Articles tagged with Testicles
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The COVID-19 virus replicates using cellular machinery responsible for testosterone production, altering lipid metabolism and potentially leading to lower testosterone levels. This study reveals the mechanism by which SARS-CoV-2 targets testicular cells, offering insights into male vulnerability to COVID-19.
A new Zika virus vaccine developed by Brazilian researchers has been shown to be safe and effective in tests with mice, inducing an immune response and protecting against brain and testicular damage. The vaccine uses a technology known as 'virus-like particles' (VLPs) without genetic material from the pathogen.
A study on hybrid fish found that allelic genes and testis-specific genes play a crucial role in maintaining fertility, while orphan genes facilitate adaptation to new genetic environments. The research used long-read sequencing and Hi-C technology to construct high-quality genomes for reciprocal hybrids.
Researchers found that it took 13 years for cervical cancer screenings to halve among women over 65, and even longer for prostate cancer screenings to decrease significantly. The study emphasizes the need for more effective tracking mechanisms to identify and reduce inappropriate screening practices.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
This study reveals NAT10 is crucial for spermatogonial proliferation and differentiation. In Nat10-deficient mice, infertility occurs with reduced testicular sizes, germ cell depletion, and a loss of spermatogonial homeostasis.
Richard Willson, a University of Houston professor, has been elected Fellow of the Royal Society of Chemistry for his contributions to the chemical sciences. He has developed innovative methods to detect viruses and other biological threats using glow-in-the-dark nanoparticles.
A deficiency of TLE6 protein, associated with female infertility, was also linked to abnormal sperm morphology and reduced motility in male mice. The study suggests that TLE6 plays a crucial role in energy production in sperm cells.
Researchers at U of T mapped the spatial distribution of long non-coding RNAs in testes, finding higher levels than previously estimated. The study suggests lncRNAs play a more significant role in male reproduction and may influence sperm development and behavior.
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
Researchers found SARS-CoV-2 in male reproductive cells even when PCR testing failed, revealing a prolonged infection period of up to 90 days. The virus can remain in sperm for 110 days, reducing semen quality and raising concerns for natural conception and assisted reproduction.
A University at Buffalo-led research team has found that the same genes whose mutations gave rise to a low functioning male gorilla reproductive system may also be responsible for human male infertility. Researchers identified 109 reproductive-related gorilla genes that are often mutated when present in infertile men.
Researchers found that altering a male mouse's gut microbiota increases the probability of low birth weight and premature death in their offspring. The study suggests a 'gut-germline axis' exists, connecting the gut microbiota to the germline and potentially influencing inherited traits.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
A new study from Uppsala University found that women with germ cell tumors have a significantly lower five-year survival rate (85.2%) compared to men (98.2%). The researchers suggest that concentrating patients in fewer hospitals and using treatment strategies for testicular cancer could improve survival rates and reduce side effects.
The team successfully created 'laboratory testicles' that closely simulate a natural testicle, allowing for the potential production of sperm cells in the lab. The artificial testicles were cultured from immature testicular cells sampled from neonatal mice and showed signs of meiosis, a process in which gametes are produced.
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
A team of researchers has identified a key gene responsible for ovarian development in mice, shedding light on the early stages of sex determination. The -KTS variant of WT1 is essential for female gonad formation, regardless of XX or XY chromosomes, and may hold clues to understanding disorders of sex development.
New study finds that men who suffered from mild COVID-19 have lower sperm concentrations and motility even three months after recovery. The researchers believe that the virus may cause permanent damage to male fertility, leading to long-term decline in semen quality.
A new study found an association between lower extremity spasticity and cryptorchidism treatment in boys with cerebral palsy. Boys with more severe spasticity were especially likely to have had the surgery, suggesting a potential link between affected muscles and testicle development.
A research team at Leibniz-IZW identified molecular markers for testicular cell types in domestic cats and four wild feline species, allowing for the clear identification of Leydig and Sertoli cells, spermatogonia, and advanced germ cell stages. This breakthrough enables the maturation process of male germ cells in vitro.
