Tumor Samples

TAILORx and RxPONDER trials shift to a discovery platform for analyzing breast cancer recurrence using advanced tumor profiling and AI

Researchers are analyzing paired original and recurrent breast cancer tumors to identify biological factors driving recurrences years after treatment. The TAILORx and RxPONDER trials have provided a large dataset of clinically annotated tumor samples, enabling the study of late recurrence and potential prevention strategies.

Study may help predict response to chemotherapy in triple-negative breast cancer

Research to expand options for hard-to-treat cancers

Researchers are expanding options for patients with hard-to-treat cancers using a personalized approach that identifies effective therapies by testing large libraries of drugs on living tumor cells. The approach has shown stronger responses than initial findings, suggesting it can reveal opportunities missed by traditional methods.

Genetic mutations linked to toxin exposure found in firefighters’ brain tumors

A new study by Mass General Brigham researchers has found a link between genetic mutations and toxin exposure in firefighters' brain tumors. The study identified a unique pattern of genetic mutations, known as a mutational signature, in many firefighter samples, especially those who had spent more years firefighting.

A new way to predict cancer's spread? Scientists look at 'stickiness' of tumor cells

Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.

Scientists find new biomarker that predicts cancer aggressiveness

Researchers found a biomarker, RNA Polymerase II (RNAPII), associated with tumor aggressiveness and recurrence in meningioma and breast cancers. The study developed a novel profiling technology, Cleavage Under Targeted Accessible Chromatin (CUTAC), to measure gene transcription activity from DNA, which predicted cancer outcomes.

Predicting how childhood kidney cancers develop

A new study has mapped genetic differences across children with Wilms tumour, a type of childhood kidney cancer, to understand how it develops and responds to treatment. The research suggests that inherited genetic changes predetermine tumour development, growth, and response to treatments.

Cancer Cooperative Group leaders propose a re-engineering of the nation’s correlative science program for cancer

The Cancer Cooperative Group System is being re-engineered to bring new money to correlative science research through public-private partnerships, aiming to remove barriers for researchers to access biological samples. This will facilitate the integration of innovative science into cancer clinical trials.

MicroDicer and MicroGrater make quick work of tumor dissection

MicroDicer and MicroGrater tools enable efficient creation of uniform organoids from tumor samples, allowing researchers to test multiple cancer therapies and improve data quality. The precision cutting tools facilitate bespoke, personalized cancer therapy by standardizing process flow and organoid sizes.

Advancing towards a novel, highly accurate method for cervical cancer screening

A research team has identified novel biomarkers in cervical mucus samples that show high diagnostic power for detecting cervical cancer. The findings suggest that analyzing local expression levels may offer a superior diagnostic strategy, potentially reducing the need for invasive procedures.

RNAs may help identify stage II colon cancer patients who may benefit from chemotherapy following surgery

A new study has identified specific RNAs that may help identify stage II colon cancer patients who are likely to benefit from chemotherapy following surgery. The researchers found that certain housekeeping RNAs were up-regulated in patients with recurrence, suggesting their potential role in the metastatic process.

One bad apple spoils the barrel: New study uncovers multiple molecular subgroups in liver cancer with most aggressive driving clinical outcomes

A recent study published in Journal of Hepatology found that over 40% of liver cancer samples harbor more than one molecular subtype, leading to a

Rapid test of cerebrospinal fluid decreases time to diagnosis for brain tumors

Researchers developed a rapid genotyping test for patients with central nervous system lesions, detecting key mutations associated with brain cancers in samples taken during a lumbar puncture. The test eliminated the need for surgical brain biopsies in seven cases and significantly accelerated time to treatment, from an average of 12 d...

Advancing cancer tracking: DiFC detects rare cells noninvasively

Researchers developed DiFC, a two-color diffuse flow cytometry system that detects rare cancer cells in the bloodstream without invasive methods. The technology provides insights into cancer progression and response to treatments by studying different subpopulations of cancer cells simultaneously.

