Articles tagged with Fructose
Research finds that sorbitol, a common sugar substitute, can induce similar effects on the liver as fructose, leading to steatotic liver disease. The study also shows that gut bacteria play a crucial role in clearing sorbitol, and that excessive consumption can overwhelm them.
A study published in Nature reveals that dietary fructose promotes tumor growth in animal models of melanoma, breast cancer, and cervical cancer. The liver converts fructose into usable nutrients for cancer cells, a finding that could lead to new treatment avenues.
A study published in Cell Metabolism reveals that fructose inhibits the polarization of M1-type tumor-associated macrophages, promoting colorectal cancer development. Fructose interacts with hexokinase 2 and inositol 1,4,5-trisphosphate receptor type 3 to suppress calcium levels and activate p38 MAPK and STAT1.
This study validates a two-stage process for producing polyhydroxyalkanoates (PHA) using peanut oil and propionate with Cupriavidus necator. The findings show that peanut oil is the most beneficial carbon source, leading to increased biomass and PHA production.
Researchers developed a novel PET tracer that can map fructose metabolism, differentiating diseased tissues from healthy ones. This non-invasive technique has the potential to detect diseases such as stroke, brain metastases, and heart attacks more sensitively.
Scientists at the University of Ottawa have developed a new radiotracer called [18F]4-FDF that can map how cells use fructose for energy. This allows for earlier detection of diseases like cancers, heart and brain inflammation, using fructose as a metabolic fuel.
Rats fed high-fructose diets exhibit disturbances in autonomic nervous and cardiovascular systems, increasing risk of chronic diseases like diabetes and obesity. Fructose consumption by parents is also associated with impaired physiological regulation of their offspring's cardiovascular system.
A new study led by Richard Johnson, MD, suggests that fructose is the key driver of obesity, bringing together long-incompatible theories on dietary causes. Fructose lowers active energy in the body, triggering hunger and food intake, and fatty foods become the major source of calories driving weight gain.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers at CU Anschutz Medical Campus identify fructose as a central conduit to obesity and diseases. Fructose works differently than other nutrients by lowering active energy, stimulating food intake and leading to weight gain.
Researchers found that dietary fructose is necessary for increased germline stem cells after mating, which leads to enhanced post-mating egg production. The study reveals that circulating fructose stimulates the fructose-specific taste receptor in insects.
A comprehensive review of 169 clinical trials found that the effect of fructose-containing sugars on adiposity varies among food sources and energy control. High doses of certain sources, like SSBs, lead to increased body weight, while others, such as fruit and honey, show moderate beneficial effects when consumed in moderation.
A study suggests that fructose metabolism in the brain may be driving the development of Alzheimer's disease, an evolutionary survival pathway gone awry. Researchers found that fructose reduces blood flow to areas involved in self-control and memory, leading to progressive brain atrophy and neuron loss.
A new light-based sensor harnesses the light-guiding properties of spider silk to detect and measure small changes in the refractive index of a biological solution, including glucose and other types of sugar solutions. The sensor is practical, compact, biocompatible, cost-effective, and highly sensitive.
Research suggests that high fructose consumption is associated with a higher chance of developing non-alcoholic fatty liver disease (NAFLD), especially among Mexican Americans and non-Hispanic Blacks. The study analyzed data from over 3,200 participants and found that those consuming the highest amount of fructose were at greatest risk.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
A new study found that a specific type of carbohydrate called ‘fodmaps’ can aggravate intestinal problems, but its impact is not as significant as previously believed. IBS symptoms were found to be influenced more by psychological factors and individual differences in metabolism and intestinal flora.
A comprehensive review reveals how excessive fructose intake can disrupt metabolic pathways, leading to diseases such as diabetes, fatty liver disease, and heart disease. The study highlights the role of protein transporters, gluconeogenesis, and gene-level changes in regulating fructose metabolism.
A preclinical study found that high-fructose diets alter villi in the small intestine, leading to increased nutrient absorption and weight gain. Fructose's primary metabolite promotes elongation of villi and supports intestinal tumor growth.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
A low-protein diet with mostly resistant starch produces the healthiest outcomes, while a 50:50 glucose-fructose mixture leads to obesity and poor metabolic health. This study builds on previous findings that low protein-high carbohydrate diets in mice result in long lifespan and cardiometabolic health.
Even moderate amounts of sugar increase fat synthesis in the liver, leading to a longer period of overactive fat production. Fructose and sucrose are found to have particularly detrimental effects, doubling fat production beyond food intake.