A study published in Nature Communications reveals a small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility. The research team discovered that mice lacking NICOL were sterile, indicating its importance for the sperm-maturation pathway.
A new study found that overweight boys tend to have lower testicular volume, putting them at risk for infertility in adulthood. The research suggests that weight loss could help patients avoid infertility later in life.
A new study has confirmed that chronic THC use can negatively impact male reproductive health, including testicular function and sperm quality. Discontinuing use of THC for at least four months can partially restore these effects, providing a critical window for family planning and conception.
A study by Rockefeller University scientists found that older male fruit flies are more likely to pass mutations onto their offspring due to less efficient mutation repair mechanisms. This could have implications for inherited-disease risk in humans.
A new stem cell model allows researchers to study the earliest stages of sex determination in mice and humans, providing insights into Disorders of Sex Development (DSD). The model enables the creation of a 'mini testis' in a dish, which could lead to better understanding of DSD, infertility, and fertility restoration.
Heidelberg researchers decoded genetic regulation of sperm formation across various mammal species, including humans. The study revealed a time-related pattern of gene expression differences, highlighting the rapid evolution of spermatogenesis.
Researchers at Hokkaido University discovered a novel sex-determination mechanism in the Amami spiny rat, a species lacking the Y chromosome and Sry gene. The mechanism involves the upregulation of Sox9 gene on chromosome 3, induced by a new regulatory element similar to Enh14.
Scientists have detected monkeypox virus in the testes of macaques during acute infection and found preliminary evidence of persistent infection in two convalescent animals. The study highlights the potential for sexual transmission of the virus in humans, particularly in convalescent male patients.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A new study has discovered that rare pieces of genetic code can serve as another layer of control in the genome, essential for fertility and evolutionary innovation. Researchers found that certain tissues are more tolerant of diverse codons, particularly the testes, which may play a critical role in fertility.
Researchers found that frozen testicular tissue from rats can be reimplanted and produce viable sperm after over 20 years, but with reduced fertility. The study has important implications for treatment of boys with cancer and may provide a method to recover lost fertility.
Research reveals that older men with higher BMI display reduced reproductive health, particularly in terms of sperm cell production. The study also highlights the potential biomarkers for diagnosis of testis aging and directions for potential treatment.
A recent study suggests that severe COVID-19 may cause long-term damage to the testes, leading to reduced sperm count and quality. The virus's interaction with testicular cells and potential effects on fertility are being explored through an experimental framework.
A study published in Cell Reports Medicine reveals the molecular and cellular changes in testicular tissue of infertile men, identifying alterations in spermatogonial stem cell compartment. The research provides new insights into male infertility and prepares ground for better diagnosis.
Researchers developed magnetic, biodegradable nanomaterials that reduced the likelihood of mice fathering pups for at least 30 days. The nanoparticles were non-toxic to cells and gradually eliminated from the body.
A new study found that SARS-CoV-2 can infect the testes of infected hamsters, a finding with implications for men's health. The virus was detected in the testes of all infected hamsters during the first week but tapered off over time.
A new AI-based scoring model for testis images has been developed to assess patients with severe male infertility, simplifying the diagnosis process. The model achieved high accuracy in classifying histological images of the testis, with an average precision of 82.6% and recall of 60.96%, without requiring programming expertise.
A new study published in Scientific Reports found a link between geographical location and male reproductive health, with pollution levels varying by region. The researchers analyzed dog testes to identify correlations between environmental exposures and reproductive health.
A study found a significant increase in boys born with undescended testicles in France between 2002 and 2014. The researchers identified clusters of cases in areas with high levels of environmental pollution from industries such as coal mining and metal works.
A new marker of testicular cell capacity identified as a promising biological marker, INSL3, shows suppressed levels in former steroid users compared to never-users. Long-lasting impaired gonadal capacity found in previous anabolic steroid users, increasing risk of hypogonadism later in life.