New research platform assesses brain cancer mutations during surgery

A new surgical platform using mass spectrometry identifies key gene mutations in brain cancer, including IDH mutations, during surgery. This allows for rapid diagnosis, prognosis, and tumor resection to improve patient outcomes.

Hyperspectral dark-field microscopy for rapid and accurate identification of cancerous tissues

Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.

Blood samples enhance B-cell lymphoma diagnostics and prognosis

Researchers have identified an inflammatory protein profile associated with poor survival in aggressive B-cell lymphoma patients. Protein profiles from blood samples can help classify subtypes of the disease and monitor patient response to treatment.

Lower relapse risk in triple-negative breast cancer with high immune cell levels

A study by the University of Gothenburg found that women with triple-negative breast cancer and high immune cell levels have a lower relapse risk after surgery. This suggests that these patients may not need chemotherapy, despite having faster-growing tumors and higher relapse rates than other breast cancers.

Groundbreaking treatment approach shows promise in hard-to-treat cancers

A groundbreaking treatment approach that combines genetic testing with individualized drug testing on tumor samples has shown promising results in treating relapsed pediatric cancer patients. The study achieved an impressive 83% improvement rate, including Logan Jenner's successful treatment after his leukemia relapse.

Analytical validation of NeXT Personal®, an ultra-sensitive personalized circulating tumor DNA assay

NeXT Personal assay detects up to ~1,800 somatic variants specific to the patient's tumor with a detection threshold of 1.67 PPM and 99.9% specificity. The assay showed linearity over a range of 0.8 to 300,000 PPM.

Researchers take new AI approach to analyze tumors

A new AI method combines satellite imaging and ecological analysis techniques to interpret large amounts of data from tumor tissue, providing insights into how cancer works. This approach aims to tailor cancer treatments to individual needs and avoid unnecessary side effects.

Real-time live tissue sensitivity assay for pancreatic adenocarcinoma

Researchers developed a reliable and reproducible real-time live tissue sensitivity assay (RT-LTSA) using fresh tumor samples to predict patients' clinical response to chemotherapy. The study showed improved disease-free survival and reduced recurrence rates in patients who received RT-LTSA sensitive adjuvant regimens.

Tumor Metabolism Atlas offers a new way to discover cancer mechanisms

Researchers created the Cancer Atlas of Metabolic Profiles (CAMP) to analyze gene activity and metabolite levels in tumor samples. The atlas reveals two broad classes of gene-metabolite connections, pointing to mechanisms at work across cancer types.

A new tool for diagnosing cancer

Researchers developed a new tool called Orion that integrates histologic and molecular information to improve cancer diagnosis and treatment. The tool uses a digital imaging platform to analyze tumor samples, identifying biomarkers that predict patient outcomes.

Comparing the polarimetric properties of fresh and preserved brain tissue

Researchers found that formalin fixation does not significantly alter the polarimetric properties of brain tissue, making it suitable for training machine-learning models. The study suggests that formalin-fixed brain tissue specimens can provide high-quality data for rapid and accurate diagnostic imaging in surgery.

Research shows that lymph node sampling during kidney tumor surgery is safe

Researchers analyzed outcomes for 144 Colorado patients who had lymph node sampling at the time of surgery for kidney tumors between 2005 and 2019. They found no statistically significant difference in clinically significant complications between patients who underwent more extensive lymph node sampling than those who didn’t.

Cleveland Clinic research predicts cancer patients’ response to chemotherapy agent cisplatin

Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.

Georgia Cancer Center awarded $2.3 million National Cancer Institute grant for acute myeloid leukemia research to improve patient survival

Acute myeloid leukemia is a cancer that affects blood cells and can lead to infection, anemia, and easy bleeding. The Georgia Cancer Center has received a $2.3 million grant to study how cancer cells resist treatment and propose new options to improve patient survival.

Creating an artificial pathologist

A team of scientists at Max Planck Institute for the Science of Light developed a method to quickly and accurately diagnose cancer using artificial intelligence and real-time deformability cytometry. The method reduces analysis time from hours to under 30 minutes, enabling faster decision-making during surgery.

