Researchers developed a novel fluorescent nanosensor to detect IPA, an emerging biomarker linked to gut health and disease. The sensor offers rapid detection within minutes, distinguishing IPA from closely related metabolites, enabling accurate measurement even in complex biological environments.
Researchers discovered a key issue in the production of purines, molecules required for DNA repair, and its link to ALS. The mechanism may be reversible, offering new hope for therapeutic development.
A national cohort study found that living in high-segregation neighborhoods was associated with lower likelihood of live donor liver transplant (LDLT) access. Candidates from high-segregation neighborhoods with larger racial and ethnic minority populations had a lower likelihood of LDLT compared to those from white populations.
A new adaptive charging strategy for lithium-ion batteries reduces battery degradation and improves efficiency. The strategy uses real-time monitoring and adjusts charging currents to prevent lithium plating, resulting in improved charge capacity utilisation and charging efficiency.
Researchers developed a 'walking fish' robot that mimics modern fish's ability to walk on land, and computer models showed similar modes of locomotion across several unrelated species. This undulating tripod gait is one of life's most ancient solutions to escaping predators or moving habitats.
A study reveals that farmers' moral motivations are equally important as financial interests when adopting organic practices. The research found a strong balance between utilitarian and moral dimensions, highlighting the need for tailored policies to promote sustainable farming practices in Andalusia.
Researchers developed an ultra-stretchable, anti-freezing hydrogel electrolyte using liquid metal particles, enabling flexible energy storage devices to operate reliably in harsh environments. The material maintains stable electrochemical performance even at -20 °C and retains 98% of its performance after 45,000 charge-discharge cycles.
A recent study published in Science Direct found that patients with detectable circulating tumor DNA (ctDNA) benefit from chemotherapy, with a three-year relapse-free survival rate of 77 percent. The test can help identify patients who require more targeted treatment, potentially reducing the risk of recurrence.
Scientists at La Jolla Institute for Immunology have discovered that 'cross-reactive' T cells can recognize multiple species of paramyxovirus, including measles and Nipah viruses. This broad protection is essential in combating emerging diseases with unknown viral strains.
A Stanford-led team has identified the molecular basis of Hechtian structures, which maintain plant cell membranes connected to the wall during water loss. Plants with more Hechtian structures recover better once water returns.
The latest publication from Wroclaw Medical University reveals that gastrointestinal health is influenced by culture, social relationships, economic status, and individual functioning within society. Chronic stress disrupts communication between the brain and gut, leading to increased symptom severity and reduced quality of life.
A new study by the American Society of Hematology finds that stem cell transplantation is the most cost-effective option for long-term care of sickle cell disease in adults. Gene therapy, while promising, comes with an astronomical cost and requires a significant price reduction to be competitive.
A recent study published in Nature Food found that people without access to clean drinking water are more likely to experience food insecurity and food safety threats. The research analyzed survey data from over 124,000 respondents across 121 countries and highlights the urgent need for coordinated global action to address these issues.
The African Engineering and Technology Network (Afretec) has signed its tenth university partner, Addis Ababa Science and Technology University (AASTU), to drive digital transformation in Africa. The network, led by Carnegie Mellon University Africa, aims to create long-term sustained change across the continent through research, educa...
The State of Carbon Dioxide Removal report reveals that current pledges fall short of pathways limiting warming to 1.5°C by more than 5 billion tonnes of CO2 per year by 2050. CDR must grow at rates comparable to or faster than the most rapid clean energy transitions, including solar power.
The investigation highlights the lack of research on AI toys' impact on early cognitive and socioemotional development, while also raising concerns over security risks and potential harm to minors. Experts advocate for mandatory labeling and regulation to ensure safer deployment of these devices.
The first national audit of advanced heart failure referrals reveals significant gaps in access to life-prolonging therapies, particularly for women. Women represent just 1 in 3 referrals, despite comparable disease burden.
A new study published in the Journal of Big Data highlights the journal's emergence as a leading publication in data science and artificial intelligence research. The study found that JBD has become a central hub for high-impact research worldwide, with significant contributions from top researchers.
Researchers have discovered that different flu viruses use distinct strategies to infiltrate cells and found a cellular pathway that blocks virus entry into lung cells. This study provides fundamental insights into how seasonal influenza viruses infect people and illuminates a path for developing better medications.
The International Congress of Mathematicians (ICM) 2026 will take place in Philadelphia from July 23 to July 30, featuring the announcement of Fields Medals and top talks on cutting-edge developments in mathematics. The conference will also explore the impact of artificial intelligence on mathematics.
