Articles tagged with Covid 19 Vaccines
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La Jolla Institute researchers discovered that prior exposure to a common cold coronavirus partially protects mice from lung damage during a subsequent SARS-CoV-2 infection. Harnessing 'cross-reactive' T cells may lead to novel vaccines with broad, pan-coronavirus protection.
A new study finds that infants born full-term to mothers infected with COVID-19 during pregnancy are three times more likely to develop respiratory distress compared to uninfected infants. Vaccination prior to infection was found to be protective, reducing the risk by half.
A recent study of 2,261 infants found no significant adverse effects on neurodevelopment after in utero exposure to COVID-19 vaccination. The research suggests that maternal COVID-19 vaccination is safe for infant development up to 18 months.
A prospective cohort study of 220 pregnant individuals found that receiving three or more COVID-19 vaccine doses before delivery resulted in significantly higher cord anti-Spike antibody levels. Maternal antibody concentration was a more important factor than delivery gestational age in determining these levels.
Research reveals memory T cells formed after Omicron breakthrough infection provide enhanced immunity against future variants. The study suggests the immune system adapts to combat emerging strains, leading to higher chances of inducing memory T cell defenses.
A University of Alberta-led international network is studying very rare adverse events after vaccination, using cutting-edge techniques and unprecedented data from around the world. The goal is to enhance vaccine safety assessment and inform health authorities on the most appropriate type of vaccine for specific outbreak settings.
A new vaccine design has been developed by a UC Riverside-led research team, which uses preexisting immunity to the influenza virus to help kickstart the production of antibodies against SARS-CoV-2. The vaccine aims to speed up the immune response and provide better protection for people who still lack immunity to the coronavirus.
A large retrospective study found that vaccination against SARS-CoV-2 reduces the risk of persistent health problems in children after COVID-19. Vaccination provides stronger protection for adolescents, who are at higher risk of developing long COVID.
A UK study found that between a third and a half of the population had not received the recommended number of COVID vaccinations by summer 2022. The research suggests that this under-vaccination led to over 7,000 hospitalisations and deaths that might have been avoided with better vaccine coverage.
A new study suggests a universal coronavirus vaccine could have saved millions of lives and prevented suffering by offering some degree of protection against a range of strains. The study found that having a universal vaccine at the start of the pandemic would have been cost-saving even with low efficacy rates.
Researchers designed a synthetic antigen with high expression levels and stability, offering potential for quick adaptation to new variants. The vaccine candidate triggered strong immune response in animal models and showed enhanced protective efficacy.
A nationwide cohort study found that COVID-19 survivors exhibit lower all-cause mortality and congestive heart failure but higher acute myocarditis and deep vein thrombosis risks. Younger, non-vaccinated patients with preexisting cardiovascular risk factors face elevated cardiovascular complications.
Researchers have successfully used mRNA technology to correct a rare genetic disease in mice, demonstrating its potential therapeutic use. The treatment corrected the lethal consequences of the disease and restored glutathione metabolism.
A recent study found that only 18% of US hospitals reported consistent COVID-19 reporting directives across government agencies. The research highlights the need for standardized protocols and automation to improve data submission efficiency and enhance public trust in healthcare.
Researchers at Karolinska Institutet have developed a nasal spray with IgA antibodies that can protect mice from SARS-CoV-2 infection. The treatment significantly diminished virus load in infected mice and showed stronger binding to the spike protein compared to original IgG antibodies.
Researchers at Duke-NUS Medical School have discovered a potential intranasal vaccine candidate that provides improved, longer-lasting immunity against COVID-19. The vaccine boosts mucosal antibody response and enhances long-term immune protection through preferential induction of airway-resident T cells and central memory T cells.
A new study reveals that people with sickle cell disease are nearly two times less likely to get vaccinated against COVID-19 compared to those without the disease. Vaccination rates were particularly low in children and teens with sickle cell disease, who face a higher risk of hospitalization and death if infected.
A study of over 5,000 adults found that acute hospital care at home (AHCaH) is associated with low mortality, escalation, and readmission rates among medically complex and socially vulnerable patients. AHCaH was also linked to improved experiences and physical activity levels.
A real-world study found that COVID-19 vaccines are highly effective in protecting children and adolescents from infection, with 98% reduced risk during the delta variant phase. Vaccine effectiveness slightly declined during the omicron wave, but still provided strong protection against severe illness and cardiac complications.
The BA.2.86 omicron subvariant can infect human lung cells more efficiently than previous omicron variants, raising concerns about potential severe disease symptoms. While bivalent mRNA vaccines can neutralize BA.2.86, the efficiency is reduced, emphasizing the importance of getting a newer booster vaccine.
