Researchers at the University of Copenhagen have discovered that resistant bacteria can hide resistance genes in inactive bacteria within biofilms, creating a reservoir of resistance that can be drawn upon when antibiotics are not present. This new understanding challenges the long-held assumption that resistant bacteria lose their res...
SourceUniversity of Copenhagen - Faculty of Science·Journalnpj Biofilms and Microbiomes·DateDec 16, 2021
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Researchers at USC developed a new peptide that stimulates the host's immune response to fight bacterial infections, offering an alternative to antibiotics. The peptide, MTD12813, is highly effective in clearing infections and modulates inflammation, reducing the risk of complications.
SourceKeck School of Medicine of USC·JournalScientific Reports·TypeExperimental study·DateDec 6, 2021
A study by Anglia Ruskin University has identified potentially dangerous Pseudomonas bacteria in 21% of wild bird faeces collected from locations near the River Cam. The bacteria, which can be passed on to humans through cross-contamination, were resistant to multiple antibiotics.
SourceAnglia Ruskin University·JournalEcology and Evolution·DateNov 17, 2021
Researchers at Hebrew University of Jerusalem discover a 'disrupted' state in bacteria that resists current antibiotics, requiring new pharmacological agents to combat. The breakthrough model predicts bacterial population responses to treatments, offering avenues for better treatments against cancer cells.
SourceThe Hebrew University of Jerusalem·JournalNature·TypeExperimental study·DateNov 17, 2021
Researchers identified a bacterium on healthy cats that produces antibiotics against severe skin infections in humans and pets. The discovery may lead to new treatments for MRSP infections in dogs and potentially other inflammatory skin diseases.
SourceUniversity of California - San Diego·JournaleLife·DateOct 19, 2021
Researchers have identified a new prophage-mediated defence system in Salmonella Typhimurium ST313 called BstA, which efficiently suppresses phage attacks. This discovery opens up a new avenue of research and could potentially lead to the development of new biotechnologies.
SourceUniversity of Liverpool·JournalCell Host & Microbe·TypeExperimental study·DateSep 30, 2021
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Researchers discovered azole-resistant Aspergillus fumigatus strains isolated from a tulip bulb have genetic recombination and resistance to multiple fungicide classes. Plant bulbs serve as an ideal niche for the pathogens to evolve their resistance, posing a global health threat.
SourceUniversity of Tsukuba·JournalEnvironmental Microbiology·DateSep 3, 2021
A recent study published in Clinical Infectious Diseases documents the person-to-person transmission of antimicrobial-resistant pneumonic plague in an outbreak in rural Madagascar. The AMR strain was resistant to streptomycin but susceptible to co-trimoxazole, and all patients treated with antibiotics survived.
SourceNorthern Arizona University·JournalClinical Infectious Diseases·TypeObservational study·DateAug 12, 2021
A rapid and affordable molecular assay using high-resolution melting technology accurately identifies antimicrobial resistant determinants in Neisseria gonorrhoeae, enabling real-time surveillance to control the spread of drug-resistant gonorrhea.
SourceElsevier·JournalJournal of Molecular Diagnostics·DateOct 26, 2020
Scientists have identified a novel R gene in a diploid wild potato that confers high resistance to the oomycete Phytophthora infestans, the causative agent of late blight. This discovery provides new resources for breeding improved potato varieties and offers insights into the mechanisms underlying plant immunity.
SourceAmerican Phytopathological Society·JournalPhytopathology·DateSep 21, 2020
The University of Sussex has developed the most sensitive strain sensor, capable of detecting strains as low as 0.1% and up to 80% with a gauge factor of ~20. This technology could revolutionize wearable devices for vital sign monitoring and building structural integrity assessment.
SourceUniversity of Sussex·JournalAdvanced Functional Materials·DateJun 4, 2020
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers identified 497 genes expressed in resistant mice and 22 genes in susceptible mice, showing the development of disease depends on host genetics. The study aims to develop biomarkers for diagnosis and treatment of leishmaniasis.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateMar 24, 2020
Researchers discovered genetic differences between families of the same fish that confer resistance to the lethal virus. This finding could help protect tilapia stocks worth nearly $10 billion to the global economy and alleviate hunger in developing countries.
SourceUniversity of Edinburgh·JournalAquaculture·DateFeb 25, 2020
A highly contagious intestinal bacteria, Shigellosis can cause 190 million cases of diarrhoea globally each year. In Victoria, a drug-resistant Shigella strain has emerged, making treatment with oral antibiotics impossible, requiring hospitalization and intravenous antibiotics instead.
