A phase 1 study found a tolerable dosing schedule with promising activity, with anti-cancer activity seen across various dosing schedules and tumor types. The regimen was selected for further evaluation, offering hope for expanded treatment options for patients with HER2-expressing advanced solid tumors.
Researchers have developed a quantum-enhanced in-memory stochastic computing system based on a room-temperature quantum memory, leveraging intrinsic randomness to perform computations securely and efficiently. The system outperforms classical methods in terms of coincidence rates and processing speed.
Researchers at Adelaide University found that a seaweed-derived compound can significantly reduce methane emissions from beef cattle, with no negative effects on calf growth or development. The study showed strong potential for reducing emissions in real-world farming conditions.
Researchers found that the loss of flight in Prosopocoilus hachijoensis is linked to atrophy of flight muscles and reduced relative wing size. The species' increased reliance on ground-based locomotion, particularly in females, may have driven this adaptation.
A new catalyst enables continuous hydrogen production and recovers high-purity magnesium hydroxide in seawater electrolysis. The innovation prevents cathode scaling and maintains stability over 5,000 hours., Researchers achieved a purity of 99% for the valuable byproduct Mg(OH)₂.
Researchers discovered that limonene can be used as a reaction solvent for the Mitsunobu reaction, allowing efficient separation and purification. This characteristic promotes high reaction efficiency and simplified purification, making it an attractive alternative to traditional methods.
Researchers at St. Jude Children's Research Hospital identified therapy-specific mutations that could guide safer treatments among childhood cancer survivors. The study analyzed genetic mutations in subsequent neoplasms of 160 survivors who developed breast, thyroid malignancies and meningiomas after treatment.
SKKU researchers have developed a novel device that captures greenhouse gases and generates electricity. The Gas Capture and Electricity Generator (GCEG) uses an asymmetric structure to produce continuous direct current power without external energy input.
Researchers found a promising response rate of 52% and disease control rate of 93% in patients treated with zoldonrasib. The study also showed favorable safety and tolerability profiles, with no grade 4 treatment-related adverse events observed.
A phase I clinical trial found that QLS5132 demonstrated an objective response rate of 50% and a disease control rate of 94.4% in patients with late-stage, platinum-resistant ovarian cancer. The study also showed a favorable safety profile for the treatment.
Researchers found SIRT6 is essential for maintaining protein homeostasis, regulating the protein life cycle to prevent protein aggregates that contribute to neurodegenerative diseases. Reduced SIRT6 levels play a critical role in aging and age-related neurodegeneration.
The Phase I MYTHIC trial demonstrated a strong synergy between zedoresertib and lunresertib, showing durable regressions and consistent tumor shrinkage in patients with ovarian cancer. The combination achieved an overall disease control rate of 68.5% and a molecular response rate of 47%.
Researchers outline blueprint for precision nutrition and sustainable diets, integrating AI, multi-omics and digital twin technology to provide personalized dietary recommendations and address environmental impact.
A new study found that elisrasib, a next-generation KRAS-G12C inhibitor, demonstrated a favorable safety and tolerability profile. In patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), elisrasib showed promising response rates of 58.8% and disease control rate of 98.5%. The treatment also improved outcomes...
A study analyzing meconium samples from newborns found high prevalence of antibiotic resistance genes, including those linked to carbapenem resistance. The findings suggest that maternal transmissions and early hospital exposure contribute to the establishment of these genes in the neonatal gut.
Researchers found that antiretroviral therapy reduces accelerated biological ageing in people with HIV by nearly four years. The plasma proteomic ageing clock tool estimated biological age and showed a statistically significant mean reduction of 3.7 years.
A landmark trial presented at ESCMID Global 2026 finds that improving oral hygiene for hospital patients reduces the risk of non-ventilator-associated hospital-acquired pneumonia (NV-HAP) by 60%. The study, involving over 8,000 patients, shows a substantial improvement in oral care practices among hospital patients.
Teenagers who begin using cannabis show slower gains in thinking and memory skills as they grow. The study found that teens who used cannabis showed restricted growth over time compared to those who did not.
NYU Langone Health experts present platform talks on practical strategies to counter medical misinformation, phase 3 X-TOLE2 trial results for novel epilepsy treatment, and exploring healthcare accessibility for patients with disabilities. The Department of Neurology features over 80 presentations from faculty members.
A new University of Michigan study tested a family-centered approach to firearm safety, which showed high feasibility and community support. Participants reported reduced concerns and improved communication with family members after completing the Family Safety Net intervention.
