Researchers developed a machine learning model, DefensePredictor, to predict bacterial immune systems. The model identified hundreds of previously unknown immune systems and validated their function in 42 cases.
Fábio Rosa's research has enabled genetic reprogramming of various cancer cell types to activate the immune system and bring about their own destruction. His approach uses tools from gene therapy to generate rare and functionally specialized immune cells that trigger powerful anti-tumor responses.
The report proposes new strategies for digital safety, including AI-powered tools to detect and intervene in harmful situations. Experts also recommend involving children and youths in the design process, particularly schools, to promote agency and well-being.
A new study published in PLOS Medicine found that sugary drink taxes had no effect on beverage calorie purchases from Taco Bell locations with and without such taxes. The analysis of nearly 7 billion transactions suggests that these policies may not be effective in reducing sugar consumption in fast-food restaurants.
Researchers have developed a technique to image individual atoms at solid-liquid interfaces in a range of non-aqueous solvents, enabling the study of key chemical processes and catalysts. The 'nano-aquarium' method uses graphene windows to contain tiny liquid cells, allowing for atomic-scale imaging and tracking of millions of atoms.
In a breakthrough, researchers have developed a method to assemble conductive polymers within living tissues using natural blood proteins and whole blood as catalysts. This approach enables targeted control of neuronal activity in living mice using near-infrared light.
A male octopus's dual-purpose arm can detect progesterone, a hormone produced by the ovaries, allowing it to locate the oviducts for fertilization. This specialized organ demonstrates how sensory systems can shape reproductive behavior and potentially influence speciation.
A newly discovered fossil site in southwest China reveals that many key animal groups evolved before the start of the Cambrian Period. The study found fossils of ancestors of modern starfish, sea cucumbers, and chordates, pushing back the timeline of complex animal life by at least 4 million years.
Researchers identify 'mitochondrial pearling' as key process for maintaining uniform spacing of nucleoids in mitochondria. Pearling involves a transient transformation that helps redistribute mtDNA clusters, ensuring efficient energy production and preventing disease.
Researchers develop Dynamic Infiltration Rate (DIR) biomarker to quantify tumour growth and predict patient survival. The DIR integrates volumetric growth and mechanical effects on brain tissue, enabling differentiation between aggressive tumours.
A new fossil assemblage in Yunnan, Southwest China has provided insight into the transition between Ediacaran and Cambrian periods. The site contains over 700 specimens, including bilaterian animals with preserved eating and locomotion structures, suggesting early animal diversification.
Researchers at University of Michigan have developed a fast method to measure the effectiveness of plasma-based air disinfection, which can deactivate up to 99.9% of virus particles. The approach harnesses UV fluorescence to track changes in aerosol infectivity in real-time, providing essential information for public health guidelines.
The Global Virus Network meeting highlighted advances in artificial intelligence, antiviral therapeutics, and immunology that could shape future pandemics. Researchers showcased next-generation inhibitors targeting the SARS-CoV-2 main protease and demonstrated how AI can predict viral evolution.
Researchers analyzed 20 years of fishery survey data to understand how environmental change affects marine ecosystems. The study found a decline in biodiversity, with biomass concentrated in fewer species, mirroring Maine's coastal economy.
Scientists have successfully developed wheat with dramatically reduced levels of asparagine, without affecting yield, using CRISPR genome editing. The study resulted in a significant reduction in free asparagine concentrations, up to 93%, without impacting yield, and lower acrylamide formation in food products.
A study reveals CHKA and EGFR cooperate to activate the MAPK pathway, driving glioma progression. CHKA knockdown suppresses tumor growth, while EGFR overexpression rescues this effect.
Researchers at University of Liège develop mouse model to study Stard7's role in intestinal cancers, revealing protein's dual effects on tumour development. In some cases, Stard7 deficiency reduces tumour growth, while in others it accelerates it.
Researchers create highly conductive ferroelectric charged domain wall in 2D indium selenide material, exhibiting high conductivity and controllability. The discovery may advance the development of neuromorphic devices and reconfigurable electronics.
The American Heart Association and NFL will welcome thousands to train in Hands-Only CPR at the NFL Draft, a lifesaving skill that can double or triple a person's chance of survival. This effort aims to empower fans, families, and communities with a simple yet powerful message: be ready to save a life.
