A new study published in the Journal of Hepatology shows that durvalumab plus GemCis significantly improves overall survival for patients with advanced biliary tract cancer. The three-year follow-up analysis found that over twice as many participants treated with durvalumab plus GemCis remained alive compared to those treated with a pl...
SourceElsevier·JournalJournal of Hepatology·TypeRandomized controlled/clinical trial·DateJul 10, 2025 A pilot study evaluated Nutri, a clinical decision support tool for brief diet counseling in safety-net clinics. PCPs found the system usable and satisfactory, while patients effectively engaged with the intervention.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeRandomized controlled/clinical trial·DateJul 9, 2025 Researchers found that Prozac's impact on mood behaviors is critical to the timing of its administration, with early postnatal exposure leading to increased anxiety- and depression-like behaviors, while adolescent exposure had the opposite effect. This study provides crucial mechanistic insights into alterations in neurocircuits that r...
A study found a significant increase in adolescent vaping of THC, CBD, and synthetic cannabinoids from 2021 to 2023. The prevalence of THC vaping peaked in 2022, while SCs continued to rise, with females having a higher rate of vaping these substances.
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateJul 1, 2025 A new study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging found that individuals with remitted depression show increased habenula activity and reduced connectivity between the habenula and dopamine-producing regions, suggesting a heightened sensitivity to negative cues. This suggests that even after recove...
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateJun 26, 2025 A study published in the Journal of the Academy of Nutrition and Dietetics found that 19% of packaged foods and beverages sold in the US contain synthetic food dyes. Synthetic dyes are particularly prevalent in products marketed to children, with confectionery and sugar-sweetened beverages being the top categories.
SourceElsevier·JournalJournal of the Academy of Nutrition and Dietetics·TypeData/statistical analysis·DateJun 25, 2025 A recent study published in The American Journal of Pathology has discovered that ADAM10 regulates abnormal blood vessel growth in the retina, which can cause vision loss or impairment. The findings suggest that targeting ADAM10 or its downstream effectors, such as Ephrin B2, may offer novel strategies for managing or preventing retina...
A novel study in Biological Psychiatry highlights the layered and complex interactions between clinical symptoms and neurobiological sources of variation in depression. The research found that multiple brain profiles may manifest as the same clinical symptoms, supporting the presence of both one-to-one and many-to-one heterogeneity.
A new study finds pregnant women in abortion-ban states have worse access to routine medical care and pregnancy coverage due to skimpy Medicaid programs. The researchers identified three Medicaid policies driving this disparity, highlighting the need for Congress to expand coverage and ensure all women can get needed care.
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateJun 5, 2025 Researchers found that greenspace exposure is associated with widespread patterns of structural brain development during early adolescence, leading to better academic and mental outcomes. This study highlights the importance of integrating natural environments into urban and educational settings.
A recent study published in the American Journal of Preventive Medicine reveals a significant correlation between socioeconomically disadvantaged areas and increased cannabis retailer presence. Neighborhoods with higher concentrations of low-income Black residents had 2.53 times more cannabis retailers than high-income predominantly Wh...
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateJun 2, 2025 Researchers identified C5aR1 as a novel prognostic biomarker and potential therapeutic target for treating metastatic skin cancer. Elevated C5aR1 presence suggests increased metastasis risk and poor survival in patients with cutaneous squamous cell carcinoma.
Researchers have identified two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition disease in Americans of European and African descent. This discovery opens up promising new avenues for targeted prevention and treatment of CPPD disease, which is currently lacking effective options.
SourceElsevier·JournalAnnals of the Rheumatic Diseases·TypeData/statistical analysis·DateMay 28, 2025 Researchers found that central body fat, especially around the abdomen, is a stronger link to psoriasis risk than total body fat. This association remained consistent regardless of genetic predisposition, suggesting abdominal fat as an independent risk factor.
SourceElsevier·JournalJournal of Investigative Dermatology·TypeData/statistical analysis·DateMay 27, 2025 A study found that prescribing guideline-directed medical treatment to patients 90 years and older following their first heart attack can improve survival rates. The greatest benefit was observed in those who received all four recommended therapies, including beta-blockers and renin-angiotensin-aldosterone system inhibitors.
