Articles tagged with Resistant Strains
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Researchers have identified a new prophage-mediated defence system in Salmonella Typhimurium ST313 called BstA, which efficiently suppresses phage attacks. This discovery opens up a new avenue of research and could potentially lead to the development of new biotechnologies.
Researchers discovered azole-resistant Aspergillus fumigatus strains isolated from a tulip bulb have genetic recombination and resistance to multiple fungicide classes. Plant bulbs serve as an ideal niche for the pathogens to evolve their resistance, posing a global health threat.
A recent study published in Clinical Infectious Diseases documents the person-to-person transmission of antimicrobial-resistant pneumonic plague in an outbreak in rural Madagascar. The AMR strain was resistant to streptomycin but susceptible to co-trimoxazole, and all patients treated with antibiotics survived.
A rapid and affordable molecular assay using high-resolution melting technology accurately identifies antimicrobial resistant determinants in Neisseria gonorrhoeae, enabling real-time surveillance to control the spread of drug-resistant gonorrhea.
Scientists have identified a novel R gene in a diploid wild potato that confers high resistance to the oomycete Phytophthora infestans, the causative agent of late blight. This discovery provides new resources for breeding improved potato varieties and offers insights into the mechanisms underlying plant immunity.
The University of Sussex has developed the most sensitive strain sensor, capable of detecting strains as low as 0.1% and up to 80% with a gauge factor of ~20. This technology could revolutionize wearable devices for vital sign monitoring and building structural integrity assessment.
Researchers identified 497 genes expressed in resistant mice and 22 genes in susceptible mice, showing the development of disease depends on host genetics. The study aims to develop biomarkers for diagnosis and treatment of leishmaniasis.
Researchers discovered genetic differences between families of the same fish that confer resistance to the lethal virus. This finding could help protect tilapia stocks worth nearly $10 billion to the global economy and alleviate hunger in developing countries.
A highly contagious intestinal bacteria, Shigellosis can cause 190 million cases of diarrhoea globally each year. In Victoria, a drug-resistant Shigella strain has emerged, making treatment with oral antibiotics impossible, requiring hospitalization and intravenous antibiotics instead.
Researchers study how gonorrhea develops resistance to antibiotics, identifying key mutations and structural changes. Understanding these mechanisms can lead to the development of new treatments and diagnostic tests.
Resistance to carbapenems and polymyxins is geographically widespread in Southeast Asia, with overlapping distributions in eight countries. The study highlights the urgent need for robust antimicrobial resistance surveillance and improved infection prevention and treatment practices globally.
Researchers discovered that multiple antibiotic resistance mutations in E. coli acquired simultaneously, rather than through gradual evolution. This finding suggests a recent emergence of the pandemic multidrug-resistant strain, possibly within the last 12 years.
A study using whole genome sequencing reveals a single bacterial strain with carbapenem-resistance gene persisted in a Northern California hospital for over 3 years. The strain was transmitted from patient to patient, particularly through lengthy stays in the intensive care unit.
Researchers have developed an innovative treatment using uterine stem cell conditioned medium, showing antifungal activity against resistant strains of Candida albicans. This breakthrough opens up a new window of hope for treating vaginal candidiasis and its chronic carriers.
A Rutgers-led team has discovered two genes that make some strains of Staphyloccocus aureus resistant to treatment by copper. The discovery may open new paths for the development of antibacterial drugs and could lead to higher resistance to antibiotics.
A new study has confirmed the presence of a superbug gene in the Kongsfjorden region of Svalbard, one of the last pristine places on Earth. The blaNDM-1 gene, originally found in urban India, has been detected in Arctic soils and is associated with increased antibiotic resistance.
University of Nebraska-Lincoln researchers found epigenetic traits in Sulfolobus solfataricus, a species of archaea that thrive in acidic environments. The discovery could accelerate the study of epigenetics in humans, potentially leading to new insights into trait inheritance and management.
A study in Scientific Reports identifies mechanisms of pesticide resistance in cattle ticks, which contribute to significant economic losses. The study reveals that the ticks' ability to detoxify toxicants, including ivermectin, is a key factor in their resistance.
Researchers have discovered previously unidentified mutations in the PfCoronin and PfKelch13 genes that confer artemisinin resistance in West African malaria strains. These findings provide potential insights into the molecular mechanisms of artemisinin resistance.
Researchers studied Bacillus bacteria that produce highly resistant spores and found unique genes contributing to their resistance. The discovery sheds light on the challenges of eliminating microbes in clean rooms and spacecraft.
