A new study published in Neurology found an association between sleep apnea and reduced brain volume, particularly in the medial temporal lobe area of the brain. People with amyloid plaques who had more severe sleep apneas were also more likely to have lower brain volumes, suggesting loss of brain cells.
Scientists have developed a new method to genetically modify brain organoids, allowing for quick and effective analysis of gene function in early stages of brain development. This breakthrough enables comparative studies across primate species and simulates neurological diseases without animal experiments.
The CEBRA algorithm captures brain dynamics with high accuracy, allowing for the prediction of complex information such as visual stimuli and arm movements in primates. By analyzing brain signals alone, researchers can decode hidden structure in data, enabling new insights into how the brain processes information.
Scientists successfully opened the blood-brain barrier using a novel ultrasound device, delivering chemotherapy to treat glioblastoma patients. The treatment increased drug concentrations by 4-6 times and was safe and well-tolerated.
New research shows that rhythmic brain activity helps organize transient bursts of activity in the brain to maintain short-term connections. Brain rhythms coordinate overlapping populations of neurons to store different pieces of information at the same time.
A new study at Umeå University reveals that tick-borne encephalitis virus infects distinct brain cell types and regions depending on the immune system's activation status. The researchers mapped the virus's behavior in the brain, identifying specific areas and cells infected by TBE virus.
A Penn Medicine study identified a developmental sequence in brain maturation during adolescence, revealing regions supporting cognitive and social functions remain malleable until late adolescence. The study found that socioeconomic environments have a significant impact on brain development in these regions.
A new study published in Neurology shows that younger brain age is associated with superior post-stroke outcomes, suggesting a potential biomarker for stroke rehabilitation. The research team used multi-site data sets and 3D brain structural MRIs to analyze the relationship between brain age and stroke recovery.
The Human Brain Project has achieved significant scientific breakthroughs, including world-leading 3D brain atlases and personalized medicine based on computational modeling. The project's legacy will leave a lasting impact on the research community.
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
Researchers used a novel brain imaging technique to visualize subtle brain changes in pre-symptomatic Alzheimer's patients. They found that individualized brain fingerprints can detect variations in brain function associated with worsening information processing.
Researchers at the Human Brain Project present novel clinical uses of advanced brain modelling methods, enabling clinicians to simulate epileptic seizures and identify target areas. The approach has broad applicability in neuroscience, medicine, and neurotechnology, with potential improvements in data resolution and patient specificity.
Researchers found that eating small amounts of high-fat and sugar foods regularly rewires the brain to prefer these types of foods. The brain's dopaminergic system is activated, leading to a subconscious preference for rewarding food.
A study at Imperial College London used advanced brain imaging to track DMT's effects on brain activity before, during, and after the experience. Increased connectivity across the brain and dysregulation of high-level brain systems were found in areas linked with imagination.
Researchers discovered a novel waste removal factor, CDNF, that treats brain haemorrhage by accelerating lesion resolution, reducing brain swelling, and improving functional outcomes. The treatment also alleviates cell stress and promotes scavenging by immune cells, leading to better recovery.
A new approach using nanoparticles has been shown to transport drugs across the blood-brain barrier in mice with medulloblastoma. The nanoparticles target a protein called P-selectin, which binds naturally to cancer cells, and trigger transcytosis to deliver drugs to brain tissue.
Researchers at Stanford University have developed a novel AI-powered approach to analyzing traumatic brain injury, using artificial intelligence to identify the most accurate model of mechanical stress on the brain. This breakthrough could lead to better understanding of when concussions lead to lasting brain damage and inspire new pro...
A study found that people with long COVID who experience anxiety and depression months after a mild case of COVID-19 may have brain changes that affect the function and structure of the brain. The study also revealed widespread functional changes in brain networks, suggesting potential problems with memory and thinking skills.
The new Cell Atlas updates reveal that 20% of all neurons in the mouse brain are inhibitory, with detailed information on morphological and electrophysiological properties. The atlas combines various datasets to create a coherent framework for simulating neural circuits.
Researchers have developed a novel experimental platform that combines optical and fMRI techniques to study large-scale brain networks. The platform identified the anterior insular cortex as a key player in controlling the Default Mode Brain Network, which is active during daydreaming, memory retrieval, and envisioning the future.