Researchers at UT MD Anderson found that high-dose radiation delivery significantly improves patient outcomes, with a median survival of 28.7 months compared to 11.9 months for chemotherapy alone.
A new methodology, ADeLe, offers precise explanations and predictions regarding AI model performance in unseen tasks. It identifies limits of models' reasoning capacity, allowing errors to be anticipated before deployment.
Researchers reveal that high levels of hypoxia-inducible factor-2 (HIF-2) in pancreatic tumor microenvironment protects cells from ferroptosis, a promising target for therapy. The study identifies key biochemical pathways activated by HIF-2 to limit ferroptotic cell death.
Researchers found that Stentor coeruleus uses geometric features to navigate its environment, with a preference for corner spaces. The microorganism changes its shape to interact physically with surfaces, allowing it to locate and settle into protected niches.
The São Paulo School of Advanced Science on Regulatory Governance explores emerging regulatory frontiers in Latin America. The program features speakers from leading international institutions and offers a range of activities, including flash talks, poster presentations, and paper development workshops.
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
The Heinz Maier-Leibnitz Prize is awarded annually by the Deutsche Forschungsgemeinschaft to recognize excellence in scientific research. This year's winners have made significant breakthroughs in various fields, including quantum computing and materials science.
Researchers develop method to model record correlations in synthetic data, preserving global and local distributions. This approach significantly outperforms current state-of-the-art methods, offering high utility and robust privacy protection.
A new software package called CREsted has been developed to analyze and design gene regulatory elements in a systematic and scalable way. The framework turns enhancer modeling from one-off analyses into a reusable workflow, enabling researchers to study enhancer logic across biological systems.
Dr. Cudjoe's research examines the influence of social connection on health and developing interventions to address social isolation in older adults. He is a recipient of several awards, including the National Institute on Aging GEMSSTAR award and the Robert Wood Johnson Foundation Amos award.
Researchers used supercomputer simulations to study how red blood cells deform under stress, shedding light on hemolysis risks in blood pump conditions. The study offers new insights that could lead to safer and more effective blood pump designs.
The oXiris membrane addresses complex sepsis by integrating diffusion, convection, and adsorptive properties to remove inflammatory mediators. Early physiological improvements and potential benefits for cardiac surgery-associated acute kidney injury and severe COVID-19 have been reported in observational studies.
A team of researchers from the IBMCP has discovered a new molecular mechanism that regulates the formation of vascular tissues in plants. Thermospermine acts as a biological switch to control the production of key proteins, influencing water transport and structural support.
Therapy-related myeloid neoplasms (t-MN) pose a significant threat to female cancer survivors, with limited treatment options and high mortality rates. New therapies and diagnostic approaches, such as CAR-T and hypomethylating agents, offer hope for improved treatment outcomes and prevention.
The team successfully developed a multifunctional catalyst incorporating palladium and copper complexes on mesoporous silica, enabling the efficient activation of ketones and allyl alcohols. This process accelerates the allylation reaction by up to a factor of 15.5 compared to previous catalysts.
A new framework called CH4Vision uses hyperspectral satellite imagery to estimate methane flux directly, improving accuracy and robustness. The method incorporates plume morphology and machine learning to infer emission rates, increasing reliability of satellite-based quantification.
The Association for Computing Machinery has published its inaugural issue of ACM AI Letters, a premier venue for rapid and timely AI research. The journal aims to bridge the gap between traditional conferences and journals, featuring short, peer-reviewed contributions that accelerate knowledge dissemination across academia and industry.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
Researchers identified DMBT1 as a key target of Lentinus edodes-derived β-glucan in inhibiting cervical cancer progression. The compound's anti-cancer activity was shown to be closely correlated with DMBT1 expression levels, suggesting its potential as a prognostic marker or therapeutic target.
Researchers developed a new sensor called CAMEO to monitor electrical activity in human cerebral organoids, facilitating research into neurodevelopment and genetic disorders. The device is made of carbon nanotube strands, enabling low-cost and scalable monitoring.
Researchers identify Nipah virus's critical survival strategy by hijacking human protein NSUN2, facilitating viral replication. A dual-targeting antiviral strategy has been developed, combining an approved drug with an experimental inhibitor to effectively reduce virus levels and improve survival in animal models.
A randomized trial tested HabitWorks, a smartphone app offering personalized exercises to target interpretation bias. Participants reported significant improvements in interpretation bias, functioning, and overall mental health symptom severity.
