Research on depression and its treatment. Covers stress-response biology, ketamine and dopamine-targeting therapies, treatment-resistant cases, and brain mechanisms.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
Individuals who combine climate worry with actions such as volunteering, following a plant-based diet, or avoiding air travel experience fewer depressive and anxiety symptoms. Climate hope in society's ability to mitigate climate change also correlates with reduced mental health issues.
A new study found that transcranial direct current stimulation (tDCS) can enhance task engagement and activation of brain regions associated with executive function in individuals with comorbid anxiety and depression. However, it unexpectedly heightened sensitivity to threats, including increased eyeblink startle response under conditi...
Adverse experiences throughout life increase dementia and stroke risks, with depression as a mediating factor. Implementing life-course interventions addressing psychological trauma and mental health can reduce neurovascular disease burden.
A Swedish study of prematurely born adults found increased morbidity in physical and mental health, yet they reported a high quality of life. The study, which followed participants from birth to age 26-29, suggests that premature birth does not necessarily limit daily life.
A study by SWPS University researchers found that sedentary lifestyle in adolescents can negatively impact their parents' mental health, leading to symptoms of depression. The study also showed that teenagers spend more time sitting than their parents, highlighting the need for family-based health-promoting interventions.
A new study finds that transcranial magnetic stimulation (TMS) is a cost-effective treatment option for moderate and severe forms of depression. TMS reduces depressive symptoms, eases pressures on informal carers, and helps people get back to work, recovering its costs over time through savings to the NHS.
Research by Université Laval found that physical exercise and living in favorable conditions reduce depression risk by maintaining blood-brain barrier integrity. Fgf2 protein plays a key role in this mechanism and may serve as a biomarker for mood disorders.
A recent survey study found a significant association between generative AI use and increased depressive symptoms in US adults. The magnitude of the effect varied by age group, suggesting that further research is needed to understand the causal relationship and underlying factors.
Research from the University of Warwick finds that teenage girls who manage their bodies through constant dieting and exercise face heightened risks of psychological health issues. By age 20, these young women are more likely to experience anxiety and depression, highlighting the need for a broader approach to mental health support.
A new medical large language model (LLM) achieved over 91% accuracy in identifying female participants diagnosed with major depressive disorder after analyzing short WhatsApp audio recordings. The LLMs showed greater accuracy when classifying women compared to men, particularly when given the 'describe your week' data.
A recent study by King's College London found that diagnosis rates for depression, asthma, and osteoporosis remained lower than expected after the COVID-19 pandemic. The study analyzed data from over 29 million people in England and found that diagnosis rates recovered differently across ethnic and socioeconomic groups.
The updated edition provides a comprehensive overview of major mental health conditions that emerge during adolescence, discussing treatment strategies and prevention methods. The book emphasizes the importance of addressing stigma, promoting evidence-based treatments, and integrating positive youth development into policy agendas.
A study of over 500 survivors found severe psychological trauma with somatic symptoms persisting decades after the attack. The results highlight the need for culturally sensitive mental health services, compensation, and ongoing care for chemical attack survivors.
Adults with asthma who experience depressive symptoms have elevated blood levels of brain-derived neurotrophic factor (BDNF), a protein typically reduced in major depressive disorder. Physical activity may also play a role in depression management, as lower activity levels are linked to worse moods.
Researchers from Korea University report a breakthrough in reviving an abandoned depression drug target by redesigning the molecular structure of neurokinin-1 receptor antagonists. New compounds exhibiting antidepressant-like effects have been identified, reducing depressive-like behavior and brain inflammation in mice.
A nationwide study found that depression frequently precedes the diagnosis of Parkinson's disease and Lewy body dementia. The risk of depression rises steadily in the years leading up to diagnosis, peaking before diagnosis, and remains elevated for several years afterward.
A study found that a small, implanted vagus nerve stimulation device produced substantial and sustained improvements in depressive symptoms, quality of life, and daily function in patients with treatment-resistant depression. The device showed lasting benefits even after two years, with nearly one-third of participants who didn't respo...
Research found that prolonged heavy drinking induces neuroinflammation, promoting negative emotional states lasting for weeks into abstinence. Inhibiting proinflammatory microglia activation during alcohol exposure blocks the development of anxiety and fear memory.
Adolescents bullied or engaging in bullying face lasting mental, physical and social challenges. The study identified socioeconomic disadvantages, race, physical differences, and pre-existing health conditions as risk factors for bullying.