The partnership aims to create high-quality jobs, advance innovation, and establish the Coquimbo region as a leader in astronomy. A national visitor and education center will showcase technological innovation and scientific discoveries, supporting workforce development and promoting astronomy tourism.
Researchers found that younger mice had lower cancer spread, while middle-aged mice were more likely to experience aggressive melanoma. Middle-aged mice also had fewer immune cells called gamma delta (γδ) T cells, which help prevent cancer from spreading.
A study found that economic interests influenced Japanese legislators' behavior, with sanction-hit industries supporting military-backed policies and procurement sectors showing no shift. This challenges the common view of economic beneficiaries as authoritarian supporters.
A study identified exosomal microRNA-122-3p as a key driver of MASLD pathogenesis. Elevated miR-122-3p levels induced triglyceride accumulation and reactive oxygen species production in liver cells.
Construction on Sandia's largest project of the past decade is nearing completion with the installation of the final beam. The 136,000-square-foot facility will replace an aging site and provide a more efficient design for power sources research and development. Completion is expected in 2028 at a projected cost of $400 million.
A first-in-human trial shows that an infusion of immune cells derived from a donor's blood can prime the recipient's immune system to accept a donor liver, potentially reducing lifelong immunosuppression. Eight out of 13 participants achieved complete withdrawal of immunosuppression and remained off for more than three years.
Scientists at Kyushu University have developed a simple method to produce hydrogen gas by mixing methanol with iron ions and irradiating it with UV light. The reaction produces a considerable amount of hydrogen gas comparable to that of previously reported systems, opening up new possibilities for sustainable hydrogen technologies.
Researchers have successfully imaged the detailed workings of a cell membrane protein, called TMEM16 scramblase, which has essential roles in all animals. The discovery could lead to new therapeutic strategies for blood coagulation disorders, cancers, and other conditions in which the protein works abnormally.
A new report published in Nature Metabolism sheds light on fructose's distinct role in driving metabolic disease, separate from its caloric contribution. Fructose bypasses key regulatory steps, leading to increased fat synthesis and cellular energy depletion, which may contribute to metabolic syndrome.
A team of undergraduate students built a cavity detector to search for axions and set new experimental limits on their properties. The result was achieved with relatively limited resources, showcasing the potential for small-scale experiments in precision cosmology.
Researchers found that incorporating data from ocean bottom seismometers could improve ShakeAlert's detection time by 5-9 seconds. This technology has the potential to increase warning times for regional offshore earthquakes by up to 40 seconds.
The study demonstrates the potential for rapid deployment of fiber optic cable and Distributed Acoustic Sensing in environments where burying the cable isn't feasible, capturing aircraft speed and maneuvering.
A unique machine learning study identified over 60,000 earthquakes during the 2025 Santorini seismic crisis. The researchers found six times more earthquakes in the first 30 days compared to traditional monitoring, providing insights into fault networks and magma movement.
Emerging AI technologies are enabling faster, smarter, and more integrated solutions to global challenges. AI-powered systems can track pollution levels, detect anomalies, and predict future risks in water, soil, air, and waste systems.
The BioCAT beamline supports techniques including fiber diffraction, micro-diffraction, and small-angle X-ray scattering for studying biological systems. The facility has produced nearly 800 articles cited over 58,000 times, with an h-index of 114.
A newly-developed AI-powered tool, CAMPER, helps identify peptides that target antibiotic-resistant bacteria by breaking down their outer defenses. The study found that CAMPER is effective in developing treatments against MRSA and other difficult-to-treat pathogens.
Researchers discovered that the river flowed into an upstream lake before flowing into the Grand Canyon, marking its transition to a continental-scale river. The study provides new insights into the formation of the Grand Canyon and the Colorado River's path.
A 42-year-old theory about children's body mass index (BMI) decrease before continuous rise is refuted by new analysis. Increasing muscle mass, not fat, causes the increase in BMI seen around age 5-7 years.
Researchers at Ohio State University Wexner Medical Center are refining specialized lymphatic microsurgery techniques to treat and prevent lymphedema. The new procedures, including lymphatic bypass and lymph node transfer, offer patients more options and improved quality of life.
Researchers at UCF used human-on-a-chip technology to study how genetic mutations associated with familial Alzheimer's affect movement. They found that motor deficits may be an early indication of Alzheimer's disease, which could help delay central nervous system symptoms.
