Articles tagged with Parasitic Diseases
A newly discovered protozoan parasite, Tritrichomonas musculis, has been found to protect mice from intestinal bacterial infections by activating the inflammasome in gut epithelial cells. This discovery highlights the importance of considering non-bacterial microorganisms in studying the microbiome.
Researchers have identified Zika virus in mosquito species other than Aedes aegypti, raising concerns about alternative transmission sources. However, studies show that Culex species mosquitoes are highly unlikely to transmit the infection to humans, highlighting the need for targeted mosquito control efforts.
Researchers at the University of Georgia have discovered a new drug that can be administered orally to treat human African trypanosomiasis, a parasitic disease affecting rural communities in sub-Saharan Africa. The study's lead author hopes to accelerate development of new treatments for this complex disease.
Researchers found that resistant mice have higher levels of reactive oxygen species proteins and a more rapid tissue repair response in the liver. This suggests that highly oxidative conditions may be key to murine resistance to Ascaris infection.
Scientists have identified a clear distinction between two strains of mice susceptible to Ascaris infection, with the resistant strain showing an earlier immune response and more rapid tissue repair. The study suggests manipulating hepatic ROS levels may confer resistance to Ascaris in susceptible mice.
Researchers discovered that metacyclic trypanosomes are highly infectious and can colonize the skin of mice, leading to systemic infection. A subpopulation of parasites stays in the skin for at least 7 days, multiplying and interacting with local fat cells and collagen fibers.
Researchers discovered TNF's mechanism to protect against intracellular pathogens like Leishmania major. By inhibiting arginase 1, TNF increases nitric oxide production, which suppresses the pathogens, providing a plausible explanation for increased infection susceptibility during anti-TNF treatments.
Researchers at Johns Hopkins have found that emetine, an old drug once used to treat amebiasis, can also halt the replication of cytomegalovirus (CMV), a herpesvirus causing serious disease in immunocompromised individuals. Lower concentrations and less frequent doses of emetine may be effective for CMV inhibition.
Researchers have created summative world maps of mammal-to-human diseases, revealing understudied patterns and insights into zoonotic disease emergence. The maps show that hotspots of zoonotic diseases don't match hotspots of biodiversity closely, with more zoonotic hosts in the tropics but more zoonotic diseases in temperate regions.
A novel combination therapy has been found to clear the infection and prevent recurrence of babesiosis up to 122 days after treatment. The study used a mouse model to test the efficacy of atovaquone and ELQ-334, two drugs that work together to attack the parasite's target enzyme.
Researchers from Tomsk State University have discovered that bats can act as transmitters of infections, including those caused by bacteria and nematodes. The study found gamasid mites in bat samples, which are common among rodents, indicating close contact between the two species.
Researchers found that human activities drive disease distributions at local scales for diseases like West Nile virus and Lyme disease, while climate change impacts regional scales. The study highlights the importance of considering multiple spatial scales to understand human ecological impacts on biodiversity and disease emergence.
A new study published in PLOS Neglected Tropical Diseases found that nearly three-quarters of poor children in a Bangladeshi slum were infected with Cryptosporidium, leading to stunted growth and malnutrition. The parasite can cause permanent damage to the intestines' ability to absorb nutrients, even if symptoms are not present.
Researchers found high levels of varroa mites and fungal parasites, with severe correlations to viral diseases like Chronic Bee Paralysis Virus. The study provides crucial baseline data for tracking future trends in honey bee health.
An intervention at a Canadian acute care facility screened and isolated asymptomatic C. difficile carriers, leading to a 50% decrease in health-care associated infections. The study estimated that the intervention prevented approximately 63 cases, suggesting a cost-effective strategy for preventing C. difficile infection.
A study found that infected brine shrimp were more resistant to arsenic toxicity, with increased fat-containing droplets and changes in oxidative stress markers. The researchers suggest that parasite infection may protect the shrimp against pollutants through a mechanism known as 'survival of the fattest',
A recent study published in PLOS Pathogens found that nitric oxide plays a protective role in the blood-brain barrier, reducing parasite invasion and inflammation. The researchers discovered that NO inhibits inflammatory molecules, such as TNF and MMP-9, which can lead to BBB damage.
A new Penn study reveals that fish induce production of a specific antibody, IgT, in response to pathogen exposure on their gills. The researchers found that IgT coats the microbiota in the gills, helping control the community of friendly microbes.
Researchers have developed a method to make mosquitoes resistant to arboviruses like Dengue and Zika by introducing two strains of Wolbachia parasite. The superinfected mosquitoes showed improved virus inhibition and reduced transmission, making it a potential tool to combat mosquito-borne diseases.
