Articles tagged with Immune Response
Researchers found that birds infected with lipopolysaccharide from bacteria reduced their body temperature by 2°C to conserve energy. In contrast, chicks fed and warm did develop fever. The study suggests that regulated hypothermia is an energy-saving response during severe infection, prioritized over maintaining a fever.
A population-scale study found COVID-19 vaccination is effective in most cancer patients but offers lower protection and wanes quickly. Vaccine effectiveness was lower (65.5%) in cancer patients compared to the general population (69.8%), with higher hospitalization and death risks despite vaccination.
Scientists discovered a novel biochemical mechanism in which plant immune receptors defend plants against invading microorganisms. TIR domains of these receptors break down NAD+ and process RNA/DNA molecules, leading to the production of cyclic nucleotides that activate cell death responses.
A new study analyzing 8 cohorts of COVID-19 patients found that antibody responses in previously infected individuals were relatively stable, providing protection from reinfection unless the new infection was the Omicron variant. Vaccination also boosted protection, with rapid immune responses observed even after a single vaccine dose.
A new study by Gladstone Institutes and UC San Francisco found that infection with the Omicron variant provides weak immune response in unvaccinated individuals, failing to confer broad protection against other variants. In contrast, vaccinated individuals show stronger immunity against multiple COVID-19 strains.
Two studies found that a third dose of mRNA vaccine generates high enough antibody levels to neutralize BA.2 and deltacron, as well as other omicron sublineage variants. Booster shots show stronger protection against these variants than just two doses, particularly against deltacron.
The study reveals that ZNG1 is a protein that puts zinc into other 'client' proteins, playing a crucial role in regulating cellular zinc homeostasis. ZNG1's identification opens up a new area of biology for exploration and may be one of the most important regulatory strategies by which humans cope with severe zinc starvation.
A study published in PLOS Medicine found that mRNA vaccines show better protection against COVID-19 variants compared to viral vector vaccines. The research, conducted among healthcare workers, revealed higher neutralizing antibody responses in mRNA vaccine recipients against VOCs, including Omicron.
Researchers compared SARS-CoV-2 antibody titers after Pfizer-BioNTech and Moderna COVID-19 vaccines in immunosuppressed patients. The study found differing antibody responses among these individuals, who have decreased immune responses to standard vaccines.
A new biomaterial-based technique has improved islet transplants for type 1 diabetes treatment by inducing permanent immune acceptance. The microgels educate the immune system to accept the graft, making it possible to regulate blood glucose levels without chronic immunosuppression.
Researchers found that COPD leads to premature senescence of the immune system, reducing CD4+ and CD8+ T cells. This disruption impairs the immune system, making COPD patients more susceptible to infections.
Researchers found that a single mRNA vaccine booster shot can provide the same level of protection as three doses, making it a promising investment for resource-poor countries. The study suggests that this strategy could benefit billions of people worldwide and help combat emerging COVID-19 variants.
Emory University researchers have identified a mechanism for skin cell death that could lead to new treatments for skin infections, alopecia, hives, and potentially melanoma. The study reveals that a protein called gasdermin A induces pyroptosis in skin cells, serving as an early warning system against bacterial attack.
The new center aims to advance a groundbreaking combination of focused ultrasound and cancer immunotherapy, potentially revolutionizing cancer treatment. The partnership will focus on overcoming existing limitations of immunotherapy and expanding treatment options for various types of cancer.
Researchers at the University of Birmingham found that infected fruit flies continue to engage in courtship and mating behaviors, similar to uninfected flies. The study suggests that animals may invest more in reproduction when faced with a potential life threat, potentially to pass on genes to the next generation
A new NIH-funded study will investigate the effects of semi-volatile organic compounds (SVOCs) on infant and childhood immunity, filling a knowledge gap in SVOC health impacts. The research aims to identify specific SVOCs or mixtures that impair immune function, which could lead to new preventive measures and interventions.
Researchers developed a new test method to detect tuberculosis (TB) progression from latent infection in elephants using IgG antibodies against Antigen 85B. High levels of IgG against ESAT6/CFP10 remained constant, while IgG against Ag85B increased before disease onset and declined with treatment.
A University of Washington model found that the body's ability to create cloned immune cells falls significantly with age, leading to increased susceptibility to COVID-19 in the elderly. The study suggests that genetic limits on cell division may play a role in the devastating effects of COVID-19 on older adults.