SourceUniversity of Melbourne·JournalNew England Journal of Medicine·DateDec 18, 2019
Researchers study how gonorrhea develops resistance to antibiotics, identifying key mutations and structural changes. Understanding these mechanisms can lead to the development of new treatments and diagnostic tests.
SourceMedical University of South Carolina·JournalJournal of Biological Chemistry·DateAug 23, 2019
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Resistance to carbapenems and polymyxins is geographically widespread in Southeast Asia, with overlapping distributions in eight countries. The study highlights the urgent need for robust antimicrobial resistance surveillance and improved infection prevention and treatment practices globally.
SourceGeorgetown University Medical Center·JournalInternational Journal of Antimicrobial Agents·DateAug 12, 2019
Researchers discovered that multiple antibiotic resistance mutations in E. coli acquired simultaneously, rather than through gradual evolution. This finding suggests a recent emergence of the pandemic multidrug-resistant strain, possibly within the last 12 years.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateJul 1, 2019
A study using whole genome sequencing reveals a single bacterial strain with carbapenem-resistance gene persisted in a Northern California hospital for over 3 years. The strain was transmitted from patient to patient, particularly through lengthy stays in the intensive care unit.
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Researchers have developed an innovative treatment using uterine stem cell conditioned medium, showing antifungal activity against resistant strains of Candida albicans. This breakthrough opens up a new window of hope for treating vaginal candidiasis and its chronic carriers.
SourceUniversity of the Basque Country·JournalFrontiers in Microbiology·DateFeb 8, 2019
A Rutgers-led team has discovered two genes that make some strains of Staphyloccocus aureus resistant to treatment by copper. The discovery may open new paths for the development of antibacterial drugs and could lead to higher resistance to antibiotics.
SourceRutgers University·JournalJournal of Biological Chemistry·DateFeb 8, 2019
A new study has confirmed the presence of a superbug gene in the Kongsfjorden region of Svalbard, one of the last pristine places on Earth. The blaNDM-1 gene, originally found in urban India, has been detected in Arctic soils and is associated with increased antibiotic resistance.
SourceNewcastle University·JournalEnvironment International·DateJan 27, 2019
Apple Watch Series 11 (GPS, 46mm)
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University of Nebraska-Lincoln researchers found epigenetic traits in Sulfolobus solfataricus, a species of archaea that thrive in acidic environments. The discovery could accelerate the study of epigenetics in humans, potentially leading to new insights into trait inheritance and management.
SourceUniversity of Nebraska-Lincoln·JournalProceedings of the National Academy of Sciences·DateDec 3, 2018
A study in Scientific Reports identifies mechanisms of pesticide resistance in cattle ticks, which contribute to significant economic losses. The study reveals that the ticks' ability to detoxify toxicants, including ivermectin, is a key factor in their resistance.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateNov 13, 2018
Researchers have discovered previously unidentified mutations in the PfCoronin and PfKelch13 genes that confer artemisinin resistance in West African malaria strains. These findings provide potential insights into the molecular mechanisms of artemisinin resistance.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateNov 12, 2018
Researchers studied Bacillus bacteria that produce highly resistant spores and found unique genes contributing to their resistance. The discovery sheds light on the challenges of eliminating microbes in clean rooms and spacecraft.
SourceUniversity of Houston·JournalBMC Microbiology·DateJun 27, 2018
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The rise in resistance to antifungal treatments mirrors the well-established threat of bacteria, which have become resistant to antibiotics. Fungal infections, including blights affecting food crops, yeast and mould-related infections in humans and livestock, can be fatal for those with underlying conditions.
SourceImperial College London·JournalScience·DateMay 17, 2018
Researchers discovered a new resistance mechanism in Acinetobacter baumannii that blocks the critical antibiotic colistin. The mechanism involves disruption of the hns gene by an insertion sequence element, leading to increased expression of genes that boost colistin resistance.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateApr 30, 2018
Researchers at Osaka University found that short trips to developing countries significantly increase the appearance of colistin-resistant bacteria in Japanese travelers. The study tracked 19 participants who traveled for less than 2 weeks and discovered nearly 90% of travel events resulted in resistant strains.
SourceOsaka University·JournalInfection and Drug Resistance·DateApr 10, 2018
The gonorrhea bacterium has developed resistance to multiple antibiotics, with ceftriaxone being the last effective option. Researchers identified mutations that enable resistance to ceftriaxone, which also impairs growth rate, but lab experiments showed resistant strains can quickly outcompete non-resistant strains.
