Articles tagged with Dogs
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Researchers have identified the Jagged1 gene as a potential target for therapies to combat Duchenne muscular dystrophy, a genetic disorder characterized by progressive muscle degeneration. Increasing expression of JAG1 was shown to prevent the development of degenerative disease in zebrafish models.
Researchers found that injecting viruses carrying gene codes into the brain's ventricles can slow down Batten disease progression. The treatment improved symptoms and reduced damage caused by the disease in dogs with a similar disorder.
Researchers have developed a gene therapy approach that delays symptoms and extends lifespan in dogs with a comparable disease to Batten disease. The treatment involves delivering a working version of a gene to produce a key enzyme, resulting in striking clinical improvements and slowed disease progression.
Researchers have uncovered fossils of seven giant rat species in East Timor, with the largest weighing around 5 kilos. The discovery sheds light on human migration and its impact on ecosystems, as humans are believed to have driven the rats to extinction around 1,000 years ago.
A Swedish study found that children growing up with dogs have a lower risk of developing asthma, with a 15% reduction compared to those without dogs. The study analyzed over one million children and controlled for confounding factors.
A Johns Hopkins University research team has validated a theory on the brain's mechanism of learning, finding that 'eligibility traces' effectively tag neural synapses activated by stimuli, linking actions with rewards. This discovery could enhance teaching methods and lead to treatments for cognitive problems.
A multi-center trial found that therapy dogs can reduce anxiety levels and improve heart rate stability in children with cancer, as well as their parents. The study provides the first solid data on the psychosocial benefits of animal-assisted interventions for pediatric cancer patients.
Researchers successfully treated dogs with Duchenne Muscular Dystrophy using gene therapy, developing a miniature version of the dystrophin protein that protects all muscles. The treatment uses a common virus to deliver the gene, which has shown no symptoms in human bodies and is being planned for human clinical trials.
A study funded by the NIH has shown that gene therapy can preserve vision in dogs with late-stage retinitis pigmentosa. The treatment halted disease-associated cell death and preserved photoreceptor structure, improving visual performance under dim light conditions. Further research is needed to assess its safety and potential toxicity...
A Penn study shows that gene therapy can cure canine X-linked retinitis pigmentosa, even when treatment is started at mid- or late-stage disease. The treatment successfully halted photoreceptor cell loss and maintained vision in dogs for over three years.
Researchers are working on a multi-year project to help end Internet trickery by verifying true network owners and legitimate traffic paths. The team will deploy new protocols such as RPKI, updating router software and adding servers to the routing infrastructure.
A new study published in Nature Neuroscience found that individuals with autism spectrum disorder struggle to transfer learned knowledge to new contexts when trained through repetition. In contrast, breaks in repetition allow autistic individuals to learn efficiently and generalize, promoting broader concept understanding.
Researchers at MIT develop a new way of doing machine learning that enables semantically related concepts to reinforce each other. In experiments, their system outperformed conventional training methods in predicting Flickr tags and even when considering semantically similar tags.
Researchers characterized two genetic mutations linked to achromatopsia in dogs and found that they destabilized molecular channels essential to light signal transduction. The findings provide new insights into the molecular cause of blindness and present opportunities for conducting preclinical assessments of curative gene therapy.
Researchers discovered that genetic background affects mutations in lymphoma tumors across different dog breeds. The study identifies breed-specific genes and molecular subtypes, offering a unique model for understanding how genetics influence cancer development.
Kolltan Pharmaceuticals presents substantial tumor shrinkage with KTN0158 in dogs with spontaneous mast cell tumors, with favorable results from non-clinical toxicology studies. The company plans to file an IND for the drug candidate in oncology this year.
A study by Duke University analyzed data from 500 citizen scientists worldwide, who played the same games as researchers use in labs. The results showed that dogs rely on memory over sense of smell to solve problems. The dataset also revealed unique cognitive skills among dogs, including communication and problem-solving abilities.
A study by Dr. Raffaella Leoci and colleagues found that a specific ultrasound treatment regime can permanently sterilize male dogs without affecting testosterone levels. The method involves three applications of ultrasound at 1 MHz, lasting five minutes, and resulted in significant reduction in testicular volume and degeneration.
A team of researchers at Penn Vet has identified a form of congenital night blindness in dogs, which shares similarities with human forms of the condition. The discovery may lead to the development of gene therapy to correct the dysfunction in both humans and dogs.