The rise in resistance to antifungal treatments mirrors the well-established threat of bacteria, which have become resistant to antibiotics. Fungal infections, including blights affecting food crops, yeast and mould-related infections in humans and livestock, can be fatal for those with underlying conditions.
Researchers discovered a new resistance mechanism in Acinetobacter baumannii that blocks the critical antibiotic colistin. The mechanism involves disruption of the hns gene by an insertion sequence element, leading to increased expression of genes that boost colistin resistance.
Researchers at Osaka University found that short trips to developing countries significantly increase the appearance of colistin-resistant bacteria in Japanese travelers. The study tracked 19 participants who traveled for less than 2 weeks and discovered nearly 90% of travel events resulted in resistant strains.
The gonorrhea bacterium has developed resistance to multiple antibiotics, with ceftriaxone being the last effective option. Researchers identified mutations that enable resistance to ceftriaxone, which also impairs growth rate, but lab experiments showed resistant strains can quickly outcompete non-resistant strains.
Researchers analyzed the genome of a deadly, drug-resistant bacterial strain to identify molecular drivers of resistance. The study found four genes responsible for resistance to beta-lactams and other antibiotics.
A new study published in The Lancet suggests that the current WHO strategy for yaws eradication is insufficient and may not be effective against antibiotic-resistant strains. Researchers recommend treating every individual living in an endemic zone to cure latent infections and achieve elimination.
A comprehensive genetic study reveals that multidrug-resistant malaria parasites emerged and spread aggressively in Cambodia, under-reporting for years. Ongoing genomic surveillance is vital to inform public health malaria control strategies and detect patterns of resistance.
A team of researchers has identified the first rust virulence molecule that triggers built-in wheat resistance, allowing plants to fend off devastating stem rust disease. This breakthrough could help prioritize resistance genes and inform fungicide use in high-yielding wheat varieties.
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
Researchers at UC Davis identified a gene that enables resistance to Ug99, a devastating strain of stem rust threatening global food security. Breeders can use molecular markers to select for the genes and develop varieties with multiple resistance levels.
Researchers developed a mathematical model of cefixime resistance in Neisseria gonorrhoeae, estimating that treating up to 25% of cases with cefixime would not lead to resistance re-emerging. The study suggests cefixime may be an effective alternative to current treatments in the fight against antimicrobial-resistant gonorrhea.
A UK plant pathologist has uncovered an important genetic link to the devastating wheat blast fungus. The research found that a mutation in a key gene allows the fungus to escape wheat resistance, compromising crop yields and sparking global efforts to breed blast-resistant wheat.
Researchers developed a more tailored approach to combat soybean rust by identifying resistance genes in specific varieties. While no single variety could resist all rust strains, some showed promise against African rust strains, offering hope for breeding programs worldwide.
A new method, MDK99, measures bacterial tolerance to antibiotics, allowing for more effective treatment and reduced risk of resistance. This metric helps classify bacteria as tolerant, resistant, or persistent, guiding treatment decisions.
A new method, MDK99, measures bacterial tolerance to antibiotics, allowing clinicians to effectively treat antimicrobial-tolerant strains. This metric can also estimate the duration of antibiotic treatments and provide insights into the prevalence of tolerance, ultimately reducing treatment failure and resistance.
Researchers identified a secondary pathway to reactivate EthA enzyme in resistant TB strains, boosting treatment efficacy. The combination of SMARt-420 and ethionamide effectively treated resistant TB strains, reducing bacterial load in mouse lungs.
Researchers from Michigan Technological University found that fruit flies' resistance to mushroom toxins corresponds to the mammalian target of rapamycin (mTOR) pathway, regulating cell physiology and metabolism in humans. This discovery opens up new avenues for studying diseases like cancer, obesity, type 2 diabetes, depression, and n...
A new study reveals that disease-causing bacteria become resistant to antibiotics by acquiring mutations that allow them to tolerate the antibiotic. The research found that strains with pre-existing tolerant mutations developed resistance more quickly than those without tolerance.
A recent study found that antibiotic use among travelers increases the risk of contracting antibiotic-resistant ESBL intestinal bacteria. In fact, up to 80% of those taking antibiotics brought the most resistant strains back home with them. The use of antibiotics while traveling selects for the broadest spectrum of resistance.
Researchers at UConn have developed experimental antibiotics that successfully target and kill MRSA bacteria by blocking the enzyme pathway critical to its survival. By understanding the molecular structure of the enzyme and designing tailored inhibitors, the team created compounds that evade previously resistant strains.
