Articles tagged with Immunotherapy
Researchers at Mayo Clinic discovered a link between the protein Bim and predicting patient responses to immunotherapy for metastatic melanoma. They found that patients with higher levels of Bim were more likely to respond to immunotherapy, offering hope for better treatment outcomes.
A study found that a house dust mite immunotherapy tablet improved time to first moderate or severe asthma exacerbation when added to maintenance medications. The treatment reduced the risk of exacerbations and increased allergen-specific antibodies.
A new NIH-funded study suggests that changes in immune cell subtypes after oral immunotherapy for peanut allergy can help predict treatment success. The research, published in Proceedings of the National Academy of Sciences, found a novel T-cell population that likely would not mount an allergic response expanded with treatment.
Two studies found that a specific gut bacteria, Bifidobacterium, is positively associated with anti-tumor T cell responses and upregulates genes critical for anti-tumor responses. Fecal transplants also slowed tumor growth in mice treated with immunotherapy agents.
A new study by Fred Hutchinson Cancer Center researchers found that immunotherapy can boost survival from pancreatic cancer by more than 75% in mice, even without chemotherapy or radiation. The therapy targets mesothelin, a protein overproduced by virtually all pancreatic tumors.
A Mayo Clinic study found that nearly three-quarters of patients with autoimmune cerebellar ataxia were women. The median duration from symptom onset to last follow-up was 25 months, with 51 patients experiencing physician-reported neurologic improvement with immunotherapy and cancer therapy.
A study of 118 adults with autoimmune cerebellar ataxia found that nonparaneoplastic disorders, detection of PMP antibodies, and GAD 65 antibodies predicted better immunotherapy response and neurological outcomes. Among the patients, 45.8% showed physician-reported neurologic improvement.
Researchers developed nanoparticles that deliver allergens to specific cells, reducing side effects. The new approach could lead to safer and more effective treatments for allergies and other conditions.
Researchers have found that combining aspirin with immunotherapy can slow cancer growth and unleash the immune system's full power. By stopping the production of PGE2, a molecule that dampens down the immune response, COX inhibitors like aspirin may lift the protective barrier around tumors, making cancer more susceptible to treatment
A recent study by the UC Davis team has discovered that an early inflammatory response can 'paralyze' CD4 T cells, a crucial component of the immune system. This finding could lead to more effective cancer treatments and new approaches for managing autoimmune conditions.
Researchers at Johns Hopkins Medicine have developed a method using magnetic nanoparticles to train and rapidly multiply immune system white blood cells. The technique, which separates naive T cells from other cells in the blood, has shown promise in expanding these cells' numbers by an estimated 5,000 to 10,000 times.
Ludwig Cancer Research and the Cancer Research Institute launched clinical trials to evaluate immunotherapeutic strategies for brain cancer and various solid tumors. The trials will test MedImmune's checkpoint blockade antibody durvalumab in patients with glioblastoma multiforme, a deadly form of adult brain cancer.
A special issue of Immunotherapy explores emerging concepts in adoptive cell immunotherapy (ACT) to extend its effects to a wider range of solid and hematological cancers. The journal reviews new strategies to address challenges and potentially improve treatment options for more cancer types.
Researchers found that combining immunotherapy drugs nivolumab and ipilimumab significantly increases progression-free survival in advanced melanoma patients, with a median PFS of 11.5 months compared to 6.9 months for nivolumab alone.
Immunotherapy with pembrolizumab was effective in 24.8% of patients with recurrent or metastatic head and neck cancer, resulting in significant tumor shrinkage and improved outcomes.
A new study from UTMB reveals that a single dose of immunotherapy reverses memory problems in an animal model of Alzheimer's disease. The therapy targets toxic tau oligomers, which are also linked to amyloid beta levels.
Hay fever sufferers can benefit from state-of-the-science treatments like sublingual immunotherapy. The American Academy of Otolaryngology recommends this treatment for patients with specific allergies who don't respond to other treatments, with a completion period of up to five years. Other key recommendations include diagnosing and t...
Krishnaraj Rajalingam, a leading molecular cell biologist, has been awarded the Gutenberg Research College fellowship to establish a research team at Mainz University. His research focuses on understanding cellular signaling pathways to develop novel therapeutics for major human diseases like cancer.
Researchers at UC Davis found that immunotherapy regimens can be lethal to obese mice due to increased body fat, which affects the immune system's response. The study suggests a link between obesity and toxicity in cancer treatment outcomes.
Researchers found combining immunotherapy with radiotherapy helps the immune system target and destroy cancer cells resistant to initial treatment. This approach improved survival rates and protected mice against disease recurrence.
