Articles tagged with Genome Sequencing
A new assay can analyze small amounts of material to estimate metastatic risk, enhancing prostate cancer evaluation. The Next-Generation Copy Number Alteration (NG-CNA) assay is a targeted amplification sequencing technique that can process samples faster and decrease the cost per sample.
Researchers from Technical University of Munich identified a previously unknown virus causing mass mortality in brown trout. The piscine reovirus is related to the virus infecting salmon in North Atlantic and Pacific, causing significant economic damage.
The tegu lizard's genome has been sequenced to an unprecedented level of quality, revealing its ability to regulate its body temperature and potentially threatening native species. The high-quality genome assembly will aid scientists in studying other lizards and snakes, shedding light on their evolutionary history.
Scientists discover functional genes for producing terpenes and carotenoids in mites, which could lead to new ways of controlling chigger bites and potentially treating scrub typhus. Ancient horizontal gene transfer from soil bacteria and fungi is found to be responsible for these genetic surprises.
Researchers have developed a comprehensive catalog of the Aedes aegypti genome, which could lead to novel strategies for reducing mosquito-borne illnesses. The new tool has revealed genes coding for ionotropic receptors that detect odors, and enzymes neutralizing toxic effects of insecticides.
Scientists have assembled a comprehensive map of Aedes aegypti mosquito DNA using long-read sequencing technology, providing a much more complete and accurate picture of gene elements. The new genome has already revealed critical clues into how the insects sense chemical cues and has identified 49 new genes involved in immune responses.
A comparative analysis of eight Pezizomycete fungi reveals that truffle-forming species have evolved independently due to symbiotic relationships with host plants. The study also highlights the importance of underground networks in shaping these ecosystems and impacting global carbon cycling.
Using a dataset of over 500 single-stranded RNA viruses, researchers developed a model that can predict animal reservoirs and arthropod vectors directly from viral genome sequences. This approach enables faster evaluation than existing methods, which often require years, and could aid in rapid response to emerging infectious diseases.
University of Kent researchers have created chromosome-level assemblies for three falcon species, providing insights into their biology and ecology. The study's findings reveal a unique pattern of genome organization not typical in birds.
A recent study published in Genome Biology found that the rapid growth of genomic databases is affecting the accuracy of bacterial species identification. The research, led by Rice University scientist Todd Treangen, reveals that the imbalance in database coverage hinders the ability to quickly identify pathogens.
Researchers have sequenced the Eurasian perch genome, which is three times smaller than the human genome yet contains over 23,000 genes. The study reveals the genetic mechanisms behind the species' ability to adapt to extreme environmental conditions and its significant impact on methane cycle in lakes.
Researchers report genome assemblies of Eurasian trembling aspen and North American quaking aspen, highlighting the influence of gene network connectivity on genetic diversity. The study suggests that genetic variation is shaped by gene expression levels and regulation in these species.
Researchers from UChicago used genetic analysis and CRISPR/Cas9 editing to discover a single gene that controls the white or yellow spots on the wings of Heliconius butterflies. This gene, called aristaless1 (al1), acts as a switch for color variation, with elevated expression leading to white spots.
Researchers at OIST and Vietnam Academy of Science and Technology have decoded the entire genome of the striped catfish, revealing new details about its evolutionary lineage and genes related to disease resistance. The genome data will enable aquaculturists to develop molecular markers for optimal breeding
Researchers traced cacao trees' origin to a single domestication event around 3,600 years ago in Central America. The study found that domestication selected for desirable traits like flavor and disease resistance but also introduced counterproductive genes that lowered crop yields.
Researchers build a genetic profile for section Nigri of Aspergillus fungi, allowing for comparisons within and across the subgroup. The study reveals thousands of new genes, species-specific gene clusters, and insights into species diversification and evolution.
Scientists at OSU propose that the CRISPR adaptive immune system contributed to the loss of genes in deadly bacteria Rathayibacter toxicus. This discovery could help track and prevent the spread of this toxic species.
Researchers found that most hospital-acquired bloodstream infections come from patients' own gut, with 15 of 30 patients having the same strain in both stool and blood samples. The study used bioinformatics software to rapidly identify the source of infections, which could help address risk factors and prevent recurrence.
The study found that the selfish genes were unrelated to each other and use different mechanisms to kill sibling spores, suggesting they may be more common than previously thought. The discovery provides new insights into the genetics of fungal fratricide and has implications for understanding evolutionary patterns.
A UBC team has sequenced the complete genome of lavender, opening doors for further research and analysis. The draft genome helps identify genes directing essential oil production and regulatory elements controlling its expression.