SourceUniversity of North Carolina Health Care·JournalmBio·DateApr 4, 2018
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Researchers analyzed the genome of a deadly, drug-resistant bacterial strain to identify molecular drivers of resistance. The study found four genes responsible for resistance to beta-lactams and other antibiotics.
SourceAmerican Society for Microbiology·JournalmBio·DateApr 3, 2018
A new study published in The Lancet suggests that the current WHO strategy for yaws eradication is insufficient and may not be effective against antibiotic-resistant strains. Researchers recommend treating every individual living in an endemic zone to cure latent infections and achieve elimination.
SourceBarcelona Institute for Global Health (ISGlobal)·JournalThe Lancet·DateFeb 7, 2018
A comprehensive genetic study reveals that multidrug-resistant malaria parasites emerged and spread aggressively in Cambodia, under-reporting for years. Ongoing genomic surveillance is vital to inform public health malaria control strategies and detect patterns of resistance.
SourceWellcome Trust Sanger Institute·JournalThe Lancet Infectious Diseases·DateFeb 1, 2018
A team of researchers has identified the first rust virulence molecule that triggers built-in wheat resistance, allowing plants to fend off devastating stem rust disease. This breakthrough could help prioritize resistance genes and inform fungicide use in high-yielding wheat varieties.
SourceUniversity of Minnesota·JournalScience·DateDec 21, 2017
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
SourceThe Lancet·JournalThe Lancet Infectious Diseases·DateNov 29, 2017
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Researchers at UC Davis identified a gene that enables resistance to Ug99, a devastating strain of stem rust threatening global food security. Breeders can use molecular markers to select for the genes and develop varieties with multiple resistance levels.
SourceUniversity of California - Davis·JournalProceedings of the National Academy of Sciences·DateNov 16, 2017
Researchers developed a mathematical model of cefixime resistance in Neisseria gonorrhoeae, estimating that treating up to 25% of cases with cefixime would not lead to resistance re-emerging. The study suggests cefixime may be an effective alternative to current treatments in the fight against antimicrobial-resistant gonorrhea.
A UK plant pathologist has uncovered an important genetic link to the devastating wheat blast fungus. The research found that a mutation in a key gene allows the fungus to escape wheat resistance, compromising crop yields and sparking global efforts to breed blast-resistant wheat.
SourceUniversity of Kentucky·JournalScience·DateJul 6, 2017
Researchers developed a more tailored approach to combat soybean rust by identifying resistance genes in specific varieties. While no single variety could resist all rust strains, some showed promise against African rust strains, offering hope for breeding programs worldwide.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalPlant Disease·DateJun 28, 2017
A new method, MDK99, measures bacterial tolerance to antibiotics, allowing for more effective treatment and reduced risk of resistance. This metric helps classify bacteria as tolerant, resistant, or persistent, guiding treatment decisions.
SourceThe Hebrew University of Jerusalem·JournalBiophysical Journal·DateJun 21, 2017
Apple iPad Pro 11-inch (M4)
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A new method, MDK99, measures bacterial tolerance to antibiotics, allowing clinicians to effectively treat antimicrobial-tolerant strains. This metric can also estimate the duration of antibiotic treatments and provide insights into the prevalence of tolerance, ultimately reducing treatment failure and resistance.
SourceCell Press·JournalBiophysical Journal·DateJun 20, 2017
Researchers identified a secondary pathway to reactivate EthA enzyme in resistant TB strains, boosting treatment efficacy. The combination of SMARt-420 and ethionamide effectively treated resistant TB strains, reducing bacterial load in mouse lungs.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateMar 16, 2017
Researchers from Michigan Technological University found that fruit flies' resistance to mushroom toxins corresponds to the mammalian target of rapamycin (mTOR) pathway, regulating cell physiology and metabolism in humans. This discovery opens up new avenues for studying diseases like cancer, obesity, type 2 diabetes, depression, and n...
SourceMichigan Technological University·JournalPLOS ONE·DateFeb 27, 2017
A recent study found that antibiotic use among travelers increases the risk of contracting antibiotic-resistant ESBL intestinal bacteria. In fact, up to 80% of those taking antibiotics brought the most resistant strains back home with them. The use of antibiotics while traveling selects for the broadest spectrum of resistance.
SourceUniversity of Helsinki·JournalTravel Medicine and Infectious Disease·DateFeb 9, 2017
A new study reveals that disease-causing bacteria become resistant to antibiotics by acquiring mutations that allow them to tolerate the antibiotic. The research found that strains with pre-existing tolerant mutations developed resistance more quickly than those without tolerance.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateFeb 9, 2017
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at UConn have developed experimental antibiotics that successfully target and kill MRSA bacteria by blocking the enzyme pathway critical to its survival. By understanding the molecular structure of the enzyme and designing tailored inhibitors, the team created compounds that evade previously resistant strains.