Researchers found that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cells, increasing the effect of new therapies. The study also showed increased memory cells, allowing the immune system to attack tumors more effectively.
A new vaccine candidate, GP2, has shown a 57% reduction in recurrence rates among high-risk breast cancer patients. The vaccine targets CD8+ cells and was combined with an immune stimulant to enhance its effectiveness.
Researchers at the University of Bristol have made a breakthrough in understanding how cells convert from attacking healthy tissue to protecting against disease. This discovery could lead to the development of a new treatment approach using antigen-specific immunotherapy, which may improve the lives of millions worldwide.
A new triple therapy combining two immunotherapies and targeted radiation has prolonged the survival of mice with glioblastoma brain cancer by up to 67 days. The treatment induces an immune response against tumors, creating long-term immunity.
Researchers found that treating a peanut allergy with oral immunotherapy changes the DNA of immune cells, which could serve as a basis for a simple blood test to monitor long-term effectiveness. The study involved 20 peanut-allergic children and adults who completed two years of immunotherapy.
Dr. Rodriguez's award-winning research identified a potential new therapeutic approach to make T cells resistant to tumor suppression, enhancing anti-tumor activity and overcoming immune suppression. His findings suggest Notch-1 may be an effective new approach for T cell-based immunotherapy.
Research suggests that pregnant women who receive allergy shots may reduce their child's risk of asthma, food allergies, and eczema. Allergy shots, also known as immunotherapy, can modify and prevent disease progression.
A study by Timothy Craig, MD, found that allergy shots decrease anxiety and depression in those allergic to wasp, bee, and ant stings. Allergy shots are the only treatment known to modify disease progression, making them life-saving for severe allergy sufferers.
Researchers identified seven potential candidate genes as targets for melanoma immunotherapy, including cancer-testis genes and melanoma-related genes. The NCI is currently conducting clinical trials using this technology to treat various cancers.
Researchers developed prognostic biomarkers to determine melanoma patient benefit from new immunotherapy agents. Epigenetic regulators like microRNAs were found to inhibit metastasis and improve chemotherapy response in triple negative breast cancer.
A new two-step immunotherapy approach, combining dendritic cell vaccination and adoptive T-cell therapy, showed a 75% clinical benefit in 31 ovarian cancer patients. The treatment preserved tumor cells alive and used them to manufacture personalized vaccines that taught the immune system to attack the tumor.
Researchers found moderate evidence supporting the use of sublingual immunotherapy to improve asthma symptoms and decrease medication use by over 40% in treated patients. The treatment also showed promise for reducing symptoms of allergic rhinitis and conjunctivitis, with no reported episodes of anaphylaxis or death.
A new study published in The Journal of Allergy & Clinical Immunology shows that immunotherapy using peanut protein drops can desensitize patients to peanuts by up to 10 times. After 44 weeks, 70% of participants increased their safe consumption level from 3.5mg to 496mg.
A new study funded by NIH suggests that sublingual immunotherapy (SLIT) can reduce the allergic response to peanut in adolescents and adults, increasing their tolerance to peanut. The treatment approach involves placing a small amount of allergen under the tongue under medical supervision.
Combining chemotherapy and immunotherapy results in enhanced anti-tumor effect, contrary to previous assumption that they would cancel each other out. The mechanism involves the upregulation of mannose-6-phosphate receptor on tumor cells, which is triggered by autophagy.
Researchers found that administering immunotherapy for three years can achieve long-term control of allergic asthma and reduce symptoms. After three years, 50 percent of children with dust mite-induced asthma experienced remission, needing reduced or no controller medications.
A multi-center study of 55 children found that oral immunotherapy reduced allergic reactions, allowing most to consume eggs without symptoms. The therapy showed promise in desensitizing children to egg allergies, representing a promising therapeutic intervention.
A study published in Archives of Neurology found that early-initiated immunotherapy is associated with improved seizure outcomes among patients with autoimmune epilepsy. In a cohort of 32 patients, 81% reported improvement after immunotherapy and 44% were seizure-free within 12 weeks.
A study published in NEJM describes a rare case of the abscopal effect in a melanoma patient, where combining targeted radiation therapy with immunotherapy led to a strong immune response and favorable clinical outcome. The patient's pre-existing immunity to NY-ESO-1 antigen played a crucial role in the enhanced tumor regression.
A new study found that combination immunotherapy nearly doubles five-year survival among patients with advanced Sezary Syndrome, a rare leukemic form of cutaneous T-cell lymphoma. The therapy approach comprised extracorporeal photopheresis and systemic immunostimulatory agents.
A new Cochrane Systematic Review finds sublingual immunotherapy significantly reduces symptoms of allergic rhinitis and medication requirements. The treatment has very few serious adverse effects and is effective in children, offering a convenient alternative to injection immunotherapy.
