Articles tagged with Cell Death
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Researchers summarize itaconate biology highlighting its chemical reactivity and therapeutic potential in treating infectious diseases, sepsis, autoimmunity, neurodegenerative disorders. Itaconate exerts biological effects through post-translational modifications, altering protein activity and signaling pathways
Researchers at Helmholtz Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis. A single mutation in the GPX4 gene disrupts its function, leading to severe neurodegeneration in children with early-onset dementia.
Australian researchers have discovered a drug combination that can bypass the cellular defenses developed by neuroblastoma tumors, making it more effective against relapsed cases. The combination reduces tumor growth and extends survival time compared to standard treatment alone.
Researchers at the University of Tokyo have developed a new microscope that can detect signals over an intensity range 14 times wider than conventional microscopes, enabling label-free observations of cells and particles.
Researchers at Hebrew University of Jerusalem unlock natural pathway to immortalize cow cells, overcoming major barrier to affordable cultivated beef. The study reveals bovine cells can spontaneously renew themselves indefinitely without genetic modification.
A team of researchers from Aarhus University has discovered a protein called VCAM1 that can predict whether kidney cells will survive or die after acute injury. The finding could lead to the development of targeted treatments and benefit millions of patients worldwide.
Researchers explore ZBP1-mediated programmed cell death, its mechanisms, and therapeutic strategies for systemic diseases. The review also discusses ZBP1's involvement in various types of cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis.
Scientists discovered that the APOE4 gene blocks brain cells from using alternative energy sources as we age, significantly increasing Alzheimer's risk. This knowledge could pave the way for new treatments by targeting lipid metabolism.
Researchers identified Phaedra1 as a gene essential for stress-induced cell death in Drosophila melanogaster. The mTOR-Zeste-Phae1 pathway controls lethal stress-dependent individual death. Suppressing this pathway increases survival rates after exposure to lethal stress.
Researchers discovered PRMT5 regulates ACSL4 methylation, which promotes ferroptosis in renal cell carcinoma. Inhibiting PRMT5 increases ferroptosis and enhances immunotherapeutic treatment efficacy.
A team of researchers from the University of Ottawa has developed a new workflow to study autophagy, a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out components. The study reveals novel signaling mechanisms regulating autophagy in response to numerous disease-related stress conditions.
A team of scientists has developed a protein-based therapeutic tool called Crunch to target and remove specific living cells, such as cancer cells or overactive immune cells. The new system uses the body's natural waste removal system to clear out unwanted cells, offering hope for improved treatments.
Researchers identified a new strategy to repair damaged heart tissue by reactivating the PSAT1 gene through synthetic modified messenger RNA. The study found that mice treated with PSAT1-modRNA showed robust increases in cardiomyocyte proliferation, reduced tissue scarring, and improved heart function.
Researchers discovered a compound, EPS3.9, produced by deep-sea bacteria that triggers pyroptosis to inhibit tumor growth and exhibit potent anti-cancer effects. The study highlights the importance of exploring marine microbial resources for developing new drugs.
This study identifies ANXA2+ migratory hepatocytes as crucial for liver regeneration, highlighting their role in promoting wound closure and treating acute liver failure. The research also explores the therapeutic potential of targeting these cells, offering new avenues for regenerative medicine approaches in hepatology.
Chemotherapy-induced pyroptosis in bladder cancer can actually make the disease more resistant to treatment by fueling cancer stem cells. Blocking this inflammatory process with belnacasan may overcome chemoresistance in preclinical models.
Research on MCL-1 protein reveals its critical role in cell survival and energy production, offering a roadmap for designing targeted cancer therapies with reduced side effects. The findings also shed light on fatal metabolic diseases in infants, providing potential new targets for future treatments.
Some precursor plasma cells in patients with MGUS and SMM enter cellular senescence, a dormant state that prevents cancer progression. In contrast, patients who develop bone marrow cancer lack this protective mechanism. The discovery offers hope for early intervention and potential treatments that promote or inhibit senescence.
A study has discovered a connection between ferroptosis, a type of iron-dependent cell death, and inflammatory bowel disease. Lipid ROS activate ferroptosis, which drives cell death in the colon lining, and inhibiting this process may lead to new treatment options for IBD.
Researchers have discovered a novel cell-clearance pathway linked to diseases such as Chediak-Higashi Syndrome, which affects immune system function. The study used CRISPR/Cas9 gene-editing technology and live imaging to characterize this pathway and identify key genes involved.
