Researchers created human organoid models of fatty liver disease to shed light on drug responses and disease biology. The models identified a common mechanism for effective drugs that block lipid generation from sugars, suggesting personalized medicine applications.
A study published in eLife has linked infection with the bacterium Fusobacterium nucleatum to an increased risk of cardiovascular disease. The researchers found that individuals with high genetic risk scores for coronary heart disease were at elevated risk for cardiovascular events.
A recent study published in BMC Medicine found that higher consumption of free sugars is associated with a higher risk of cardiovascular disease. The researchers analyzed data from 110,497 individuals and found that consuming more free sugar, particularly from sugary drinks and sweets, increases the risk of heart disease and stroke. In...
Scientists have discovered that wrinkles in the cellular nucleus may be involved in common metabolic diseases such as diabetes and fatty liver disease. The new findings suggest that targeting these wrinkles could lead to novel treatments for non-alcoholic fatty liver disease, which affects 40% of people over age 70.
Researchers at Bar-Ilan University have developed a new treatment for Alzheimer's disease that targets the earliest, pre-symptomatic signs of the disease. The treatment, using cyclic peptides, has shown promise in diagnosing and preventing progression of the disease by blocking the formation of toxic oligomers.
A study found that unintentional weight loss in people with Down syndrome coincides with brain changes associated with Alzheimer's disease, indicating it could be an early predictor. The researchers suggest that weight loss may be a useful tool for making an earlier diagnosis.
A study found that people with coeliac disease have a 27% increased risk of cardiovascular disease compared to those without the condition. Despite this, they tend to have lower BMI and blood pressure, which are traditional cardiovascular risk factors.
Lithuanian researchers have developed an AI system to detect early symptoms of Parkinson's disease using voice data. The study found that patients with early-stage Parkinson's often speak in a quieter, more monotonous tone, which can be difficult to notice by ear.
A new study identifies a protein called GFAP as a possible biomarker for very early stages of Alzheimer's disease, which can be detected ten years before symptoms arise. This breakthrough discovery could lead to earlier diagnosis and treatment of the disease.
Researchers at Mount Sinai developed a digital marker for coronary artery disease using machine learning and electronic health records. The model accurately measures CAD on a spectrum, revealing distinct gradations of disease risk and survival, which may otherwise be missed with conventional binary frameworks.
A Cedars-Sinai study found that even subtle forms of liver disease directly impact heart health, with elevated FIB-4 scores associated with abnormalities in heart function and vascular dimension. Cardiac MRI scans revealed that nearly 86% of patients had at least one heart abnormality.
People with rheumatoid arthritis have a higher risk of cardiovascular disease due to inflammation. However, new research suggests that commonly used treatments for RA can also lower this risk by reducing arterial inflammation and disease activity. The study found that immunomodulators like methotrexate and TNFi drugs reduced heart dise...
Researchers identified formic acid as a sensitive urinary biomarker for early-stage Alzheimer's disease, which could lead to large-scale screening programs. The study found that formic acid levels correlate with cognitive decline and can predict disease stage when combined with blood-based biomarkers.
A new study suggests that ships may be spreading a deadly coral disease across Florida and the Caribbean. Researchers found that transport through ship ballast water could contribute to disease spread.
Scientists discovered the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE). The study suggests a therapeutic strategy for the disease, which currently lacks treatment.
Researchers at UTA analyzed how seven reef-building coral species in the Caribbean respond to white plague disease, identifying three consistent patterns of gene expression and adaptation. The study provides a novel framework for understanding broad coral disease resistance traits and their relationship to immune responses.
A new study led by NYU researchers has developed a topical gel that targets the succinate receptor to suppress inflammation, reduce bacterial imbalance, and prevent bone loss. The treatment has shown promise in reducing gum disease symptoms, including inflammation and tooth loss.
Researchers established a novel strategy to treat Huntington's disease by converting the disease-causing form of the huntingtin protein into its disease-free form. This process maintains the original function of the protein, offering a new approach to tackle the neurodegenerative disorder.
A recent study has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease. The research highlights the causal role of mesenchymal cells in intestinal inflammation, shedding light on the genetic roots of inflammatory bowel disease.