A Dartmouth study identifies a novel target for using psilocybin to treat depression and anxiety without hallucinations. The serotonin 1B receptor is found to promote the therapeutic benefits of psilocybin, providing a potential new approach for developing safer and more cost-efficient medications.
A team from Chongqing Medical University developed a model that integrates sMRI and fMRI data to predict treatment responders, achieving high accuracy rates. The dual-branch graph attention network (DBGAN) captures coordinated brain changes linked to emotion regulation and memory processing.
A study of 168 second-time mothers found that those who breastfed were less likely to experience depression and anxiety 10 years after pregnancy. Each week of lifetime exclusive breastfeeding was associated with a 2% lower likelihood of reporting depression and anxiety, after accounting for influential factors.
Children with adverse prenatal exposures showed higher rates of behavior problems, faster cortical thinning, and more depressive symptoms than children with fewer APEs. Researchers found a persistent association between multiple APEs and increased odds of mental health problems as kids grew older.
A Cochrane review found that exercise can reduce depressive symptoms similarly to psychological therapy, with moderate-certainty evidence from ten trials. Long-term effects are unclear due to few studies following participants after treatment.
A cohort study found associations between exposure to multiple fine particulate matter components and increased depression risk among US Medicare population members. The study highlights the importance of targeted regulation to protect vulnerable populations from harmful air pollution.
Research found that older women with younger biological ages were more likely to experience increased depressive symptoms during the pandemic. The study suggests that this may be due to reduced social connections and daily routines, which can affect mental health.
A special issue of Child and Adolescent Psychiatric Clinics of North America seeks to transform how clinicians, educators, and policymakers think about girls' mental health by focusing on systems that support or fail to support them. The issue explores intersectionality, trauma-informed approaches, and the impact of social media on bod...
Scientists at Salk Institute find protein CCN1, secreted by astrocytes, maintains stable neural circuits in adult brains. The discovery could lead to new therapeutics for brain injury and stroke.
A large international study of 220,947 participants found that concurrent physical frailty and depression significantly increase the risk of dementia. The interaction between these two factors contributes approximately 17% to the overall risk, while individual associations were found for frailty (2.5 times higher risk) and depression (...
A new study suggests that midlife depression is driven by a small cluster of specific symptoms, rather than depression overall. The six symptoms are loss of self-confidence, difficulty coping with problems, and poor concentration, which can lead to reduced social engagement and decreased cognitive reserve.
A subset of depressed individuals with chronic, low-grade inflammation may benefit from anti-inflammatory treatment, according to a systematic review and meta-analysis. The study found that anti-inflammatory medications significantly reduced depressive symptom severity and anhedonia in these patients.
A new study reveals that 16% of teens exposed to both phases of the Russo-Ukrainian war experience PTSD symptoms, while over 10% experience severe depressive symptoms. The study highlights the need for immediate and sustained attention to support Ukrainian youth's mental health needs.
Teenagers who struggle with their bodies are at risk of developing eating disorders and depression in early adulthood, according to a new study. The research, which followed over 2,000 twins, found that body dissatisfaction at age 16 predicted greater symptoms of mental health issues well into the twenties.
Dr. Eric J. Nestler's research has fundamentally reshaped global understanding of addiction and depression by focusing on resilience rather than pathology. His laboratory identified distinct molecular, cellular, and circuit changes in resilient brains that maintain normal behavioral function despite exposure to drugs or stress.
A study by the Annenberg Public Policy Center finds that the US suicide rate is lowest in December, with a significant decline during the year-end holiday season. However, some news outlets continue to perpetuate the false myth that suicides increase around the holidays.
A study from Harvard T.H. Chan School of Public Health found that school reopenings significantly reduced mental health diagnoses among children, including anxiety and depression, by 43% compared to periods before schools reopened. The benefits were especially pronounced among girls.
A new study from the University of Southern Denmark reveals that depression is significantly more common among women with gynaecological disorders—both before and after receiving a diagnosis. The study highlights the need for earlier detection and a more integrated approach between somatic and psychiatric care.
A new FAU study reveals significant mental health differences between dark web users and surface web users, with dark web users reporting substantially higher levels of depressive symptoms and paranoid thoughts. The study also found substantial differences in suicidal thoughts, non-suicidal self-injury, and digital self-harm.
