The IASLC published a comprehensive summary of the year's key developments in thoracic oncology, covering prevention, early detection, pathology, staging, surgery, adjuvant therapy, radiotherapy, and immunotherapy. The publication highlights significant progress in small cell lung cancer and malignant mesothelioma.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateJun 8, 2017
Researchers found that pathologists outside of academic centers were more likely to misdiagnose appendix tumors as invasive cancer. A significant number of patients had their diagnoses changed after a second evaluation, emphasizing the importance of expertise in appendix cancer diagnosis.
SourceUniversity of California - San Diego·JournalPLOS ONE·DateJun 7, 2017
Dr. Katerina A. Politi has made significant contributions to the understanding and treatment of EGFR mutant lung cancer. Her research has led to a paradigm-shift in the diagnosis and treatment of lung cancer, including the early adoption of molecular profiling.
Dr. Michael A Gimbrone, Jr has made significant contributions to the field of vascular biology through his research on endothelial cells and the development of methods for culturing these cells. His work has led to a paradigm shift in our understanding of vascular diseases and has paved the way for countless studies and discoveries.
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Dr. Xiao-Ming Yin's pioneering research has significantly impacted our understanding of cellular degradation pathways, leading to novel cancer treatment approaches and potential therapeutic strategies for non-alcoholic fatty liver disease.
A demo version of a new Pathology Atlas will be presented on April 2-5 at AACR17, offering information on human gene expression levels and their relationship with cancer patients' clinical outcomes. The atlas provides analysis on nearly 8,000 cancer patients across various major cancers.
SourceKTH, Royal Institute of Technology·DateApr 3, 2017
A new gene variant has been identified in the PTPRD gene that is associated with the accumulation of neurofibrillary tangles (NFTs) in the brain. The study found that this variant affects more than one mechanism of tangle accumulation and may be a key target for developing therapies targeting Tau pathology.
SourceRush University Medical Center·JournalMolecular Psychiatry·DateMar 24, 2017
Researchers at Brigham and Women's Hospital have discovered a new genetic variant linked to Tau pathology in Alzheimer's disease. The study, published in Molecular Psychiatry, highlights the potential for targeting the protein tyrosine phosphatase receptor-type delta (PTPRD) gene as a therapeutic strategy.
SourceBrigham and Women's Hospital·JournalMolecular Psychiatry·DateMar 24, 2017
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
The Association for Molecular Pathology published consensus recommendations to validate next-generation sequencing (NGS)-based oncology panels. The guidelines address NGS test development, optimization and familiarization, and best practices for establishing test performance characteristics.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateMar 22, 2017
A study published in PLOS Medicine found that six unsaturated fatty acids are associated with Alzheimer's disease cognitive symptoms and neuropathology. The researchers analyzed brain tissue samples from older individuals with healthy brains, those with tau or amyloid proteins but no memory problems, and those with Alzheimer's disease.
A new study found that a diabetes drug called amylin improved learning and memory function in AD patients and reduced AD pathology in their brains. The findings suggest a potential blood test for AD using pramlintide.
SourceBoston University School of Medicine·DateMar 8, 2017
Scientists at the University of Alberta have developed synthetic DNA motors that can be used for improved disease detection and drug delivery. The nanomachines demonstrate the potential for early diagnosis and targeted release of drugs within patients, resulting in fewer side effects.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalNature Communications·DateMar 6, 2017
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at the University of Pittsburgh School of Medicine have identified a novel genetic mechanism and marker that may predict response to a class of drugs in many cancer types. Elevated levels of IGF2BP3 protein were found in both thyroid and other common cancers, suggesting its potential as a biomarker for treatment response.
SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalProceedings of the National Academy of Sciences·DateFeb 20, 2017
A new approach to surgical pathology in brain tumor patients uses stimulated Raman histology, improving speed and diagnostic efficiency. The method, tested in an operating room, produces accurate results faster than conventional methods.
