The study found that patients taking anifrolumab had lower rates of infections requiring hospitalization compared to those on conventional immunosuppressants. Anifrolumab also reduced the need for systemic antibiotics and increased the likelihood of viral infections, offering distinct benefits over conventional treatments.
Aging reprograms skin genetic activity by increasing inflammatory gene expression in the epidermis, leading to a loss of skin function. This mechanism is mediated by the collaboration of two proteins, BMAL1 and YAP, which normally maintain skin homeostasis.
A new compound called ampyrone safely increases melanin production in human skin, offering a potential treatment for hypopigmentation disorders. The discovery could improve visual function and enhance patient quality of life for those with severe genetic forms of albinism.
Research reveals multifloral honey's protective effects on human skin cells from UV radiation, promoting cell recovery and preventing aging. The study found that honey increased stemness-related markers and reduced aging-associated genes in skin stem cells and fibroblasts.
Researchers found that camels have a more flexible and coordinated response to heat stress, allowing them to maintain stability even at higher temperatures. In contrast, human cells tend to respond in a more rigid way, making them less adaptable under heat stress.
Researchers have created lab-grown human skin organoids that can form complex microvascular networks similar to those in native human skin. These self-organizing structures function similarly to native skin, responding to inflammatory stimuli and re-growing after injury.
The study reveals that hair follicles contain specialized sentinel cells that monitor environmental exposure and microbial presence, potentially linking immune detection to sensory signaling. The discovery may have implications for understanding skin infections, immune disorders, and topical therapeutics.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Researchers at Harvard University have discovered a way to fully regenerate skin in mice by unblocking an embryonic healing mechanism. The study suggests that removing the block on this mechanism may be sufficient to allow regeneration to occur, potentially leading to new therapies for human patients.
Researchers reveal that skin-cell calcium channel TRPV3 is activated by plant-derived fragrant molecules, leading to enhanced immune responses and potential new vaccine adjuvants. The study provides a novel understanding of immune crosstalk and offers a safer approach to enhancing vaccine efficacy.
Researchers developed a novel mouse model that accurately mirrors the progression and dynamic shift between disease states of lupus. The model demonstrates a direct link between skin defects and systemic disease, with dynamic features including remission and relapse cycles.
Researchers discovered an mRNA-based therapy that instructs skin cells to produce telomerase reverse transcriptase (TERT), reducing DNA damage and protecting against genomic DNA injury. This breakthrough could lead to new therapies preventing radiation burns and long-term scarring, improving quality of life for millions of cancer patie...
Researchers discovered that a gene called ZNF750, active in skin cells, is essential for supporting Langerhans cells and building the body's first line of immune defense. The study found that ZNF750 controls the production of IL-34, a molecule released by skin cells that acts as a survival signal for Langerhans cells.
Researchers found that indoor tanning users in their 30s and 40s have more skin mutations than people twice their age, particularly in areas exposed to tanning beds. This can lead to an increased risk of skin cancer, including melanoma.
Researchers at the University of Arizona Comprehensive Cancer Center are investigating novel immune-based approaches to prevent keratinocytic skin cancers. They aim to identify early immune signals that can activate the body's own immune defenses to prevent cancer before it starts.
Researchers have identified the cells and connections underlying a fish's ability to dynamically change color to match its surroundings. The study found that specialized skin cells called melanophores control the color change, which helps the zebrafish evade predators by lightening its skin over tens of minutes.
The congress will focus on key mechanisms of skin ageing, including cellular senescence, mitochondrial dysfunction, and microbiome-skin interactions. Top experts in dermatology and longevity science will present new strategies for enhancing skin vitality and combating age-related decline.
Researchers at UC Davis discovered how desmosomes, which stick cells together, respond to mechanical stress. They found that the intermediate filaments transmit forces to a desmosome protein, causing it to open up and expose a site for signal transmission.
Researchers identify PIEZO2-expressing fibroblasts as key drivers of keloid formation and recurrence. These cells sense mechanical pressure, leading to excessive collagen production and scarring. The study's findings hold significant implications for future diagnosis and treatment options.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
Researchers found that new strains of Cutibacterium acnes, a species believed to contribute to acne development, are acquired during the early teenage years. This transitional stage could be the best window for introducing probiotic strains of C. acnes to prevent acne.
Researchers identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions. The study found that one subtype, C10, becomes more prevalent with age and is harder to kill with existing drugs.
Researchers have discovered that pyrvinium pamoate, a common pinworm medication, can inhibit cancer cell growth and reverse neuroendocrine features in Merkel cell carcinoma. The medication also reduced tumor growth in mouse models of the disease.
Researchers found basal cell carcinomas (BCCs) have an immune-excluded phenotype with minimal HLA-I expression, even in early development. A stem-like quiescent program suppressed APM genes, which could be reversed to enable BCC immunotherapy.
Researchers discovered that endoperoxides derived from ergosterol and 7-dehydrocholesterol induce the death of melanoma cells. This finding paves the way for expanding the use of photodynamic therapy in fighting skin cancer.
A new method using UV light and machine learning can detect microbial contamination in cell cultures, providing a quicker yes/no assessment within 30 minutes. This technology aims to reduce the time spent on sterility tests, making it crucial for life-saving treatments.
A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research. The study suggests new avenues for drug development to reduce the risk of developing both diseases by targeting alpha-synuclein.
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
Researchers from TU Graz and Vellore Institute of Technology have developed a 3D-printed skin imitation with living cells to test nanoparticles from cosmetics. The skin imitation mimics human skin's three-layer tissue structure and biomechanics, made possible by hydrogel formulations printed together with living cells.