A study of 22 million patients found that those with autoimmune disorders have a substantially higher risk of developing cardiovascular disease. The excess risk is similar to that of type 2 diabetes and affects the entire cardiovascular disease spectrum.
Researchers at Lund University have developed a new method for studying Huntington’s disease by reprogramming skin cells into aged neurons. The results show several defects that explain some of the disease mechanisms in neurons from patients with Huntington’s disease, including problems with protein breakdown and recycling. This innova...
A VA study found nearly identical genetic variations contributing to coronary heart disease risk across major racial and ethnic backgrounds. The findings suggest that other factors like access to healthcare contribute to higher heart disease rates in certain populations.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that people with sedentary lifestyles and unhealthy sleep behaviors are at risk for developing fatty liver disease. Moderate improvement in sleep quality was related to a 29% reduction in the risk for fatty liver disease.
A team of scientists has discovered a key link between the protein αSyn and Parkinson's disease, finding that it interacts with immune responses in neurons. This interaction may play a critical role in the development of the disease, suggesting a potential new approach for treatments by targeting inflammatory pathways.
Researchers have created a new DNA atlas that provides insights into how genes in specific cells contribute to coronary artery disease. The atlas identifies over 200 independent genetic markers associated with disease risk, offering a potential roadmap for interpreting non-coding variants.
A new study published in Neurology found that people with non-alcoholic fatty liver disease are at a higher risk of developing dementia. The study, which analyzed 30 years of Swedish patient registry records, also found that those with liver disease and cardiovascular conditions had an even greater risk.
A study published in The American Journal of Medicine found that regular physical activity can substantially reduce the risk of chronic kidney disease in individuals from lower socioeconomic backgrounds. Participants with higher levels of fitness showed a significantly lower risk of developing the disease, even among those with low soc...
Researchers discovered that copper accelerates protein aggregation in Parkinson's disease, forming ring-shaped structures that can be used as therapeutic targets. The study provides new clues to the development of the neurodegenerative disease.
Researchers discovered that lean individuals with non-alcoholic fatty liver disease (NAFLD) are at a higher risk of developing cardiovascular diseases compared to those who are overweight or obese. Despite lower rates of other health conditions, lean patients with NAFLD exhibited increased prevalence of cardiovascular disease.
A new study found that lean individuals with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease compared to those who are overweight or obese. Despite having lower risks for other metabolic and cardiovascular conditions, lean patients with NAFLD were more likely to develop cardiovascular disease.
An artificial intelligence model trained on histological images of surgical specimens accurately classified patients with and without Crohn disease recurrence. The model revealed previously unrecognized differences in adipose cells and mast cell infiltration, enabling stratification by prognosis for postoperative Crohn disease patients.
A new study from Norway found that COPD patients have a higher degree of coronary artery calcification and narrower coronary arteries. The researchers discovered an increased risk of coronary disease in COPD patients, independent of disease severity, emphasizing the importance of early detection.
A new study published in Radiology: Cardiothoracic Imaging found that aspirin therapy did not reduce major cardiovascular events in patients with non-obstructive coronary artery disease. Statin use, however, was associated with a significant reduction in cardiovascular events.
A study by University of Gothenburg researchers has identified two biomarkers that can distinguish between patients with subcortical small-vessel disease, Alzheimer's disease, and mixed dementia. The discovery opens up new possibilities for diagnosis, treatment, and medication development.
A combination of two biomarkers has been found to identify patients with subcortical small-vessel disease, a common cognitive diagnosis. This discovery improves the potential for treatment and medication development for this patient group.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
Researchers developed a new cell model of the olfactory mucosa, which is impaired in patients with Alzheimer's disease. The study provides new insights into the disease pathophysiology, including the potential role of viral infections and air pollutants in brain function.
Researchers discovered that deficient mitophagy leads to human disease and developed a method to analyze mitochondrial recycling in diseased muscle. Pharmacological activation of mitophagy reversed the progression of mitochondrial muscle disease, offering potential treatment for this condition.
A comprehensive review highlights recently discovered associations between lncRNAs and specific diseases, including fatty liver disease and liver cancer. The study suggests that a diverse group of molecules known as long noncoding RNAs could emerge as biomarkers for liver disease.
