Articles tagged with Cardiac Function
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
Researchers at Sahmyook University repurposed meclofenamate to treat abnormal respiratory mucus, reducing mucin secretion and characteristics of respiratory mucus. This study offers an alternative solution for patients with respiratory diseases, saving time and costs compared to conventional drug development strategies.
Researchers at EMBL Heidelberg discovered that mutations in the RBM20 gene cause familial DCM by disrupting normal RNA splicing, leading to detrimental cytoplasmic granules. Targeted gene editing via CRISPR-Cas9 and restoring nuclear localisation of RBM20 could improve therapy options for patients.
Rice University scientists use light-activated molecular machines to trigger intercellular calcium signals, revealing a powerful new strategy for controlling cellular activity. The technology could lead to improved treatments for people with heart problems, digestive issues, and more.
Researchers developed a soft, wireless implant that monitors the heart and delivers electrical stimuli to stop atrial fibrillation. The device dissolves harmlessly in the body after a clinically relevant period, reducing healthcare costs and improving patient outcomes.
Researchers have developed a method for producing heart valves in just minutes, using focused rotary jet spinning. The valves mimic the extracellular matrix and showed immediate functionality in sheep, with potential for regenerative properties. Long-term studies are needed to test their endurance.
A large-scale study found that patients with pulmonary embolism treated with mechanical thrombectomy showed significant improvement in symptoms, quality of life, and cardiac functions. Long-term data also suggested low mortality rates following treatment with the FlowTriever System.
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
A recent study published in the British Journal of Nutrition found that children who met more UK Government dietary guidelines during childhood had better cardiometabolic health when they became young adults. The study, which analyzed data from the Children of the 90s cohort, found that almost a third of children only met one out of ni...
The study used magnetic resonance imaging (MRI) to measure acute pressure changes inside the heart, discovering that pressure increases when patients receive a specific medication called adenosine. This technology can help doctors better diagnose and monitor patients with heart disease and heart failure.
Researchers developed a graphene 'tattoo' implant that senses irregular heart rhythms and delivers electrical stimulation without constraining the heart's natural motions. The device is optically transparent, allowing for external light to record and stimulate the heart through the device.
A new study found that sedentary time increases cardiac mass by 3.8g/m2.7, while moderate-to-vigorous physical activity results in a smaller increase of 1.2g/m2.7. Light physical activity shows no effect on cardiac mass but improves cardiac function.
A new study finds that wireless pacemakers can safely regulate slow heartbeats in select pediatric patients. The leadless pacemaker, a miniature device implanted directly into the heart, has shown stable performance with no reported complications in children aged 4-21.
A new study published in Nature finds that artificial intelligence (AI) surpasses human sonographers in accurately assessing cardiac function from echocardiogram studies. The research, conducted at the Smidt Heart Institute, demonstrates AI's potential to improve the quality and effectiveness of heart evaluations.
A recent study suggests that cardiac sphericity, or the roundness of the heart, may be a useful indicator for diagnosing cardiovascular conditions. The research used machine learning to analyze medical images and found a link between increased sphericity and future heart troubles.
A study published in Lasers in Surgery and Medicine suggests that light therapy, known as photobiomodulation (PBM), can improve heart function and reduce the thickness of the cardiac wall in middle-aged mice. The research also found improved neuromuscular coordination and a significant survival rate among mice with severe heart disease.
Adolescents with blood pressure above 130/85 mmHg are at risk of premature heart damage, which doubles in prevalence over a 7-year period. The study found significant differences in heart damage risks between males and females.
Researchers at The Hospital for Sick Children have discovered that dysregulation of energy production is an early sign of heart failure. They found that lysine demethylase 8 (Kdm8) helps maintain balanced energy use, but its suppression leads to changes in metabolism.
A new study found that a medication previously used to treat seizures can reprogram donor hearts to boost the production of beneficial enzymes, increasing storage time and improving post-transplant function. This technology could lead to a paradigm shift in extending heart storage and reducing primary graft dysfunction.
Excessive trabeculation of the left ventricle does not coalesce into a compact myocardial wall, making 'LV non-compaction' an inaccurate term that should be discouraged. The review recommends using 'excessive trabeculation', which can be observed across various health and disease states.