A study found that vaccines induce immune responses beyond neutralizing antibodies, involving T cells and the Fc receptor, to control viral replication and prevent severe disease. The researchers observed dose-dependent effects on these immune mechanisms, providing insights for future vaccine design and boosting.
Researchers found that individuals with a diverse population of macrophage cells, which include M2 and regulatory macrophages, are better protected against severe COVID-19. The study suggests that a balance between pro-inflammatory and anti-inflammatory responses is key to preventing the worst symptoms.
Researchers discovered that aging lymph nodes near the skin deteriorate faster than those deeper in the body, compromising the immune response. This can lead to weakened immunity against skin infections, vaccinations, and even skin cancers.
Researchers found that salicylic acid and jasmonic acid increase in response to fungal infection, increasing plant resistance without negatively affecting growth. High levels of both hormones make trees more resistant to fungal attack.
The study found that T-cell immunity was effective against Omicron variants in approximately 90% of vaccinated Europeans. The researchers identified a specific HLA-DRB1*03:01 variant that allowed the virus to evade immune recognition, particularly affecting individuals with this genetic variation.
A UCLA-led team found that an abnormally suppressed immune system, not a persistently hyperactive one, may be to blame for some cases of long COVID-19. The study suggests boosting immunity in those individuals could be a treatment option.
A blood test can predict which patients with COVID-19 pneumonia are most likely to become severely ill. Researchers found that levels of certain host proteins increased or decreased at different stages of hospitalization, providing insight into the progression of disease.
Researchers at the University of Oklahoma are testing a novel therapy that combines local laser ablation and immunostimulants to treat metastatic pancreatic cancer. The treatment aims to stimulate the immune system to fight cancer cells, with promising preliminary results in pre-clinical studies and clinical trials.
A new study found that Black kidney transplant recipients exhibit a faster clearance rate of tacrolimus, an immunosuppressive drug. The study suggests that considering both sex and race when dosing tacrolimus may reduce adverse effects and enhance transplant outcomes.
A team of researchers developed a novel chip-based infection model to study invasive aspergillosis, a mold infection that affects the lungs. The model allows for live microscopic observation of damage caused by fungal hyphae and the response of immune cells.
Researchers at La Jolla Institute for Immunology discovered a Zika virus mutation that boosts its ability to replicate and infect humans. This mutation allows the virus to evade protective immunity from previous dengue exposure, increasing its transmission potential.
Researchers at UC San Diego found that ovarian cancer tumors activate FAK protein to regulate CD155 expression, creating a shield against immune detection and evading treatment. New molecular targets may boost immune response and lead to new combinatorial strategies for this disease.
Researchers developed a virus that infects cancer cells, killing them while sending signals to nearby uninfected cells for viral attack. This approach shrinks tumors and enhances cancer-killing efficacy in various models, including pancreatic and ovarian cancers.
Researchers identified a genetic variant associated with increased response to anti-PD-1 therapy and higher immune-related side effects in lung cancer patients. The variant, found in 15.7% of exceptional responders, may be used to identify patients who would benefit from treatment.
Researchers discovered that individuals with depressive disorders have increased blood cell deformability, particularly in lymphocytes, monocytes, and neutrophils. This suggests a potential link between immune system changes and sustained immune responses.
Researchers analyzed genomic profiles of over one million cells from 1,000 people, identifying a link between specific genes and immune cell types in autoimmune diseases. The discovery could lead to tailored treatments and refine clinical trials.
A third dose of COVID-19 vaccine significantly increases immune responses in patients with multiple myeloma, but a subset remains vulnerable. The study found that 88% of patients developed antibodies after the third dose, leading to improved neutralization of the wild-type virus.
Researchers at Gladstone Institutes create mini-livers on a chip to study the immune system's response to hepatitis C infection. The platform enables precise control over cellular interactions, allowing for detailed insights into how the liver interacts with the virus and T cells.
Ira Mellman, PhD, is being honored with the 2022 AACR-CRI Lloyd J. Old Award in Cancer Immunology for his seminal work on dendritic cell function and its impact on atezolizumab and neoepitope vaccines. His research has made a major impact on cancer immunology and has the potential to stimulate new directions.
The COVID-19 Variant Immunologic Landscape (COVAIL) trial aims to understand the immune responses to various additional COVID-19 booster shots and prototype vaccines. The study is being conducted to inform booster shot recommendations and protect against future variants.
