Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
SourceDartmouth Health·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMay 15, 2023
Researchers identified compounds in Labrador tea leaves that have antimalarial properties, particularly ascaridole, which has activity against drug-resistant Plasmodium falciparum parasites. The study highlights the importance of investigating and protecting plants used in traditional medicines.
SourceAmerican Chemical Society·JournalACS Omega·DateMay 11, 2023
A new study has identified a second key gene, AAT1, involved in malaria's resistance to the drug chloroquine. The finding, published in Nature Microbiology, has implications for the ongoing battle against malaria.
SourceTexas Biomedical Research Institute·JournalNature Microbiology·DateMay 11, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Research from Boston Medical Center found that pulmonary tuberculosis enhances HIV antibody responses and increases the prevalence of antibody-resistant strains. This study has significant implications for HIV vaccines and antibody-based therapies, highlighting the need for novel strategies to generate broad and potent antibodies.
SourceBoston Medical Center·JournaliScience·DateMay 9, 2023
A study published in The Lancet Regional Health - Western Pacific found that carbapenem-resistant Acinetobacter baumannii (CRAB) contaminated the entire ICU, with samples detected on bed units, ventilators, and equipment. The researchers highlight the urgent need for targeted infection prevention and control measures to stem the global...
SourceUniversity of Birmingham·JournalThe Lancet Regional Health - Western Pacific·TypeObservational study·DateMay 9, 2023
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
SourceTokyo University of Science·JournalNeuropharmacology·TypeExperimental study·DateMay 8, 2023
A new study has provided insight into the mysterious evolution of DNA rings in tumors, revealing that nearly one-third of all tumors have these genetic structures. The researchers used a technology to trace the path of DNA ring development in neuroblastoma cells, finding that large rings contain cancer genes spurring cell growth.
SourceCharité - Universitätsmedizin Berlin·JournalNature Genetics·DateMay 4, 2023
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
SourceMass General Brigham·JournalJournal of the American Medical Association·TypeCase study·DateMay 1, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A research tool developed at the Garvan Institute has uncovered unprecedented detail about pancreatic cancer drug response and resistance. The molecule AKT, a key driver of cancer growth and spread, is activated in distinct parts of the tumour, including areas of low oxygen supply where it forms pockets of resistance to therapy.
SourceGarvan Institute of Medical Research·JournalScience Advances·TypeExperimental study·DateApr 30, 2023
Scientists have found a rare yeast pathogen, Lodderomyces elongisporus, causing neonatal outbreaks in India despite strong disinfectant bleach. The fungus is rapidly evolving and has been linked to hospital equipment and apples treated with fungicides.
SourceMcMaster University·JournalmBio·TypeObservational study·DateApr 27, 2023
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalBlood Cancer Discovery·DateApr 17, 2023
A new target for drug-resistant ovarian cancer has been identified through a preclinical study led by researchers at Penn Medicine. An antibody-drug conjugate targeting B7-H4 showed significant anti-tumor activity and sustained response in treatment-resistant models.
SourceUniversity of Pennsylvania School of Medicine·DateApr 16, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The new CALANGO software helps untangle genetic factors associated with shared characteristics, such as antibacterial resistance and agricultural improvements. It enables scientists to explore vast amounts of genomic data across thousands of organisms.
SourceAston University·JournalPatterns·TypeData/statistical analysis·DateApr 14, 2023
Researchers at the University of Stirling found that microplastics can transport harmful bacteria from wastewater to beaches in Scotland. The study suggests that these bacteria can survive for up to 7 days on beach sand and show resistance to common antibiotics.
Researchers discover loss of neurofibromin 1 (NF1) gene leads to resistance to alpelisib, a common treatment for advanced breast cancer. Dietary supplement N-acetylcysteine restores sensitivity to this treatment, offering new hope for improving treatment outcomes.
SourceUniversity of Basel·JournalCell Reports Medicine·DateApr 11, 2023
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
SourceCity University of Hong Kong·JournalNature Synthesis·TypeExperimental study·DateApr 6, 2023
Researchers at Universitatsklinikum Bonn used CRISPR gene scissors to identify NAE1 as a driver of cisplatin resistance in testicular cancer. Inhibiting this protein with MLN4924 restores cisplatin's effectiveness and has an additional killing effect on tumor cells, offering new treatment options.