A new study published in Nature Communications found that high fructose diets can cause the immune system to become inflamed, leading to damage and increasing the risk of disease. The research also suggests a link between fructose consumption and obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
New research suggests that high fructose intake may drive aggressive behaviors, ADHD, and bipolar disorder by triggering a foraging response. This process, meant for survival during starvation, can lead to impulsive behavior in excess sugar intake.
A new study suggests that high fructose intake exacerbates intestinal inflammation common to IBD, potentially worsening the condition for patients. Researchers found that a western diet, including fructose, is associated with increasing rates of obesity and diabetes, which may further increase IBD risk.
A new study suggests that excessive fructose metabolism in the brain may be a key driver of Alzheimer's disease. The research proposes that high fructose levels disrupt cerebral metabolism and neuronal function, leading to progressive loss of energy and eventual neuronal death.
A new study from the University of California, Davis links combining fructose and glucose in high fructose corn syrup to increased risk factors for heart disease. The researchers found that the interaction between the two sugars had a more significant impact on health risks than previously thought.
A new study published in Nature Metabolism suggests that excessive fructose consumption can lead to a leaky gut and subsequently cause fatty liver disease. The researchers found that the high fructose corn syrup disrupts the epithelial barrier protecting internal organs from bacterial toxins, leading to chronic inflammatory conditions.
A high fructose diet in pregnant women can alter the metabolism of their offspring, researchers found. The study, published in Frontiers in Endocrinology, showed that fructose intake before and during pregnancy led to significant changes in maternal metabolic function and milk composition.
A new study reveals that excessive fructose consumption overwhelms the gut's ability to break down sugar, leading to fatty liver development. The research found that consuming food slowly mitigates adverse effects, highlighting the importance of rate-dependent fructose processing.
A new study led by St. Michael's Hospital researchers found that different types of sugars showed varying associations with cardiovascular disease. Higher intake of total or fructose-containing sugars was linked to increased death from cardiovascular disease, while higher sucrose intake was associated with decreased mortality.
Researchers found that high fructose diets specifically inhibit the liver's ability to metabolize fat, while glucose improves fat-burning function. High fructose diets damage liver mitochondria, leading to an increase in fatty liver disease risk and metabolic syndrome.
A University of Otago study confirms the low FODMAP diet is effective in alleviating bowel symptoms in children. Complete resolution was observed in 92% of children with bloating, 87% with diarrhoea and 77% with abdominal pain.
Jane Reznick has been awarded an ERC Starting Grant to investigate the metabolism of naked mole rats, which live up to 30 years old without heart disease or cancer. Her research aims to understand how these animals adapt to oxygen deficiency and potentially develop new therapies for humans.
A team of researchers at UW-Madison has developed a new process for producing 5-hydroxymethylfurfural (HMF) from plant sugars, which is a versatile chemical crucial for building a renewable economy. The process uses an inexpensive solvent system and can be integrated into existing industrial systems.
A study found that consuming high-fructose corn syrup accelerates intestinal tumor growth in mouse models, independent of obesity. The sugar directly feeds cancer growth via increased fructose and glucose levels, leading to fatty acid production and tumor progression.
Researchers found that dietary sugars, particularly fructose and glucose, decrease the abundance of a protein called Roc required for Bacteroides thetaiotaomicron colonization. A resistant strain engineered by researchers outcompeted the wild-type strain in mice fed high-sugar diets.
A study published in Palgrave Communications found a strong negative correlation between median household income and obesity rates in the US. Since 1990, the rise of obesity has been fastest among the poorest regions, with lower-income households facing a higher likelihood of suffering from obesity and diabetes.
Fruit and naturally occurring fructose have no negative impact on blood glucose levels, while sweetened drinks may pose a greater risk. Researchers analyzed 155 studies to assess the effect of different food sources of fructose sugars on blood glucose levels.
A study by Maria Antonietta Ricci and colleagues found that fructose forms the shortest and strongest hydrogen bonds with water, allowing it to bind more snugly with protein receptors. This interaction enables greater stimulation and perception of sweetness. Mannose, on the other hand, forms longer and weaker hydrogen bonds with water.
Infant formulas with fructose or sucrose pose a risk to babies with hereditary fructose intolerance, who may experience acute liver failure if fed these sweeteners. Parents can avoid this risk by switching to formula without fructose and labeling products with explicit warnings.
