Articles tagged with Rheumatology
Researchers at Hospital for Special Surgery identified SPP1ʰmacrophages that promote excessive joint tissue expansion in rheumatoid arthritis. These cells work with structural cells and protein scaffolds to drive abnormal growth, suggesting a coordinated interaction between immune cells, structural cells, and the extracellular matrix.
Scientists discover autoimmune vicious cycle in Sjögren's disease, where CD4+ T cells recognize Ro60 protein and sustain antibody production. This process forms a self-reinforcing loop, contributing to chronic disease, and could lead to targeted therapies with fewer side effects.
A new review highlights advances in preventing bone loss in people with rheumatoid arthritis, showing that modern antirheumatic therapies can significantly reduce both localized erosions and generalized bone loss. Emerging imaging technologies like HR-pQCT have been found to detect subtle bone erosions earlier and more sensitively.
A new review highlights that vitamin D deficiency is common and clinically important in patients with inflammatory rheumatic diseases, but the current evidence does not support a direct disease-modifying effect. Vitamin D supplementation shows modest benefits in some patients, particularly those with low baseline vitamin D levels.
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.
A multidisciplinary patient organisation provides accessible, person-centred support through professional counselling, offering a non-clinical setting to discuss everyday challenges and work-related issues. The service also offers unique insights into unmet needs, such as medication shortages and administrative barriers.
New AI algorithms demonstrate improved accuracy in evaluating radiographic data and assessing joint inflammation. These innovations include the RADAR algorithm, ADMIRA, and thermography-based systems, offering promising alternatives to traditional imaging methods.
A new approach to managing fatigue in inflammatory arthritis combines physical activity and cognitive behavioral techniques. Digital patient education is shown to be cost-effective and efficient in improving patient outcomes. Caregiver-focused interventions are also crucial in supporting daily functioning and disease management.
Researchers present findings on a novel therapeutic strategy for PsA, using synovial biopsy-driven treatment with biologics targeting IL-17/23 axis. A separate study evaluates the effectiveness of personalized dietary interventions in improving clinical outcomes.
The updated ASAS-SPARTAN revised classification criteria for axSpA prioritize MRI of the sacroiliac joints and incorporate a focused set of clinical variables. The new recommendations also emphasize the role of imaging in diagnosing and managing both axial and peripheral SpA.
A new study presented at EULAR 2026 highlights the importance of structured cardiac evaluation in systemic sclerosis, particularly for patients with multi-system disease. The research also identified PDE4B as a promising therapeutic target across various tissues and cell subsets, offering potential benefits for patients with early dise...
A population-based cohort study found that IIM subtypes differ in incidence, particularly by sex and ethnicity. Automated quantitative nailfold videocapillaroscopy (NVC) model shows superior discriminative capacity for predicting disease activity compared to traditional serum biomarkers.
Researchers have developed operational definitions of srSLE based on disease activity and treatment exposure, showing strong predictive performance. A novel autoantibody signature has also been identified to predict atherosclerosis progression in juvenile-onset systemic lupus erythematosus
Comorbidities such as cardiovascular disease, cognitive impairment, and osteoporotic fractures are common in RMD patients. Systemic autoimmune diseases increase the risk of cardiac arrhythmias and mortality. PPI use is linked to a higher risk of major osteoporotic fractures, while JAKi therapy may pose a risk of venous thromboembolism.
The study evaluated digital platforms and AI chatbots for improving health literacy in patients with RMDs. The results showed high usability, perceived usefulness, and trust among participants, suggesting a promising approach to patient education.
A new study suggests that adding low-dose glucocorticoids to maintenance treatment for ANCA-associated vasculitis (AAV) does not reduce the risk of major flares, but is associated with an increased risk of chronic damage and hospitalization. In contrast, rituximab use was linked to a lower risk of major flares.
A new study using the EUSTAR database found that patients with active disease at baseline had higher cumulative incidence rates of organ and multi-system involvement. Early disease activity monitoring is crucial for identifying patients at risk, guiding treatment decisions, and improving patient outcomes.
