The AACR Trailblazer Cancer Research Grant Program awards $1 million grants to early-stage and mid-career investigators over three years. The program aims to advance cancer biology, drive translational science, and improve patient outcomes.
A phase 3 clinical trial shows that adding pembrolizumab to standard-of-care therapy increases tumor shrinkage and prolongs cancer-free survival by nearly two years. Patients with locally advanced head and neck cancers benefited from this addition, marking a significant change in standard-of-care for the disease.
The treatment demonstrated early signals of efficacy, with 65.7% of patients experiencing lasting stable disease, and was generally well-tolerated, with most adverse events being mild and manageable.
Researchers identified cartilage oligomeric matrix protein (COMP) as a key driver of abnormal collagen I accumulation in OSF. Targeting COMP's interaction with collagen XIV may halt or reverse the disease's progression, offering hope for more effective treatments.
The American Association for Cancer Research (AACR) announces its 2025 Scientific Achievement Award recipients, honoring outstanding contributions to cancer research. This year's awardees include Rakesh K. Jain, PhD, FAACR, and Han Liang, PhD, recognized for their groundbreaking work on tumor microenvironment and cancer bioinformatics,...
The American Association for Cancer Research (AACR) will honor Senator Tammy Baldwin and Senator Shelley Moore Capito for their national leadership in advancing cancer prevention and treatment. The organization also recognizes Larry Saltzman, MD, a cancer survivor who has surpassed his expected lifespan due to NIH funding.
Researchers discovered temperature influences plant cell fate by regulating epigenetic marks. Low ambient temperatures can rescue developmental defects by compensating for PRC2 loss, highlighting the importance of H3K27me3 in maintaining cellular identity.
Dr. Richard Pazdur, MD, receives the 2025 AACR Enduring Impact Award for his quarter century of service in cancer science and medicine. He has led an era of progress at the FDA, improving outcomes for patients with cancer through expedited development of novel therapeutics.
KIAA1199, a secreted protein from bone marrow cells, influences both fat storage and overall energy metabolism. Researchers found that mice lacking KIAA1199 exhibited reduced fat mass and improved insulin sensitivity, suggesting targeting the protein could lead to new treatments for metabolic disorders.
Researchers uncover pivotal role of ZmCCT2 in regulating maize mesocotyl length and adapting to high altitudes. Significant associations between genetic variations and mesocotyl lengths were found, highlighting the essential function of ZmCCT2 in promoting cell elongation.
Researchers developed atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes, showcasing high turnover frequencies and regioselectivity. The catalyst's efficiency surpasses both homogeneous and heterogeneous counterparts, with applications in tritium labeling.
Researchers developed a novel process for direct production of syngas via super-dry reforming of methane using solid oxide electrolysis cells. The system achieved high CH4 conversion and selectivity toward CO and H2, showcasing potential for CO2 utilization and renewable energy storage.
Researchers developed a 1.7-gram head-mounted microscope to capture neural activity and cerebral hemodynamics in freely moving mice. The device provided simultaneous imaging of neuronal burst firing and multi-parametric hemodynamics at high spatiotemporal resolution.
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
A cohort study of pregnant individuals with opioid use disorder found that buprenorphine treatment was associated with improved maternal and infant outcomes. The study highlights the need to improve access to treatment nationwide for these patients.
A study on donor lungs preserved outside the body demonstrated that HOPE is a safe and effective method for lung preservation, with no rejections and similar short-term outcomes compared to direct transplantation. The study found that extending perfusion times can optimize donor lungs for future therapies.
A phase 3 clinical trial showed that pembrolizumab before and after standard-of-care surgery significantly extends event-free survival and substantially shrinks tumors in head and neck cancer patients. This regimen has improved outcomes without delays in surgery, marking a potential new standard of care for this patient population.
The Pediatric Heart Transplant Alliance is a coalition of six leading organizations working to advance pediatric heart transplantation through research, education, and advocacy. The alliance aims to improve patient outcomes and quality of life for children with transplanted hearts.
Researchers at ISHLT marked the 10-year anniversary of modern DCD heart donation, significantly increasing transplant volumes worldwide. Comparable outcomes have been achieved with DCD hearts compared to traditional DBD hearts, leading to a surge in DCD programs globally.
Machine perfusion technology significantly extends the time donor hearts can be transported, enabling longer-distance transplants. This innovation has already led to more organs being accepted from regions previously unsuitable due to transportation constraints.
