Disease Susceptibility
Articles tagged with Disease Susceptibility
New marker aids diagnosis for aggressive prostate cancer
Predicting genetic risk for Type 1 diabetes just got more accurate thanks to UC San Diego study
The study demonstrates that the T1GRS tool can identify children and adults at high risk for Type 1 diabetes earlier than current methods, enabling preventive measures before the disease develops. The researchers grouped individuals into four sub-types based on genetic features, each with unique clinical profiles and outcomes.
Support from a trusted adult in childhood can mitigate the long-term impact of abuse
A study published in the Journal of Aggression, Maltreatment & Trauma found that feeling safe with a trusted adult during childhood reduces the risk of depression, chronic disease, and poor health. The presence of protective adults significantly mitigates the long-term impact of abuse.
Excessive napping may be a warning sign of underlying or developing health conditions in older adults
A study of 1,338 older adults found that longer, more frequent, and morning naps were associated with higher mortality rates. Excessive daytime napping was linked to increased risk of neurodegeneration, cardiovascular diseases, and greater morbidity.
Machine-learned biomarker identifies those at high risk for liver cancer
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Critical crosstalk between blood vessels and immune system, showing shared pathways in major diseases
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
Cells that are not our own may unlock secrets about our health
Researchers are studying microchimeric cells that can play complex roles in a person's body, including healing wounds and regulating the immune system. However, more research is needed to understand their role in health outcomes, particularly pregnancy complications and autoimmune diseases.
Decades of suffering: Long-term mental health outcomes of Kurdish chemical gas attacks
A study of over 500 survivors found severe psychological trauma with somatic symptoms persisting decades after the attack. The results highlight the need for culturally sensitive mental health services, compensation, and ongoing care for chemical attack survivors.
SLU research shows surge in alcohol-related liver disease driving ‘deaths of despair’
New research from Saint Louis University School of Medicine shows a significant increase in deaths from alcohol-related liver disease, particularly among those without a college degree. The study highlights the need for targeted interventions to address social and economic stressors, as well as medical and behavioral risks.
New FAU research strengthens evidence linking alcohol use to cancer
Research from Florida Atlantic University strengthens evidence that alcohol consumption increases cancer risk, particularly for breast, colorectal, and liver cancers. Higher intake and specific groups, such as African Americans and those with obesity or diabetes, are found to be more vulnerable to the risks.
DNA methylation patterns in newborns point to susceptibility to schizophrenia
Researchers identified distinct epigenetic signatures in cord blood linked to increased schizophrenia and other neurodevelopmental conditions. Newborns with higher genetic susceptibility showed differences in DNA methylation patterns, especially in immune-related regions.
New DNA analysis approach could transform understanding of disease evolution
Researchers developed a new DNA analysis technique to study old genetic samples, shedding light on disease evolution and changes in biology over time. The approach has potential for unlocking the root causes underlying shifting landscapes of modern diseases.
Obesity drugs improve heart health: Study shows additional benefits of semaglutide and tirzepatide
Researchers analyzed insurance claims data from US health insurers to demonstrate the cardiovascular benefits of semaglutide and tirzepatide. Both GLP-1 drugs provide cardioprotective effects, reducing the risk of stroke and heart attack by 18% and 13%, respectively.
Drinking for two? Prenatal alcohol exposure rewires the brain and fuels compulsive behavior, new study finds
A new study reveals how prenatal alcohol exposure impairs key brain cells and circuits, leading to cognitive inflexibility and increased risk of compulsive alcohol use. Researchers identified a specific brain cell affected by early alcohol exposure, providing a clear target for developing more effective treatments of FASD.
It’s not just diet: where a child lives also raises type 2 diabetes risk
A recent study published in Pediatric Research highlights the impact of neighborhood environments on childhood type 2 diabetes risk. The research found associations between library presence, neighborhood walkability, and caregiver health, suggesting that social and environmental factors play a significant role in T2D development.