City of Hope launches nationwide platform to share messages of encouragement with cancer survivors and their loved ones, offering tailored survivorship care and coordination between specialists and primary care physicians. The organization's data-driven model integrates supportive care from diagnosis through decades of follow-up.
Scientists at The University of Osaka have successfully fabricated protein networks in living cells using a focused laser beam. The approach allows for non-invasive control over network formation and exhibits dynamic motions similar to those observed in living cells.
A team of researchers from the Norwegian University of Science and Technology conducted a study on 28 individuals who experience an unexplained buzzing or humming sound. The investigation tested two hypotheses: measuring the sound waves from human-made infrastructure and industry, as well as those produced by nature itself.
The Trace Institute aims to develop a unified mathematical theory of conscious observers and traces, potentially transforming our understanding of physics, neuroscience, and spirituality. With AI-assisted models, the institute seeks solutions to long-standing problems in these fields, innovating new technologies for society.
A new study maps careers as rivers to show how researcher independence unfolds over time, influenced by relationships, external conditions and internal growth. The findings reveal a dynamic, lifelong process formed by both individuals and the systems they work within.
Research finds that individuals who have overcome adversity are less likely to support reforms that make it easier for others to achieve similar goals. This is because they want to protect the value of their own hard work and achievements.
A new study found that adults feeling older than their chronological age experience more insomnia symptoms, less regular sleep, and greater daytime sleep-related impairment. The mismatch between subjective age and actual age is associated with poorer self-reported physical health.
A new study finds that individuals with later sleep schedules report poorer mental health, higher general loneliness, and greater nocturnal loneliness. Nighttime loneliness is a key pathway connecting later sleep patterns to anxiety.
The development of AI-enabled research platforms poses a risk of unequal access, potentially excluding scientists without resources or connections. As decisions about platform accessibility are made in the next five years, it will shape the geography of global discovery for generations.
A retrospective analysis of over 110,000 women found that GLP-1 medication users were 30% less likely to develop breast cancer. The study suggests that GLP-1s may inhibit tumor growth and reduce systemic inflammation, which could play a role in breast cancer development.
Binghamton University researchers have developed a new way to reduce troublesome fake information in AI chatbots, with high accuracy in identifying disease terms and drug names. The protocol harnesses multiple large language models to verify answers through 'voting', increasing confidence in the results.
AI models struggled to maintain focus on a task, degrading in accuracy as the word list length grew longer. Human performance, however, remained stable even with long lists, suggesting fundamental limitations in AI decision-making abilities.
Researchers have tested a new experimental cancer drug called gamitrinib in its first-in-human study. Gamitrinib is designed to target the mitochondria of cancer cells, where it can disrupt their energy systems.
A new study found that middle-aged women who experienced poor sleep problems had lower psychological well-being nine years later. The association remained significant even after adjusting for other health and lifestyle factors, suggesting that sleep may play an outsized role in how women feel and function later in life.
Women experience anxiety and depression at higher rates due to factors such as hormonal imbalances, violence, and discrimination. The authors advocate for evidence-based solutions like group therapy, telehealth, and policy changes to reduce women's stress, including paid maternal leave and financial support.
Researchers at Tokyo University of Science engineered CYP107J1 enzyme from Bacillus subtilis into a more practical tool for selective oxidation chemistry. The modified enzyme showed 28-fold higher catalytic activity and successfully converted indole into indigo, a commercially important blue dye.
Researchers identify previously unknown protein RAK1, crucial for three-dimensional growth and division in moss, a step towards understanding plant colonization of land. The study provides new insight into fundamental mechanisms underlying plant growth and evolution.
Researchers at ETH Zurich developed biohybrid microrobots that combine living neural progenitor cells with magnetoelectric nanoparticles to guide stem cells to injury sites and stimulate repair. The microrobots demonstrate promising results in animal experiments, including improved nerve cell regeneration and recovery of motor function.
Researchers found that tissue rigidity is regulated by cell-cell adhesion and influences morphogen signalling, which determines cell polarity and fate. Increasing tissue stiffness leads to the formation of fluid-filled lumens and traps developmental signals, providing instructive cues for development.
Researchers measured wind speeds on seven hot, Jupiter-like exoplanets and found that magnetic fields govern the winds. The team's findings provide the strongest evidence yet of magnetism on planets outside our Solar System.