A recent study reveals that syphilis has re-emerged globally, primarily caused by a pandemic strain cluster named SS14-Ω. This cluster exhibits high levels of antibiotic resistance, particularly to azithromycin, posing a significant public health concern. The researchers hope that their findings will contribute to a better understandin...
A new study published in The Lancet Infectious Diseases found that HIV patients in Africa are developing resistance to both older generation drugs like thymidine analogues and modern drugs like tenofovir. This highlights the need for genetic testing before prescribing first-line treatments.
Surgeons must take a leadership role in promoting antimicrobial stewardship to address the urgent problem of antibiotic overuse. The World Society of emergency Surgery and the Surgical Infection Society have issued a call to action, urging surgeons to standardize antibiotic use and support multidisciplinary collaborations.
Researchers found that some mutations enabling chloroquine resistance in malaria parasites also enhance their growth rates, contradicting previous findings. These mutations impact metabolic pathways and digestive processes, contributing to multidrug resistance phenotypes.
A study has found a link between chlorhexidine exposure and antibiotic resistance in Klebsiella pneumoniae bacteria. The researchers discovered that certain strains of the bacteria could survive high concentrations of chlorhexidine and develop resistance to colistin, a last resort antibiotic.
Researchers created a device called MEGA plate to observe bacteria adapting to increasing antibiotic doses, revealing key insights into the spread of resistance. The study provides a powerful visualization of bacterial movement and evolution.
Researchers isolated MCR-1 gene from a diabetic patient's foot infection in Brazil, marking the first detection of the gene in humans. The discovery highlights the potential for antibiotic resistance to spread within countries.
Researchers found that resistant mice have higher levels of reactive oxygen species proteins and a more rapid tissue repair response in the liver. This suggests that highly oxidative conditions may be key to murine resistance to Ascaris infection.
Scientists have identified a clear distinction between two strains of mice susceptible to Ascaris infection, with the resistant strain showing an earlier immune response and more rapid tissue repair. The study suggests manipulating hepatic ROS levels may confer resistance to Ascaris in susceptible mice.
Researchers found that antibiotic treatment in men who have sex with men (MSM) speeds up the spread of antibiotic-resistant Neisseria gonorrhoeae, contrary to intuitive expectations. The study suggests that increased screening and treatment may inadvertently drive resistance, highlighting the need for balanced treatment recommendations.
A large study found tenofovir-resistant strains in 60% of HIV patients in sub-Saharan Africa, highlighting a significant concern for global HIV control strategies. The study suggests that up to 15% of HIV patients will develop resistance in the first year of treatment alone.
Researchers at Boyce Thompson Institute have discovered a gene in wild tomato species that imparts resistance to the bacteria causing speck, a devastating disease affecting NY tomato crops. The gene, qRph1, has been mapped and is being used to develop resistant varieties of cultivated tomatoes.
A new study uses computational software to design variants of an HIV-1-targeting antibody, revealing improved stability and broadened neutralization capabilities. The findings may inform the development of effective HIV-1 vaccines.
A study analyzing individual virus sequences from 287 published studies found that most HIV-1 transmitted drug resistance strains arose independently in sub-Saharan Africa and south/southeast Asia. The study suggests screening for specific high-prevalence mutations could identify patients with TDR before therapy initiation.
Researchers at the University of East Anglia have discovered five strains of yeast capable of breaking down agricultural by-products into bioethanol. This breakthrough could lead to the production of over 400 billion litres of bioethanol annually from crop waste, reducing reliance on fossil fuels.
Researchers have discovered a new mechanism of antibiotic resistance in bacterial cells, which could help develop solutions to the growing problem of antibiotic resistance. The study found that a mutation in the efflux pump makes it more efficient at pumping antibiotics out of bacterial cells.
Researchers at the University of Toronto found that only a few strains of Candida albicans became resistant to combination therapy, and that resistance came at a cost to the fungus. The resistant strains grew poorly in stress conditions and were vulnerable to immune cells.
A study published in Nature Communications reveals that mutations can converge on similar physical changes in bacteria, leading to resistance to multiple antibiotics. The researchers found a common set of features responsible for the development of resistance, which could help combat this growing problem.
A highly resistant strain of E. coli was associated with an outbreak at a hospital in Illinois, where contaminated duodenoscopes were found to be the source of transmission. The study suggests that current reprocessing methods may not be sufficient to prevent the spread of antimicrobial-resistant organisms.
A new study reviewing nearly 70 antimicrobial resistance studies suggests that aggressive treatment may not always be the best way to prevent resistant pathogens. The review found that varying drug dosages and treatment durations may affect resistance emergence, and moderate treatment could be a more effective strategy for some diseases.