DNA nanospring measures cellular motor power
Scientists have developed a DNA nanospring to measure the force of protein motors like KIF1A, which can lead to improved diagnosis and treatment of diseases. The technique uses fluorescent imaging to detect the stretching of the DNA nanospring, allowing researchers to accurately measure the motor's power.
Kidney cancer cases are projected to double by 2050, says study
A study published in European Urology predicts a doubling of kidney cancer cases worldwide over the next 25 years. Modifiable risk factors such as obesity, smoking, lack of exercise, diabetes, and hypertension are expected to drive this rise.
Arts programs can help prevent heart disease, diabetes, and other leading causes of deaths, large study finds
A large international study found that arts-based programs can make health messages more memorable and relevant to people's lives, improving health behaviors and cultural relevance of disease prevention programs. The study suggests that arts could be a vital part of the toolkit for promoting health and preventing disease.
Researchers uncover relationship between gut fungi, human genetic variation and disease risk
Researchers found 148 fungi-associated genetic variants linked to 9 fungal taxa and associated with chronic disease risk. The study sheds light on the human genetic determinants of the mycobiome, a previously understudied group of gut microorganisms.
Mouth to gut bacteria migration explains why smoking is good for inflamed bowels
Researchers discovered that smoking produces metabolites that encourage mouth bacteria to grow in the large intestines, triggering an immune response. These bacteria, specifically Streptococcus mitis, help reduce inflammation in ulcerative colitis by triggering a specific immune response.
New statistical tool reveals hidden genetic pathways in complex diseases, paves way for personalized genetic medicine
A new method called Causal Pivot detects hidden genetic drivers and subgroups patients by true biological causes of their illnesses. The tool paves the way for major advances in personalized genetic medicine by revealing genetic "routes" into diseases.
Want to improve early detection of diabetes? Look in the same households as those with abnormal blood sugar
A study found that almost 50,000 adults with prediabetes and 30,000 with type 2 diabetes lived in the same households as index cases. The researchers analyzed electronic health records to identify household members with diabetes risk factors, including obesity and abnormal blood fats.
Risk of long COVID increases with social and economic hardship
A nationwide study found that financial hardship, food insecurity, lack of healthcare access, and other social risk factors increase the risk of long COVID. The RECOVER-Adult cohort study analyzed 3,700 participants and found significant associations between individual-level social risk factors and increased risk of developing long COVID.
Demographics, risk factors and prevalence of chronic cough in Asian general adult population: a narrative review
Chronic cough is a common symptom in the Asian general adult population, related to risk factors such as age, allergy, smoking, and air pollution. The physical and psychological burden of chronic cough is notable, particularly among older patients or those with comorbidities.
NUS Medicine researchers develop a better and more accurate biological ageing clock
Researchers developed an improved biological ageing clock, LinAge2, that offers doctors a practical way to assess how quickly a person is ageing and what can be done to slow it down. The new algorithm-powered tool outperforms other clinical models in predicting long-term mortality and health outcomes.
New study sheds light on health differences between sexes
Researchers found that only a small fraction of proteins have genetic differences between males and females. Instead, lifestyle, education, and access to resources also contribute to the health gaps experienced by men and women.
New study discovers link between delayed puberty and early-onset type 2 diabetes for the first time
A new study has discovered a link between delayed puberty and an increased risk of developing type 2 diabetes in boys. According to the research, adolescent boys who experience delayed puberty are 37% more likely to develop type 2 diabetes in early adulthood, regardless of their weight or socio-economic status.
Researchers reveal why young plants may be more vulnerable to disease
A University of Maryland study reveals that young plants face a hidden trade-off between fighting disease and growing, leading to reduced reproductive fitness. Plants with stronger disease resistance as seedlings produce fewer flowers and seeds over their lifetime.
Hidden virus harboured by fruit flies may influence experimental accuracy
A new study reveals that the presence of Nora virus in laboratory strains of Drosophila fruit flies can increase their sensitivity to bacterial infection and limit their lifespan. Flies with persistent viral infections have higher stem cell growth rates, making them more susceptible to secondary pathogenic infections.