A new study led by Columbia researchers discovered a link between serotonin and heart valve disease, specifically degenerative mitral regurgitation. The study found that patients taking selective serotonin reuptake inhibitors (SSRIs) were more likely to develop severe mitral regurgitation and require surgery at a younger age.
A team of researchers has identified a protein called hemopexin that may help protect the heart from damage caused by anthracycline chemotherapy. Levels of hemopexin in the blood were associated with increased cardiac toxicity, but administering hemopexin prevented the development of cardiac dysfunction in mice.
Cardiac reprogramming converts scar tissue into healthy heart muscle, reducing fibrosis and improving heart function in mice with chronic myocardial infarction. This approach could lead to a new treatment for patients with heart attack and heart failure.
A Cedars-Sinai study found that even subtle forms of liver disease directly impact heart health, with elevated FIB-4 scores associated with abnormalities in heart function and vascular dimension. Cardiac MRI scans revealed that nearly 86% of patients had at least one heart abnormality.
A new gene therapy approach has been developed to boost the expression of the beta-3 adrenergic receptor in heart cells, improving mitochondrial function and preventing or reversing heart failure in a mouse model of aortic stenosis. This could potentially provide new therapeutic options for patients with this condition.
Researchers found that exposure to e-cigarettes, marijuana, and tobacco led to increased scarring, decreased blood vessels, and changes in heart nerves, all contributing to an increased risk of arrhythmias. These substances can cause similar harm to the heart as traditional cigarettes.
A national study published in The New England Journal of Medicine finds that early intervention with catheter cryoablation can halt disease progression and reduce serious health risks. Cryoablation is more effective than antiarrhythmic drugs in reducing the risk of persistent AF, hospitalization, and adverse events.
Dr. David Kass, a Johns Hopkins professor, has advanced understanding of heart disease and its treatments through pioneering clinical studies and molecular research. His work has led to the development of new therapies for heart failure, obesity, muscular dystrophy, and potentially immunotherapy for cancer.
Researchers from Hokkaido University have identified a link between succinyl-CoA levels and energy metabolism in heart cells affected by chronic heart failure. Supplementation with 5-aminolevulinate acid improved heart function and oxidative phosphorylation capacity in mice with surgically blocked blood supply.
Researchers from Temple University Health System developed a device that significantly reduces blood clot size in pulmonary arteries, leading to improved heart function and shorter treatment duration. The breakthrough is based on data collected in the NIH-sponsored RESCUE trial.
Researchers discovered that blocking the ion channel TRPC6 prolongs survival and improves muscle function in mice with severe Duchenne muscular dystrophy. The study also reduced bone deformities associated with weak muscles.
Scientists have discovered three proteins with therapeutic potential to prevent cardiac damage and preserve cardiac function after a heart attack. The proteins, Chrdl1, Fam3c, and Fam3b, were identified through an innovative technology called FunSel that screens human proteins for protective effects.
A Kaiser Permanente study found that patients in home-based cardiac rehabilitation had fewer hospitalizations than those in center-based rehab, with benefits seen across diverse patient populations. The home-based program improved accessibility and outcomes for high-risk patients.
Researchers at Temple University hospital found that maternal-fetal mortality can be reduced to zero through patient-tailored management of right heart function prior to delivery. Women with pulmonary hypertension who received specialized care had excellent outcomes, with 100% survival for mothers and infants.
Researchers developed a polygenic risk score to predict sudden cardiac death in coronary artery disease patients. The study found that patients with high genetic risk scores had a 77% increased risk of sudden cardiac death.
A RCSI study has found that babies born with Down Syndrome experience impaired changes in heart function and blood pressure in their lungs over the first two years of age. The research suggests that all babies with Down Syndrome should have their heart function monitored during childhood due to these common issues.
The study found that patients with severe stress-induced myocardial ischemia are likely to benefit from heart bypass surgery or angioplasty, while those with mild or no ischemia are not. Early revascularization was associated with a more than 30 percent reduction in mortality compared to patients treated with medication.
Researchers have discovered that mutations causing Duchenne muscular dystrophy slow electrical activity in the heart, leading to abnormal heart rhythms. This finding may help explain why up to 60% of DMD patients experience life-threatening heart rhythm abnormalities and could lead to new treatment strategies.
