Researchers at Ulsan National Institute of Science and Technology developed foldable molecular paths using zeolitic imidazolate frameworks, which can adjust size, shape, and alignment in response to temperature, pressure, and gas interactions. This technology has potential applications in creating filters that adapt to capture harmful ...
A new experimental technique has developed a molecular flashlight to monitor molecular changes in the brain caused by cancer and other neurological pathologies. The technique uses vibrational spectroscopy to illuminate nerve tissue, allowing for the analysis of molecular changes caused by tumours or injuries.
A new technique detects brain metastasis in mice by inserting a thin probe into the brain, providing information on chemical composition. The technique uses vibrational spectroscopy and has the potential to analyze molecular changes caused by tumors or injuries without altering the brain beforehand.
A UC Riverside-led team, funded by the NIH, aims to uncover molecular factors governing gene regulation and chromatin organization in P. falciparum. The project focuses on long non-coding RNAs, which play a crucial role in regulating gene expression and influencing disease progression.
A pioneering study has unlocked precision medicine for breast cancer, providing a detailed roadmap of the disease's molecular evolution. The research enables targeted therapies tailored to individual tumors' molecular fingerprints, elevating survival rates and improving patient outcomes.
Researchers at Chiba University have created an electronically controllable sliding molecular machine using a newly modified ferrocene molecule. The discovery overcomes the challenge of stabilizing the fragile ferrocene molecule on a flat surface, enabling precise control of its motion through electrical signals.
The open-access journal Seed Biology has been successfully indexed in the Emerging Sources Citation Index (ESCI) in the Web of Science. This milestone strengthens the journal's academic discourse and impact, making its articles searchable and citable worldwide.
Georgios Skiniotis joins St. Jude as a faculty member in structural biology, establishing a Center of Excellence for Structural Cell Biology. The center will advance understanding of cell biology from atomic to micron scales using cryo-ET and vEM imaging.
Researchers at Brown University identified key growth cycle phases and molecular mechanisms that make some tomato varieties more heat tolerant. The discovery could inform a strategy to protect the food supply in the face of climate instability.
A new study provides deeper understanding of Myotonic Dystrophy Type 1 (DM1) by revealing an unexpected link between the cardiac condition and SCN5A protein. The research found that reducing fetal SCN5A expression did not correct heart defects, suggesting alternative approaches may be needed to address the condition.
Researchers create magnetically switchable materials by introducing chiral hydrogen bonds, allowing precise control over electron transfer. The study highlights the importance of molecular chirality in material performance.
Researchers used quantum mechanics/molecular mechanics and molecular dynamics to investigate the interaction between ATP and insulin-degrading enzyme in Alzheimer's disease. The study revealed crucial information for developing IDE inhibitors against ATP interactions, potentially slowing down AD progression.
Scientists discovered a unique way in which yeast cells adapt to starvation by coating their mitochondria with massive molecular complexes called ribosomes. This adaptation has potential implications for cancer treatment as it may help overcome the challenges faced by cancer cells when they are starved of nutrients.
Researchers identified a molecular mechanism that controls embryonic diapause in humans, allowing cells to temporarily slow down development. This dormant state is characterized by reduced cell division and slower development, and can be reversed when the mTOR pathway is reactivated.
Scientists have developed a unique strategy to control molecular conductance using shape-persistent ladder-type molecules. This approach enables the synthesis of diverse, charged molecules with consistent electronic properties, paving the way for reliable and efficient devices.
Researchers identified a small molecular glue that targets USP7 to increase P53 stability, suppressing tumor growth. The discovery of this platform may facilitate the identification of novel molecular glues stabilizing tumor suppressor proteins.
The American Society for Biochemistry and Molecular Biology has announced its annual awards, recognizing outstanding scientific achievements and community contributions. The winners will give talks about their research at the society's annual meeting in April, with cash prizes ranging from $2,000 to $35,000.
Researchers at PolyU have successfully developed a quantum microprocessor chip that can simulate large-structured and complex molecules with high accuracy. The breakthrough enables scientists to tackle complicated quantum chemistry problems beyond the capabilities of classical computers.
Researchers developed a new theoretical modelling technique to study molecular junctions, enabling significant light emission and high harmonic generation. The symmetries in configuration can enhance or suppress certain light frequencies, making it suitable for switch or amplifier applications.
Researchers from Max Planck Institute of Molecular Cell Biology and Genetics found a new mechanism for shaping animal tissues through collective, programmed cell behaviors. This discovery could help understand how tissues form in animals and provides a new approach to studying tissue-shaping processes.