Mayo Clinic researchers study causes of rapidly progressive dementia
Researchers at Mayo Clinic are conducting a study to understand the factors that contribute to rapid progression of dementia in patients with Alzheimer's disease and Related Dementias. The team aims to identify biomarkers and disease-modifying targets that can improve diagnosis and treatment outcomes for these patients.
From height to health: Largest global genetic study reveals hidden risks and benefits linked to stature
A global genetic study has discovered new links between predicted height and diseases, including mental disorders and the endocrine system. The research used data from diverse ancestries and found significant associations that could improve early diagnosis and patient care.
Researchers uncover surprising link to stroke risk
A new study from the University of Texas at Arlington found that Americans aged 65 and older who experienced parental divorce as children were more likely to suffer a stroke compared to their peers. The study analyzed data from over 13,000 older Americans and found that about 14% had experienced parental divorce during childhood.
Marine herbivores chomp eelgrass, making it susceptible to wasting
Sea snails and isopods grazing on eelgrass create wounds that make it susceptible to wasting disease. The study found a significant association between invertebrate grazing and disease prevalence across the Pacific Coast.
Study shows some species are susceptible to broad range of viruses
Researchers found positive correlations in susceptibility to viruses across diverse fruit fly species, suggesting a general pattern of resistance. The study's findings have implications for understanding viral evolution and predicting pandemics.
Understanding aging requires more than counting birthdays
A new study from Penn State finds that oral tissue samples significantly affect epigenetic clock accuracy, leading to older age estimates. Researchers tested five tissue types and seven epigenetic clocks, concluding that blood-based samples are more accurate in measuring biological age.
Study reveals cause of common cancer immunotherapy side effect
Researchers found impaired PD-1 activity can significantly reduce antibody diversity and quality in memory B cells. This may explain the increased rates of infection reported in patients with cancer receiving checkpoint inhibitor therapy.
Novel app tracks travel-related illnesses
A new app has tracked travel-related illnesses globally, showing that travelers experience health issues more often than expected. The Illness Tracking in Travellers (ITIT) app recorded gastrointestinal symptoms most frequently among Asian travelers and respiratory diseases in Europe.
Leukocyte telomere length and disease severity in cystic fibrosis
A new study found that cystic fibrosis patients with more severe disease characteristics exhibit shorter leukocyte telomere length and greater LTL attrition. This association may accelerate aging and increase susceptibility to age-related diseases, emphasizing the importance of early CF diagnosis and timely therapeutic intervention.
Future enterovirus outbreaks could be exacerbated by climate change
Researchers at Brown University found that temperature increases enterovirus transmission, with a similar effect seen in polio historically and more recent enteroviruses causing hand, foot and mouth disease. Climate change may lead to increased intensity of outbreaks, particularly in regions with larger seasonal temperature ranges.
Genes or environment? A new model for understanding disease risk factors
A new model developed by Penn State researchers more accurately predicts the causal relationship between genetic and environmental factors in disease development. The study found that lifestyle and environmental factors play a larger role than previously believed, offering new opportunities to mitigate disease risk.
Building a molecular brain map to understand Alzheimer’s disease
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
New pathway in immune defense discovered
Bonn researchers decode the interaction between monocytes and platelets, revealing a new intercellular communication mechanism that regulates monocyte function. This discovery has implications for treating immune disorders such as immune thrombocytopenia and other inflammatory diseases.
Global consensus for sarcopenia
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
Could auto-antibodies be linked to severe COVID-19?
Researchers found auto-antibodies against type I interferons in severe and critical COVID-19 patients, compromising their immune response. This discovery highlights the importance of detecting these auto-antibodies in regular health checkups to better prepare for viral infections.
Sewage overflows linked to increase in gastrointestinal illnesses
A new BU study links sewage overflows to increased risk of acute gastrointestinal illnesses in downstream communities. Residents are at a 62% higher risk of developing AGI within four days after large-volume combined sewer overflows, regardless of drinking water source.