A study by Stanford Medicine and the Undiagnosed Disease Network has diagnosed over 100 patients with previously unknown ailments, providing actionable information for treatment. The network, created in 2014, uses a combination of traditional medicine and cutting-edge genomic technologies to solve mysterious cases.
Researchers from Uppsala University have identified previously unknown retroviral insertions in European rabbits, shedding light on how ERVs spread in host populations. The study reveals substantial variation across ERV insertions in different rabbit populations, providing a genomic record of retrovirus-host associations.
Researchers at IST Austria identified two genes that determine magenta and yellow flower colors in snapdragons, which are separated by a hybrid zone. The study found that selection favored new variants of these genes, making the flowers more attractive to bees, while also creating barriers to gene exchange.
Researchers sequenced 141,431 women's genomes using non-invasive prenatal testing data, identifying patterns in ethnic groups' evolutionary history and novel genetic loci linked to height and BMI. The study provides insights into disease risk and epidemiology in Chinese populations.
The decoded genome of Ulva mutabilis reveals that the seaweed has stolen genes from bacteria to adapt to stresses like excessive light and dehydration. This discovery provides insights into how evolution acts on genomes to modify biology and may help predict future trends under climate change.
A large-scale genome analysis of over 10,000 TB pathogen strains has shown that genome sequencing can improve treatment and potentially replace traditional resistance testing. This method enables precise prediction of drug resistance and individualized treatment plans, saving resources and time.
The All of Us Research Program has awarded $28.6M to establish three genome centers, generating genomic data from 1 million biosamples contributed by program participants. These centers will provide critical data for precision medicine research and support studies on various health questions.
Researchers have confirmed that genome duplication drives the evolution of polyploid plant species, such as Arabidopsis kamchatica. The study found that the double genome allows for advantageous genetic mutations and increased adaptability to environmental conditions.
A team of researchers has successfully sequenced and assembled the cane toad genome, providing a reference for understanding its interplay with ecosystems. The findings also identify three new viruses that could potentially be used as biocontrol agents, offering new hope in controlling the invasive species' population.
The Brigham Genomic Medicine program uses state-of-the-art genomic technologies to diagnose and discover genetic underpinnings of disease. By analyzing genomic data with a multidisciplinary team, the program has identified culprit genes for 30 families, providing critical information for diagnostics and treatment.
Researchers at Michigan State University have developed a new genetics tool called conStruct to analyze large datasets of genetic variation. The tool helps identify patterns of relatedness among individuals and populations, overcoming previous statistical challenges.
Researchers have successfully mapped the orange clownfish's genome using high-tech sequencing tools, creating a comprehensive genetic blueprint. The completed genome contains over 26,000 protein-coding genes and will aid in understanding reef fish biology, sex change, larval dispersal, and ocean acidification impacts.
A new study finds that individuals with a disease-associated mutation can have vastly different symptoms due to the total amount of rare mutations in their genome. The researchers discovered a correlation between the number of mutations and cognitive development, IQ scores, and head size.
Researchers have determined the DNA code of the opium poppy genome, unlocking key steps in how the plant evolved to produce vital medicines. The discovery may lead to improved yields and disease resistance, securing a reliable supply of effective pain relief medications.
Scientists investigate the recent yellow fever outbreak in Brazil, finding that it originated from nonhuman primates in the forest and spread to humans. The study highlights the importance of real-time disease monitoring and public health countermeasures.
Researchers at York University found that inbreeding and disease are likely causes of the yellow-banded bumblebee's rapid decline in North America. The study reveals that bumblebees' immune genes are under selection, pointing to disease as a likely cause.
The study reveals geographical patterns in epigenetic changes between 100 landraces of wheat, suggesting that these changes have arisen due to environmental conditions. This discovery provides breeders with a new tool to improve how plants respond to local conditions, enabling farmers to grow the best possible crop for their environment.
A new EU-wide study found that more than half of severe listeriosis cases belong to clusters, which are often not detected quickly enough by current surveillance systems. The use of whole genome sequencing could lead to faster detection of multi-country outbreaks, saving up to 5 months of investigations.
The University of Maryland has contributed to the publication of two collaborative papers in Science that detail the full genome sequence of wheat. The research uses this genome sequence to examine gene expression related to heat, drought, and disease stressors, paving the way for more resilient and sustainable wheat varieties.
The study will recruit 400 newborns with a wide variety of possible genetic disorders, comparing whole genome sequencing to targeted genomic sequencing for accuracy and effectiveness. The researchers aim to determine if the targeted panel can be safely integrated into newborn care, eliminating ethical dilemmas and saving healthcare costs.