SourceUniversity of Connecticut·JournalCell Chemical Biology·DateDec 22, 2016
A recent study reveals that syphilis has re-emerged globally, primarily caused by a pandemic strain cluster named SS14-Ω. This cluster exhibits high levels of antibiotic resistance, particularly to azithromycin, posing a significant public health concern. The researchers hope that their findings will contribute to a better understandin...
SourceUniversity of Zurich·JournalNature Microbiology·DateDec 5, 2016
A new study published in The Lancet Infectious Diseases found that HIV patients in Africa are developing resistance to both older generation drugs like thymidine analogues and modern drugs like tenofovir. This highlights the need for genetic testing before prescribing first-line treatments.
SourceUniversity College London·JournalThe Lancet Infectious Diseases·DateNov 30, 2016
Surgeons must take a leadership role in promoting antimicrobial stewardship to address the urgent problem of antibiotic overuse. The World Society of emergency Surgery and the Surgical Infection Society have issued a call to action, urging surgeons to standardize antibiotic use and support multidisciplinary collaborations.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalSurgical Infections·DateNov 15, 2016
Researchers found that some mutations enabling chloroquine resistance in malaria parasites also enhance their growth rates, contradicting previous findings. These mutations impact metabolic pathways and digestive processes, contributing to multidrug resistance phenotypes.
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A study has found a link between chlorhexidine exposure and antibiotic resistance in Klebsiella pneumoniae bacteria. The researchers discovered that certain strains of the bacteria could survive high concentrations of chlorhexidine and develop resistance to colistin, a last resort antibiotic.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateOct 31, 2016
Researchers created a device called MEGA plate to observe bacteria adapting to increasing antibiotic doses, revealing key insights into the spread of resistance. The study provides a powerful visualization of bacterial movement and evolution.
SourceHarvard Medical School·JournalScience·DateSep 8, 2016
Researchers isolated MCR-1 gene from a diabetic patient's foot infection in Brazil, marking the first detection of the gene in humans. The discovery highlights the potential for antibiotic resistance to spread within countries.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateAug 8, 2016
Scientists have identified a clear distinction between two strains of mice susceptible to Ascaris infection, with the resistant strain showing an earlier immune response and more rapid tissue repair. The study suggests manipulating hepatic ROS levels may confer resistance to Ascaris in susceptible mice.
SourceTrinity College Dublin·JournalPLOS Neglected Tropical Diseases·DateAug 4, 2016
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Researchers found that resistant mice have higher levels of reactive oxygen species proteins and a more rapid tissue repair response in the liver. This suggests that highly oxidative conditions may be key to murine resistance to Ascaris infection.
SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateAug 4, 2016
Researchers found that antibiotic treatment in men who have sex with men (MSM) speeds up the spread of antibiotic-resistant Neisseria gonorrhoeae, contrary to intuitive expectations. The study suggests that increased screening and treatment may inadvertently drive resistance, highlighting the need for balanced treatment recommendations.
A large study found tenofovir-resistant strains in 60% of HIV patients in sub-Saharan Africa, highlighting a significant concern for global HIV control strategies. The study suggests that up to 15% of HIV patients will develop resistance in the first year of treatment alone.
SourceUniversity College London·JournalThe Lancet Infectious Diseases·DateJan 28, 2016
Researchers at Boyce Thompson Institute have discovered a gene in wild tomato species that imparts resistance to the bacteria causing speck, a devastating disease affecting NY tomato crops. The gene, qRph1, has been mapped and is being used to develop resistant varieties of cultivated tomatoes.
SourceBoyce Thompson Institute·JournalThe Plant Genome·DateNov 9, 2015
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A new study uses computational software to design variants of an HIV-1-targeting antibody, revealing improved stability and broadened neutralization capabilities. The findings may inform the development of effective HIV-1 vaccines.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 18, 2015
A study analyzing individual virus sequences from 287 published studies found that most HIV-1 transmitted drug resistance strains arose independently in sub-Saharan Africa and south/southeast Asia. The study suggests screening for specific high-prevalence mutations could identify patients with TDR before therapy initiation.
Researchers at the University of East Anglia have discovered five strains of yeast capable of breaking down agricultural by-products into bioethanol. This breakthrough could lead to the production of over 400 billion litres of bioethanol annually from crop waste, reducing reliance on fossil fuels.
SourceUniversity of East Anglia·JournalBiotechnology for Biofuels·DateMar 26, 2015