Researchers at the Queensland Brain Institute developed a new ultrafast fMRI technique to study brain activity. The technique revealed that brain activity follows preferential circuits depending on cell type organisation, and blood signals can reflect network organisation and cell type distribution.
Researchers created monthly infant brain atlases to track normative trends in brain development. The atlases reveal changes in brain structure, cortical geometry, and tissue contrast, shedding light on conditions like ADHD and dyslexia. The study aims to facilitate discovery of new insights into child cognition and social behavior.
Researchers from the University of Queensland created a detailed outline of the cuttlefish brain structure and neuronal network, shedding light on their camouflage abilities. The study reveals that the cuttlefish's brain adaptations reflect their daily life requirements and ecology.
Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
A survey of researchers and the public reveals a high percentage are in favor of proceeding with neuroscience research and brain-related information use. The general public expresses hopeful feelings about this research, while major differences exist between the two groups on ELSI topics.
Researchers investigate technologies to interact with the brain at different levels, enabling paralyzed patients to control robotic arms and prosthetics. Deep brain regions are heavily involved in basic life functions, and understanding their activities is crucial for clinical applications.
A study published in Journal of Hepatology found that non-alcoholic fatty liver disease (NAFLD) can cause a decrease in oxygen supply to the brain and inflammation to brain tissue. The research identified Monocarboxylate Transporter 1 (MCT1) as a potential therapeutic target for protecting against NAFLD-induced brain dysfunction.
Researchers at Tohoku University used fiber photometry to analyze astrocytes' activity and found an acid response linked to intensified epileptic seizures. This breakthrough may lead to new therapeutic strategies for epilepsy, stroke, trauma-induced brain injury, and memory enhancement in dementia treatment.
The Julich Brain Atlas provides detailed maps of brain cells and receptors, enabling better understanding of brain connectivity and function. The atlas allows for correlation between brain network activity and underlying anatomy, aiding in the diagnosis of psychiatric disorders.
A new study successfully tested an implantable pump that delivers chemotherapy directly to the brain, bypassing the blood-brain barrier. The treatment effectively kills brain tumor cells and offers a safe way to treat patients with brain cancer.
Researchers propose a new network approach to understand brain function, suggesting that connections between brain regions are key to cognitive tasks. This new view also sheds light on individual variability and can be applied to predict symptoms in patients with brain lesions.
Twenty early-career researchers from Canada will receive funding for their innovative projects on brain disorders, including epilepsy, depression, and multiple sclerosis. The grants aim to reduce the social and economic burden of these conditions through prevention, early diagnosis, and treatment.
A new study has identified two distinct brain networks associated with risk and resilience in depression. The salience network is linked to increased depression symptoms, while the default mode network is linked to decreased depression symptoms. These findings may lead to new treatments for depression using neuromodulation therapies.
A study found that infant brains can reorganize language abilities to the right side of the brain after a stroke in the left hemisphere. Participants showed consistent pattern of language activation on the right hemisphere, regardless of damage extent.
Krembil Brain Institute researchers propose a new mechanistic model for Alzheimer's as an autoimmune condition that attacks the brain. This new approach challenges traditional views on brain diseases and opens the door to innovative therapies.
Researchers at UCLA and UCSF will map gene regulatory regions to understand how genetic variants affect brain development. They aim to build a comprehensive catalog of cell types in the developing brain and identify specific cell types and genomic regions that mediate the risk of brain diseases.
The Allen Institute is leading a global collaboration to create detailed atlases of the human brain and its cells. The project aims to understand brain function and structure, with applications in treating diseases of the brain.
The Center for BrainHealth has launched three research projects to develop objective metrics of improved brain systems in response to interventions. These projects aim to determine the changes in the brain's physiology, structure, and function linked to gains in comprehensive psycho-social measurements over time.
Researchers produced human and chimpanzee brain organoids to investigate the role of ARHGAP11B in brain evolution. The study found that the gene is essential for neocortex development, with its absence or inhibition leading to decreased levels of critical brain stem cells.
Rare-earth based materials are used for high-resolution brain imaging and efficient diagnosis of brain diseases through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. Additionally, they can be used for targeted therapy, overcoming the blood-brain barrier.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
A study led by University College London found that poor heart health at age 36 predicts a higher brain age later in life, with men having older brains than women of the same age. The research used machine learning to estimate brain age from MRI scans and found an association between brain age and increased brain shrinkage over time.