Researchers present results from Phase 1 trials of CAR-T cell therapies in patients with refractory rheumatoid arthritis and systemic sclerosis, showing improved disease activity and clinical remission. The findings suggest an immunological 'reset' strategy may offer true curative potential for these severe diseases.
A study found that patients continuing ULT remained flare-free for longer over 24 months, with a cumulative flare incidence of 12.3% compared to 31.8% in the ULT discontinuation attempt group. Effective weight management and exercise are key to managing gout and rheumatoid arthritis.
Research studies reveal suboptimal adherence to treat-to-target strategies in rheumatoid arthritis, with lower rates among spondyloarthritis patients. Additionally, data from registries show the potential benefits of glucagon-like peptide-1 receptor agonists for weight loss and disease activity management in RMD.
Researchers have discovered a previously underappreciated mechanism that helps immune cells respond rapidly to infections by altering RNA splicing. This study provides new insights into immune-mediated diseases such as rheumatoid arthritis and lupus, and may lead to more targeted therapies.
The Capture the Fracture program has achieved a major milestone, identifying over one million patients with fragility fractures every year. This growth reflects increasing recognition of coordinated post-fracture care services as an essential component of modern hospital care.
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
Professor Radmila Matijevic received the IOF CNS Medal for her outstanding work in advancing bone health awareness, diagnosis, and management. Her contributions to osteoporosis research and clinical practice have improved patient care in Serbia and the wider Balkan region.
Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.
The International Osteoporosis Foundation has awarded Professor Roland Chapurlat the prestigious IOF Olof Johnell Science Award for his seminal contributions to understanding and managing osteoporosis, osteoarthritis, and skeletal rare bone diseases. He is recognized as one of the leading clinical academics in the field worldwide.
Professor Thierry Chevalley has received the prestigious IOF President's Award for his significant contributions to advancing bone health and osteoporosis prevention. With extensive research expertise in geriatrics and bone health, he serves on various scientific committees and leads efforts to develop fracture liaison services.
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
Researchers have shown that PEPITEM supplementation can prevent or delay inflammatory arthritis by regulating the immune system. The study found that PEPITEM reduced arthritic joint swelling and inflammatory changes comparable to current standard care.
The EULAR recommends a multidisciplinary approach to managing Behçet's syndrome, aiming to prevent irreversible organ damage and maximize quality of life. The updated guidelines prioritize monoclonal TNFi for patients with eye, vascular, or nervous system involvement, promoting earlier recognition and more consistent care.
A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.
The 2025 update provides 5 overarching principles and 9 individual recommendations for managing rheumatoid arthritis, emphasizing patient-centered care and simplifying clinical approaches. The update prioritizes treatment targets, monitoring frequency, and the role of methotrexate, glucocorticoids, biologics, and JAK inhibitors.
A new review highlights the need for planned sequential bone therapy to reduce the risk of spontaneous vertebral fractures after denosumab therapy. Denosumab discontinuation can trigger a 'rebound phenomenon' marked by rapid bone turnover, bone loss, and potentially multiple vertebral fractures.
Mesenchymal stromal cell (MSC) therapy has been validated as a transformative solution for rheumatoid arthritis through preclinical and clinical evidence. MSCs target RA via immunomodulation, tissue repair, low immunogenicity, and targeted migration, resulting in sustained benefits with minimal side effects.
The European Alliance of Associations for Rheumatology (EULAR) has introduced three overarching principles and 11 points to consider for assessing disease activity in AOSD. The guidelines emphasize the importance of adopting a valid, reliable, and easily transferable definition of disease activity, which includes fever, skin rash, arth...
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
A recent study found that TikTok videos about gout are often misleading, inconsistent, or inaccurate. Gout is a painful inflammatory arthritis caused by high urate in the blood, and there are persistent gaps in awareness among patients and the public.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
The European Alliance of Associations for Rheumatology has developed a new disease activity score (EAPSDAS) to assess clinical manifestations in antiphospholipid syndrome (APS). The score evaluates thrombotic, obstetric, microvascular, and non-thrombotic symptoms, providing insights into disease activity and treatment response.