Dr. Paul Lucassen's research on adult neurogenesis reveals the link between early life experiences, lifestyle factors, and depression/dementia risk. His work has implications for therapeutic approaches to brain health and disease.
A new study found that long-term antidepressant use has increased by nearly 20% among young people aged 10-24, raising concerns about potential overprescribing. The study also found no meaningful improvement in efforts to wean patients off antidepressants, highlighting the need for a stronger framework for safely tapering medications.
A major meta-analysis found that nitrous oxide can offer fast-acting depressive symptom relief for adults with major depressive disorder and treatment-resistant depression. The study showed significant improvements in mood within 24 hours, but repeated dosing over several weeks was needed to sustain clinical benefit.
Researchers at the University of Plymouth have successfully used transcranial ultrasound stimulation (TUS) to change the function of a deep region of the human brain, specifically the nucleus accumbens. This tiny element is triggered by enjoyable experiences and helps us learn behaviours that lead to rewards.
A 1-week social media detox in young adults was associated with reduced symptoms of depression, anxiety, and insomnia. The study's findings suggest a potential therapeutic benefit of reducing social media use for mental health concerns.
Researchers found that a protein involved in ATP release, connexin 43, plays a key role in depressive- and anxiety-like behaviors. Restoring connexin 43 in the hippocampus improved behavioral outcomes and boosted ATP levels in stressed mice.
A new genetic study found that people without prior suicidal thoughts or behaviors have fewer psychiatric diagnoses and genetic risk factors for psychiatric conditions compared to those with known suicidality. This suggests that conventional wisdom on how to reduce suicide may need to be rethought.
Researchers identified a potential biomarker that could inform personalized treatment with deep brain stimulation. Half of the participants showed significant improvements, including nine achieving remission, with brain activity at specific frequency ranges predicting response to treatment.
A new study found that individuals with a history of major depression showed higher MRI markers associated with neuroinflammation in the VTA, suggesting increased extracellular inflammatory processes. Current depressive symptom severity was associated with distinct microstructural changes indicating different underlying pathophysiologi...
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
A new study published in the Hypertension Journal found that chronic pain in adults may increase their risk of developing high blood pressure, with depression playing a significant role. The study analyzed data from over 200,000 adults and found that widespread pain was associated with a higher risk of high blood pressure.
A University of Sydney-led study found that 42% of Australian adults experienced traumatic events as children, leading to a 50% higher risk of developing mental health or substance use disorders. Childhood trauma is linked to chronic physical health conditions and can have lifelong consequences.
A recent Finnish study found an association between severe nausea during pregnancy and depression, both before and after childbirth. Women who experienced severe nausea were more likely to develop depression and receive earlier diagnoses.
A recent study published in Nature Genetics found that depression beginning before age 25 has a stronger hereditary component and is associated with a higher risk of suicide attempts. The research identified 12 genetic regions linked to early-onset depression, highlighting the potential for precision medicine in psychiatry.
A recent landmark study identifies adenosine as the critical mediator of rapid antidepressant action, connecting ketamine, ECT, and hypoxia. The discovery raises questions about the potential interference of caffeine with these treatments, highlighting the need for further research on adenosinergic modulation in depression.
Researchers have discovered that stress hormones can silence crucial neuronal genes by interacting with long noncoding RNAs and the polycomb repressive complex 2. This mechanism may provide a new understanding of how stress affects gene expression, particularly in relation to synaptic function and calcium signaling.
A recent study from the University of Eastern Finland found that dancing alleviates perceived symptoms of depression, improves self-esteem and body awareness, and fosters self-actualization. Dancing reduces stress hormones and increases dopamine, allowing participants to process emotions in a creative, non-verbal way.
A new UCLA Health study found that a child's early gut microbiome may influence their risk of developing depression, anxiety or other internalizing symptoms in middle childhood. The effect appears to be related to the way bacteria are linked to communication across emotion-related brain networks.
A new analysis of the PANDA trial found that sertraline contributes to improvements in low mood and suicidal thinking within two weeks of taking the drug. The study also revealed an improvement in emotional symptoms of depression within two weeks, with continued benefits from six weeks to 12 weeks.
A new study suggests that message-based psychotherapy is as effective as live video therapy for treating depression. The research found that patients improved at similar rates regardless of the format used.
The Mount Sinai team will investigate neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.