A recent study reveals that 91% of athletes display dysfunctional breathing patterns, which can lead to increased risk of musculoskeletal injuries. The study emphasizes the importance of screening and addressing these patterns through targeted interventions and breathing training protocols.
A study found that colchicine significantly improved survival rates for patients hospitalized with worsening heart failure. Colchicine may also reduce the risk of heart attack and stroke in patients with a buildup of cholesterol in their arteries.
The DIPRA study found no significant difference in hand function between distal radial artery access and conventional proximal radial artery access. Radial artery occlusion occurred more frequently with PRA, but the risk was negligible.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A study found that maternal obesity impairs heart health and function of the fetus, altering gene expression and increasing risk of cardiac problems in later life. Sex differences were observed, with females experiencing impaired cardiac function that worsened with age, while males showed impairments from birth.
Researchers have found that flu viruses can directly infect heart cells, leading to electrical malfunctions and scarring. The study suggests that clearing the viral infection may be key to reducing flu's effects on the heart.
A new study published in the European Heart Journal shows that MRI is superior to echocardiography for diagnosing heart failure and predicting patient outcomes. The research found that MRI can accurately measure left ventricular filling pressure, leading to improved diagnosis and reduced need for invasive assessments.
A new cell therapy has shown promising results in slowing the progression of Duchenne muscular dystrophy, a rare genetic disorder. The treatment uses heart cells to improve skeletal muscle and heart function, offering a potential cure for advanced disease cases.
A study by TUM confirms that physically fit primary school pupils perform better in terms of concentration and health-related quality of life. The results show a positive correlation between physical fitness, concentration, and overall well-being.
Research from the University of Minnesota found that lower left atrial function was associated with higher risk of developing dementia. Atrial myopathy, characterized by abnormal left atrial function and size, was identified as an independent risk factor for dementia.
A comprehensive literature review found that consuming plant-based alpha-linolenic acid (ALA) rich in walnuts and flaxseeds can lower cardiovascular disease risk by 10% and fatal coronary heart disease risk by 20%. ALA may also benefit heart health when combined with other omega-3s.
Researchers at Lewis Katz School of Medicine at Temple University discover a molecular pathway driving maladaptive processes in heart failure, revealing the importance of GRK5's catalytic activity and nuclear presence. The study opens doors to new therapeutic strategies for treating this devastating condition.
A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
Researchers at Michigan Medicine found that a medium-chain fatty acid called octanoic acid can reduce further injury and improve heart function after a heart attack. This discovery could lead to the development of a new therapy to treat heart attacks, targeting the interplay between energy metabolism and epigenetics.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
Researchers from NYITCOM are using a new imaging technique to study diabetic heart failure and its causes. They hope to develop new treatments by tracing how lysosomes, the body's defense system, are impaired in heart muscle cells.
A study found that using two cannulas to place newborns in respiratory failure on life-sustaining ECMO increases mortality rates. The safest path is a single cannula in the right internal jugular, which can remove oxygen-poor blood and add oxygen before returning it to the baby.
Researchers discovered two simple physical maneuvers to effectively reduce blood pressure drops and alleviate symptoms of IOH in young women. Lower body muscle preactivation (thighs) and tensing improved cardiac output and stroke volume, respectively, leading to a reduction in symptoms upon standing.
A study found that subtle changes in heart structure and function between early adulthood and middle age are associated with declines in thinking and memory skills. The research, published by the American Academy of Neurology, suggests that a single echocardiogram may help identify people at higher risk of cognitive impairment.
Researchers from Osaka University created patient-derived heart cells that exhibit reduced contractility and impaired desmosome assembly when carrying a mutation associated with arrhythmogenic cardiomyopathy. Replacing the mutated gene restored normal function, suggesting a potential treatment approach for this disease.
Researchers at UNC School of Medicine discovered that VE-cadherin is a key player in the maintenance and function of lymphatic vessels in the heart. However, they found that loss of these vessels was not associated with decreased heart function, contradicting previous assumptions.
The International Cardiac Rehabilitation Registry (ICRR) is designed to assess the quality of cardiac rehab programs worldwide, improving patient outcomes. The registry enables programs in low- and middle-income countries to benchmark their services against international standards.