Articles tagged with Connectomics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Notre Dame investigated how brain networks are organized and work together to form a unified system. They found evidence for system-wide coordination in the brain that is both robust and adaptable, suggesting that intelligence reflects how brain networks are coordinated and dynamically reconfigured.
Researchers developed an experimental protocol to monitor brain activity in mouse models, finding that brain activity shifts from inner layers to cortex throughout the day. This discovery could lead to new methods for assessing fatigue and understanding mental health issues.
Researchers identified five phases of brain structure, each supported by four turning points between birth and death, revealing key developments in cognitive performance, neural efficiency, and regional compartmentalization. The study provides context for understanding why brains develop differently at various stages of life.
Researchers used data from the Human Connectome Project to build computational models that linked connectivity with brain activation across various cognitive processes. The findings show a consistent correlation between connectivity and function, suggesting that specific patterns of connectivity can predict brain activity.
Researchers developed a new method to correct for variations in brain imaging measurements, reducing bias and increasing the accuracy of studies on ADHD. The traveling-subject method demonstrated reduced measurement bias while maintaining sampling bias, revealing decreased brain volume in critical regions for cognitive functions.
A study found that evaluators' musical experience influences the sight-over-sound effect, reducing its impact for those with auditory expertise. The study used Japanese high school brass band competitions and found no significant evidence of the effect in musicians, but a stronger presence in non-musicians.
A new study reveals that Alzheimer's risk genes influence tau buildup and spread in distinct pathways, challenging traditional views of the disease. Four gene types were identified: Network-Aligned Vulnerability and Resilience, and Network-Independent Vulnerability and Resilience.
A new microscopy method, LICONN, developed by ISTA scientists and Google Research, can reconstruct mammalian brain tissue with all synaptic connections between neurons. This technique uses standard light microscopes and hydrogel to achieve high resolution and opens up possibilities for visualizing complex molecular machinery.
The Open Brain Institute launches a groundbreaking platform to simulate and study digital brains, empowering researchers to explore brain complexity and diseases. With its virtual neuroscience laboratories, the OBI enables global collaboration and access to cutting-edge virtual labs.
Researchers have constructed a comprehensive map of synaptic connections between clock neurons in Drosophila, identifying novel neurons and connections that influence feeding, mating, and sleep behaviors. The study also reveals the role of light input pathways and neurotransmitters in regulating clock neuron function.
Researchers used super high-resolution 3D electron microscopy images to study primary cilia in mouse brain tissue, revealing new information about their organization and function. The findings provide insights into how cilia behave in their natural environment and could help scientists understand their role in disease.
Researchers discovered a brain functional connectome phenotype related to multiple cerebrovascular disease markers that contributes additively to cognitive decline and neurodegeneration alongside Alzheimer's disease. The study highlights the role of cerebrovascular disease in reshaping our understanding of dementia.
Scientists have uncovered how aggression affects vision in female fruit flies, revealing three distinct mechanisms that regulate visual attention. This breakthrough provides insight into the link between sensory information and social behaviors, with potential implications for understanding and treating neuropsychiatric disorders.
Researchers at SFSU have created three-dimensional molecular and anatomical maps of the inner neuronal circuitry of octopus arms. These 3D reconstructions revealed that cells at the tip of an arm are different from those at the base, allowing for new questions to be posed about how cells communicate with one another.
Researchers reconstructed the entire anterior visual pathway of a fruit fly, a complex series of connections between eyes and brain navigation center. This insight contributes to understanding intricacies of animal brains and ultimately human brain wiring.
Researchers discovered two distinct neural mechanisms, 'Walk-OFF' and 'Brake', that control halting behavior in flies. The 'Walk-OFF' mechanism inhibits forward walking by suppressing neurons driving movement, while the 'Brake' mechanism increases leg joint resistance to prevent stepping.
Researchers have created the largest and most complete map of the fruit fly brain, detailing over 50 million connections between neurons. The study provides critical information about brain wiring and underlying signals, paving the way for future studies on larger-brained animals.
A Princeton-led research team has built the first neuron-by-neuron and synapse-by-synapse roadmap through the brain of an adult fruit fly. The map reveals connections within the brain at every scale, enabling researchers to better understand its underlying logic and potentially develop tailored treatments for brain diseases.
Using AI and the connectome, researchers can now predict individual neuron activity in living brains. The new model predicts neural activity in response to visual input and accurately reproduces over two dozen experimental studies.