SourceUniversitatsklinikum Bonn·JournalBritish Journal of Cancer·DateApr 6, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
WVU engineers developed a new electrode cuff called MouseFlex to test electric current treatments, overcoming previous challenges with stability and durability. The device can withstand high electrical stimulation and may benefit patients with conditions like rheumatoid arthritis and drug-resistant epilepsy.
SourceWest Virginia University·JournalActa Biomaterialia·DateApr 3, 2023
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalJournal of Medicinal Chemistry·DateMar 30, 2023
Researchers studied how tumors adapt to Sotorasib and found that gene amplification and transcriptional programs lead to resistance. This knowledge can help develop targeted treatments for patients with KRAS mutations, potentially increasing survival rates.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalJournal of Clinical Investigation·TypeExperimental study·DateMar 17, 2023
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers found that Matcha tea powder reduces depression in mice by activating dopaminergic neural circuits and improving mood. The study's results suggest that Matcha's antidepressant-like effects depend on the animal's prior mental state, with stress-susceptible mice showing a significant response.
SourceKumamoto University·JournalNutrients·TypeExperimental study·DateMar 15, 2023
A new study published in The Lancet found that an existing drug, sulfadoxine-pyrimethamine, protects pregnant women from sexually transmitted and reproductive tract infections. Researchers tested this drug alongside a promising new treatment, dihydroartemisinin-piperaquine, which showed unique ability to prevent malaria.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalThe Lancet·TypeRandomized controlled/clinical trial·DateMar 14, 2023
A new study by Tufts University researchers has identified a small molecule, Compound 350, that may help treat people with epilepsy whose condition has become resistant to traditional anti-seizure drugs. The compound was found to reduce seizure activity in rodents with drug-resistant seizures and lower brain cell death.
SourceTufts University·JournalCell Reports Medicine·DateMar 14, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A remote hypertension program, operated by Mass General Brigham, successfully supported patients through the COVID-19 pandemic in achieving their blood pressure goals. Participants who enrolled during the pandemic reached and maintained their goal blood pressures an average of two months earlier than in the pre-pandemic period.
SourceMass General Brigham·JournalJournal of the American Heart Association·TypeObservational study·DateMar 13, 2023
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
SourceImpact Journals LLC·JournalOncotarget·TypeLiterature review·DateMar 13, 2023
Researchers developed synthetic peptide nanonets that selectively entrap bacteria, rendering them vulnerable to antimicrobial components. The nanonets displayed both trapping and killing functionalities, demonstrating potential as an anti-infective strategy.
SourceNational University of Singapore·JournalAdvanced Functional Materials·TypeExperimental study·DateMar 2, 2023
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Scientists at St. Jude Children's Research Hospital demonstrate a framework to develop solutions to evade detoxification networks in drug development, potentially reducing side effects. By altering the structure of a small molecule, they found a way to stretch out binding regions, making it energetically unfavorable for drugs to bind a...
SourceSt. Jude Children's Research Hospital·JournalProceedings of the National Academy of Sciences·DateFeb 28, 2023
Researchers created a statistical model to predict who is resistant to COVID-19, using health characteristics from electronic records. The model identified patterns in patients with similar features, suggesting that genetic and environmental differences influence their defense against the virus.
SourceJohns Hopkins Medicine·JournalPLOS ONE·DateFeb 22, 2023
Researchers at the University of Texas M. D. Anderson Cancer Center have identified CD70 as a novel therapeutic target for eliminating drug-resistant cancer cells in EGFR-mutant non-small cell lung cancer. CD70 targeting strategies showed significant anti-tumor activity, eliminating resistant cells in laboratory models.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalCancer Cell·DateFeb 13, 2023
The NCI is funding a $587,000 research grant to improve KRAS treatment resistance in pancreatic cancer. Dr. Andrew Waters aims to develop personalized medicine approaches by studying unique resistance mechanisms.
A new study predicts global antimicrobial use in food-producing animals will increase by 8% by 2030 if stronger regulations are not implemented worldwide. The findings highlight the need for stricter controls on antimicrobial use, which has raised concerns over antimicrobial resistance.
SourcePLOS·JournalPLOS Global Public Health·DateFeb 1, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new microbiome therapeutic, SER-109, has been shown to improve the quality of life of patients with Clostridium difficile (C. diff) infections by reducing symptoms and restoring colonization resistance. The treatment was found to be associated with significant improvements in health-related quality of life scores as early as Week 1.