Researchers from CNRS found that applying a mixture of sunscreen and insect repellent simultaneously decreases UV protection. The study used skin biopsies and computer tool analysis to measure the stress response of skin cells to radiation.
Researchers from UMass Amherst have discovered that epithelial cells communicate with slow electrical signals, 1,000 times slower than nerve impulses. This finding could enable new applications in wearable sensors, wound healing and more.
Researchers at MIT have devised a simplified process to convert skin cells directly into neurons, bypassing the stem cell stage and achieving yields of over 10 neurons from a single skin cell. This approach could potentially be used to treat patients with spinal cord injuries or diseases that impair mobility.
A groundbreaking study from Okayama University reveals that keratinocytes, not fibroblasts, are responsible for dermal collagen formation in humans and other vertebrates. Keratinocytes produce collagen fibers in a structured arrangement before fibroblasts modify them.
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
A new study published in Cell Press journal suggests that the International Space Station is overly sterile, and introducing more natural microbes could help astronauts. Researchers found that human skin was the main source of microbes on the ISS, while chemicals from cleaning products were ubiquitous.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
Researchers at Pusan National University have developed a novel drug delivery system that uses nanoparticles to target and kill colorectal cancer cells. The system, which involves encapsulating cancer cell-activated nanoconjugates in an alginate matrix, can selectively deliver drugs to tumor cells while minimizing side effects.
New cyanine-carborane salts show promise in eradicating metastatic breast cancer tumors with minimal side effects. The therapy targets specific proteins in cancer cells, allowing for precise killing of diseased cells while sparing healthy tissue.
A new clinical study by the BfR found that tattoo ink contains smaller amounts of liquid components than previously thought. The researchers were able to detect metabolites in blood samples shortly after tattooing began and showed that metabolism functions differently when substances are taken up through the skin.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Researchers use generative AI to predict chromatin structures in single cells, overcoming limitations of existing experimental methods. The technique can generate thousands of structure predictions in minutes, enabling faster study of how 3D genome organization affects gene expression.
Researchers developed mucoadhesive films combining xyloglucan and green tea extract to treat oral mucositis, a painful inflammation caused by cancer treatment. The films demonstrated high strength and adhesion forces comparable to commercial products, showing promise as a novel treatment for oral mucositis.
Researchers at Uppsala University found that people with psoriasis have invisible inflammation in their small intestine, which can lead to gastrointestinal problems and an increased risk of developing Crohn's disease. Half of the study participants had a leaky gut, allowing bacteria and harmful substances to leak through the intestinal...
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
A recent NUS Medicine study found that a molecule called DUSP6 plays a major role in helping colorectal cancer grow, with higher levels linked to poorer prognosis and decreased survival. Researchers suggest blocking DUSP6 could lead to new therapies for CRC treatment.
Research found that intermittent fasting inhibits hair growth in mice by causing oxidative stress on stem cells. A clinical trial showed a similar effect in humans, with a 18% reduction in hair growth speed.
Researchers at Johns Hopkins Medicine have discovered that excessive Gata4 protein accumulation in vascular smooth muscle cells contributes to aortic aneurysm vulnerability in Loeys-Dietz patients. The study's findings may help refine treatments for this genetic disorder, which affects connective tissue systems.
Researchers have developed a 3D artificial skin model with all three layers, simulating diseases and injuries more accurately. The model can replace animals in toxicological studies of medicines and cosmetics, enabling the development of new treatments without animal testing.
Researchers identified three subtypes of fibroblasts in skin cancer: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). The distribution of these subtypes varies with tumor aggressiveness. iCAFs produce signaling factors to activate immune cells, while mCAFs prevent T cell invasion.
Researchers have created a comprehensive database of protein changes in mice tissues due to aging, providing new insights into age-related diseases. The study reveals proteins that increase with age and improve understanding of the molecular mechanisms underlying aging.
Developed by University of Copenhagen researchers, a new nanofiber patch reduces psoriasis treatment frequency to once a day, improving comfort for patients. The patch releases two active ingredients at different rates, addressing the need for multiple products in psoriasis treatment.
A team of researchers at the University of Toronto has discovered a unique stem cell type, the neural crest stem cell, which can be reprogrammed into different cell types. This discovery challenges longstanding theories in cellular reprogramming and highlights the potential of these cells for stem cell transplantation to treat disease.
Researchers at MD Anderson Cancer Center have made significant advancements in understanding tissue regeneration, with a focus on epigenetic regulation and retrotransposon suppression. MicroRNAs have also been identified as potential biomarkers for COVID-19 severity in cancer patients, while a novel protein complex drives lung regenera...
Researchers at Weill Cornell Medicine identified a unique enzyme called FTSJ1 that enables melanoma cells to escape oxidative stress and spread. By targeting this enzyme, therapies may prevent or treat metastasis with minimal side effects.
The study reveals hormone-dependent molecular mechanisms that cause sexual dimorphism in chicken feathers, including the role of thyroid hormone activation/inactivation system. The findings also shed light on the cultural significance of chickens in Japanese society and its impact on promoting social cohesion.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
Scientists at St. Jude Children's Research Hospital found that nutrient availability affects T cell development and mitochondrial activity, inhibiting T cell formation in lysosomes. The study highlights the crucial role of organelle signaling, such as mitochondrial and lysosomal function, in shaping tissue immunity.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
Researchers at Johns Hopkins University mapped variation in human stem cells, revealing unique developmental patterns and gene expression traits that modify conserved steps. The findings may aid personalized regenerative therapies and advance understanding of cellular variation in humans.
Researchers discovered that DNA methylation patterns, like cellular memory markers, prevent reprogrammed cells from fully adopting new identities. This limitation limits the effectiveness of long-term treatments and therapies.