Articles tagged with Muscle Cells
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Aging muscles heal more slowly after injury due to increased levels of protein NDRG1 in aged muscle stem cells. NDRG1 helps stem cells survive longer but reduces their ability to activate and repair tissue.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
A severe form of muscular dystrophy has been found to impair muscle regeneration, with researchers identifying a genetic defect that affects laminin-α2 protein production. This discovery opens up new avenues for therapies targeting both muscle fibers and stem cells to slow disease progression.
Muscle stem cells secrete c1qtnf3, which redirects macrophages from immune to regenerative functions, promoting tadpole tail regeneration. This discovery offers insights into the regenerative capabilities of certain animals and paves the way for further research into potential applications in mammals.
A naturally occurring gene called Cyclin A2, normally silenced in humans, can make new functioning heart cells and aid in the heart's repair. The breakthrough discovery could lead to new techniques for repairing damaged hearts as an alternative to transplants or implanted cardiac devices.
Researchers at Sanford Burnham Prebys have developed a new method to generate more and potent skeletal muscle progenitor cells. The study found that blocking the activity of Janus kinase 2 (JAK2) yields a twofold increase in cell yield, while also delivering more mature and effective cells for regenerative medicine treatment.
Researchers have developed a new class of artificial muscles that respond to ultrasound, enabling precise movements and wireless control. The technology has vast potential for future medical and technical applications, including drug delivery, cardiac patches, and minimally invasive procedures.
A new study found that mice who stopped exercising for four weeks and then retrained showed greater muscle mass gains compared to those who exercised continuously. The researchers discovered that the second bout of exercise activated genes involved in mitochondrial function, leading to increased muscle growth.
A study published in PLOS Computational Biology reveals that different cell types and variation within these cells play a crucial role in muscle remodeling during Drosophila development. The findings show that sarcolytes, hemocytes, and fat body cells work together to break down larval muscles and scatter the fragments.
Two new studies from Karolinska Institutet investigate how somatic mutations in muscles and blood vessels affect ageing. The results show that such mutations can reduce muscle strength and accelerate blood vessel ageing.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers identified a new strategy to repair damaged heart tissue by reactivating the PSAT1 gene through synthetic modified messenger RNA. The study found that mice treated with PSAT1-modRNA showed robust increases in cardiomyocyte proliferation, reduced tissue scarring, and improved heart function.
A recent study published in Stem Cell Reports found that microgravity accelerates skeletal muscle degeneration, leading to a decline in muscle strength and protein content. The researchers used an ISS lab-on-chip model to simulate ageing-related muscle loss and discovered that electrical stimulation can mitigate these changes.
Researchers at the Institute of Industrial Science, The University of Tokyo, found that increasing levels of free amino acids in the culture medium can increase intracellular free amino acids and influence flavor compounds in cultured meat. Glutamic acid was the most prominent amino acid, while alanine was higher in conventional beef.
Estrogen-related receptors play a crucial role in regulating muscle cell metabolism and energy production. Researchers discovered that these receptors can increase mitochondrial numbers and enhance energetic output when muscles need more energy, making them a promising therapeutic target for metabolic disorders.
MIT engineers have developed a way to grow artificial muscles that twitch and flex in multiple coordinated directions. This breakthrough allows for the creation of soft, wiggly robots with enhanced flexibility and range of motion.
A new study found that female professional footballers' lactate levels can be predicted by their finger length and height. Research showed that tall women and those with a long ring finger relative to their index finger produced low levels of lactate during exercise.
A team from Tokyo Metropolitan University has successfully implanted myoblasts onto healthy muscle in mice using an extracellular matrix scaffold. This breakthrough treatment could treat ageing-related muscular atrophy without scarring, offering a promising avenue for regenerative medicine.
A new algorithm proposes measuring quadriceps muscle mass for more accurate sarcopenia diagnosis, potentially leading to earlier detection and better treatment options. Ultrasound imaging is recommended as a cost-effective and practical solution for diagnosing sarcopenia in clinical settings.
