Articles tagged with Liver
A study presented at Digestive Disease Week found that nearly 40% of TikTok posts about liver disease contain false or misleading information. Inaccurate claims often push fad diets, detox drinks, and herbal remedies as cures, with little engagement compared to accurate posts.
Researchers found that heavy alcohol use and the presence of metabolic syndrome were associated with a higher risk for advanced liver disease. The study suggests an increasing interaction effect between MetS, heavy alcohol use, and a recent surge in alcoholic liver disease-related mortality.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Researchers at West Virginia University found that bariatric surgery significantly reduces the risk of major cardiovascular events and death in patients with NAFLD. The study included 9,374 adult patients with NAFLD and obesity, who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy.
A new study suggests that the US liver allocation policy remains biased towards certain regions, with a customized approach to equalize supply-to-demand ratios being recommended. The researchers developed a model that accurately predicts the change in a patient's organ-offer acceptance probability due to changes in policy.
A comprehensive study found that wild boar liver can be used as a bioindicator for PFAS contamination in the environment, detecting hot-spots in regions with elevated PFAS levels. The researchers discovered that PFAS concentrations are highest in areas where industrial activities and agricultural practices have led to contamination.
A recent study by Osaka Metropolitan University researchers found that the Japanese diet pattern, rich in soy products, seafood, and seaweed, inhibits liver fibrosis progression. High muscle mass, also associated with this diet, shows a lower degree of liver fibrosis progression.
Alcohol consumption increased substantially across US during COVID-19 pandemic, particularly among American Indian and Alaska Native populations, leading to a six-fold increase in deaths from alcohol-associated liver disease compared to white people. The study highlights the need for urgent action by public policy leaders to address th...
Researchers have discovered that manipulating Yes-associated protein (YAP) expression in liver progenitor cells can improve their ability to regenerate and repair liver tissue. This could lead to new treatments for chronic liver diseases.
A team of researchers from Indiana University School of Medicine has identified Pyruvate dehydrogenase kinase 4 (PDK4) as a crucial mediator of alcohol-induced liver injury. PDK4 plays a key role in the formation of calcium channels at the ER-mitochondria interface, leading to mitochondrial dysfunction and accumulation of calcium ions.
Researchers at UC Davis School of Veterinary Medicine discovered that tissue resident memory cells are crucial for inducing a powerful immune response against Salmonella. Molecules like interleukin-1 and 2 enhance the formation of these cells in the liver, providing a rapid-response force.
Jeong Min Lee, KSR President and professor at Seoul National University Hospital, is honored with ARRS membership. He has published over 470 scientific articles and serves on the editorial board of several publications.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
A genetically engineered probiotic has been shown to blunt the ill effects of alcohol in mice by reducing alcohol absorption and prolonging tolerance. The treatment also shortened recovery time after alcohol exposure and reduced liver damage. Further research is needed to confirm its effectiveness in humans.
Researchers created the integrated-gut-liver-on-a-chip platform to examine how gut and liver cells interact, particularly in relation to non-alcoholic fatty liver disease. The study showed significant changes in gene expression and DNA damage when free fatty acids were introduced, leading to cell death similar to severe cases of NAFLD.
A study published in the Journal of Internal Medicine found that patients with liver disease who took the drug ursodeoxycholic acid had a 46% lower odds of being infected with SARS-CoV-2. This was associated with reduced symptoms and severity of COVID-19.
A study reveals that neutrophils destroy liver cells undergoing apoptosis by burrowing into them, contradicting previous beliefs about their role in immune responses. The findings also suggest that a lack of neutrophils may contribute to human autoimmune liver disease.
A new study by Cedars-Sinai investigators found that ChatGPT can provide easy-to-understand information about basic knowledge, lifestyle, and treatments for cirrhosis and liver cancer. The AI system has the potential to play a role in clinical practice and empower patients with knowledge about their disease.
A study published in Journal of Hepatology found that some patients with chronic hepatitis B can achieve sustained immune control by discontinuing antiviral therapy after four years. This suggests a potential cure for the disease, which affects an estimated 350 million people worldwide.