Pediatric hearts fail due to acquired and genetic disorders or congenital heart disease, requiring mechanical circulatory support (MCS) devices. However, adult devices are often used off-label in pediatric patients, deterring innovation and limiting access to life-saving technology.
A CFD simulation method based on biological experimental data analyzed the aerodynamic performance of pigeons during different flight stages. The study found that pigeons enhance lift during takeoff by attaching leading-edge vortex earlier and maintain stable lift during leveling flight.
Researchers found that the Onsager reciprocity principle is violated in the cell model of an ion-exchange membrane. The violation occurs when gradients of external forces do not coincide with local gradients within the framework of linear thermodynamics.
A team from Peking University achieved a major breakthrough in imaging 15 cellular structures simultaneously using lipid membrane probes, dual-color spinning-disk confocal microscopy, and deep learning. This method enables real-time, long-term organelle tracking with improved efficiency and reduced phototoxicity.
Researchers develop a novel self-assembling prodrug, LDO, that targets glycolysis and STING signaling to alleviate inflammation and improve survival in sepsis animal models. LDO reprograms macrophage polarization, reducing cytokine storms and acute lung injury.
A day-long conference brought together experts to present ground-breaking outcomes research on CTEPH treatments. The session covered new medications, refined techniques, and innovative approaches to improve diagnosis and treatment outcomes.
Researchers at Beijing Institute of Technology developed a steering control strategy for cyborg insects using unilateral cercus electrical stimulation, achieving high memory scores in cockroach training. The study demonstrates the potential for electrical stimulation to promote spatial learning and recognition in insects.
The first-ever Cardiogenic Shock Academy features a simulation lab, providing hands-on training for treating patients in cardiogenic shock. More than 160 healthcare practitioners from around the world attended the academy, which aimed to address the lack of conclusive research for managing CS.
A scientist from Tokyo Metropolitan University has resolved the thirty-year mystery of dissonance in gravitational waves emitted by a black hole. The phenomenon was caused by resonance between two distinctive modes, which is not a rare incident but turns up universally in a range of modes.
The new atomic fountain clock, NIST-F4, has been established as one of the world's most accurate timekeepers by NIST researchers. The clock measures a constant frequency in cesium atoms and has improved time signals used billions of times daily for various applications.
A new study reports on five patients with Canavan disease who have a novel variant identified through targeted long-read sequencing, revealing an SVA_E retrotransposable element that disrupts gene function. The findings enhance genetic diagnostics and enable improved guidance for families.
Research by NIOO-KNAW reveals that less intense farming practices, such as reduced ploughing and increased grass-clover mixtures, can improve soil health and multifunctionality in both conventional and organic agriculture. This approach, known as 'productive de-intensification,' aims to retain crop yields while enhancing soil functions.
The Arctic Great Rivers Observatory, a multinational project founded at the Marine Biological Laboratory, has been recognized as a National Champion by the Frontiers Planet Prize for its publication on recent trends in the chemistry of major northern rivers. This recognition highlights the value of sustained international collaboration...
A recent study suggests that computer science teachers have greater education and classroom experience compared to teachers of other subjects. The study found that students' learning in computer science was positively impacted by teachers' experience teaching the subject.
A Yale-related nonprofit, Mati Carbon, has won the four-year, $100 million XPRIZE Carbon Removal competition with its method of crushed rocks to remove heat-trapping CO2 from the atmosphere. The process, called Enhanced Rock Weathering (ERW), also improves soil health for farmers.
Researchers with City of Hope will present innovative clinical trial results, breakthrough diagnostic techniques, and advances in treatment options at the AACR Annual Meeting. Highlights include a phase 3 clinical trial showing promising results for novel immunotherapy against nasopharyngeal carcinoma.
A new study from Thomas Jefferson University investigates the use of ondansetron to ease withdrawal symptoms in newborns with neonatal opioid withdrawal syndrome (NOWS). Researchers found that a specific concentration of ondansetron can significantly reduce withdrawal symptoms.
Researchers at Thomas Jefferson University used computational biology to analyze blood samples from people with and without ALS, discovering different combinations of small non-coding RNAs associated with disease progression and survival times.
A new voluntary program, the Medicare Prescription Payment Plan (MPPP), could greatly reduce out-of-pocket costs for Medicare patients taking expensive oral cancer drugs. By spreading annual costs across 12 monthly payments, patients can avoid large upfront payments and make treatment more affordable.
The University of Tennessee and Volkswagen Group of America have partnered on strategic research projects accelerating technology discovery and commercialization. The two have collaborated on lighter composites, high-power wireless charging and material upcycling, influencing Volkswagen brands globally.