Scientists found that an ancient and unrelated endogenous retroviral element is inserting itself into the new retrovirus via recombination, deactivating it. This process may be a molecular defense mechanism of hosts against new retroviral attacks.
The fox genome study identifies genomic regions associated with tame and aggressive behaviors, revealing potential links to domestication in dogs and Williams-Beuren syndrome in humans. A single gene, SorCS1, is found to be linked to specific behaviors in foxes.
Researchers assembled a high-quality soybean genome from an Asian accession, revealing large genetic variations and improving functional genomics study. The new genome enables the identification of important agronomic genes and facilitation of crop improvement.
A team of researchers has discovered a new species of Placozoa, a phylum of simple multicellular animals, by analyzing its genetic makeup. The study, published in PLOS Biology, used taxogenomics to describe the new species, which was previously thought to be a single species, Trichoplax adhaerens.
Researchers have sequenced the first complete mitochondrial genome of Anopheles funestus, a major malaria vector in sub-Saharan Africa. The study reveals significant genetic diversity and ancient lineage differences that could inform new strategies to prevent malaria transmission.
An international collaboration sequenced and analyzed the genome of Chara braunii, a freshwater green alga closely related to land plants. The study identified key genes that originated in a common ancestor shared by Chara and land plants, revealing that some important plant functions evolved before land plants existed.
Scientists sequenced the dodder genome, shedding light on the evolution of plant parasitism. The study found significant gene losses, including those related to photosynthesis and flowering time control, which underlie the parasite's unique body plan.
Researchers have sequenced the genome of a tiny fern species, Azolla filiculoides, which has been found to have significant environmental applications. The fern's unique gene provides insect resistance and can be used as a sustainable fertilizer, while its symbiotic relationship with cyanobacteria allows for nitrogen fixation.
Researchers have sequenced the koala genome, uncovering unique features of its taste receptor genes and enabling it to detect toxicity levels in eucalyptus leaves. This adaptation allows koalas to optimize nutrient ingestion while avoiding toxic metabolites.
The study found that goat domestication was a complex process with genetic exchange between wild and domesticated goats, selection by early farmers, and a mix of different ancestral strands. The analysis revealed distinct patterns of genetic differentiation across the Fertile Crescent and surrounding regions.
Researchers sequenced the first fern genome, enabling insights into land plant evolution and cyanobacterial symbioses. The study revealed genes specific to Azolla's interaction with Nostoc, a cyanobiont, and an important insecticidal gene that provides protection against insect pests.
The University of California, Davis, is leading a $2.5 million USDA-funded project to develop a cow genomics program. This initiative aims to unlock the secrets of the bovine genome, enabling more efficient genetic selection for improved growth and disease resistance in cattle.
Researchers have found a new lineage of giant pandas in ancient DNA from a 22,000-year-old specimen. The findings suggest that the ancient panda separated from present-day pandas 144,000 to 227,000 years ago, indicating a distinct group not found today.
Researchers used whole exome sequencing and whole genome sequencing to detect genetic causes of neonatal death in unexplained cases. The study found a genetic cause in 23% of prospective cohort samples and strong candidates in 18% of retrospective cohort samples.
A large-scale study reveals an abundant and widely distributed suite of non-photosynthetic bacterial populations responsible for fixing nitrogen in the surface ocean. The research, published in Nature Microbiology, provides the first genomic evidence of non-photosynthetic bacteria with nitrogen fixation capabilities.
A study by deCODE Genetics reveals that most Icelanders have unmixed Norse or Gaelic ancestry, with a shift towards Norse dominance over time. The research also shows genetic divergence from ancestral populations in Scandinavia and the British-Irish Isles.
A new study reveals that Zika virus was introduced to Mexico earlier than previously thought, with evidence of two annual outbreaks across multiple regions. The research also highlights the need for better data collection to track future epidemics of mosquito-borne diseases.
Researchers sequenced bittersweet plastid genome to correct errors in genetic databases, placing it as a model for nightshade chloroplast comparative genomics. The study also presented a new hypothesis of the ancestral genome, showing structural re-arrangements coinciding with bigger evolutionary changes.
A comprehensive genomic database for fishes has resolved evolutionary relationships among 131 species, including tuna and seahorses, and identified genetic markers to track divergence through time.
Scientists have confirmed the existence of a new cryptic amphipod species, Epimeria frankei, in the North Sea. The discovery was made possible by analyzing DNA barcodes and genomic information, which revealed subtle differences between two previously thought to be one species.