Researchers classify glioblastoma's molecular profiles to develop targeted therapies, offering a nuanced view of its adaptability and response to treatment pressures. This study enhances our comprehension of this aggressive cancer and paves the way for personalized medicine.
Researchers have determined the structure of molecules within an Alzheimer's disease brain for the first time using cryo-electron tomography and fluorescence microscopy. This study revealed the molecular structure of tau protein and its arrangement with amyloid plaques, providing new insights into the pathology of the disease.
Experts at the University of Bristol have identified potential hazards in AI research for engineering biology, including inconsistencies in measurements and privacy concerns. The study proposes additional data hazard labels to describe these risks, aiming to ensure the safe development of novel biological compounds.
Researchers propose a new way to teach synthetic biology, breaking it down into five components: molecular, circuit/network, cellular, biological communities and societal. The approach incorporates ethics at each scale, with successful piloting in Northwestern University courses.
Researchers at Tampere University analyzed the molecular activity of over 10,000 genes to investigate the efficacy of ZED1227, a transglutaminase 2 inhibitor. The study found that ZED1227 effectively prevented gluten-induced intestinal mucosal damage and inflammation in celiac patients.
A team of researchers, including OHIO's Nate Szewczyk and students, published a comprehensive package of papers in Nature journals that transform our understanding of human space biology. The studies reveal how molecular biology and precision medicine can guide humanity into more challenging missions beyond Earth.
A team of scientists from Tohoku University and Kyoto University created a DNA-based molecular controller that enables swarm molecular robots to assemble and disassemble autonomously without external manipulation. This technology marks a significant step towards advanced autonomous molecular systems.
The Association for Molecular Pathology has published guidelines for tumor mutational burden (TMB) testing, aiming to standardize calculation and reporting of TMB as a predictive biomarker for immune checkpoint inhibitor therapies. These recommendations emphasize the importance of comprehensive methodological descriptions in publications.
Researchers found that hyaluronic acid with a specific molecular weight improves host inflammation by modulating the gut microbiota and metabolites. The optimal molecular weight range of hyaluronic acid to improve host inflammation has been identified, providing new strategies for alleviating inflammation.
Nach0 was trained on diverse tasks, including natural language understanding, synthetic route prediction, and molecular generation. The model performed well on molecular tasks using molecular data and outperformed ChatGPT, making it a significant step toward unlocking the full potential of LLMs for drug discovery.
Molecular biologist John Tower proposes a new 'rule of biology,' selectively advantageous instability (SAI), which suggests that some volatility in biological components provides an advantage to cells. SAI plays a key role in evolution, allowing for genetic diversity and adaptability, and may also contribute to aging.
A team at the University of Münster developed an improved method for explaining machine predictions of chemical reactions, using mechanisms such as reproduction, mutation and selection. The algorithm creates customised molecular fingerprints that predict chemical reactions with surprising accuracy, suitable for predicting quantum chemi...
A team from Pohang University of Science & Technology has developed a memory transistor that can adjust its threshold voltage through photocrosslinking. The innovation combines two molecules with a polymeric semiconductor to form a stable bond, enabling precise control of the semiconductor layer's structure.
Researchers conducted a groundbreaking study supported by the NIH Common Fund to examine the molecular effects of exercise on healthy adults and children. They discovered varied changes across the body, particularly in adrenal glands, and observed gender differences in molecular responses, especially in white fat tissue.
Scientists have found that prolonged physical activity causes extensive cellular and molecular changes in all 19 organs studied in rats. The study provides potential clues into many human health conditions, including non-alcoholic fatty liver disease and inflammatory liver disease.
Researchers have created a more efficient light-driven molecular motor, which can be used for various applications such as controlling molecular self-assembly and creating chiral dopants in liquid crystals. The new design also enables the motor to work more efficiently in medical applications due to its longer wavelength absorption.
SpatialData unifies spatial omics data from various technologies, enabling holistic analysis of cellular interactions and tissue function. The framework provides a unified representation and implements ergonomic operations for convenient processing of spatial omics data.
The Hevolution/AFAR New Investigator Awards support 18 researchers studying age-related diseases and healthspan. The program aims to advance basic biology of aging and geroscience research.
The ALMA radio telescope detected over 100 molecular species in the starburst galaxy NGC 253, a significant increase from previous studies. This knowledge will help astronomers understand the factors leading to starbursts and plan future observations.
Molecular quantum computing may connect quantum biology and cognitive science through shared concepts like quantum degrees of freedom. Researchers explore potential links between charge movement, spin states, and biological processes in neurons and photosynthesis.