The Parsemus Foundation has awarded the second round of the Timmy Prize to three winners who contributed substantial information on the use of Calchlorin nonsurgical sterilant. The data sharing prize aims to increase understanding of the method's effectiveness and refine its methodology.
A new study proposes a logical classification scheme for dogs and wolves, revealing that domestic dogs are descendants of two interbred species: an extinct Asian wild dog and the grey wolf. This finding has implications for wolf conservation, as some hybrids have evolved into full species.
A team of astronomers discovered 48 Dust Obscured Galaxies (DOGs) using the Hyper Suprime-Cam instrument on the Subaru Telescope. These rare galaxies are thought to harbor rapidly growing black holes, providing insights into the co-evolution of galaxies and supermassive black holes.
Researchers are exploring clinical trials on dogs with naturally occurring cancer to develop new treatments for humans. By studying the genetic basis of canine tumors, scientists hope to gain valuable insights into human cancer treatment.
Researchers from Penn and Baylor have precisely quantified the loss of insulin-producing beta cells in dogs with diabetes, revealing a key similarity with human type I diabetes. The study also identifies features unique to canine diabetes, highlighting potential insights into treating human patients.
Researchers at the University of Missouri found that resveratrol simultaneously increases and decreases dog's immune systems, leading to mixed signals. The study aims to better understand how this chemical affects human diseases, potentially leading to valuable treatments like cancer therapy.
Dogs evolved to pursue-pounce predators in response to climate change, shifting from ambushing to endurance running, according to a new fossil study. The research suggests that predators adapt to changing habitats rather than their prey's anatomy.
A new study by an international team of scientists found that competition from cats drove the extinction of many ancient dog species. The researchers analyzed over 2000 fossils and discovered that felids had a deadly impact on the diversity of the dog family, contributing to the demise of up to 40 species.
Researchers investigated dog food processing methods to combat pet obesity, finding that particle size affects digestibility. Maize and sorghum-based diets required coarser grinding for optimal gelatinization, whereas rice-based diets were more easily digested regardless of particle size.
A recent study has identified a face-selective region in the temporal cortex of dogs, which responds significantly to human and dog faces. The research suggests that this ability is hard-wired through cognitive evolution and may help explain dogs' sensitivity to human social cues.
Researchers identified three novel candidate genes, KIRREL3 and SLIT1, involved in immune cell development, and SERPINA9 expressed exclusively at the germinal center where B-cells produce IgA. A new method for analyzing complex traits was also developed to facilitate robust genome-wide association studies (GWAS) in dogs.
A new study finds that a moderate amount of stress stimulates mellow dogs, while hyperactive dogs perform poorly under increased stimulation. Researchers tested pet and assistance dogs, finding that their baseline temperament plays a crucial role in determining optimal stress levels.
Researchers describe skull, skeleton, and dental replacement of Tiarajudens eccentricus, a Brazilian species with remarkable features. The discovery reveals that head-butting and canine display during male-male combat were already present in mammals 270 million years ago.
Research published in Veterinary Record found that one in four UK show dogs competing at Crufts was overweight, despite breed standards emphasizing ideal condition. The study suggests that widespread online exposure of show dog images may be normalizing canine obesity.
Researchers at the University of Liverpool found that up to 26% of show dogs, particularly pugs, Basset hounds, and Labradors, are overweight due to their breeding history for physical activity. The team graded body condition and found significant health issues such as arthritis, diabetes, and respiratory diseases in obese dogs.
Children learn general facts about broad categories effortlessly and may struggle to recognize when they learn something new. This 'knew-it-all-along' illusion suggests that kids' minds absorb information about categories more readily than specifics.
Saber-toothed cat canines took years to grow and fully emerged later in life compared to living relatives. Researchers used a novel technique to calculate the eruption rates of their teeth.
New research on Smilodon fatalis reveals that the saber-toothed cat's permanent upper canines didn't fully develop until about three years of age. The growth rate was double that of an African lion's teeth, at 6 millimeters per month.
Recent changes to EU regulations have led to an increase in imported pets from Eastern Europe, where rabies is endemic, raising concerns about the effectiveness of current checks. The study found that many stray and rescue dogs had low antibody levels against rabies, suggesting potential risks for these animals.
Researchers found that when people perceive more variety in a product's usage situations, they like the product less. Lower variety situations led to customers feeling they were getting value from their sneakers, while higher variety situations made them feel they used the sneakers less often.