The SAVE program, a NIH initiative, provides real-time risk assessment of SARS-CoV-2 variants on immune protection. It uses a coordinated approach to identify and curate data about these variants, their impact on immunity, and their effects on vaccine protection.
Researchers found that prior infection with common human coronaviruses does not provide immunity against SARS-CoV-2 due to limited cross-reactive antibodies. This suggests no significant adverse effects from antibody-dependent enhancement, reducing the risk of COVID-19 complications.
Researchers discovered that obesity changes molecular underpinnings of allergic inflammation in both mice and humans. The treatment in obese mice makes their skin worse instead of healing, but a specific drug can 'de-fatten' obese mice without changing body weight.
Researchers at Temple University found that individuals with prior COVID-19 infection experienced rapid antibody production after the first vaccine dose, but showed little increase after the second dose. This contrasts with those without a history of infection, who exhibited massive responses after the second dose.
Researchers discovered that mice infected with tuberculosis are resistant to developing COVID-19, suggesting a potential protective effect against the virus. The findings may explain why double infections of both diseases are rare in humans and contribute to the high rates of infection for each disease individually.
A team led by Professor Charles Gauthier is developing a glycoconjugate vaccine using sugars expressed on the surface of Burkholderia pseudomallei. The vaccine aims to stimulate an immune response and increase its efficacy.
Researchers develop novel therapeutic approach for treating tuberculosis using phosphatase inhibitors, offering potential benefits for TB research and basic biology exploration. The discovery provides a promising alternative to traditional antibiotic-based treatments and has significant implications for combating antimicrobial resistance.
A study found that double vaccinated individuals generate a potent and broad neutralizing antibody response after a delta breakthrough infection. This response provides protection against current variants of concern, including omicron.
Researchers at the University of Huddersfield have identified a key mechanism by which the coronavirus causes inflammation in the brain's immune cells, potentially explaining some symptoms experienced by COVID-19 patients. The study suggests that adequate funding is needed to further develop this research and its potential applications.
Researchers have developed a vaccine using CRISPR technology to protect against Leishmania mexicana, a parasite causing cutaneous leishmaniasis in the Americas. The vaccine is safe and effective in mice, preventing skin lesions and infection for over 10 weeks.
A comprehensive review of over 60 studies confirms that COVID vaccination is around 80% effective in protecting people with cancer against SARS-CoV-2 infection. The mRNA vaccines were found to be the most effective, and multiple vaccinations are recommended for better protection.
Researchers at Texas Biomedical Research Institute have found that adding an antibody to the widely-used TB vaccine significantly improves its long-term effectiveness. The combination of the vaccine and an IL-10 blocker allows for better control of TB infection in mice, with improved lung health and increased memory immune cells.
A Moffitt study found that COVID-19 vaccination led to seroconversion in most cancer patients, but with differing antibody response rates among various cancer types and treatments. Patients with blood cancers had lower seroconversion rates compared to those with solid tumors, highlighting the need for personalized immune responses.
The investigational vaccine targets both the spike and nucleocapsid proteins, producing neutralizing antibodies and inducing T cell responses against SARS-CoV-2. COH04S1 is being studied in Phase 2 trials for immunocompromised patients and as a booster for healthy adult volunteers.
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
Researchers discover unique glycoprotein structure of Nipah and Hendra viruses, which could provide blueprint for vaccine design and antibody treatments. The findings suggest a multi-pronged approach to prevent and treat these deadly illnesses.
A new study by University of Bonn researchers found that cow's milk protein casein triggers an autoimmune response in mice, damaging neurons and myelin sheath. This cross-reactivity can occur when the immune system mistakes similar molecules for each other.
Mutations in SARS-CoV-2's spike protein can resist neutralizing antibodies and therapeutics, highlighting the need for improved vaccines and treatments. The study mapped out these 'escape variants' to understand their molecular mechanisms.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
A new study found that gender-affirming hormone therapy can affect certain regions of DNA, influencing immune function and susceptibility to autoimmune disease. The research has important implications for counseling transgender children and adolescents about the effects of hormone therapies.
Researchers have revealed that during Type 1 Diabetes development, pancreatic duct cells reprogram to suppress autoimmune T cell responses. This discovery advances understanding of the disease by creating a map of pancreatic islet cells over time.
A new study from Oregon Health & Science University found that people infected with SARS-CoV-2 develop durable immunity against variants for at least 11 months. The research suggests that immune protection may endure long-term, potentially reducing the need for vaccine booster shots.