A machine-learning enabled risk assessment model detects 72.8% of variants causing over 1,000 cases per million people within a week, increasing to 80.1% after two weeks. The model identifies key factors such as variant spike mutations and early infection trajectories.
Researchers found that vaccinated B cell-deficient individuals have a robust T cell response to SARS-CoV-2, despite lack of anti-spike antibodies, resulting in markedly reduced rates of hospitalization and severe COVID-19. This study provides reassuring evidence for immunocompromised patients to get vaccinated.
Researchers have developed a mineral coating that maintains mRNA activity for up to six months at room temperature. This breakthrough enables the storage of mRNA therapeutics like COVID-19 vaccines on medical shelves, bridging the gap between rich and poor communities.
A new study found that COVID-19 vaccine effectiveness decreases after six months, highlighting the importance of continued booster shots. Researchers analyzed over 10 million cases and discovered a significant reduction in mortality rates among vaccinated adults.
A new study finds that most US parents intend to vaccinate their infants and young children against COVID-19, influenza, and respiratory syncytial virus (RSV), with 40% planning to vaccinate against COVID-19. The study also highlights the growing concern of vaccine hesitancy and its potential impact on public health.
Scientists have developed a new system to display epitopes in mammal cells for immunization studies, potentially speeding up the immunization process. This method allows for targeted immune responses against specific viral proteins without the need to purify antigens.
Two Melbourne-made COVID-19 vaccines demonstrated strong boosting capabilities against SARS-CoV-2 variants in a Phase 1 clinical trial. The vaccines focus the immune response on the receptor binding domain, potentially providing a more efficient approach to boost immunity.
A major study found that patients with inflammatory conditions can boost their antibody response to a COVID-19 booster vaccination by interrupting their treatment for two weeks. The improved protection lasts for six months, and patients who interrupted treatment reported more flare-ups but most were self-managed.
Researchers at La Jolla Institute for Immunology found that most T cells can still target epitopes on the new Pirola variant, suggesting people may be able to mount a response against it. The study's findings provide positive news in the fight against SARS-CoV-2, emphasizing the importance of vaccination with updated vaccines.
A study by Sean O’Leary and colleagues found that COVID-19 vaccine hesitancy remained stable in Colorado, but parental trust vacillated during the pandemic. The researchers used a validated survey to track vaccine attitudes of parents, revealing trends indicating that misinformation has affected parental trust in childhood vaccines.
Researchers have identified a sequence within therapeutic mRNAs that causes unintended immune responses and found a way to correct these errors. By designing 'slip-resistant' mRNAs, the team aims to produce future mRNA vaccines with improved safety and efficacy.
Researchers found that vaccination increases immune cell production and antibody levels effective against all tested variants of SARS-CoV-2, including Omicron. Convalescent plasma therapy research provides insight into how the body fights COVID-19 variants.
A new study reveals that threats against public health workers increased and changed in nature during the COVID-19 pandemic, affecting nearly half of local health directors and leading to increased turnover and burnout. The study calls for expanded legal protections and resilience training for the public health workforce.
Researchers found a strong preference for extroverted virtual assistants and increasing personality similarity led to higher ratings, more careful assessment of information, and resistance to persuasive attempts. The study's findings may have implications for ways to increase user resistance to misinformation.
Researchers assessed Veterans Affairs participants' coping strategies over three timepoints, finding that stable coping styles are associated with lower levels of anxiety and depression. The majority of the sample (71%) changed their coping style at least once during the study period.
A new Stanford University study found that COVID-19 vaccination during pregnancy lowered the risk of preterm birth. The research analyzed natality data from California and found a significant reduction in preterm births among vaccinated mothers compared to unvaccinated ones.
A recent study found that COVID-19 transmission rates in child care centers were only about 2% to 3%, with 1 in 20 symptomatic children testing positive. Vaccination is still highly recommended, as vaccines are a safe and effective way of preventing serious infection.
Researchers developed a practice facilitation program to support family physicians in identifying unvaccinated patients and addressing vaccine hesitancy. The intervention provided resources such as scripts and medical student volunteers to work as physician-delegates, resulting in improved vaccination rates.
A new study found that COVID-19 caused a significant spike in premature births, but vaccines played a crucial role in reducing the risk of preterm birth to pre-pandemic levels. The research analyzed California birth records and found that maternal COVID infection increased the risk of preterm births by 1.2 percentage points.