A study by researchers from the University of Michigan and international institutions recommends prioritizing grid upgrades targeting long-term demand expectations to minimize total costs. By upgrading the grid first, utilities can create a more efficient infrastructure that leverages Vehicle-to-Grid (V2G) chargers more effectively.
A study published in The Lancet Regional Health – Americas found that carefully selected older adults can safely undergo surgery and achieve outcomes comparable to younger patients. The research challenges longstanding assumptions about age and cancer treatment, suggesting that older adults should not be excluded from potentially curat...
Researchers have developed a new artificial intelligence framework called CLAK that enables drones to localize themselves in GPS-denied environments using non-visual sensors such as LiDAR, barometric altitude, and inertial measurements. The model improves localization accuracy while remaining lightweight enough for practical deployment.
A large-scale study published in Nature found that hundreds of researchers reanalyzing the same data often reached divergent conclusions. The study highlighted the critical role of collaboration and exchange across disciplines in achieving robust results.
Children with rare food allergy FPIES exhibit atypical gut microbiota compared to healthy peers, according to a new Umeå University study. The analysis of stool samples revealed differences in bacterial composition associated with FPIES, which may contribute to the development of more individualized strategies for diagnosis and treatment.
The Mount Sinai Hospital has pioneered a new minimally invasive liver cancer treatment method that allows doctors to treat patients on more days of the week, improving access and reducing wait times. This breakthrough innovation, called TheraSphere Y-90 Any Day Dosing, enables flexible scheduling and seamless care coordination.
The University of Cincinnati has established a new Center for Public Health, led by Dr. Suzanne Judd, a renowned epidemiologist and expert in health disparities. The center aims to transform community health through innovative research, education, and strategic advocacy.
A large-scale study found a reciprocal relationship between sleep disturbance and the gut microbiome, improving dementia risk prediction accuracy. The protein-based model identified key proteins associated with dementia risk, offering potential therapeutic targets.
Calls to poison centers about kava, a plant-based drug promoted as a healthy alternative, rose 383% between 2011 and 2025. The number of exposures leading to severe health outcomes also increased, with 32% in 2025.
Researchers developed a blood-based test that analyzes circulating tumor HPV DNA to inform personalized treatment strategies for HPV-associated throat cancer. The study found that ctDNA levels change before and after surgery, influenced by tumor biology and kidney function.
MILCAnet, a dominant feature attention framework, enhances multimodal data analysis in depression detection by combining key feature extraction and feature fusion. This innovative approach offers a more efficient and accurate solution for non-contact depression screening.
This cross-sectional study found that direct care worker unionization and employer ownership are independently associated with workforce turnover rates. State policies facilitating DCW unionization or public employment of DCWs may improve retention rates, according to the study.
A new study proposes an innovative framework called SEA-SQL, which uses zero-shot prompts and GPT-3.5 to perform the Text-to-SQL task more effectively and economically. The method enhances database content with semantic information and eliminates biases in SQL queries.
A new class of ultra-high strength and ductility steel has been created using machine learning, achieving a rare balance of extreme strength and ductility. The resulting metal resists corrosion and degrades slowly in salt-water tests.
A new portable AI-powered scanning slit-light device makes low-cost eye disease screening more accessible, providing quantitative measurements and qualitative assessments of anterior-segment abnormalities. The lightweight AI model allows for on-device analysis, reducing operator dependence and improving portability.
A new virulence regulator called Fis is found to play a crucial role in regulating the virulence of Yersinia pseudotuberculosis, a diarrheal pathogen. The protein represses virulence genes at cooler temperatures outside the host.
A study using Arabidopsis revealed that germline segregation occurs earlier than previously thought, with some cells segregating during inflorescence meristem formation. This finding supports Weismann's germ plasm theory and provides insight into how plants balance developmental plasticity with safeguarding genetic integrity.
Researchers introduced a self-attention network to analyze micro-expression temporal features, improving recognition performance. The approach preserves richer variation features through complete sequence analysis, marking a technological breakthrough.
A lower semaglutide price could generate savings that offset the cost of treating an additional 550,000 to 3.6 million Medicare beneficiaries eligible for expanded obesity-indication coverage. This voluntary price agreement may lead to substantial savings for Medicare spending on semaglutide treatment.