Researchers found that residual inflammation in psoriasis patients is linked to obesity, metabolic dysfunction, and increased systemic inflammation. This study suggests that despite good skin response to biologics, patients may still exhibit broader health implications, such as cardiovascular disease and fatty liver disease.
A new open-source tool, greenfeedr, is introduced to simplify the process of analyzing GreenFeed data from livestock. The R package offers functions for downloading, processing, and generating reports, allowing researchers and producers to automate routine tasks and gain insights into methane and carbon dioxide emissions.
Researchers discover certain skin bacteria metabolize cis-urocanic acid using enzyme urocanase, fine-tuning immune response to UV radiation. This finding opens the door to microbiome-aware sun protection, where resident microbes are considered in sun protection strategies.
Researchers identified platelets, C-reactive protein, and chromogranin A as markers that can predict the failure of hormone-sensitive prostate cancer treatment. The study also found that miR-375 expression and lymphocyte-to-monocyte ratio are negative predictors for therapy failure in castration-resistant prostate cancer patients.
Previous depression survivors exhibit reduced motivation for everyday tasks but become equally motivated with large and certain rewards. This research sheds light on subtle motivational deficits persisting in recovered depression, guiding targeted treatment for sustained recovery.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeComputational simulation/modeling·DateMay 1, 2025 Researchers developed a novel rat model that closely replicates human COPD-associated cor pulmonale, exhibiting chronic lung inflammation, pulmonary hypertension, and right ventricular hypertrophy. The model provides insights into the underlying mechanisms of disease progression and potential therapeutic targets.
A new study identified 56 non-clinical risk factors associated with sudden cardiac arrest (SCA), finding that improving unfavorable profiles could prevent up to 63% of SCA cases. Lifestyle habits and environmental factors were found to be the most impactful in preventing SCA cases.
A global study analyzing data from eight countries found a significant link between the consumption of ultraprocessed foods and preventable premature deaths. The study estimates that up to 14% of all-cause premature deaths are attributable to UPF consumption, with higher rates in low- and middle-income countries.
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateApr 28, 2025 A new study published in the American Journal of Preventive Medicine found that victims of police shootings were shot far more times than those killed by civilians. The study analyzed data from the US National Violent Death Reporting System and found significant disparities in rates of gun-related crime and police practice across regions.
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateApr 23, 2025 A recent study in Ghana highlights key factors influencing maternal nutrition and infant feeding practices, revealing food insecurity and economic constraints as significant challenges. The study emphasizes the importance of creating tailored nutrition education programs that address the specific needs of young mothers.
Researchers have developed an innovative optical genome mapping technique that can identify structural variants and copy number variations across the entire genome in a single test. The method has been shown to reduce material requirements and improve prognostic stratification for patients with multiple myeloma.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
A study published in Heart Rhythm has found that handheld electro-shockers can interact with cardiac implantable electronic devices (CIEDs) such as pacemakers, posing a risk to individuals. The risk is primarily based on the applied voltage, but also on the manufacturer and type of implanted CIED.
Researchers analyzed brain tissue from individuals with severe Tourette syndrome and identified three key changes: altered gene activity, regulatory element modifications, and interneuron loss. These findings provide unprecedented insights into the disorder's biology and may explain why individuals experience involuntary movements and ...
Researchers identified key constructs shaping diet and health outcomes, including access to healthy foods, social dynamics, and coping mechanisms. The study highlights the importance of addressing barriers such as affordability, accessibility, and chronic stress to promote nutrition security and health outcomes.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeMeta-analysis·DateMar 31, 2025 Researchers found that digital PCR for BCR::ABL1 is more sensitive and accurate than conventional real-time quantitative PCR to detect ultralow levels of residual leukemic disease. The technology enabled the detection of stable deep molecular remission in 97% of patients, allowing for safe discontinuation of treatment.
A study published in Biological Psychiatry identified the Shisa7 gene as a key driver of heroin addiction. The research team used machine learning to analyze brain tissue from human opioid users and found that modulating this gene's expression influenced heroin-seeking behavior and cognitive flexibility.