Researchers argue that necrosis, a form of uncontrolled cell death, presents an opportunity for intervention in age-related conditions. Interrupting necrosis could lead to new treatments for kidney disease, cardiac disease, neurodegeneration, and aging.
Researchers from Queen Mary University of London and the University of Dundee have discovered how microtubules decide whether to grow or shorten, a fundamental mechanism governing cellular processes. This breakthrough sheds new light on cell division and opens potential avenues for cancer treatment.
A new study suggests that a drug used to prevent alcohol abuse can also interrupt runaway cell death and inflammation triggered by severe trauma, particularly in female mice. The findings may lead to therapies that could shorten hospital stays and improve survival rates if administered promptly after traumatic injuries.
A team of researchers has discovered a small molecule that can selectively block cell death, which could lead to new treatments for neurodegenerative conditions. By targeting the killer protein BAX, the molecule can prevent excessive cell death in neurons, potentially slowing or halting disease progression.
Researchers from Kyushu University found that lipid peroxidation of lysosomes plays a key role in ferroptosis-mediated cell death, leading to iron leakage and membrane permeabilization. Administration of chloroquine promotes ferroptosis even in cancer cells less susceptible to the process.
A study analyzing 17,500 individuals found that immune resilience counters factors of aging and mortality through TCF7 gene regulation, reducing mortality risk by 69% in midlife. This promotes salutogenesis, actively fostering health and well-being.
A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research. The study suggests new avenues for drug development to reduce the risk of developing both diseases by targeting alpha-synuclein.
Researchers found that gasdermin D promotes atrial arrhythmogenesis by facilitating the formation of pores in cell membranes and releasing cytokines. A mitochondrial-targeted therapy approach may prevent AF triggering, positioning gasdermin D as a promising therapeutic target.
Researchers at Doshisha University reveal that 25-hydroxycholesterol causes a specific type of cell death called ferroptosis, which could contribute to various diseases. The study identifies two key mechanisms by which 25-OHC induces ferroptosis, including inhibition of cellular pathways and disruption of antioxidant systems.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
A fungal infection has been shown to trigger a fruit fly's own immune system to destroy brain cells leading to signs of neurodegeneration. The fungus makes the fly's innate immune system release Sarm, which suppresses the immune response and kills brain cells.
Researchers identified two venom genes in parasitoid wasps that degrade adult tissue precursors in host fly larvae, ensuring successful parasitism. The findings provide insights into the molecular mechanisms behind the sophisticated survival strategy of these wasps.
Researchers from Osaka University found that selenoproteins are essential for counteracting lipid peroxides and maintaining hematopoiesis in human cells. The study also showed that dietary Vitamin E can protect hematopoiesis and repair impaired B cell differentiation, providing potential strategies for fighting age-related diseases.
Researchers discovered that cells caught up in sepsis send out messages to other cells, causing them to die and fueling the spiraling inflammation. By understanding this process, scientists may be able to develop a treatment for inflammatory diseases like sepsis.
Regular aerobic exercise has been shown to significantly reduce disease markers associated with Alzheimer's, protecting healthy brain cells and restoring balance in the aging brain. The study highlights the potential for aerobic exercise to serve as a cornerstone in preventive strategies for Alzheimer's.
Researchers discovered that DNA repair determines how cancer cells die following radiotherapy, with specific pathways triggering cell death noticed by the immune system. Blocking these pathways can force cancer cells to die in a manner that alerts the immune system, leading to new potential treatments.
Physical signals from mechanical forces play a crucial role in determining the fate of cells being extruded from tissues. The study reveals that the intensity and duration of these forces determine whether dead or live cells are eliminated, with implications for tissue homeostasis and cancer progression.
Macronucleophagy helps maintain cell viability in nitrogen-starved yeast by modulating micronucleophagy. Uncontrolled micronucleophagy causes cell death, but a critical role for macronucleophagy was found to prevent this.
Researchers at Indian Institute of Science discover that viruses like SARS-CoV-2 mimic host proteins to trigger excessive cell death and tissue damage in humans. In contrast, bats show mild symptoms despite harbouring similar viruses, highlighting species-specific responses to viral infections.
Researchers at the University of Konstanz have discovered that different mutations of the tumour suppressor p53 affect pancreatic carcinomas differently. The study found that two variants of p53 selectively control distinct metabolic pathways, providing new insights into cancer development.