The roadmap outlines six themes focusing on technical capacity, products and production methods that capitalize on engineering biology to reduce carbon intensity. It aims to limit harmful anthropogenic impacts, enable adaptation to climate change and create sustainable alternatives.
This year's Discover BMB program includes top experts unveiling groundbreaking discoveries and revolutionary approaches in biochemistry and molecular biology. Advances in natural product biochemistry and biotechnology will be showcased, along with a deeper understanding of RNA biology, its role in cancer and neurodegenerative diseases,...
Researchers from Nano Life Science Institute discovered how genetically designed peptides form single-molecule thick crystals on graphite surfaces. The behavior is directly related to their molecular architecture, with negatively charged and positively charged peptides forming unique oblique lattices.
Scientists have created a new molecular system based on manganese that can oxidize various organic substrates and emit NIR-II light after excitation. The complex has two different photoactive states, one of which is extremely oxidizing and exists only briefly, while the other is moderately oxidizing and longer-lived.
The American Society for Biochemistry and Molecular Biology's annual meeting features a stimulating group of high-profile speakers discussing various topics including climate change, microbial communities, and RNA regulation. The conference includes plenary sessions, award lectures, and other exciting events.
A team of scientists developed a technique to modify individual molecule units in a controlled manner, achieving structural isomerization and synthesizing reactive diradicals. This breakthrough enables the creation of novel carbon nanostructures with designer molecular units.
Researchers observed molecular gas outflow from quasar J2054-0005 using ALMA, revealing suppression of star formation in its host galaxy. The findings confirm theoretical predictions and provide strong evidence for powerful molecular gas outflows in early Universe quasars.
Scientists at Linköping University have successfully developed molecular gears with controlled rotary motion, overcoming previous challenges of single bond rotation. This breakthrough paves the way for future applications in medical drug delivery and solar energy storage.
Researchers at St. Jude Children's Research Hospital have developed a molecular glue that sticks to the cancer-related protein casein kinase 1 alpha (CK1α), leading to its destruction. The compound, SJ3149, displays broad anti-cancer activity and may have clinical utility as an alternative to conventional small molecule inhibitors.
Researchers at IBS achieve real-time observation of molecular ion formation and structural evolution using MeV-UED, unveiling a stable 'dark state' and ring-shaped intermediate ions. This breakthrough advances understanding of ion chemistry and its applications.
The American Society for Biochemistry and Molecular Biology (ASBMB) has announced its 2024 class of 17 new fellows, who have demonstrated immense commitment to the society. The fellows will be recognized at ASBMB's annual meeting in San Antonio in March.
The American Society for Biochemistry and Molecular Biology is offering complimentary press passes for its annual meeting, Discover BMB, taking place in San Antonio from March 23-26. Qualifying journalists can register to attend the event or access press materials electronically.
Researchers demonstrate a new method to synthesize complex-frequency waves (CFW) to amplify molecular signals in graphene-based surface-enhanced infrared absorption (SEIRA). This approach increases the sensitivity of traditional SEIRA technologies, enabling the detection of trace molecules currently undetectable. CFWs enhance molecular...
Researchers at IRB Barcelona developed BioExcel-CV19, a repository of Molecular Dynamics simulations to understand SARS-CoV-2 infection. The database provides over 10,000 trajectories for key proteins and facilitates community-wide analysis.
The Association for Molecular Pathology published a report outlining considerations for a slice testing strategy, including gene selection and quality. This approach combines the advantages of high-quality gene panels with flexibility and broad scope of exome sequencing.
Scientists have identified a novel class of molecular glue degraders, which can hijack cellular machinery to control disease-causing proteins. These glues bridge the gap for undruggable proteins and could lead to new treatments for cancer and other diseases.
A team of researchers has made a significant leap forward in molecular chemistry by modifying azaarenes, unique molecular puzzle pieces crucial to many everyday products. Using photoenzymatic systems, they have discovered novel chemical reactions that were previously thought to be out of reach.
A team of scientists has developed a single-molecular Raman switch that can be controlled using both electrically driven conformational switching and optical inputs. The study demonstrates the use of near-field-enhanced techniques to manipulate molecular states, enabling highly accurate methods for nano-scale systems.
A research team developed a novel interfacial molecular bridge strategy to enhance the performance of perovskite solar cells. The strategy redistributed localized electrostatic potential by employing ammonium cations as a molecular bridge, improving device performance and carrier extraction.
Researchers have discovered a protostar leaving its birthplace using high-resolution molecular spectral lines. The study found the core to have a significant blue shift of -2.3 km/s relative to its parental cloud, indicating an escape velocity less than 4,000 years ago.