Researchers Dr. Marx and Prof. Gilon propose a novel tripartite mechanism of neural memory based on metal-centered complexes within the nECM/PNN, enabling the encoding of emotive states through biochemical interactions. This new understanding underscores the need for a more holistic approach to grasp brain function and mental processes.
Researchers create detailed wiring diagram of motor circuits in fruit flies, revealing complex nerve coordination for leg and wing movements. The study advances understanding of how the central nervous system coordinates individual muscles for various behaviors.
A high school student, Michelle Du, helped develop a novel method to predict neurotransmitters from insect connectomes using neural networks. The method has been used in various neuroscience studies and provides valuable insights into brain circuit function.
Researchers discovered that cerebellar nuclei make a surprising contribution to associative learning by strengthening connections with mossy fibers. Optogenetic experiments also showed that the nuclei can support well-timed learning. The study's findings have implications for understanding cerebellum function and potential treatments f...
A team of neuroscientists and physicists at Princeton University studied the brain of Caenorhabditis elegans to understand how information flows through a network of interacting neurons. They used optogenetics to activate individual neurons and observe how other neurons responded, shedding light on the complex neural connections.
The Digital Twin Brain platform combines intricate brain atlases and dynamic neural models to simulate human brain functions. This innovative approach holds promise for advancing artificial general intelligence and precision mental healthcare.
Researchers found that fly brain uses a three-step computation to distinguish motion patterns, dividing the workload across multiple levels. This approach helps flies detect even slight changes in motion and stay on course.
A UMass Amherst neuroscientist is mapping the brain of a sea slug to study how neurons are added to functional neural circuits, shedding light on how this process contributes to neurological conditions. The project aims to provide an unprecedented look at brain development and potentially inform human brain development.
Researchers used brain imaging to identify multiple subtypes of depression, finding distinct deviation patterns in functional connectivity among brain regions. This study provides leads for developing better treatments and personalized therapeutic interventions.
A study by Mayo Clinic researchers found that brain transmission speeds continue to increase into early adulthood, reaching a plateau around age 30-40. This may help clinicians offer therapies to treat disorders such as anxiety and depression that emerge during late adolescence and early adulthood.
Researchers used a novel brain imaging technique to visualize subtle brain changes in pre-symptomatic Alzheimer's patients. They found that individualized brain fingerprints can detect variations in brain function associated with worsening information processing.
Researchers have completed the most advanced brain map to date, tracing every neural connection in the brain of a larval fruit fly. The team's achievement is expected to underpin future brain research and inspire new machine learning architectures.
Researchers have built the first ever map showing every single neuron and how they're wired together in the fruit fly larva's brain. This huge step forwards in science will help us understand basic principles of signal travel through the brain, leading to behavior and learning.
The Janelia FlyLight Project Team has released over 74,000 images of fruit fly brain neurons, generated from more than 5,000 different genetically modified fly strains. These images are now freely available for scientists to quickly and easily find the neurons they need to test theories about the nervous system.
Researchers aim to create comprehensive maps of how neurons connect to each other, exploring neural circuits that underlie behavior. By studying connectivity and neural activity, scientists hope to understand the structure of the brain and its role in our sense of self.
The Human Brain Project researchers have developed a unique method called 3D Polarised Light Imaging (3D-PLI) to visualize nerve fibers at microscopic resolution. By combining different experimental methods and integrating data into multilevel atlases, the team gained new insights into brain connectivity.
Researchers found that experiencing reward enhances connectivity between the default mode network (DMN) and the ventral striatum. This effect was specific to the DMN and correlated with personality characteristics related to openness. The study used data from the Human Connectome Project, a database of healthy participants.
Researchers at Northwestern University found that a thermometer-like brain circuit promotes midday siestas on hot days. The study, which used fruit flies as a model organism, identified absolute heat receptors in fly heads, leading to increased midday sleep in flies and potentially humans.
Researchers at the University of Illinois found that certain characteristics of the brain's connectome can be inherited from one generation to the next. This may contribute to differences in cognitive abilities between individuals.
Electrical synapses play a vital role in brain function and stability, influencing individual nerve cell activity. In Drosophila, researchers found electrical synapses occur in almost all brain areas, affecting visual processing and neuron stability.
A study published in PLOS Biology found that despite the functional importance of connections between far-reaching brain regions, the actual number of these connections is low. Researchers estimated 2.5 billion long-range axons in the cerebral cortex, but found that only a small percentage directly connected key functional areas.