Researchers have deciphered how the beneficial fungus Serendipita indica successfully colonizes plant roots of Arabidopsis thaliana. The fungus secretes enzymes that produce a molecule called deoxyadenosine (dAdo), which activates cell death in plants, enabling colonization without causing significant harm.
A team of researchers has identified a mechanism that interferes with the splicing process in a more subtle way, leading to cell death. The study reveals that spliceosome subunits U4, U5, and U6 are normally stabilized by protein USP39, but when mutated or absent, stability is compromised, causing incorrect connections during splicing.
Researchers at Osaka University uncovered the molecular details of how Drosophila fruit fly cells are removed during development, challenging the common assumption that clustered apoptosis poses a disadvantage to organisms. This study may help determine how abnormal cell death leads to congenital defects in humans.
Researchers at Michigan Medicine found that SLC13A3 transporter impairs tumor immunity by endowing ferroptosis resistance. This discovery suggests a potential target for improving immunotherapy responses in cancer patients.
Researchers decode mechanism by which oxidative stress influences cell death, revealing proteasome's role in ferroptosis. Enzyme DDI2 identified as key player in regulating protein recycling, protecting cells from death.
Researchers at Hokkaido University have identified a key gene, glutathione peroxidase 4 (Gpx4), that enables Syrian hamsters to survive extreme cold by limiting cellular damage. The discovery could lead to new treatments for human health, such as improving organ preservation and using hypothermia as a therapeutic tool.
Researchers found that fever temperatures increase helper T cell metabolism, proliferation and inflammatory activity, while causing mitochondrial stress, DNA damage and cell death in a specific subset of Th1 cells. These findings may explain how chronic inflammation contributes to cancer development and suggest a fundamental way cells ...
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Scientists at Rockefeller University have identified a dual sensor system that detects dying and living cells in hair follicles, clearing debris before tissue damage occurs. This innovative mechanism, involving local epithelial cells rather than phagocytes, may hold insights into human skin pathologies and hair loss.
Researchers at Michigan State University discovered a protein pair, BAP2 and IRE1, that work together to regulate the response to ER stress in plants. This finding has significant implications for breeding crops more resilient to drought and heat conditions.
Researchers developed a lipid nanoparticle formulated miR-193a-3p mimic that enhances T cell mediated immune responses and induces immunogenic cell death in tumors. This study demonstrates the potential of this therapy to prolong animal survival and reduce metastasis, offering new hope for cancer treatment.
A landmark study unveiled new automated diagnostic techniques, including liquid handling robots, to detect necroptosis in patients with ulcerative colitis or Crohn's disease. The findings provide critical insights into how necroptosis contributes to various inflammatory diseases and offer practical methods for treatment.
Scientists at St. Jude Children's Research Hospital discovered that NLRC5 plays a crucial role as an innate immune sensor, triggering PANoptotic cell death. The findings suggest that targeting NLRC5 could lead to therapeutic development for infections, inflammatory diseases, and aging.
A new study by Columbia University researchers identifies ferroptosis as the major cell death mechanism underlying COVID-19 lung disease. This discovery offers hope for improving treatment outcomes and combating life-threatening cases of the disease.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
A team of researchers has discovered the role a specific protein complex plays in certain forms of immune dysregulation. SHARPIN deficiency is linked to autoinflammation and immunodeficiency, but unexpectedly does not manifest dermatological issues. Treatment with anti-TNF therapies resolves symptoms.
A specific protein, TRBP, regulates the balance between apoptosis and interferon response to suppress viral replication. This study sheds light on a previously unclear mechanism of defense against viruses in mammalian cells.
A newly developed compound called UH15-38 has been shown to safely and efficiently block necroptosis, a key receptor in lung cells causing excessive inflammation and lung damage. The study demonstrates that UH15-38 can prevent influenza deaths even when administered late in the course of an infection.
Researchers have discovered that a rare type of lipid, with two polyunsaturated fatty acyl tails, promotes ferroptosis, a form of cell death. This finding could lead to new treatments for neurodegenerative diseases and induce cancer cell death.
A novel drug principle has been successfully tested in a mouse model and brain organoids of ALS patients, preventing cell death and improving motor abilities. The discovery of the TwinF interface inhibitor FP802 offers a promising path for fighting ALS and could lead to the development of effective treatments.