SourceMichigan Medicine - University of Michigan·JournalNature Biomedical Engineering·DateFeb 6, 2017
A new report in The American Journal of Pathology reveals that potent cytotoxins produced by group A streptococcus (GAS) contribute to the severity of 'flesh-eating disease'. Production of both NADase and streptolysin O is necessary for full virulence, and infections can be controlled better with toxin-deficient bacteria.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateFeb 2, 2017
The Association for Molecular Pathology (AMP) has published a joint guideline to standardize the interpretation and reporting of sequence variants in cancer. The guidelines aim to improve patient care by establishing standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateDec 16, 2016
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Research at McGill University has identified a link between decreased X chromosome gene PPP2R3B expression and tumor progression in melanoma. The findings suggest that genetic specificity of the X chromosome plays a role in gender differences observed in melanoma prognosis.
SourceMcGill University·JournalScience Translational Medicine·DateDec 14, 2016
A new study published in The American Journal of Pathology found that over 90% of bladder cancers lack the enzyme argininosuccinate synthetase 1, making them susceptible to arginine-degrading therapy. This approach has shown promising results in treating bladder cancer with low ASS1 expression.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateDec 12, 2016
Researchers developed an improved animal model of Alzheimer's disease using tau protein isolated from patient brains. The model replicates the formation and spread of brain fibrils associated with AD, offering new opportunities for investigating therapies to stop or slow their progression.
SourceUniversity of Pennsylvania School of Medicine·JournalJournal of Experimental Medicine·DateNov 16, 2016
Researchers identify direct link between brain inflammation and CTE, with longer football careers predicting increased inflammation and disease progression. The study suggests that treating inflammation could prevent or lessen CTE development, offering potential biomarkers for early identification.
SourceBoston University School of Medicine·JournalActa Neuropathologica·DateNov 2, 2016
The Association for Molecular Pathology released a new report highlighting the potential of MALDI-TOF-MS in identifying invasive infectious diseases. The technology has been shown to accurately identify filamentous fungi and mycobacteria, but more testing is needed before its use can be recommended.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateOct 19, 2016
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at Kansas State University have designed a soybean variety that protects against nematode parasites, which are the No. 1 soybean disease in the nation. The new variety could potentially save the soybean industry millions of dollars per year by controlling nematodes and their reproduction cycles.
Researchers at Temple University Health System will investigate the combined impact of tobacco smoke and opiates on HIV-induced tissue damage in brain, lungs, and other organs. The study aims to better understand the pathology of HIV infection and develop new treatments for affected individuals.
The Association for Molecular Pathology has developed a new framework for defining the clinical utility of molecular diagnostics, emphasizing the importance of context in interpreting test results. This approach aims to improve patient care by providing clinically useful and appropriate testing based on realistic evidence levels.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateAug 17, 2016
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
SourceUniversity of Colorado Anschutz Medical Campus·JournalInternational Journal of Surgical Pathology·DateAug 16, 2016
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
SourceJohns Hopkins Medicine·JournalThe American Journal of Surgical Pathology·DateAug 8, 2016
The College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology announced a revised evidence-based guideline for molecular testing in lung cancer patients. The guidelines aim to improve patient selection and targeted therapies.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateJun 28, 2016
Researchers at Allina Health have developed an algorithm to simplify the complex pathology classification process for pituitary adenomas. The new system helps pathologists make a more accurate diagnosis with fewer tests, saving time and reducing costs.
Researchers found that blocking acetylcholine in genetically modified mice caused Alzheimer's-like pathology, highlighting the importance of this neurotransmitter for brain health. The study suggests that targeting one of the affected messenger RNA pathways may lead to a reversal of dementia progression.
SourceUniversity of Western Ontario·JournalCerebral Cortex·DateJun 22, 2016
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers found long-term damage to the blood-spinal cord barrier after ischemic stroke, leading to a 'toxic environment' in the spinal cord. This damage can cause further disability and exacerbate disease pathology, including motor neuron deterioration and motor dysfunction.
SourceUniversity of South Florida (USF Health)·JournalJournal of Neuropathology & Experimental Neurology·DateJun 13, 2016
A rare form of pulmonary hypertension has been discovered in dogs, with similar symptoms and potentially useful as a model for human PVOD. The study, published in Veterinary Pathology, could lead to new insights into the disease and its treatment options.
