascular outcomes, suggesting the need for tailored strategies to address health disparities.
Researchers from FAU's Schmidt College of Medicine recommend using high-potency statins as the primary pharmacologic approach in treating and preventing cardiovascular disease. Lifestyle changes, such as regular physical activity and a healthy diet, are also crucial in reducing cardiovascular risk.
A retrospective study found that older adults hospitalized with RSV experienced significantly longer hospital stays, transfers to intensive care, and 30-day mortality compared to patients with other conditions. Additionally, RSV hospitalization was associated with higher rates of heart failure and atrial fibrillation post-discharge.
Researchers developed a chemical probe that binds to damaged mitochondrial DNA, blocking enzymatic processes that lead to its degradation. This approach lessens mtDNA loss, preserving energy production in vulnerable tissues. The new molecule successfully reduced inflammation and maintained functional DNA despite chemical tagging.
A new study from the University of South Australia confirms that eggs are not high in cholesterol and do not contribute to cardiovascular disease. In contrast, saturated fat intake was found to increase LDL levels, highlighting the importance of dietary balance for heart health.
Researchers identified a protective RNA molecule that regulates autophagic flux and protects against cellular injury, inflammation, and fibrosis in kidney cells. Boosting this tRNA-Asp-GTC-3'tDR increases kidney protection with less scarring, inflammation, and injury.
A new study found that scar tissue in the heart of healthy male endurance athletes aged 50 or older may increase their risk of abnormal heart rhythms and sudden cardiac death. The research used magnetic resonance imaging and ECG recorders to track the participants' heart activity over two years.
Researchers developed an AI-powered screening tool, EchoNext, to identify patients at risk of structural heart disease from ordinary ECG readings. The tool accurately detected over 7,500 individuals with high-risk heart disease, leading to nearly three-quarters being diagnosed with the condition.
Researchers found that low sodium levels can disrupt the heartbeat in patients taking widely used rhythm-control medications like flecainide, increasing conduction risk. Interfering with ephaptic coupling or potassium ion flow reduces heart sensitivity to low sodium when sodium channels are blocked.
Researchers at Sutter Health tested the performance of the American Heart Association's PREVENT equations in diverse Asian and Hispanic subgroups, showing accurate prediction of cardiovascular disease, atherosclerotic CVD, and heart failure events. The study findings aim to improve cardiovascular healthcare for all populations.
A new Leicester study found that women with type 2 diabetes are nearly twice as likely as men to have hidden heart damage, according to researchers. The study used advanced MRI scans and data from four studies conducted at the NIHR Leicester Biomedical Research Centre.
Scientists have identified a set of genes in zebrafish that reactivate after damage to the heart and patch it up like new. The researchers hope to use CRISPR tools to reactivate similar genes in humans and jump-start repair of the heart and other tissues after injury.
A recent study reveals that lactate-induced mitochondrial calcium uptake 3 aggravates myocardial ischemia–reperfusion injury by promoting neutrophil extracellular trap (NET) formation. The study found that MICU3-mediated mitochondrial calcium uptake leads to mitophagy and NET activation.
Scientists are working on a genetic cure for the world's most common inherited heart disease, hypertrophic cardiomyopathy (HCM), with a new gene editing tool. The team aims to correct mutations that cause the disease, which affects 14 million people worldwide.
A study of over 2,500 adults aged 50-80 found that nearly 1 in 6 take aspirin for cardiovascular protection without a history of heart disease. Despite revised guidelines reducing aspirin use for primary prevention after age 70, many patients are unaware of the increased risk of bleeding.
A new study finds that women with lower social status show early signs of heart stress and inflammation, while men do not. The researchers hope their work will shift the paradigm in cardiac care by discussing mental wellness and social circumstances in routine practice.
Researchers have discovered an oral drug called MA-5 that can improve both heart and muscle problems in patients with Barth syndrome, a rare genetic disorder. The drug boosts cellular energy production by up to 50% and protects cells from oxidative stress-induced death, addressing the underlying cause of the disease.
Research using cardiac MRI found that long-term exposure to air pollution is associated with early signs of heart damage, including diffuse myocardial fibrosis. The study suggests that fine particulate matter in the air may contribute to changes in the heart structure, potentially setting the stage for future cardiovascular disease.
Researchers identified hundreds of molecular markers in saliva associated with systemic pathological processes beyond the oral cavity. These markers can reflect genetic heritability of diseases such as prostate cancer, coronary disease, and Type 2 diabetes.
Scientists at The University of Texas at Arlington identified a new enzyme, IDO1, that plays a crucial role in inflammation and cholesterol regulation. By blocking this enzyme, macrophages regain their ability to absorb cholesterol, offering a potential new way to prevent heart disease.
A new study involving 121 former elite rowers from Australia found that one in five develops atrial fibrillation, a condition that can lead to stroke and heart failure. The researchers identified genetic and clinical tools that enable early preventive strategies, highlighting the paradox that AFib is more common among fit athletes.
AIMP3 is essential to avoiding mistakes in protein synthesis, not affecting protein production, according to Brown University researchers. The discovery could lead to new treatments for heart diseases linked to homocysteine buildup and has implications beyond the heart.
Research reveals significant drop in heart attack deaths, while increases observed in deaths from heart failure, arrhythmias, and hypertensive heart disease over the past 50 years. Studies suggest advancements in medical treatment, bystander CPR, and public health initiatives have contributed to these findings.
Elevated cortisol levels in preterm fetuses disrupt normal heart development, potentially leading to increased cardiovascular disease risk. Cortisol exposure accelerates heart development in ways that may not be beneficial, ultimately compromising heart health.
Research found that certain heart rate variability patterns can predict future health conditions, including stroke, depression, and cognitive dysfunction. The study suggests that nocturnal HRV provides a unique window into how the body functions during sleep.
A new study published in the Journal of the American Heart Association found that residents in U.S. coastal counties near ocean waters with high concentrations of microplastics are at higher risk for Type 2 diabetes, coronary artery disease, and stroke. The study analyzed data from 152 counties and found a significant association betwe...
Obesity can lead to coronary microvascular dysfunction, causing impaired blood flow to the heart and increased risk of heart problems. Studying pannexin-1 protein, a key player in this process, could help develop treatments to prevent heart issues before they start.
Research suggests that consuming more phytosterols could lower the risk of heart disease and type 2 diabetes. Higher intake was associated with better insulin regulation, reduced inflammation, and differences in the gut microbiome. This supports a healthy plant-based dietary pattern rich in vegetables, fruits, nuts, and whole grains.