Researchers found that using rice malt instead of milled rice in beer brewing can decrease production costs by 2-12%. Malted rice also requires less crop-growing acreage, making it a viable alternative for craft brewers. The study suggests that malting could open up new markets for Arkansas rice and ensure its long-run sustainability.
The Westermarck Archives, stored at Åbo Akademi University Library, have been inscribed on the UNESCO Memory of the World Register. The collection contains correspondence, manuscripts, notes, and photographs from Westermarck's field studies in Morocco, providing insights into anthropology, sociology, and local cultures.
A misfolded protein in spinal fluid facilitates reliable Parkinson's diagnosis even in its early stages. The biomarker has a sensitivity and specificity of over 90%, making it a promising tool for disease management and potential therapy development.
Scientists have developed a cutting-edge technology to analyze protein turnover in individual cells, enabling them to identify treatment-resistant cancer cells and understand the impact of specific drugs. This breakthrough could lead to advancements in disease diagnostics and treatment strategies.
Researchers at Northwestern University propose a new approach to therapeutic development using structural precision in nanomedicine. By fine-tuning the interaction between nanomedicines and the human body, scientists can design interventions that are more effective, targeted, and beneficial for patients.
A recent study published in Journal of Experimental Medicine found that immune cells play a major role in the development of spastic paraplegia type 15. The research, led by Professor Elvira Mass and Dr. Marc Beyer, suggests that severe inflammation in the brain precedes neuronal damage and could be relevant to Alzheimer's disease.
The new Priority Program will focus on developing IT components utilizing altermagnetism, which combines the benefits of ferromagnets and antiferromagnets. Researchers aim to overcome current limitations and achieve a significant increase in efficiency and speed.
Researchers at City of Hope discovered a novel target for preventing age-related abdominal fat by identifying the cellular culprit behind midsection widening in middle age. The study found that aging triggers the arrival of new adult stem cells and enhances the body's massive production of new fat cells, especially around the belly.
Methyl eugenol has demonstrated notable antioxidant and antiproliferative activity, with potential therapeutic benefits for diseases like Alzheimer's disease and cancer. However, its toxicological risks, including hepatotoxicity and alterations in the gut microbiota, pose concerns for its application.
Researchers developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack, showing effectiveness up to five weeks after injection.
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
A recent study published in PLOS Biology found that behavioral experiments with insects exhibit a high level of non-reproducibility, with some results varying as much as 42%. Despite this, at least half of the findings could be successfully reproduced.
This study examines the effectiveness of combining microvascular decompression with nerve combing for patients with atypical trigeminal neuralgia, a chronic pain condition that does not respond well to conventional treatments. The procedure has shown promising results in reducing pain levels and improving patient outcomes.
Researchers have discovered important differences in how a targeted therapy behaves in the body over time, allowing for more tailored treatment strategies. A new PET/CT scanner also shows promise for accurate imaging with dramatically reduced exposure, especially for sensitive patients like children or those needing repeated scans.
A new study compares tropical mountain ice cores to climate model simulations, revealing discrepancies in Earth's average temperature trends. Researchers found that ice core data and computer models match for polar regions like Greenland and Antarctica, but not for tropical mountains.
A new NYU Langone Health study found that lung immune cell type nerve and airway-associated interstitial macrophages (NAMs) play a critical role in regulating inflammation during SARS-CoV-2 infection. NAMs promote disease tolerance by restraining the immune response, leading to better survival rates among infected mice.
Researchers at Tohoku University developed a surface reconstruction pathway to produce durable non-noble metal-based cathodes for efficient hydrogen evolution reaction (HER) performance, paving the way for affordable commercial production.
The study estimates that expanded Medicare coverage for GLP-1RAs would increase access to these treatments and reduce obesity-related comorbidities. However, this would come with substantial costs over a decade, projected at $8 billion, highlighting the need for further price reductions and cost-saving strategies.
Researchers at MD Anderson Cancer Center present promising results from clinical trials in three minisymposia abstracts. The studies explore personalized vaccine combination therapy for colorectal cancer, radiotherapy to avoid toxicities of systemic treatments for kidney cancer, and engineered exosomes to silence mutant KRAS in pancrea...
A team of researchers at POSTECH has identified a hidden mechanism in Electrochemical Random-Access Memory (ECRAM) technology, enabling faster and more efficient AI computations. This breakthrough could lead to significant improvements in data processing and reduced energy consumption.