SourceMichigan State University·JournalVeterinary Pathology·DateMay 12, 2016
Researchers at Griffith University identified significant impairments in cellular function of CFS patients. They found dysfunctional signalling may contribute to impaired cell activity, aligning with symptoms. The study provides further evidence for the pathology of this disabling illness.
SourceGriffith University·JournalJournal of Translational Medicine·DateMay 10, 2016
A study found that nearly half of routine tests for monoclonal gammopathy are unnecessary and costly. An algorithm-driven approach can improve efficiency and reduce healthcare costs by putting more decision-making power in the hands of pathologists.
SourceMedical College of Georgia at Augusta University·JournalAmerican Journal of Clinical Pathology·DateApr 26, 2016
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers found that about 5% of patients experienced unexpected relapses of cancer after laparoscopic radical cystectomy (LRC) despite favorable pathology. The use of pneumoperitoneum during LRC may have played a role in these recurrences, according to the study published in The Journal of Urology.
SourceElsevier Health Sciences·JournalThe Journal of Urology·DateApr 26, 2016
Researchers from Regenstrief Institute and Indiana University have found that machine learning algorithms can detect cancer cases from free-text pathology reports with similar accuracy to human reviewers. The computerized approach is faster and less resource-intensive, facilitating timely health department action.
SourceIndiana University·JournalJournal of Biomedical Informatics·DateApr 21, 2016
Scientists at the University of Wisconsin-Madison have created a mouse model to study Zika virus, allowing researchers to test vaccines and antivirals while understanding the virus's effects on human brains. The model, lacking key immune system defenses, shows the virus causes severe pathology in brain tissue.
SourceUniversity of Wisconsin-Madison·JournalPLOS Neglected Tropical Diseases·DateApr 19, 2016
A new publication by the Association for Molecular Pathology provides cost and value analysis of gene panels, including non-small cell lung cancer and hearing loss. The study demonstrates economic value in optimizing care for patients with hereditary diseases and cancer through targeted gene panels.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateApr 13, 2016
A study in the American Journal of Pathology finds that serotonin deficiency is associated with worse rheumatoid arthritis (RA) symptoms and pathology in mice. Serotonin or its agonists can reduce RA effects, suggesting a new therapeutic target for this debilitating disease.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateMar 9, 2016
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers at Massachusetts General Hospital found that inducing the hypoxia response, the body's reaction to low oxygen levels, may relieve symptoms of mitochondrial diseases. Activation of this response alleviated mitochondrial pathology and extended survival in animal models.
SourceMassachusetts General Hospital·JournalScience·DateFeb 25, 2016
The locus coeruleus is a critical brain region that releases norepinephrine, regulating heart rate, attention, memory, and cognition. It is vulnerable to toxins and infection, making it the first place affected by late-onset Alzheimer's disease.
SourceUniversity of Southern California·JournalTrends in Cognitive Sciences·DateFeb 16, 2016
The Association for Molecular Pathology (AMP) has updated its pathology residency curriculum recommendations, focusing on 10 major molecular pathology topics. The new report aims to equip pathologists with the latest scientific breakthroughs and technological innovations in molecular pathology.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateFeb 5, 2016
Researchers found elevated concentrations of synaptic soluble amyloid-β (Aβ) oligomers in early-stage AD patients compared to controls. The study suggests that therapies targeting synaptic Aβ oligomers may be more effective than anti-amyloid therapies in preventing or delaying AD-related dementia.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateDec 21, 2015
Researchers at Mayo Clinic found significant evidence of chronic traumatic encephalopathy (CTE) in males who participated in amateur contact sports, including football, wrestling, and rugby. The study suggests that these sports may increase the risk of developing CTE, a progressive degenerative disease caused by repetitive brain trauma.
SourceMayo Clinic·JournalActa Neuropathologica·DateDec 2, 2015
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A study by UPMC and KingMed Diagnostics researchers found that international telepathology consultations significantly improved patient care in China, altering treatment plans for over half of cases. The consultation service expanded access to pathology expertise, facilitating the diagnosis of rare malignancies.
SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalJournal of Pathology Informatics·DateNov 30, 2015
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
Researchers used genetically-modified mice to study hereditary deafness caused by mitochondrial dysfunction. Reducing enzyme activity in mice showed promise for preventing or delaying deafness, according to new research.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateNov 6, 2015
A study published in Human Pathology found that lung cancer patients without the retinoblastoma tumor suppressor protein (pRB) experience significantly improved survival rates when undergoing chemotherapy. The absence of pRB was detected in 15% of patients, with a 92% 5-year survival rate compared to 49% for those with the protein.
SourceLawson Research Institute·JournalHuman Pathology·DateNov 3, 2015
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers found that a humanized mouse model of gluten sensitivity showed increased immune responses and gut damage when exposed to gluten, but protection was seen in mice with a balanced microbiome. The study suggests that microbial imbalance may contribute to the development of celiac disease.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateOct 8, 2015
The new 2015 WHO Classification of Lung Tumors provides standard criteria for pathology diagnosis and clinical practice. The updated classification focuses on histologic subtyping and classification according to predominant subtype, leading to multiple new discoveries in lung adenocarcinoma.
SourceInternational Association for the Study of Lung Cancer·DateSep 8, 2015
Research suggests retinal changes can serve as measures of brain pathology in schizophrenia, predicting disease risk and progression. The findings may help guide future treatment adjustments.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalSchizophrenia Research·DateAug 17, 2015
Researchers found that repeated exposure to stimuli can lead to recurring mast cell degranulation and long-term pathological eye changes. Inhibiting this release with substances like disodium cromoglycate may offer new ways to treat serous retinal detachment.
SourceElsevier Health Sciences·JournalAmerican Journal Of Pathology·DateJul 21, 2015
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A study published by the American Academy of Neurology found that Alzheimer's disease causes different changes in the brain, or pathologies, in African-Americans compared to white Americans of European descent. African-Americans were more likely to have mixed pathologies and blood vessel disease in their brains.
SourceAmerican Academy of Neurology·JournalNeurology·DateJul 15, 2015
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.
SourceWayne State University - Office of the Vice President for Research·DateJul 1, 2015
A study of 197 patients with breast cancer found that more selective use of biomarker testing could save up to $117 million annually. Testing larger excisional biopsies instead of reflexively testing smaller core biopsies would help pick up tumors eligible for targeted therapy, reducing unnecessary costs.
SourceJohns Hopkins Medicine·JournalThe American Journal of Surgical Pathology·DateJun 23, 2015
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
SourceElsevier Health Sciences·JournalJournal of Molecular Diagnostics·DateJun 8, 2015
Two studies analyze amyloid prevalence among adults of varying ages and its association with cognitive impairment. The findings indicate that key risk factors for Alzheimer's disease are also risk factors for amyloid positivity in cognitively normal persons.
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
The Association for Molecular Pathology compiles current research on liquid biopsy approaches for cancer diagnostics. The review supports the notion that these minimally invasive tests allow for earlier diagnosis, faster and more targeted treatment, reduced costs, and increased quality of life.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateApr 22, 2015
The BMC protocol provides a set of predetermined guidelines for processing and preserving forensic evidence in surgical specimens after a terrorist attack. Key findings include the importance of identifying a team to handle all surgical specimens, obtaining labeled photographs and x-rays, and storing forensic evidence securely.
SourceBoston University School of Medicine·JournalArchives of Pathology & Laboratory Medicine·DateApr 21, 2015
Researchers found that in muscular dystrophy, abdominal muscles take over more of the respiratory function as diaphragm muscle damage progresses. This study highlights the importance of supporting cardiopulmonary function in neuromuscular disease.
SourceIOS Press·JournalJournal of Neuromuscular Diseases·DateFeb 26, 2015
A new analysis has identified over 58,000 long non-coding RNA genes that may play a role in cancer. The study also found that one lncRNA, SChLAP1, is a potential biomarker for aggressive prostate cancer.
SourceMichigan Medicine - University of Michigan·JournalNature Genetics·DateJan 19, 2015