Researchers are using pet dogs with naturally occurring tumors to test new cancer drugs, which could lead to innovative therapies for both humans and animals. The dogs' physiological similarities to humans and conserved genetics between some dog and human cancers make them an ideal model for studying new treatments.
Researchers have discovered that starfish can remove deeply embedded foreign objects from their bodies by squeezing them out through the skin at the arm tips. This unique ability allows for quick healing and has implications for understanding animal physiology.
Researchers investigated how training affects dogs' ability to follow human gaze. They found that formal training and short-term training decrease dogs' gaze following performance. In contrast, aging does not significantly affect this ability.
Researchers found a 35,000-year-old wolf bone in Siberia that reveals the most recent common ancestor of modern wolves and dogs. The discovery sheds light on the early origins of dog domestication, with implications for our understanding of human-wolf relationships.
A study published in Journal of Pediatric Surgery highlights the risks of dog bites, particularly from family dogs. The research found that over 50% of dog bite injuries treated at a children's hospital came from immediate family members.
A new study by University of Georgia researchers shows that CEOs have a substantial influence on company performance, accounting for around 25% of profits. This increased impact is attributed to advancements in technology and changes in compensation packages, which provide strong incentives for CEOs to make strategic decisions.
A new analysis of archived calls from North Atlantic right whales reveals distinctive traits that might be used to identify and track individuals. The researchers found that a combination of variables, including call duration and fundamental frequency change, could distinguish between upcalls of individual whales.
As the global population is projected to reach 10 billion by 2050, robotic pets are becoming increasingly popular, offering alternatives for those who cannot have live pets. However, concerns arise about the ethics of relying on robots for companionship and potential impacts on human relationships with real animals.
A multi-year contraceptive injection is being developed to extend surgical TNR efforts, offering a potential solution to reach more feral cats. The project aims to provide safe, effective, and affordable non-surgical fertility control for cats worldwide.
The Calchlorin neuter shot has been shown to be safe and effective in both dogs and cats, providing an affordable solution to pet overpopulation. The injection eliminates the need for surgical sterilization, reducing health and welfare concerns globally.
Researchers challenge previous convention that males were much larger than females in the early hominid species Australopithecus afarensis. The study uses Lucy and Kadanuumuu as templates to determine size variation and finds moderate levels of sexual dimorphism within human-like species
Researchers focus on olfactory and cognitive optimization to improve canines' scent recognition and memory. The goal is to expand their recognition of odors within diverse elements and in what ratios, as well as determine how long they retain scent memory.
A new library of authenticated canine cancer cell lines, FACC-29, has been established to aid in research and drug development. The panel includes 29 cell lines from various cancers, allowing researchers to test new treatments and predict responses.
A breakthrough study discovered a novel neurodegenerative disease in Lagotto Romagnolo dogs caused by an ATG4D gene mutation. The research sheds light on the function of neurons and may aid in developing treatments for neurodegenerative disorders, as similar mutations have been linked to human diseases.
A global study on canine rabies found that 160 people die daily from the disease, with annual economic losses totaling $8.6 billion. Collaboration between human and animal health sectors is essential to eliminate rabies, with vaccination of dogs being the most cost-effective way to prevent the disease.
A study found that some dogs can mount an immune response to human norovirus, suggesting they may be infected. However, the risk of canine infection and transmission to humans is unclear.
At least 30 dogs in England have died from a mysterious kidney disease, with evidence found in 15 breeds including English springer spaniel, Labrador retriever and cocker spaniel. The disease is believed to be Alabama rot, which causes skin lesions and kidney failure.
Breeding dogs solely based on DNA tests can increase inbreeding and reduce genetic diversity, experts warn. A combined approach of DNA analysis, health screening, and pedigree information is necessary to minimize inherited diseases and improve the health of pedigree lines.
A new cancer drug called PAC-1, which targets cancer cells by restoring an enzyme's activity, is now entering phase I clinical trials in humans. The drug was first tested in pet dogs with spontaneously occurring cancers and showed promising results.
A study published in Veterinary and Comparative Oncology reveals an association between frizzled-6 protein expression and more aggressive behavior in canine bone cancer. The findings may provide a new pathway for tumor formation and improve outcomes for dogs with the disease.
A global survey has found that most countries where rabies is common lack effective reporting systems, making it difficult to control the disease. Accurate data is crucial for implementing vaccination programs and preventing further outbreaks.