Study unravels pathophysiological role of Dectin-1 in promoting colorectal cancer

A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.

Creating an artificial pathologist

A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.

Groundbreaking lymphoma tumor model paves way for new therapies

Researchers at Georgia Institute of Technology developed a synthetic tumor model to understand the impact of microenvironment on targeted therapies for Activated B Cell-like Diffuse Large B cell lymphoma. The model showed promise in demonstrating how combining therapeutics can overcome tumor resistance to inhibitors.

The largest genomic study of rare cancer metastathic pheochromocytoma identifies patients at highest risk of metastasis and those who would respond to immunotherapy

Researchers have identified markers associated with an increased risk of metastasis in patients with metastatic pheochromocytoma, allowing for personalized clinical management. The study also identifies patients who could benefit from immunotherapy treatments, paving the way for potential new therapies.

Certain gene signaling rewires tumors after immunotherapy

Researchers found that certain gene signaling pathways, such as interferon γ and beta-catenin, can lead to tumor hyperprogression after immunotherapy. Targeting these pathways may prevent hyperprogression in preclinical models.

Multimodal sequencing achieves high-quality results from small volumes of frozen tumor specimens

Researchers developed a new technique to analyze frozen tumor specimens, enabling the study of rare cancers and unique patient histories. This breakthrough increases the number and variety of tumor samples available for scientific analysis.

Artificial intelligence tool developed to help make real-time diagnoses during surgery

A new AI tool developed by Brigham and Women's Hospital improves the accuracy of time-critical pathology diagnostics during surgery. The tool, which leverages deep-learning technology, translates frozen tissue samples into high-quality images, increasing diagnostic accuracy and reducing the need for lengthy laboratory tests.

Genes & Cancer | Systems biology network reveals the correlation between COX-2 expression and Ch 7q copy number alterations in Ch 11q-deleted pediatric neuroblastoma tumors

Researchers analyzed COX-2 levels and segmental chromosome aberrations in pediatric neuroblastoma tumor samples. Positive correlations between pre-CT Ch 7q gain and COX-2 expression were found, as well as negative correlations between Ch 7q gain and Ch 11q deletion.

CNIO researchers discover how to predict the efficacy of one of the most widely used drugs against breast cancer

Researchers identify CDK4 and filamin proteins as predictors of response to paclitaxel in HER2-negative breast cancer patients. High levels of these proteins are associated with a positive response rate in 90% of cases.

Oncotarget | Treasures from trash in cancer research

A new study explores the value of 'trash data' from cancer genome sequencing, identifying new strategies to uncover previously unexplored information. The researchers found that genomic and transcriptomic data contain relevant information that can help elucidate carcinogenesis and discover putative biomarkers with clinical applications.

Research finds genes associated with most aggressive kidney cancer

Researchers identified genes associated with aggressive clear cell renal carcinoma, a subtype of kidney cancer. Anticoagulant therapies may enhance cancer treatment efficacy. Specific genes involved in blood clotting and insulin transport were found to be linked to disease progression.

Oncotarget | Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study

A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.

Gene interactions classify bowel tumors for personalized medicine

Researchers developed a new taxonomy of bowel cancer using gene interaction networks, grouping tumors into six distinct clinical and molecular subtypes. This classification system could aid in precision medicine by tailoring treatments to individual patients.

Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis

The study analyzed DNA methylation in skin tumor samples, revealing correlations between changes in proteins regulating the organism and prognosis. The results identified potential markers of patient survival and suggested a new route for understanding melanoma subtypes.

Researchers use machine learning to unlock the genomic code in clinical cancer samples

A new method using machine learning corrects damaged DNA and unveils true mutation processes in tumour samples, helping early cancer detection and accurate diagnosis. The tool predicted over 90% of developing cancer processes, offering a significant advancement in cancer patient care.

Destroying tumor cells: Targeted immunotherapy using injectable materials

Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.

Estimating tumor-specific total mRNA level predicts cancer outcomes

Researchers developed a mathematical technique to measure total tumor-specific mRNA levels from bulk tumor sequencing data, associating higher mRNA levels with reduced patient survival. The study suggests this approach could serve as a prognostic biomarker for various cancers, guiding treatment selection.