Researchers have developed a new mouse model of Huntington's disease that recapitulates more disease-like characteristics than earlier models. The study provides new clues to the mystery surrounding genetic mutations and gives researchers a powerful tool to test new therapies.
A new study found that seafloor sediments can transmit a deadly pathogen to local corals, contributing to the persistence of a devastating coral disease outbreak. Coastal construction activities like dredging and beach renourishment may further spread the disease.
Researchers have discovered that heart disease causes early brain dysfunction, leading to reduced blood flow and increased risk of dementia. A combination of heart disease and a genetic predisposition for Alzheimer's Disease also trebles the amount of beta-amyloid protein in the brain.
A recent study by researchers at Case Western Reserve University found that Candida tropicalis fungus can trigger chronic inflammation in the gut microbiome of Crohn's disease patients. This imbalance of fungi and bacteria can create a predisposition to inflammatory bowel disease.
A team of researchers found a connection between energy production and Alzheimer's disease in zebrafish with mutated genes. They discovered that Alzheimer's disease affects the use of oxygen within cells to produce energy, leading to severe deficiency in brain function.
A University of Birmingham-led study found that patients with a recorded history of gum disease are at higher risk of developing mental ill-health (37%), autoimmune diseases (33%), cardiovascular disease (18%), and cardiometabolic disorders, particularly Type 2 diabetes (26%). The study used UK primary care data to explore the associat...
Banana Blood disease has arrived in mainland Malaysia, spreading rapidly across the country and potentially threatening food security. The disease, first reported in Indonesia in 1905, has already devastated banana plantations in many parts of Southeast Asia.
A new study by Keck Medicine of USC found that food insecurity increases the risk of death among patients with nonalcoholic fatty liver disease and advanced liver disease. The study, which analyzed data from over 34,000 individuals, suggests that eradicating food insecurity could eliminate up to 7% of nonalcoholic fatty liver disease d...
A study by Weill Cornell Medicine scientists found that blocking a signaling pathway in brain immune cells can protect against Alzheimer's disease features in a preclinical model. The results suggest a new strategy to block the development of the disease or slow its progression.
A new study provides preliminary data for a human clinical trial of a treatment that targets the root cause of Alexander disease. The treatment has shown promising results in halting the progression of the disease and even reversing some symptoms in rat models, which better represent the human condition.
A new study found that regular antibiotic treatment with penicillin significantly reduced the risk of underlying rheumatic heart disease progression in children and adolescents. Early screening was critical in preventing serious disease progression and death in young children.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
Researchers found that recessive Mendelian disease-causing genes were less likely to be swept out of populations, potentially due to genetic interference. This allowed these genes to persist longer in human populations despite their harmful effects.
A recent study suggests that targeting alpha-synuclein protein in Parkinson's disease may not be sufficient to cure most patients. Instead, resolving brain inflammation caused by dysfunctional interferon-beta receptor signaling may hold the key to developing more effective treatments.
Researchers have detected the earliest effects of Huntington's disease in the first two weeks of human embryonic development. The findings suggest that the disease process starts decades earlier than previously thought, and point to new approaches for finding treatments.
Researchers at the University of Missouri have found a significant increase in chronic wasting disease among Kansas counties, with seven previously undetected cases identified. The project aims to track the spread of the disease and raise awareness among hunters, who are encouraged to test their harvested deer for the disease.
Researchers used new approaches to track Lyme disease in Texas, finding an overlap between tick-bite locations and human cases. The study suggests that tick-bite location may serve as an indicator for human disease risk in nonendemic areas.
The Cleveland Alzheimer’s Disease Research Center will receive funding to accelerate research on Alzheimer’s disease and related dementias. The center aims to develop individualized treatment approaches for individuals with aging-associated brain disorders.
Researchers from FAU Harbor Branch adapted Structure-from-Motion photogrammetry to generate 3D models for tracking lesion progression and impacts on diseased coral colonies. The study found that stony coral tissue loss disease prevalence varied significantly across location, but not through time.
A longitudinal study of infants found substantial microbial changes in the intestines months before celiac disease onset. The study's findings suggest that these preclinical alterations could inform novel strategies for diagnosis and treatment of celiac disease through microbiome manipulation.