Researchers found that climate change increases soil-transmitted parasites in pastures, leading to increased infection risk. The study also showed that host immune response affects the severity of infection, with older individuals carrying more severe infections when immune response is ineffective.
Researchers from the University of Pennsylvania School of Veterinary Medicine have identified how the parasite <em>Toxoplasma gondii</em> infects the brain by tracking its movement and reproduction in living tissues. The study provides insights into treatment strategies to combat the parasite, which can be life-threatening for people w...
Researchers used whole-transcriptome sequencing to screen for blood-borne diseases in wild lemurs and found several strains of parasites similar to those causing Lyme disease. The approach could pave the way for earlier detection of future outbreaks of zoonotic diseases that move between animals and people.
A team of scientists has identified a unique immune mechanism, microptosis, that targets and kills intracellular parasites. This process involves the release of three proteins: perforin, granulysin, and granzymes, which work together to induce programmed cell death in both the parasite and infected host cells.
A study found that frozen fecal transplantation (FMT) was noninferior to fresh FMT in treating recurrent or refractory C. difficile infections, indicating its potential as a reasonable treatment option. The use of frozen FMT offered advantages such as reduced cost and increased availability.
Researchers discovered how a common parasite, Toxoplasma, hijacks host cells to store food for decades, altering host behavior. The findings could lead to vaccines and drugs to protect against the parasite's serious risks, including miscarriage and birth defects.
The Bill and Melinda Gates Foundation has granted $478,000 to researchers at the University of Massachusetts Amherst to develop a vaccine against trypanosomiasis, a fatal disease of cattle in sub-Saharan Africa. The vaccine aims to enhance the immune response of infected hosts to control the disease.
A study found that postoperative Clostridium difficile infection rates were 0.4% per year among over 468,000 surgical procedures at the Veterans Health Administration. Patients with CDI had higher rates of postoperative illness, death, and longer hospital stays.
Research by UCSB anthropologists found that parasitic intestinal worms can impact the timing of pregnancies among Tsimane women, with hookworm infection increasing intervals between births and roundworm infection shortening them. This study suggests helminth infections may affect demographic patterns in developing populations.
A new study suggests parasitic worms can impact human reproduction rates, with roundworms increasing childbearing by up to two more children than uninfected women, while hookworms decrease it by up to three fewer children.
The Centers for Disease Control and Prevention (CDC) emphasizes the importance of antibiotic stewardship in reducing Clostridium difficile infection rates. Key components include careful prescribing, early diagnosis, isolation of infected patients, and adequate cleaning of the patient care environment.
A recent study has found that treating a parasitic worm infection can reduce lung damage and susceptibility to tuberculosis in mice. The research suggests that using inexpensive anti-parasitic drugs could be an effective way to prevent TB in areas where both infections are common.
Scientists have identified the poly(A) tail as a crucial component in LINE-1 retrotransposition, a process that can cause genetic mutations and diseases. Without the tail, the parasite's jumping ability is significantly impaired, offering new strategies for inhibiting its movement.
Researchers at McGill University Health Centre uncover mechanism behind Leishmania parasite's infectious life cycle, revealing exosomes play key role in boosting infection. The study provides potential vaccine targets and diagnostic tools for Leishmania and other parasitic diseases.
The study found that fungi change the nutritional and medicinal chemistry of milkweed leaves, affecting monarch caterpillars' susceptibility to parasitic infections. The dosage and nutrient phosphorous levels also play crucial roles in determining the outcome.
New study reveals blue crabs can survive at oxygen levels as low as 1.3mg/L, contrary to previous findings. Rising water temperatures exacerbate the effects of hypoxia on blue crabs, threatening their populations and management.
Researchers successfully silenced genes in human cells to induce immunity against the parasitic disease caused by E. histolytica, which affects 50 million people worldwide. The study identified key genes involved in managing potassium flow into and out of human cells, paving the way for new drug targets.
A new study from NIMBioS reveals that contact rates and competition play crucial roles in determining the risk of parasitic disease outbreaks in animal communities. The research found that high contact rates and strong competition can amplify parasite fitness, increasing the likelihood of disease transmission.
Researchers discovered a way to create cell immunity to the E. histolytica parasite by silencing specific genes involved in potassium transport. This approach could lead to the development of new drugs targeting the parasite and preventing deadly diseases.
Researchers demonstrate how community ecology can provide new analytical tools for understanding diseases and their impacts on multiple hosts and vectors. The approach highlights the need for a broad contextual understanding of diseases and identifies strategies such as managing symbiotic microbial communities and preserving biodiversity.