Study analyses the impact of summer heat on hospital admissions in Spain
A nationwide study in Spain found that high summer temperatures increase the risk of hospital admission for metabolic disorders, obesity, renal failure, urinary tract infections, and sepsis. The study also revealed differences in vulnerability among age groups, sexes, and pre-existing health conditions.
NIH study shows chronic wasting disease unlikely to move from animals to people
A new NIH study using human cerebral organoids suggests a substantial species barrier preventing the transmission of chronic wasting disease from cervids to people. Researchers found no infection in healthy human cerebral organoids exposed to CWD prions for up to six months.
Study implicates Neanderthal DNA in autism susceptibility
Researchers at Clemson University discovered that certain Neanderthal-derived genetic variations are more common in people with autism than in the general population. These findings suggest long-term effects of ancient human hybridization on brain organization and function, potentially leading to earlier diagnostics.
Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats, reports new global study
Global life expectancy is forecasted to increase from 73.6 years in 2022 to 78.1 years in 2050, with a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and other communicable diseases.
miR-146a rs2910164 C>G Polymorphism and Wilms tumor susceptibility in Eastern Chinese children
A six-center case-control study investigated the association between miR-146a rs2910164 C>G polymorphism and Wilms tumor susceptibility in Chinese children. No significant relationship was found, suggesting no association with increased risk.
New NIH grant aims to combat sight damage from diabetes
A new NIH grant will investigate biological processes that contribute to defects in immune response in the eyes of those with diabetes. Researchers aim to understand why diabetic patients are more susceptible to corneal infections and identify methods to reverse these effects.
Bsal and beyond: task force helps stave off amphibian disease threat
The North American Bsal Task Force has helped keep the novel pathogen at bay by developing diagnostic techniques, a rapid response template, and a surveillance program. Thirty-five of 80 North American amphibians can be infected with Bsal, causing lethal skin disease in susceptible species.
Pathogens, including multi-drug resistant “superbugs”, found on floors, ceilings and door handles of hospital toilets, UK study finds
A new study has found that hospital toilet surfaces in the UK are contaminated with multi-drug resistant superbugs, including Staphylococcus aureus and Escherichia coli. The study reveals that patient toilets were the worst affected, with higher levels of bacteria and fungi found on floors and high surfaces than hand-touch sites.
Cleveland Clinic study finds artificial intelligence can develop treatments to prevent “superbugs”
A Cleveland Clinic study uses reinforcement learning to design antibiotic regimens that minimize resistance and maximize susceptibility. The AI model predicts the most efficient treatment plans for multiple strains of E. coli, informing hospital-wide infection management.
Disease-resistant strains of carp sparks hope in aquaculture
A new study reveals that disease-resistant fish exhibit lower viral loads and higher survival rates compared to susceptible counterparts. The results demonstrate the benefits of breeding resistant animals for sustainable food production and animal welfare.
ERC Advanced Grants for Thorsten Hoppe and Jens Brüning
Thorsten Hoppe and Jens Brüning received 2.5 million euros in funding from the European Research Council to investigate protein degradation and neural circuits of metabolic control, respectively. Their projects focus on preventing neurodegeneration and developing new drugs for obesity treatment.
New mechanism discovered for the life-threatening arrhythmias in Andersen-Tawil syndrome
Researchers have discovered a direct link between the C122Y mutation in the Kir2.1 potassium channel and life-threatening arrhythmias in Andersen-Tawil syndrome, which affects fewer than 1 in a million people. The study highlights the importance of understanding the molecular mechanisms underlying cardiac arrhythmias.
JAX researchers make mice a more powerful tool to study a wide range of human diseases
JAX researchers develop platform to mimic genetic diversity in humans, allowing for precise modeling of disease mechanisms and therapeutic targets. The platform enables direct comparison between mouse and human cells, providing molecular insights into autism, intellectual disability, and other neurodevelopmental disorders.
Protein-based microcapsule saves sensors and lives
Researchers developed protein-based microcapsules to enhance aptamer sensors, enabling direct detection of target molecules in biological samples. The system demonstrates robust protection against harmful proteins and simultaneous real-time sensing of multiple targets.