Researchers found that metastatic cancer cells reprogram their metabolism to capitalize on fructose levels in the liver, leading to unchecked growth and proliferation. This discovery could lead to new therapies targeting metastatic cells and provide insight into how cancers adapt to new environments.
Researchers at Michigan Technological University developed a sugar-transporting biosensor to detect and differentiate cancer cells. The fluorescent probe targets the fructose transporter GLUT5, revealing metabolic nuances of different cancer stages.
Research suggests that excessive sugar intake can be harmful, especially to the liver, due to insulin resistance and non-alcoholic fatty liver disease. A new mouse study shows that moderate amounts of fruit sugar will not reach the liver.
Research found that consuming high amounts of fructose during pregnancy and early childhood increases the risk of developing asthma in mid-childhood. Mothers who drank a lot of sugar-sweetened beverages while pregnant were more likely to have children with asthma.
Researchers at Joslin Diabetes Center found that mice on a fatty diet who consumed high levels of fructose suffered worse metabolic effects compared to those given similar calories of glucose. The study highlighted the increased production of an enzyme called Khk, which is specifically important in fructose metabolism.
Overweight individuals can experience measurable improvements in metabolic function within two weeks of reducing their sugar intake, particularly fructose. Cutting out high-fructose corn syrup can help prevent health issues like obesity, fatty liver disease, and type 2 diabetes.
Scientists discovered that naked mole-rats can survive up to 18 minutes without oxygen by converting fructose to fuel in their vital tissues. This process allows them to avoid tissue damage associated with heart disease and stroke in humans.
Naked mole-rats can survive for at least five hours without oxygen by metabolizing fructose, reducing their movement and slowing their pulse rate. This unique adaptation may lead to new treatments for patients suffering from low oxygen conditions, such as heart attacks and strokes.
Researchers discovered that naked mole rats can survive extreme oxygen deprivation due to their ability to metabolize fructose. This alternative energy source supplies vital organs with energy when glucose is scarce, allowing them to thrive in low-oxygen environments.
A new study found that even small amounts of fructose in breast milk are associated with increased body weight and muscle content in babies. The study, published in the journal Nutrients, involved 25 mothers and infants and provided preliminary evidence for the risks of 'secondhand sugars' on infant health.
Researchers at Yale University have discovered that fructose is converted in the human brain from glucose, raising questions about its effects on eating behavior. The finding highlights the need to reevaluate the impact of fructose on chronic diseases.
A new study has found that fructose consumption is independently associated with non-alcoholic steatohepatitis (NASH) and high uric acid concentrations in individuals with non-alcoholic fatty liver disease (NAFLD). NAFLD, a growing cause of liver disease in Western countries, affects up to 30% of the general population.
Consuming a high-fructose diet during pregnancy may cause defects in the placenta and restrict fetal growth, potentially increasing a baby's risk for metabolic health problems later in life. However, administering allopurinol, a common drug prescribed to treat gout and kidney stones, appears to mitigate these negative effects.
A study by UCLA life scientists found that fructose damages brain genes, leading to diseases such as diabetes and cardiovascular disease. However, a diet rich in DHA reversed the harmful effects of fructose, suggesting a potential treatment for these conditions.
A study published in the American Journal of Obstetrics and Gynecology found that consuming high fructose during pregnancy increases the child's risk for heart disease. The research, conducted by UTMB researchers, showed that female offspring had higher peak glucose levels, blood pressure, and insulin resistance.
A study at the University of Texas M. D. Anderson Cancer Center found that normal liver cells metabolize dietary fructose differently than cancerous cells, revealing a potential diagnostic marker for liver cancer. The researchers discovered a gene called KHK that is expressed differently in healthy and tumor tissues.
The study found that pregnant mice exposed to a high fructose diet developed higher peak glucose, insulin resistance, and obesity in their offspring. Female offspring were also heavier and had more visceral adipose tissue, indicating a potential link between maternal diet during pregnancy and childhood health.
A new study suggests that chronic dehydration caused by global climate change may be responsible for the Mesoamerican Nephropathy epidemic, which has killed over 20,000 people. The disease is most prevalent among manual laborers on sugar cane plantations in Central America.
A high-fructose diet has been shown to slow down the brain's ability to recover from head trauma, according to a new US study published in the Journal of Cerebral Blood Flow and Metabolism. The research found that rats fed a fructose-infused diet took 30% longer to solve a maze after being subjected to a simulated traumatic brain injury.