SourceUniversity of Houston·JournalJAMA Network Open·DateJan 31, 2023
A new study finds that warmer temperatures cause a pathogenic fungus to experience adaptive responses, leading to increased disease-causing potential. The research, led by Asiya Gusa at Duke University, suggests that rising global temperatures may contribute to the evolution of more virulent fungal pathogens.
SourceDuke University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 30, 2023
A research team from HKUMed identified chronic Type I Interferon signalling as a driver of CD8+ T cell exhaustion and therapy resistance. The study highlights the harmful effect of IFN-I on tumour-killing CD8+ T cells, providing new insights into immunotherapy improvement.
SourceThe University of Hong Kong·JournalCell Reports Medicine·TypeExperimental study·DateJan 29, 2023
Researchers have designed a treatment that uses a modified bacterium to target and dissolve biofilms caused by Pseudomonas aeruginosa, a leading cause of hospital mortality. The treatment has shown significant efficacy in mice, reducing lung infections and doubling survival rates.
SourceCenter for Genomic Regulation·JournalNature Biotechnology·TypeExperimental study·DateJan 19, 2023
Researchers at Mass General Hospital identified a gene target, TANK-binding kinase 1 (TBK1), that enhances the effectiveness of cancer immunotherapy. Silencing TBK1 sensitizes tumor cells to immune attack, overcoming resistance to treatment.
SourceMassachusetts General Hospital·JournalNature·TypeExperimental study·DateJan 12, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Scientists have found a way to break down the resistance of mice with neuroendocrine pancreatic cancer to checkpoint blockade immunotherapy. A new drug combination, PD1-IL2v and anti-PD-L1, enhances anti-tumor immunity by stimulating specific T cells and reprogramming macrophages, leading to increased survival rates in tumor-bearing mice.
SourceEcole Polytechnique Fédérale de Lausanne·JournalImmunity·DateJan 10, 2023
MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state. The protective molecules, known as glycans, prevent Vibrio cholerae from producing the toxin that usually leads to severe diarrhea.
SourceMassachusetts Institute of Technology·JournalThe EMBO Journal·DateDec 12, 2022
Researchers at Lund University discovered an antibody with potential to protect against Strep A infection and a rare form of binding that leads to effective immune response. The finding could explain why many Group A strep vaccines have failed.
SourceLund University·JournalEMBO Molecular Medicine·DateDec 12, 2022
Scientists at the University of York have identified an enzyme that makes Leishmania infantum parasite resistant to miltefosine, a medication used to treat visceral leishmaniasis in Brazil. The discovery opens up potential for developing a blood test to predict patient outcome and tailor treatment to individual patients.
SourceUniversity of York·JournalEBioMedicine·DateDec 1, 2022
A study by North Carolina State University found that two common veterinary drugs, Fluralaner and Ivermectin, are effective in killing bed bugs on poultry farms. Fluralaner was highly effective against bed bugs with resistance to common insecticides.
SourceNorth Carolina State University·JournalParasites & Vectors·TypeExperimental study·DateNov 29, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Neuroblastoma tumour cells adapt to mimic embryonic cells, making them resistant to chemotherapy. This understanding can lead to targeted treatments that better reach the entire tumour and avoid resistance development.
SourceLund University·JournalScience Advances·DateNov 11, 2022
Researchers at CNIO have identified epigenetic changes, specifically DNA methylation, as a key mechanism behind resistance to proteasome inhibitor drugs in multiple myeloma. This finding suggests that methylation levels in the PSMD5 gene can predict treatment response and potentially reverse resistance.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalClinical Cancer Research·TypeExperimental study·DateNov 7, 2022
A study by CeMM researchers and the University of Dundee identifies mutations in E3 ligases that mediate resistances in cell cultures, but also finds that these mutations can be targeted by chemically modified degraders. This understanding has clinical relevance and enables further improvement of cancer therapy drugs.
SourceCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences·JournalNature Chemical Biology·DateNov 3, 2022
A study reveals that interleukin 34 (IL-34) modulates the balance between two myeloid-derived suppressor cell populations, leading to immunosuppression and chemoresistance in triple-negative breast cancer. Neutralizing IL-34 with a drug reduces tumor growth and susceptibility to chemotherapy.
SourceHokkaido University·JournalCancer Immunology Immunotherapy·TypeExperimental study·DateNov 1, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
SourceUniversité de Genève·JournalCancers·TypeNews article·DateOct 27, 2022
Researchers found that sapanisertib can kill the malaria parasite at several stages during its life cycle, including in the liver and red blood cells. The study's findings offer new hope against a disease that kills over half a million people annually.