Researchers at MIT have created a pacemaker that uses ultrasound technology to stimulate the heart, offering a potential surgery-free alternative to traditional cardiac implants. The device is designed as a small sticker that sends ultrasound pulses through the chest to regulate heart contractions and correct arrhythmias.
Researchers found strong magnetic fields on ultra-hot Jupiters, similar to those in our Solar System. The presence of these fields could affect planetary climates and potentially create dramatic aurorae displays.
The US overdose death rate declined by 24.4% in 2024, primarily driven by falling fentanyl-related deaths. However, deaths involving only stimulants continued to rise, and racial disparities remain severe. The study highlights the need for targeted public health interventions to address persistent inequities.
Massachusetts Medicaid members who received medically tailored meals experienced significantly fewer health emergencies, including 31% fewer hospitalizations and 20% fewer emergency department visits. The program also resulted in lower per-person healthcare costs of $3,433, offsetting 98% of the program's cost.
Researchers developed a manufacturing platform for producing targeted mixtures of beneficial gut bacteria, demonstrating comparable safety and efficacy with fecal microbiota transplants. The new approach uses defined bacterial strains isolated from donor stool and grown under controlled conditions.
Researchers developed a new reference model for the human brain using diffusion MRI scans from over 54,000 people. The model provides growth charts for white matter neural pathways, helping identify subtle changes linked to aging, Alzheimer's, schizophrenia risk and other neurological conditions.
The study provides new insight into how cells recognize and remove harmful DNA bases using human SMUG1 enzyme. The enzyme removes uracil and related damaged bases from DNA to prevent permanent mutations.
A new study identifies vgll3 as a key gene promoting rapid growth and early reproduction in vertebrates, yet increasing the risk of aging and cancer later in life. The findings provide rare experimental evidence for the theory that evolution favors early-life advantages even at the expense of long-term health.
A new spatially explicit population model for springtails in soil simulates dynamic environmental conditions, linking development and reproduction to temperature and moisture. The model provides a realistic assessment of ecosystem health under changing environments.
Researchers have identified an experimental molecule called OLE that helps restore microglia's protective function against Alzheimer's disease. The compound reduces beta-amyloid plaque size and toxicity, improving cognitive performance in memory tests.
A new framework, criticome, integrates experience until age 25, reframing autism, schizophrenia, depression, and trauma as developmental disorders. The study suggests that screen-saturated childhoods may produce adult dysfunction, highlighting the importance of early experience in brain development.
A new study found that biodiversity offset grasslands support twice the number of wild bees compared to existing grasslands, with comparable numbers of hoverfly species. While not perfect replacements, these offsets can provide important resources for pollinators and may be as effective as existing sites in terms of species richness.
A new monitoring system, NeuroSense, tracks cerebrospinal fluid at the bedside for faster intervention in intensive care units. The system detects biomarkers of infection and flow rate, enabling early warning of complications and better treatment decisions.
Acetaminophen remains the recommended medication for treating pain and fever during pregnancy. Recent studies have investigated its potential association with childhood neurobehavioral issues, but significant limitations were found in their study designs. SMFM recommends acetaminophen as a safe treatment option for pregnant patients wh...
Researchers at Mount Sinai discovered that focused irradiation can help CAR-T cells survive longer and work more effectively inside tumors. Irradiation turns dendritic cells into a local source of stimulation for CAR-T cells, promoting durable control of advanced lung tumors.
Researchers find that climate change is weakening the ability of snow cover over burn scars to offset forest fire carbon emissions. Historically, this natural process helped cool the climate after northern wildfires.
Researchers achieved near-quantitative selectivity for methane oxidation to methanol, acetic acid, and other oxygenates via the Na–Auδ⁻ interface. The catalyst demonstrated high productivity and controlled in situ generation of H₂O₂ and ·OH radicals.
Researchers have developed a new electrolyte design paradigm for constructing low-temperature-resistant lithium metal batteries. The 'polarity-contrast' electrolyte strategy constructs a stable, anion-dominated solvation structure at low temperatures by modulating ion-dipole interactions.
A new strategy for single-cell spatial proteomics has been developed using an ordered colloidal crystal chromatographic column, improving analytical throughput while maintaining deep proteome coverage. This approach enables the identification of up to 2,304 proteins from a single hepatocyte slice within 5 minutes.
A research team at Niigata University has identified a copper-HIF1α-BNIP3-mTOR pathway connecting trace elements to glial cell development in autism spectrum disorder. Lower plasma copper levels were associated with higher ASD symptoms and reduced white matter volume, which was linked to social symptoms.