Researchers have discovered a potential new treatment for pulmonary fibrosis by targeting the Piezo2 receptor, which plays a critical role in stiffness-mediated profibrotic fibroblast phenotypes. Inhibiting Piezo2 expression or function may slow disease progression and offer new therapeutic options.
A recent study in the Journal of Nutrition Education and Behavior emphasizes the value of braiding cultural food values with nutrition education to promote healthy eating among the Osage Nation community. The study's findings highlight five key concepts crucial to healthy eating, including food accessibility, community food values, and...
A new theme issue in the Canadian Journal of Cardiology emphasizes the importance of personalized heart health advice considering individual differences. The issue highlights disparities in sports participation and related health outcomes between males and females as well as socioeconomic disparities, with women showing a lower risk of...
A new study analyzing global data from 1990 to 2021 found significant cross-country disparities in Alzheimer's disease and other dementias, with approximately two-thirds of individuals living in low- and middle-income countries. The study highlights the need for targeted prevention and control strategies in different countries.
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateMar 11, 2025 A special issue of the Journal of Dairy Science provides detailed technical recommendations for developing and implementing feed additives to reduce methane emissions from ruminants. The guidelines cover testing, trial, and modeling phases to ensure efficacy and safety.
The study highlights the significant protective role of Asah1 in preventing NAFLD progression by regulating hepatic lipid homeostasis and cellular maintenance processes. The findings suggest that targeting Asah1 expression or activity may inform new therapeutic strategies for improving patient outcomes.
Researchers found that brain connectivity related to cognitive control predicted substance use initiation, while cognitive control behavior did not. Stronger connectivity between the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex was associated with delayed substance use onset.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateMar 3, 2025 A recent study identified capacity gaps as a significant barrier to sustaining SNAP-Ed programs in schools. Designating school-community partnership coordinators and tailoring solutions to unique community needs can enhance program sustainability.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeObservational study·DateFeb 28, 2025 Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
Researchers introduce a dual threshold classifier to interpret circulating tumor DNA levels, enabling earlier detection of disease progression and personalized treatment. The study confirms that ctDNA levels are superior to traditional biomarkers like CA15-3.
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
A new study highlights the importance of distinguishing between domains of physical activity. Researchers found that engaging in moderate to vigorous physical activity during leisure time reduces the risk of type 2 diabetes, while occupational physical activity has no similar benefits. The study's findings suggest that current WHO phys...
SourceElsevier·JournalAmerican Journal of Preventive Medicine·TypeData/statistical analysis·DateFeb 18, 2025 A recent study published in Mayo Clinic Proceedings found that women who care for others for more than 15 hours a week are more likely to experience moderate or severe menopause symptoms. The study highlights the need for greater advocacy and support systems for midlife women in caregiving roles.
Researchers analyzed cost-effectiveness of semaglutide for non-diabetic overweight/obese individuals with heart disease. With price reductions, semaglutide shows promise in reducing lifetime costs and improving health outcomes.
SourceElsevier·JournalCanadian Journal of Cardiology·TypeData/statistical analysis·DateJan 9, 2025 A recent study published in the Journal of Nutrition Education and Behavior reveals a significant influence of home food environments on adolescent dietary patterns. Home food availability, particularly fruits and vegetables, promotes healthier eating habits, while neighborhood fast-food options negatively affect dietary quality.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeData/statistical analysis·DateDec 18, 2024 Researchers found that a blunted response to reward feedback in teens predicts the first onset of depression, but not anxiety or suicidal ideation. This study contributes to understanding neural risk factors for mental health disorders and developing new methods to assess mental health risks.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateDec 17, 2024 Researchers developed a deep learning model that classifies pancreatic cancer into molecular subtypes using histopathology images, achieving high accuracy and rapid turnaround time. The AI tool has the potential to improve patient outcomes by enabling timely and tailored treatment strategies.
A new study reveals significant provincial and territorial variations in reimbursement criteria for cardiovascular medications in Canada. The current system leads to unequal access to evidence-based treatments, with the most vulnerable groups facing restricted access to life-saving medications.