Researchers discovered that removing arginase-II gene can slow down muscle aging in mice, leading to improved muscle health and reduced inflammation. This finding suggests targeting the Arg-II gene could help maintain muscle strength and mobility in older adults.
A new study reveals evidence of electrical signaling and coordinated behavior in choanoflagellates, the closest living relatives of animals. This finding offers key insights into the early evolution of animal multicellularity and nervous systems.
A new co-culture system uses photosynthetic microorganisms to remove waste products and enhance muscle cell growth, resulting in a 30% reduction of lactate and over 90% reduction of ammonia. This innovation provides a low-cost, sustainable alternative to animal serum for cultured meat production.
A new study reveals a promising therapy using antimiRs to treat myotonic dystrophy type 1 (DM1), a genetic disorder caused by abnormally high CTG repeats in the DMPK gene. The treatment increased MBNL1 levels and improved muscle cell functions, reducing disease symptoms.
A study found that space-traveling muscles have impaired regeneration and gene activities associated with sarcopenia. Drug treatment partially prevented the negative effects of microgravity on muscles, suggesting a potential therapeutic approach for astronauts and older adults.
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
Researchers tested a therapy combining photobiomodulation and idebenone to minimize Duchenne muscular dystrophy progression. The strategy prevented muscle degeneration and improved regenerative capacity, with synergistic effects observed when administered together.
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
A team of researchers from NUS has developed a novel method to stimulate muscle cells using magnetic therapy, which produces and releases proteins with anticancer properties. The study demonstrates that this non-invasive approach can prevent cancer cell growth and invasion, similar to exercise.
A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
Researchers developed a spring-like device that maximizes muscle contractions to power biohybrid robots. The new flexure design enables predictable and reliable movement, allowing engineers to build muscle-powered robots with increased precision and versatility.
Researchers have engineered bovine muscle stem cells to produce their own fibroblast growth factor, reducing the cost of production for cultivated meat. This innovation could lead to more affordable and accessible cultured meat products in the near future.
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
A recent study reveals that the tethering of mitochondria to the endoplasmic reticulum plays a crucial role in muscle development, regeneration, and maintenance. The researchers propose targeting the Notch signaling pathway as a potential therapeutic option for muscle atrophy caused by mitochondrial abnormalities.
Scientists have created a self-organizing neuromuscular junction model from human pluripotent stem cells to study complex neuromuscular diseases. The 2D and 3D cultures mimic the physiological situation, allowing researchers to perform high-throughput drug screening for novel treatments.
Researchers at UC Irvine have identified a critical gene for muscle repair and regeneration, enabling the creation of muscle in the lab that can support human stem cells. The discovery has immense implications for treating various chronic muscle disorders and injuries, including rotator cuff tears and Duchenne Muscular Dystrophy.
Using magnets, scientists have found a way to align muscle fibers in tissue, allowing for the development of model tissues and potential therapies for muscle injuries or diseases. The method, which involves mechanically stimulating muscle cells with magnetic forces, shows promise for understanding muscle growth and function.
Researchers created a hydrogel mat with magnetic microparticles that mimic the forces of exercise. The team found that regularly exercising muscle cells resulted in longer, aligned fibers, and improved contraction capabilities.
Researchers have developed a new method to study muscle diseases, reducing the number of experimental animals needed. This method enables the simultaneous investigation of several genes or entire signaling pathways in muscle fibers quickly and efficiently.
A Singapore study found that drinking coffee and tea at midlife is associated with reduced likelihood of physical frailty in late life. The study, led by Professor Koh Woon Puay, analyzed data from over 12,000 participants aged 45-74 years old.
Researchers have found that the protein Musashi-2 plays a crucial role in regulating type 2a muscle fiber mass and metabolism. The study reveals that Msi2 knockout mice exhibit reduced muscle mass, decreased myoglobin and mitochondria levels, and impaired sugar metabolism.
Researchers at Cold Spring Harbor Laboratory have made a significant breakthrough in transforming rhabdomyosarcoma cells into regularly functioning muscle cells using differentiation therapy. This innovative approach has the potential to spare patients and their families from pain and suffering by offering a new treatment option.