A new AI-based dynamic brain imaging technology has been introduced by Carnegie Mellon University, which can map out rapidly changing electrical activity in the brain with high precision and speed. The technology uses deep learning approaches to translate scalp EEG signals back to neural circuit activity without human intervention.
Scientists at the Allen Institute are creating a detailed atlas of brain cells in Alzheimer's disease, shedding light on the cellular roots of the condition. The massive dataset from over 1.2 million neurons could lead to new therapies to slow or halt disease progression.
Astrocytes in the thalamus play a key role in susceptibility to seizures after brain injuries. Targeting a specific protein, GAT3, in these cells may prevent long-term damage.
Scientists at Tohoku University have identified specific brain wave patterns related to social behavior in mice. These findings provide a unified understanding of brain activity underlying social behavior and its deficits in disease.
A new GPU-based machine learning algorithm, ReAL-LiFE, can rapidly analyze large amounts of data from diffusion Magnetic Resonance Imaging (dMRI) scans of the human brain. This allows for faster analysis and prediction of brain connectivity, enabling better understanding of brain-behaviour relationships at scale.
Researchers used microcircuit models of basal ganglia and thalamus areas to create multiscale models of Parkinson's patient and healthy control brain. They found that in-silico deep brain stimulation could normalize decreased firing rates in subcortical regions, but also caused differential activity in the motor cortex.
Researchers mapped neural connections throughout entire brain after TBI, finding increased connections to inhibitory neurons but disrupted relationships. Transplanted interneurons showed promise in reconnecting damaged brain regions.
Using lesion network mapping, researchers mapped addiction remission to entire brain circuits rather than specific regions, pointing to new targets for treatment. The study found a common brain circuit associated with both nicotine and alcohol addiction, suggesting a potentially therapeutic targetable neural pathway for addiction.
Research reveals that healthy brain temperature varies significantly by brain region, age, sex, and time of day. Daily brain temperature cycles strongly correlate with survival in traumatic brain injury patients, suggesting potential improvements in understanding and treatment of brain injuries.
Researchers have elucidated principles of human brain organisation across visual, auditory, somatosensory, and motor functional systems. The study revealed systematic changes in receptor architecture and gene expression within each system, reflecting increasing complexity of information processing.
A team of researchers, backed by a $8 million US Department of Defense grant, aims to identify potential treatment options and ways to block brain inflammation caused by repetitive blast exposures. They will use advanced brain imaging and blood sampling to understand the role of neuroinflammation in TBI.
A new statistical method for brain mapping is proposed to improve accuracy by removing redundant associations. The study uses simulations to test the method's performance on fake diseases and scores, revealing its superiority over existing approaches. The next step is to apply this refined analysis to study Alzheimer's disease.
A global team of experts proposes a new approach to elevate health and well-being by optimizing late-life brain capital. The model highlights the importance of preserving social connection and cognitive function in preventing elder mistreatment.
The new ASTRO guideline provides guidance on radiation therapy for brain metastases, including evidence-based recommendations for multidisciplinary planning and delivery of advanced techniques to manage intact and resected brain tumors. The guideline aims to improve quality of life and outcomes for patients with brain metastases.
Researchers used whole-brain virtual models to simulate neurostimulation effects on aging human brains, identifying key brain regions for therapeutic interventions. The study found that stimulating the precuneus region could induce a brain state similar to that of younger participants.
A study published in the Journal of Alzheimer's Disease Reports suggests that damage to the blood-brain barrier is the determining cause of Alzheimer's disease. The Lipid Invasion Model proposes that lipids entering the brain due to barrier damage lead to brain shrinkage, amyloid plaques, and tau tangles, characteristic of the disease.
Scientists reconstructed a whole-brain projectome comprising over 6,000 single neurons in the mouse prefrontal cortex, revealing 64 projectome-defined neuron subtypes. The study utilized software package Fast Neurite Tracer to analyze TB-sized imaging data and construct high-resolution intra-PFC networks.
Researchers at Aarhus University review 20 years of music and brain research, revealing music's unique property of using expectations to influence behavior and emotions. The study explores how music activates the brain's reward system through dopamine release and explains music processing mechanisms.