SourcePenn State·JournalScience Translational Medicine·TypeExperimental study·DateOct 26, 2022
A new anti-virus has been discovered in a medical lecture. The lectin, known as H84T-BanLec, is highly effective against many different types of coronaviruses, including those causing COVID-19 and MERS-CoV. Its unique mechanism makes it difficult for viruses to develop resistance, making it a potential 'pan-coronavirus' antiviral drug ...
SourceThe University of Hong Kong·JournalCell Reports Medicine·TypeExperimental study·DateOct 25, 2022
Researchers suggest new criteria for diagnosing sarcopenia, a syndrome characterized by loss of muscle mass and force, with lower cutoff points leading to improved prediction of mortality risk. The study found that raising handgrip strength thresholds can detect the onset of sarcopenia earlier and more accurately.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalAge and Ageing·DateOct 20, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
SourceGoethe University Frankfurt·JournalMicrobiology Spectrum·TypeExperimental study·DateOct 19, 2022
A team of researchers at Baylor College of Medicine has investigated how breast cancer cells lose their ER expression, revealing a mechanism that explains the process and offers possibilities to overcome it. The study found that over-expressing 14-3-3τ in cancer cells leads to ER loss, with other molecular players such as AKT and GATA3...
SourceBaylor College of Medicine·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 17, 2022
A study reveals that BA.2.75.2, a new Omicron sublineage, largely evades neutralizing antibodies and is resistant to several monoclonal antibody treatments, posing an increased risk of SARS-CoV-2 infections this winter.
SourceKarolinska Institutet·JournalThe Lancet Infectious Diseases·TypeExperimental study·DateOct 14, 2022
A new study identified a remdesivir-resistant version of COVID-19 in two kidney transplant patients treated with immunosuppressive drugs. The virus developed the V7921 gene mutation, which allows it to resist antiviral therapy, highlighting the need for continued monitoring and potential development of additional treatments.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalClinical Infectious Diseases·TypeCase study·DateSep 26, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers replicate aggressive lymphoma to identify gene responsible for drug resistance, offering new targets and causes of resistance. The CRISPR activation technology enables the replication of complex diseases on an unmatched level.
SourceWalter and Eliza Hall Institute·JournalNature Communications·TypeExperimental study·DateSep 25, 2022
Mayo Clinic researchers identified critical genomic changes associated with abiraterone acetate/prednisone resistance in advanced prostate cancer. An 11-gene drug panel predicted a worse prognosis for a subset of patients, and whole-exome sequencing data revealed mechanisms of acquired resistance.
SourceMayo Clinic·JournalMolecular Cancer Research·DateSep 22, 2022
Researchers found that ruxolitinib, a clinically approved drug, suppresses ICB-resistant melanomas by reprogramming TILs and relying on host TNF signaling. This discovery offers a potential target for bypassing therapeutic resistance in advanced melanoma patients.
SourceUniversity of Alabama at Birmingham·JournalNature Communications·TypeExperimental study·DateSep 16, 2022
Researchers have engineered an enzyme that can degrade the capsule of antibiotic-resistant B. anthracis bacteria, making it susceptible to the immune system. The new treatment, which combines the enzyme with a mouse antibody, shows promise in treating anthrax infections without antibiotics.
SourceAmerican Chemical Society·JournalACS Infectious Diseases·DateSep 14, 2022
A study found that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells. Inhibition of EGFR by lapatinib therapy in combination with lenvatinib enhanced growth inhibitory effect and inhibited tumor growth more remarkably than monotherapy.
SourceShinshu University·JournalCancer Science·TypeExperimental study·DateSep 13, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A recent study finds that fungal infections during the pandemic are a significant public health problem with limited treatment options. The interaction between pathogen and host may be different in people with compromised immunity, leading to increased mortality rates among severe COVID-19 patients.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNature Microbiology·DateSep 9, 2022
Researchers developed a novel, single-dose, intranasal treatment that reduces symptoms and viral shedding of multiple SARS-CoV-2 variants. The therapeutic interfering particle (TIP) treatment effectively blocks COVID-19 transmission in animal models.
SourceGladstone Institutes·JournalProceedings of the National Academy of Sciences·DateSep 9, 2022