Researchers at ETH Zurich have developed a method to grow functional human muscle stem cells in the lab using mRNA technology. This breakthrough could lead to new treatments for muscular dystrophy and other muscle disorders. The team successfully converted connective tissue cells into muscle stem cells, producing fully functional muscl...
A study published in Cell Reports reveals that a family of proteins involved in the regulation of fast twitch muscle fibers plays a significant role in their development. The researchers found that animals exposed to microgravity expressed higher levels of these proteins, leading to faster-to-slow muscle fiber conversion.
A team of researchers has identified TAK1 as a regulator of skeletal muscle mass, slowing down disease progression and improving muscle function in Duchenne muscular dystrophy. By targeting this protein, they can suppress muscle fiber death and enhance myofiber growth, offering a promising new approach to treatment.
A recent study by researchers at UNICAMP found that low-load with many repetitions and high-load with fewer repetitions both promote similar muscle growth. Muscle activation patterns were different, but metabolic stress was the same in both groups.
Researchers develop a technique to visualize carnitine distribution in muscle fiber cells, finding higher concentrations in slow-type fibers. The study reveals rapid transport of carnitine into muscle cells during contraction, shedding light on metabolic processes and potential therapeutic applications.
A new study from the University of Eastern Finland identified 12 cell types involved in CAD pathogenesis. The genetic risk factors for CAD take effect via smooth vascular muscle cells, which change their phenotype as the disease progresses.
Researchers discovered that mechanical loading can exacerbate inflammation in aged muscles, hindering healing. However, combining mechanotherapy with anti-inflammatory treatment significantly improves healing in aged muscles.
Researchers have successfully used AAV1.NT-3 gene therapy to improve muscle physiology and prevent age-related sarcopenia in mice. The treatment resulted in restored muscle mass, strength, and neural connections, offering a potential new option for managing this debilitating condition.
A protein complex formed of HuR and YB1 is crucial for messenger RNA stability during muscle-fiber formation. Further research could help scientists influence protein synthesis and develop novel therapeutics for muscle-related pathologies.
Researchers studied cavefish metabolism to understand how humans might adapt over long periods of inactivity, finding genetic changes that enable muscle endurance and efficient energy storage. The study suggests potential implications for understanding and mitigating the negative effects of sedentary lifestyles on human health.
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
Research reveals that α-Ketoglutarate (AKG) supplementation promotes skeletal muscle mass, improves exercise endurance, and increases blood flow, making it a potential nutritional supplement for enhancing health and exercise performance. AKG also relaxes vascular smooth muscle, allowing tissues to receive abundant oxygen and nutrients.
A new study found that bioelectrical impedance analysis can accurately assess knee muscle function, offering a non-invasive alternative to traditional methods. The findings suggest that thigh PhA is a better predictor of knee extensor strength than whole-body PhA.
Researchers discovered that blocking the ion channel TRPC6 prolongs survival and improves muscle function in mice with severe Duchenne muscular dystrophy. The study also reduced bone deformities associated with weak muscles.
Researchers at Tokyo Metropolitan University discovered that a protein excreted by type I muscle fibers can differentiate surrounding myoblasts into type I fibers, upending the notion that fiber ratios are fixed at birth. This finding has significant implications for treating conditions such as type 2 diabetes and aging populations.
A novel stem cell-gene therapy has been shown to be safe in humans, with no serious side effects reported in the first trial. The treatment targets motor neurons that die in patients with amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers at RIKEN have discovered how marsupials' hearts can regenerate for several weeks after birth, allowing for potential treatment of human heart disease. They found that inhibiting a protein called AMPK extended the period of regeneration in both mice and opossums, with minimal scarring.
Researchers from Tokyo Medical and Dental University found a novel GLP-1R agonist, PF1801, that can suppress muscle inflammation and restore muscle strength in patients with polymyositis. The study suggests PF1801 could be used to treat patients with muscle wasting disease and improve symptoms associated with inflammatory myopathies.