Researchers found that after 96 weeks, some patients achieved loss of detectable HBsAg and reduced liver inflammation levels, indicating functional cure. The study suggests that discontinuing long-term antiviral therapy may be more effective than continuing it for certain patients.
Researchers link acute severe hepatitis in children to co-infections with multiple common viruses, including AAV2. The study suggests that getting more than one infection may have made children vulnerable to severe hepatitis.
Scientists have identified an autoinflammatory disease called Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI) linked to mutations in the LYN gene. The research suggests that Lyn kinase may be a potential therapeutic target for drugs treating non-syndromic small vessel vasculitis and inflammation-induced liver fibrosis.
Cancer cells have been found to employ a strategy to evade the immune system's killer T cells by interacting with myeloid cells and suppressing type 1 interferon production. This natural pathway is crucial for recruiting killer T cells to combat cancer spread. Researchers hope to develop new therapeutic approaches, such as forcing tumo...
A retrospective analysis of blood samples and medical records from 270 patients found that CPS1 levels help predict which patients survive or die without a transplant. The study suggests that CPS1 could be a valuable clinical management tool for acetaminophen and other causes of liver failure.
A recent study found that the mitochondrial antioxidant MitoQ can reverse the detrimental effects of HIV and antiretroviral therapy on organs such as the brain, heart, and liver. The researchers used humanized mice infected with HIV and treated them with MitoQ for three months.
A bacterial molecule, ARBM101, has been found to efficiently lower liver copper levels in a rat model, offering a promising new therapeutic option for Wilson's disease. The treatment approach involves weekly applications followed by month-long breaks, significantly shortening the therapy period.
Researchers analyzed DNA from Beethoven's hair to shed light on his chronic health problems, including progressive hearing loss. They found genetic risk factors for liver disease and evidence of a hepatitis B virus infection, which likely contributed to his death.
The study sheds light on Beethoven's health problems, including progressive hearing loss and chronic gastrointestinal complaints. Genetic risk factors for liver disease were identified, and evidence of a hepatitis B virus infection was found in the composer's final months.
Researchers from Kyushu University found that the single mechanosensitive protein VGLL3 induces fibrosis, thickening and scarring tissue. The study suggests targeting this protein could lead to new treatments against fibrosis.
A new surgical therapy has proven effective in treating melanoma in the eye that has spread to the liver, with 40% of patients experiencing tumor shrinkage, and offers a promising alternative to current treatments.
Three real-world studies published in the Journal of Hepatology and JHEP Reports demonstrate that bulevirtide is well-tolerated and safe for treating chronic hepatitis delta. Long-term suppressive therapy with BLV monotherapy has the potential to reduce viral replication and improve liver function in difficult-to-treat patients.
Researchers at Houston Methodist discovered a way to reverse infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein. The study showed that this protein, called serum opacity factor, lowered HDL cholesterol levels by over 40% in three hours and restored fertility in the mice.
Researchers developed a deep learning-based AI model to automate cirrhosis identification using large amounts of data from EHRs. The model successfully identified patients with cirrhosis with a precision of 97%, offering potential for early diagnosis and improved management of the disease.
A study from George Mason University found elevated insulin and hemoglobin A1C levels in early elementary-aged Latino youth with obesity, a risk factor for cardiometabolic diseases. The research aims to identify at-risk children and implement interventions earlier to mitigate the effects of childhood obesity.
Researchers found that long-term antibiotic use during adolescence disrupts the healthy gut microbiome, leading to changes in liver metabolism that promotes central fat accumulation. The study suggests that antibiotic treatment may have lasting detrimental effects on liver metabolism and promote adiposity.
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
Researchers found that COVID-19 infections are linked to an increased risk of developing liver problems, acute pancreatitis, and other GI disorders. The study analyzed over 14 million medical records and estimated that SARS-CoV-2 infections have contributed to over 6 million new cases of GI disorders in the US.
A US FDA mandate to limit acetaminophen dosage in pills combining it with opioids significantly reduced hospitalizations and acute liver failure cases. Researchers found a persistent decline in yearly rates of these cases after the mandate was implemented in 2014.
A hormone called FGF21 protects mice from ethanol-induced loss of balance and righting reflex by activating a specific part of the brain that controls alertness. The study reveals that higher FGF21 concentrations can dramatically accelerate recovery from intoxication.