A new review provides simplified criteria for defining gout remission and proposes integrated management strategies for sustained disease control. The authors highlight the importance of individualized urate-lowering therapy and proactive flare prevention, using imaging to show patients visual proof of crystal dissolution.
Researchers developed a points-based classification model using eight variables to assess joint pain, genetic mutations, and iron loading. The criteria show promise in diagnosing haemochromatosis arthropathy with high specificity and sensitivity, paving the way for new treatment options.
The European Alliance of Associations for Rheumatology (EULAR) is hosting the EULAR 2026 Congress in London, featuring a scientific program with new clinical data and updated treatment guidelines. The congress will also provide exclusive media opportunities, including a press conference and one-on-one interviews with expert panelists.
EULAR has established new points to consider and consensus definitions for managing difficult-to-treat psoriatic arthritis, aiming to improve treatment options and care for patients. The guidelines focus on identifying the biology behind treatment non-response and promote personalized treatment approaches.
The new guidelines focus on the role of kidney biopsy, combination immunosuppressive treatment, and kidney protective drugs to prevent chronic kidney disease progression. They also address specific guidance for patients with renal response versus those with persistently active or relapsing disease.
The EWRR Congress will become an integral part of EULAR's meeting portfolio from 2027 onwards. The event aims to attract young scientists and provide opportunities for networking and collaboration.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
The new guidelines provide evidence-based recommendations for patient management, identifying high-risk individuals and enhancing outcomes. The guidelines address specific ILD management algorithms for underlying rheumatic diseases, supporting comprehensive care for patients with CTD-ILD.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Researchers explore the biological mechanisms of myopenia in RA, finding it affects individuals of all ages, with notable muscle mass loss without concurrent fat loss. The review highlights the diagnostic and therapeutic relevance of myopenia in RA, emphasizing the importance of early detection and tailored management strategies.
The European Alliance of Associations for Rheumatology (EULAR) journal Annals of the Rheumatic Diseases (ARD) has achieved a notable increase in its impact factor to 20.6, surpassing 58 other titles in rheumatology and reaffirming its status as the leading journal for original research in both basic and clinical fields. This recognitio...
A comprehensive review highlights the impact of anti-cancer treatments on bone health, increasing the risk of fractures and bone fragility. The International Osteoporosis Foundation advocates for a multidisciplinary approach to early screening and proactive bone-protective strategies.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
The recombinant zoster vaccine was found to be well-tolerated in patients with inflammatory rheumatic musculoskeletal diseases, with only a few reports of flare and serious AEs. The majority of patients tolerated the vaccine without significant adverse events.
Recent studies suggest that early biologics in severe psoriatic arthritis may not significantly benefit patients compared to standard step-up care with methotrexate. However, a study found that intensive therapy with early biologics or combination csDMARDs can rapidly control disease activity and maintain better outcomes at 1 year.
The IOF Advanced Course on Osteoporosis is a comprehensive, 18-hour online training programme designed to equip healthcare professionals with the latest knowledge in osteoporosis prevention, diagnosis, and management. The course aims to promote timely diagnosis and treatment, reduce patient burden, and improve global outcomes.
Dr. Elizabeth M. Curtis has been awarded the ESCEO-IOF Pierre Meunier Young Scientist Award for her groundbreaking research on musculoskeletal health and bone disease. Her work focuses on the epidemiology of bone, muscle health, and joint health across the lifespan.
Twelve young researchers from around the world receive ESCEO-IOF Young Investigator Awards for their groundbreaking studies on osteoporosis. The prestigious awards were presented during the World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO 2025) in Rome, Italy.
AMMOM has been recognized by the IOF for its significant contributions to osteoporosis awareness and bone health in Mexico. The organization has collaborated extensively with the IOF on various initiatives, including joint scientific meetings and advocacy efforts.
Professor Atsushi Suzuki, Chair of Endocrinology at Fujita Health University School of Medicine, Japan, received the IOF President's Award for his exceptional contributions to IOF. He has shared his expertise as a mentor and engaged member of the Capture the Fracture Governance.