Computational approach enables spatial mapping of single-cell data within tissues

Researchers developed a computational approach called CellTrek to combine parallel gene-expression profiling methods, creating spatial maps at single-cell resolution. The tool provides detailed information on individual cell types' location within tissues, enabling unique biological insights.

Surprise small-cell lung cancer discovery suggests new treatment

Researchers at UVA Cancer Center have made a groundbreaking discovery about the EP300 gene and its role in small-cell lung cancer. The study found that the gene makes a protein with properties that can both foster and prevent tumor formation, providing a new potential target for treatment.

CHOP researchers define a 3-tiered molecular classification of pediatric differentiated thyroid cancer, where fusion oncogenes predict the most invasive behavior

Researchers at Children's Hospital of Philadelphia define a 3-tiered molecular classification system for pediatric differentiated thyroid cancer, where fusion oncogenes are associated with more invasive disease and lower remission rates. The study contrasts findings from adults, who have a two-tiered system based on BRAF mutations.

Scientists demonstrate utility of Bilateral Tumor Model for evaluating anti-cancer T-cell responses

A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.

Simple, cheap urine test can detect urothelial cancers in Lynch Syndrome patients

Researchers have developed a simple, postal urine test that can detect signs of urothelial cancer in Lynch Syndrome (LS) patients, who are at high risk of developing tumors. The test uses cell-free DNA shed into the urine to identify DNA from tumor cells with characteristic microsatellite instability.

Pilot study reveals the benefits of ‘whole genome sequencing’ for children with cancer

A pilot study reveals that whole genome sequencing can refine diagnoses and provide new treatment options for children with cancer. The study found genetic variants that could change prognosis or suggest hereditary causes of the cancers, as well as treatments that may be effective but were not previously considered.

New immunotherapy insights for kidney cancer

Researchers found immune cell patterns within tumours that can predict if patients with kidney cancer will respond to immunotherapy. The study identified a specific 'clonal' T cell receptor pattern linked to a greater chance of positive immunotherapy response.

Powerful technique details brain tumors’ formidable resiliency

Researchers at Weill Cornell Medicine have profiled individual cells from patients' brain tumors in unprecedented detail, revealing distinct states and programming marks that could be targeted with future drugs. The study offers insights into glioma dynamics and may lead to better detection, staging, monitoring, and treatment methods.

First 3D-bioprinting of entire active tumor

Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.

Seeing (infra)red: Researchers develop software to enhance infrared imaging-based cancer diagnosis

A team of Beckman researchers developed software to boost infrared imaging-based cancer diagnosis, enhancing image resolution and accelerating recording speeds. The software integrates data analysis and reduces limitations associated with IR imaging, making it faster and more accurate.

Deciphering the energetic code of cells for better anticancer therapies

Scientists have developed a procedure, SCENITH, that identifies the energy status of immune and cancer cells within tumors to personalize treatment. This method uses protein synthesis as an indicator of cell activity, enabling clinicians to predict patient response and improve therapy efficacy.

St. Jude Cloud portal expands access to treasure trove of pediatric solid tumor data

The Childhood Solid Tumor Network data portal on St. Jude Cloud provides comprehensive data for studying pediatric solid tumors, accelerating discoveries and novel therapies. The portal offers interactive tools for analyzing genomic sequences, epigenetic data, and preclinical pharmacokinetic reports.

Tumor DNA platform scopes out and classifies colorectal cancer

A new noninvasive diagnostic method using circulating tumor DNA can detect colorectal cancer in at-risk patients with high accuracy. The technology, developed by Huiyan Luo et al., uses methylation markers to identify patients with a sensitivity and specificity of 87.5% and 89.9%, respectively.

Rapid tissue donation program offers feasible approach to improve research

A community-based program enables patients to donate tumor tissue and blood samples for research, allowing researchers to study genetic and molecular makeup of tumors after treatment failure. Analysis reveals similar DNA mutations and varying protein biomarker expression among samples from the same patient.