A new study found that male fruit flies with the most impressive sexual ornamentation also have super sperm that can outcompete rivals in the post-mating fertilization game. The researchers discovered a strong link between the males' competitive success at passing on their genes even after a female fly has mated with other flies.
Research by Mariana Muñoz-Romo and colleagues found that male fringed-lipped bats produce larger, more pungent forearm crusts in males with higher testosterone levels and larger testes. These findings suggest that the size of the crust is linked to mating and reproduction.
Researchers have developed a protein delivery system that restored normal sperm development and allowed previously infertile mice to father pups. The treatment delivered a key protein called PIN1 directly to mouse testicles, repairing damaged reproductive cells and improving fertility.
Testicular tissue transplantation combined with retinoic acid administration successfully produces healthy offspring in mice, offering a potential method for preserving/recovering male fertility. The researchers' findings suggest that this approach may be effective in humans without adverse effects on pregnant mothers.
Researchers discovered a novel testicular luminal protein, NELL2, that triggers a chain of events maturing sperm and enabling motility in females. Sperm production occurs in the testis, then moves through the epididymis for maturation and storage.
Researchers identify NELL2, a testicular protein that travels through the epididymis to mature sperm and enable fertilization. The discovery sheds light on male infertility and offers new avenues for diagnostic and therapeutic research.
Researchers analyzed data from Chinese men who recently had COVID-19 and found no evidence of the virus in semen or testes. However, the study's limitations mean it cannot fully rule out the possibility of sexual transmission.
A study found that the endocannabinoid system is present in human testis tissue and may be involved in regulating sperm cell development. The system includes key components such as enzymes and receptors that degrade and interact with endocannabinoids, suggesting a potential role in reproductive function.
Researchers used fruit flies to study the emergence of new genes in the testes, finding 184 de novo genes that originate from scratch. These genes show complex patterns and are most active during the spermatocyte phase of sperm development, suggesting they play roles in maturing sperm cells.
Researchers found male cane toads have smaller testes at the invasion front due to prioritizing dispersal over sex. This leads to less investment in sperm production and more energy for traveling, allowing them to stay ahead of competitors.
A study found that estradiol hormone therapy helps strengthen brain connections in transgender women, particularly in the thalamus area. This can lead to improved symptoms like hot flashes and sensory perception.
Researchers have discovered that sperm DNA taken directly from the testicles of infertile men is as good as that of ejaculated sperm from fertile men, potentially opening a new way for treatment. This finding may explain a major cause of male infertility and could lead to improved fertility outcomes.
Researchers found that androsterone, a steroid hormone produced by the placenta, plays a crucial role in male genital development. The study also suggests that placental dysfunction can lead to disorders of male genital development.
Researchers discovered a novel mechanism for sperm stem cell number control, where cells migrate and compete for fibroblast growth factors (FGFs). This self-organized process regulates stem cell density in the testis, maintaining uniformity despite the absence of a canonical niche.
Researchers found that enhancers regulate the SOX9 gene, which is critical for male development. The study reveals that disruptions to these enhancers can lead to disorders of sex development.
Research has shed light on the mechanism of sexual transmission of Marburg virus, identifying persistent infection in seminiferous tubules and specialized cells called Sertoli cells. The study suggests that targeting immunosuppressive regulatory T cells may help clear Marburg virus from the testes, preventing sexual transmission.
A population-based cohort study found that boys with undescended testes had a 2.4 times increased risk of adult testicular cancer compared to unaffected boys, as well as a 20% lower chance of paternity and higher use of assisted reproductive technologies for infertility.
The study uses DNA sequence data to analyze the evolution of testes in mammals, finding that African species lack the testicular descent process due to non-functional genes. This suggests that the testicular descent process was ancestral and lost in these species.
The study analyzed 71 placental mammalian species and found that the genes RXFP2 and INSL3 were either lost or nonfunctional in four Afrotherian species, indicating a more recent origin of testicular retention. This suggests that molecular vestiges can be used to reconstruct evolutionary changes in body parts.