A new study from MIT chemists found that changing the composition of the cell membrane can alter the function of a membrane receptor promoting cell growth. Elevated levels of negatively charged lipids can lock the receptor into an overactive state, contributing to cancer cell proliferation.
A recent study by researchers at the Netherlands Institute for Neuroscience suggests that softer, flexible brain implants may be gentler on the brain than older designs. While they have not been proven completely harmless, these new materials could bring long-term, reliable implants closer to reality.
A new MIT study suggests that exposure to NDMA, a chemical contaminant in drinking water and some medications, can cause cancerous mutations more severely in children than adults. The researchers found higher rates of DNA damage and cancer in juvenile mice exposed to low levels of NDMA.
The Estonian Research Council partnered with Luunja Stud Ltd to create the first cloned foal, named Wodan M Alpha, using a genetic copy of successful competition horse Wodan M. This achievement marks an important step in preserving genetics of top-performing horses and conserving endangered breeds.
Researchers found that sleep deprivation alters the composition of gut microbiota, leading to worse cancer progression and reduced effectiveness of chemotherapy. The study highlights the importance of maintaining a healthy microbiome through good sleep and diet.
Professor Thierry Chevalley has received the prestigious IOF President's Award for his significant contributions to advancing bone health and osteoporosis prevention. With extensive research expertise in geriatrics and bone health, he serves on various scientific committees and leads efforts to develop fracture liaison services.
A study published in Geology found that up to 75.7% of landslides occur during low or no rainfall periods, with early-stage rainfall reaching the sliding surface through three runoff supply modes and two migration stages. The team recommends mass monitoring, public education, and engineering mitigation measures to prevent such disasters.
A new study led by Dartmouth Cancer Center identifies key barriers to timely head and neck cancer treatment in rural areas, including transportation and caregiver challenges. The research highlights the importance of dedicated staff, strong community ties, and peer support in navigating the complexity of cancer care.
A study of over 1.27 million federal complaints found that older Americans and veterans receive slower responses than the general population, with a widening gap over time. The trend is particularly concerning for elderly residents in economically disadvantaged zip codes, who face the widest gaps in response times.
A new study reveals that freshwater fish are accumulating antidepressants, opioids, and other drugs of abuse in their bodies, which can alter their behavior, development, and reproduction. The research uses a novel analytical method to detect these substances in small fish living in rivers receiving urban wastewater.
Researchers at WashU Medicine discovered that mRNA vaccines can trigger strong anti-tumor responses even without certain immune cell subtypes, suggesting a novel pathway for cancer treatment. The study found that both cDC1 and cDC2 dendritic cells play a role in stimulating T-cell responses.
A Reproductive Justice (RJ) lens is crucial for addressing systemic inequities in high-risk pregnancy care, argues a new commentary. This approach recognizes that structural forces, not just medical factors, shape the options available to families navigating complex fetal diagnoses.
A bidirectional brain-computer interface (BCI) allows individuals with spinal cord injuries to control a robotic exoskeleton using brain signals and receive artificial leg sensation. The system, developed by UC Irvine researchers, demonstrates high accuracy in step counting and sensory discrimination tasks.
Artificial intelligence models provide personalized advice, but may perpetuate negative stereotypes about people with autism. Researchers found that up to 70% of the time, AI discourages those with autism from socializing.
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
A recent study by University of Ottawa professor Abel Brodeur found that 85 percent of social-science papers are computationally reproducible, suggesting improved norms for data sharing and code disclosure. This encouraging result aims to advance science and improve public trust in research.
A new study found that methylsiloxanes, a widely used industrial chemical, are present in the atmosphere across diverse environments, with concentrations up to 4.3% of total organic aerosols. The discovery raises concerns about potential health risks and climate impacts, highlighting the need for further research on these unknown effects.
A new study by University College London found that gabapentinoids, prescribed for chronic pain, double the risk of hospitalization for drug poisoning when combined with benzodiazepines or opioids. The risk persists even after starting gabapentinoid treatment, suggesting they may not be an effective solution to reduce poisoning risks.
Large, warm-bodied fish like sharks and tuna require nearly four times more energy than other fish due to their ability to retain metabolic heat. This comes with elevated energetic costs, which may constrain body size and contribute to extinction risk in both living and extinct species.
A team of researchers has discovered over 3,700 new bacteria species in coral reefs, each producing unique bioactive compounds with vast industrial and medical applications. The findings reveal the immense genomic potential of reef-building corals and highlight the importance of conserving these ecosystems.