Researchers propose new clinical trial endpoints for immunotherapies, accounting for delayed responses and novel patterns of anti-tumor activity. The immune-related response criteria (irRC) offer a revised approach to measuring treatment success, considering factors such as lymphocyte infiltration and tumor burden.
Researchers have identified three protein fragments in gluten that trigger an immune response in people with coeliac disease, leading to small intestine damage. This discovery could pave the way for a new generation of diagnostic tools, treatments, and prevention strategies.
A preclinical study suggests combining targeted therapy against the BRAF/MAPK pathway with immunotherapy may improve durability of responses in treating melanoma. Researchers found that inhibiting the MAPK pathway resulted in increased antigen expression, leading to improved recognition by T-cells.
Researchers at Yale University found that carbon nanotubes cause T cell antigens to cluster in high concentrations, stimulating the body's natural immune response. This breakthrough could improve current adoptive immunotherapy for cancer treatment by increasing T cell proliferation.
The study demonstrates a potential new treatment paradigm in oncology with improved overall survival rates for metastatic castration-resistant prostate cancer patients. The treatment, Sipuleucel-T, was shown to have well-balanced prognostic factors and mild adverse events.
A new study suggests that stimulating human lung cancer cells with TLR7 or TLR8 agonists can lead to increased tumor cell survival and resistance to chemotherapy. This approach is being investigated as an adjuvant for anticancer immunotherapies, but caution should be exercised due to these potential risks.
Researchers at Johns Hopkins Children's Center report encouraging results in children with egg allergies who consume increasingly higher doses of egg protein. The study found that more than half of the children could tolerate 5 grams of eggs without an allergic reaction, experiencing mild to moderate symptoms.
The Phase 3 IMPACT trial found that sipuleucel-T significantly prolonged overall survival by 4.1 months and improved three-year survival by 38 percent compared to placebo. This innovative immunotherapy reduced the risk of death by 22.5 percent.
Researchers found that gradually increasing doses of milk protein over time can help children with severe and persistent milk allergy tolerate the allergen, reducing symptoms and building tolerance. The study suggests oral immunotherapy may be a promising treatment option for food allergies.
Researchers at the University of Montreal and Argos Therapeutics have developed a novel method to create personalized immunotherapy treatments for HIV. The treatment uses dendritic cell-based therapies that stimulate the expansion of HIV-specific T cells, which attack and kill infected cells.
Researchers found that standard flu vaccine boosted immune function in patients with recurrent or metastatic Ewing's sarcoma and alveolar rhabdomyosarcoma, leading to higher five-year overall survival rates. The study suggests immunotherapy could be beneficial for high-risk pediatric sarcomas.
Researchers have developed a new immunotherapy technique called OPAL therapy that stimulates immunity and controls virus levels in HIV-infected individuals. The treatment involves reinfusing fresh blood cells with overlapping peptides, showing promise in preventing AIDS progression.
A six-week experimental allergy treatment has relieved hay fever symptoms for at least two years in a clinical trial. The novel DNA-based drug AIC blocks the seasonal rise in ragweed-specific IgE and reduces IL-4, hinting at successful immune system reprogramming.
A study found that children who received venom immunotherapy for moderate to severe allergic reactions had a lower risk of future reactions, including those with no prior treatment. The therapy was shown to last for up to three and a half years, making it an effective long-term solution for managing bee sting allergies.
Researchers found that children who received venom allergy shots had significantly fewer life-threatening reactions when restung, even years later. Dr. Rebecca Gruchalla recommends the shots for kids with severe allergic reactions to insect stings, which are responsible for at least 40 fatal stings per year.
A randomized clinical trial showed that adjuvant chemotherapy and immunotherapy for colon cancer patients offer no disease-free or overall survival benefits after 10 years. The improvements in 5-year survival rates observed in the past have disappeared over time, suggesting that newer chemotherapy regimens may be more effective.
IVIg is the preferred treatment for Guillain-Barré Syndrome due to its ease of use and lower complication rate compared to plasma exchange. Early treatment within two weeks of symptom onset improves chances for a better outcome.
Researchers investigating a potential new treatment for type 1 diabetes found severe allergic reactions in mice, raising concerns about its safety. The study's findings contrast with earlier mouse studies suggesting the treatment could reduce incidence of diabetes, and highlight the need for cautious evaluation of immunotherapy research.
Researchers at the University of Melbourne have developed a potential allergy vaccine using a modified rye grass protein that reduces allergenic response while boosting immune system. The vaccine, delivered in its pure form, may significantly reduce risk of anaphylactic shock and increase immunotherapy efficacy.