A large-scale study aims to understand how individual brains change over time, identifying factors that increase cognitive decline risk and those that confer resilience. The Adult Aging Brain Connectome study will follow 1,000 participants across a decade, collecting brain scans, blood samples, and demographic data.
The human brain contains trillions of contact points, requiring massive computational resources. Researchers outline the need for exascale computing power to tackle brain complexity.
Research reveals brief DBS exposure triggers significant brain state changes and sustained antidepressant response. A decrease in beta power is identified as a novel biomarker for DBS treatment optimization.
The USC Institute is launching a $3 million global consortium study to analyze brain imaging, genetics, and clinical data from 20 countries. The study aims to understand how Parkinson's disease progresses in the brain and explore genetic factors contributing to risk.
A recent study found COVID-19 survivors exhibit abnormal patterns of brain connectivity associated with increased post-traumatic stress symptoms. The research team discovered three distinct states of functional connectivity in the brains of COVID-19 survivors, which are linked to symptom severity.
Georgia State University researcher Vince Calhoun has received a $3.5 million grant to develop new methods for capturing dynamic connectivity in the brain and identifying biomarkers for early detection of Alzheimer's disease. The researchers aim to analyze real-time connectivity patterns to predict future cognitive decline.
A new study demonstrates that artificial intelligence networks based on human brain connectivity can perform cognitive tasks efficiently. Researchers created a brain connectivity pattern and applied it to an artificial neural network, which performed cognitive memory tasks more flexibly and efficiently than other benchmark architectures.
Researchers developed a predictive tool using machine learning and connectome analysis to identify neuronal network patterns and predict individual recovery outcomes. The study analyzed 92 patients' brain structural connectomes, tracking changes in connection patterns during recovery.
Researchers in Japan have used machine intelligence to fine-tune algorithms for brain mapping by MRI, improving the accuracy and reliability of connectome estimation. The new technique generates more convincing results, particularly in detecting long-range nerve fibers, crucial for understanding brain function.
Researchers used connectomic mapping to study inhibitory neuronal circuitry in developing mice brains. They found that different types of interneurons followed distinct developmental time courses to establish synaptic partners.
A large multi-site study has found a link between brain connectivity and grey matter atrophy caused by certain types of epilepsy. The study used big data analysis to accurately predict damage to grey matter over time.
Researchers developed a geometric network model to study the multiscale organization of the brain, finding that layers at different resolutions exhibit self-similar structure and efficient decentralized communication. This discovery has implications for understanding brain functioning and may lead to advanced tools for brain simulation.
Researchers found connections between newborn brain's visual word form area and language network, suggesting an innate sensitivity to visual words. The study suggests that the pre-reading VWFA is more connected functionally to the language network than other areas.
The pathoconnectome is a map of how eye disease alters retinal circuitry, offering insights into other neurodegenerative diseases like Alzheimer's and epilepsy. The research findings provide fundamental rules on how neural networks are rewired by disease, paving the way for new therapies.
Researchers have developed a new method to measure the complex interactions between different brain areas using both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). This approach reveals linked dynamics between EEG- and fMRI-derived connectomes, providing insights into neural communication. The findings s...
A study published in Radiology: Artificial Intelligence found that deep learning can improve MRI detection of ADHD by using a multi-scale approach to construct the brain connectome. This method provided significantly better performance than single-scale approaches, highlighting the predictive power of the brain connectome.
Researchers found that 3 women with no apparent olfactory bulbs could identify, detect, and discriminate between odors as well as the average person. Their brains had normal structures outside the olfactory system, suggesting alternative glomeruli maps in other brain regions.
Research published in JNeurosci found that fetal brains possess adult-like networks by 20-40 weeks gestation. The study discovered a 61% overlap in motor, visual, auditory, and cognitive functions between fetal and adult connectomes.
A team of researchers has successfully mapped the local connectome in the cerebral cortex using 3D electron microscopy, producing a connectome about 26 times larger than previous ones. The study provides insights into the density and magnitude of neuronal networks in the brain.
The Blue Brain researchers have generated statistical instances of the micro-connectome of 10 million neurons, a model spanning five orders of magnitude and containing 88 billion synaptic connections. This model reveals a surprisingly complex structure at cellular resolution, tying together neurons in different regions and at opposite ...