A new study by Weill Cornell Medicine found that the FDA's mandate to limit opioid-acetaminophen combinations resulted in significant reductions in liver injuries. The mandate, implemented in 2014, limited the dosage of acetaminophen in these drugs, leading to a decline in hospitalizations and acute liver failure cases.
A new study shows that patients with liver cirrhosis have a lower immune response to COVID-19 vaccines, but this does not affect the vaccines' effectiveness. Age, type of vaccine, and viral hepatitis etiology also play a role in immune responses.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers created human organoid models of fatty liver disease to shed light on drug responses and disease biology. The models identified a common mechanism for effective drugs that block lipid generation from sugars, suggesting personalized medicine applications.
A recent study published in JHEP Reports found that individuals with low thigh muscle volume and high muscle fat infiltration had an increased mortality risk. The researchers also discovered that poor muscle health was not associated with a worsened prognosis in people with fatty liver disease.
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
Researchers at Washington State University found that CBD inhibits a key enzyme for nicotine metabolism, slowing down its effects and allowing smokers to wait before feeling the urge to smoke. The study suggests that CBD could be a useful tool in reducing harm from smoking and quitting nicotine addiction.
Researchers have identified a blood protein snapshot that documents changes in patients with severe liver disease caused by heavy drinking, potentially leading to a simple blood test for diagnosis and treatment monitoring.
A mutant SRSF1 gene may cause severe nonalcoholic fatty liver disease (NASH), researchers have found. Mice lacking the gene develop all three hallmarks of NASH: excess fat, inflammation, and scarring in the liver. The study suggests that DNA damage in liver cells triggers this pathology, highlighting the need to protect the genome.
A recent study published in the British Journal of Surgery found that patients undergoing liver surgery fare better in higher-volume hospitals. In-hospital mortality rates were lower in these facilities, with a rate of 2.8%, compared to 3% in lower-volume hospitals.
A study identified an antibody candidate that blocks the protein VEGF-B, presenting a possible therapeutic option for fatty liver disease. The treatment method involves keeping fatty acids in adipose tissue to prevent liver accumulation.
A team of researchers from MedUni Vienna has identified the polymeric immunoglobulin receptor (pIgR) as a key player in protecting against alcohol-induced liver damage. The study found that pIgR-mediated secretion of antibodies in the intestines helps to prevent bacterial translocation and inflammation in the liver.
A new study finds that dietary choline deficiency can cause profound negative effects on the body, including organ damage and changes in brain pathology associated with Alzheimer's disease. The research highlights the importance of adequate choline intake to protect against neurodegeneration and improve overall health.
A large cohort study found that long-term low-dose hydroxychloroquine use is associated with a low risk of developing retinopathy, while higher doses increase the risk. Regular screening can identify the issue at an early stage.
Researchers found that inhibiting HSF1 signaling reduces hepatoblastoma growth and induces apoptosis, suggesting it as a viable pharmacologic target. The study also identified HSF1's role in tumor aggressiveness and its potential association with mortality.
A new study by the University of Coimbra found that higher coffee intake is associated with reduced NAFLD severity in overweight people with T2D. Caffeine and polyphenols in coffee may help alleviate liver fibrosis and improve glucose homeostasis.
A study published in Journal of Hepatology found that efficient priming of HBV-specific CD4 T cells is crucial for the success of therapeutic hepatitis B vaccination. The researchers developed a novel heterologous prime-boost vaccine, TherVacB, which induced antiviral efficacy in preclinical mouse models.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
African patients with chronic hepatitis B face limited access to treatment due to inadequate guidelines. Researchers propose lower treatment thresholds and better adapted guidelines for the African population.
Researchers at USC Keck School of Medicine found that liver cancer cells hijack circadian clock proteins to replicate and spread. Inhibiting these proteins can prevent cancer cell multiplication and potentially improve outcomes for patients with liver cancer.
Researchers at Duke University discovered that glassfrogs store nearly 90% of their circulating red blood cells in their liver when they want to be transparent. This helps them blend in with their surroundings and avoid predation during the day.