Researchers found four common bee parasites dispersed via flowers, causing diseases such as lethargy, dysentery, and colony collapse. The study suggests planting more flowers can provide bees with options, reducing parasite spread.
Researchers discovered that memory CD4+ T cells linger in the skin for up to a year after resolving Leishmania infection. These skin-resident memory cells help reduce parasite numbers during secondary infections by recruiting blood-borne memory cells, suggesting a new approach to developing anti-Leishmania vaccines.
A study found that intestinal parasites, such as Giardia, were the most commonly found parasite in cats across Austria, with over 56% testing positive. The parasites can be transmitted through contact with infected cat faeces, and households with multiple cats are at higher risk.
Researchers at the University of Georgia have developed new tools to study and genetically manipulate cryptosporidium, a major cause of life-threatening diarrhea in infants and toddlers. The breakthrough techniques will help find new treatments and vaccines for the parasite.
Researchers tracked individual bees to study the effect of a low-dose gut parasite, nosema, on their behavior. Infected bees were found to be less efficient foragers, carrying less pollen and dying younger.
Researchers found worm infection in parent birds or nestlings impacts most on others in their family group, affecting survival rates and breeding success. The study's findings could have important implications for the conservation of wild animals under threat.
A recent case study reveals that infection preventionists spend an average of five hours and eight minutes per day collecting and reporting hospital infection data, leaving little time for hands-on patient care. This finding highlights the need for adequate staffing and resources to ensure effective infection control practices.
German researchers uncover a novel mechanism by which the innate immune system combats rotavirus infection through the interaction between interferon-lambda and interleukin-22. This discovery has implications for the design of future immunotherapy concepts, including the treatment of chronic viral infections such as hepatitis.
Researchers at WSU Vancouver found that hunter-gatherer cannabis users had significantly lower rates of intestinal worm infection compared to non-users. The study suggests that the Aka people may be unconsciously using cannabis as a form of 'medical marijuana' to ward off parasites.
A study found that 67% of male Aka foragers in the Congo Basin used cannabis, protecting against parasitic worm infections, which are a major health problem in developing world populations. The researchers also suggest that tobacco use may have similar protective effects.
A study found that physical contact during social grooming increases the risk of gastrointestinal parasites in brown spider monkeys. The researchers analyzed data from 12 individual monkeys and found a strong correlation between grooming interactions and parasite infections, particularly with roundworms Strongyloides and Trichostrongylus.
A study by Penn State researchers found that wolves in packs with at least five healthy members have a similar death rate to their companions when infected with mange. This suggests that social living can help individuals cope with various chronic conditions by providing supportive care and resources.
A new study uses machine learning to pinpoint rodent species effective disease reservoirs and identify geographic hotspots vulnerable to emerging diseases. The research provides a basis for targeted surveillance efforts, highlighting the importance of collaboration with experts on the ground.
A new study by Loyola researchers shows that giving non-toxic C. difficile spores orally can stop repeated bouts of the infection, which occurs in 25-30% of patients. The treatment reduces recurrence rates to as low as 5%, offering real hope for those debilitated by recurring bouts.
Rates of C. difficile infection were highest in the Northeast region and during the spring season over the last decade, according to a study published in the American Journal of Infection Control. The study found that adults and older adults followed overall trends, with pediatric CDI being highest in winter.
Researchers found that bumblebees infected with the Crithidia bombi parasite were more likely to consume nicotine-laced nectar, delaying parasite progression. However, consuming nicotine had negative effects, suppressing the appetite of infected bees and reducing healthy bee lifespan.
A team of scientists from the University of Manchester has identified a new protein called Mbd2 that plays a key role in controlling inflammation during worm infections and allergies. By understanding how this protein functions, researchers hope to develop targeted therapies for these conditions.
Researchers developed a lab-on-a-chip device that can diagnose Cryptosporidium infections in as little as 10 minutes, offering potential improvements in treatment outcomes for rural areas in China. The device is easy to use and has diagnostic capabilities comparable to current standards, with the potential to reduce costs and timeframe.
Research demonstrates dynamic nature of fecal microbiota in FMT donors and recipients, with healthy changes sustained for up to 21 weeks after transplant. The study's findings have implications for the regulation of treatment and could influence the use of fecal transplants for a range of diseases associated with microbial imbalance.
A study by University of Georgia ecologists found that supplemental feeding can affect the spread of infectious diseases in wildlife, with some pathogens increasing transmission and others reducing it. The study provides practical suggestions for wildlife disease management and a roadmap for future research.
A study published in American Journal of Infection Control found that patients with C. difficile infection are twice as likely to be readmitted to the hospital, with significantly longer hospital stays. Researchers recommend improving antibiotic stewardship and infection control measures to prevent CDI rates.