A new study found that a half-dose of the Pfizer COVID-19 booster vaccine elicited a non-inferior immune response to a full dose in Mongolian adults, with fewer side effects. The study suggests that fractional dosing may improve booster acceptability and reduce costs.
A study found that cancer patients with COVID-19 had significantly higher mortality and hospitalization rates compared to non-cancer patients, highlighting the increased risk of severe illness. COVID-19 vaccination in cancer patients reduced this risk, emphasizing the importance of vaccination in protecting vulnerable populations.
A new study suggests that a fourth dose of the mRNA vaccine significantly reduces risk of infection and severe COVID-19 in patients with autoimmune rheumatic diseases. The study found a 41% reduction in risk for infection and 65% reduction for admission/death compared to those who did not receive a fourth dose.
Two COVID-19 studies on Singapore mothers and children found vaccination during pregnancy reduces newborn infection risk by up to 44.4%. Vaccination also showed potential protection against Long COVID in children under 18, with males more likely to experience symptoms.
A study found that 20% of patients treated with nirmatrelvir-ritavir (N-R) experienced virologic rebound, a phenomenon where viral load increases after initial decline. In contrast, only 1 untreated patient was affected. The researchers suggest considering the risks and benefits of N-R treatment in patients at low risk for severe disease.
An mRNA SARS-CoV-2 vaccination before vs. during pregnancy and omicron infection among infants study found that maternal vaccination during the antenatal period was associated with a lower risk of Omicron SARS-CoV-2 infection in infants up to six months of age.
A recent study published in eClinical Medicine found that the GB510/AS03 vaccine elicited a stronger antibody immune response against the ancestral SARS-CoV-2 strain compared to ChAdOx1-S. The vaccine demonstrated robust safety and efficacy, with no significant safety concerns identified.
The study found co-administration of the Pfizer-BioNTech COVID-19 vaccine with the seasonal influenza vaccine to be effective in preventing COVID-19 and flu-related outcomes. This may improve vaccination uptake for both vaccines.
A study by the University of Plymouth and Nottingham Trent University found that reading and writing poetry had a substantial positive impact on participants' wellbeing during the pandemic. Poetry helped reduce feelings of loneliness, anxiety, and depression, as well as supporting social and cultural recovery.
A meta-analysis of studies found guilt has only a small persuasive effect, making it less effective than previously thought. Existential guilt appeals better for broader issues like environmental and educational topics, while personal responsibility-based guilt is less effective in health communications.
A team of University of Maryland researchers developed a nasal spray vaccine that delivers the SARS-CoV-2 spike protein into cells of the airway, triggering an immune response that significantly reduced infection and spread of COVID-19. The technology can be adapted to induce immunity to other respiratory illnesses.
A University of Michigan team found that vaccinating people over 65 against COVID-19 will save the US money, while younger adults may not see significant cost savings. The analysis, commissioned by the CDC, focused on costs to insurers and the government.
A new study found that while most residents in British Columbia had been infected with SARS-CoV-2, older adults remained at highest risk of hospitalization and death due to COVID-19. The researchers estimated that the risk of hospitalization for COVID-19 was about 1 in 30 among adults 80 years and older.
A new study by Boston University School of Public Health found that COVID-19 vaccination in female and male partners does not increase the risk of miscarriage. In fact, vaccinated individuals had a slightly lower risk of miscarriage compared to unvaccinated individuals. The study analyzed survey data from over 1,800 female participants...
Scientists at the University of Birmingham have identified a mechanism that led to some patients experiencing deadly clotting following Covid-19 vaccination. The team found that Platelet factor 4 (PF4) activates the c-Mpl-Jak2 pathway in platelets, triggering clot formation.
A study found that COVID-19 transmission rates in child care centers were low, with only 2% to 3% of cases occurring within the centers. In contrast, household transmission was high, with 50% of children and 67% of adults contracting the virus once infected.
A study of 83 children in 11 child care centers found low SARS-CoV-2 incidence and transmission within the centers, as well as from infected children to households
A new model predicts the evolution of SARS-CoV-2 variants by analyzing massive data on infections and vaccinations. Human immunity now drives the virus's evolution, with continued surveillance crucial to inform future vaccines.
A study of 142,000 live births found that maternal mRNA COVID-19 vaccination during pregnancy was associated with reduced risks of severe neonatal morbidity, neonatal death, and intensive care unit admission. No increase in hospital admissions or readmissions up to age six months was observed.
A new study published in JAMA Pediatrics found that infants born to mothers who received an mRNA COVID-19 vaccine during pregnancy had lower risks of severe health outcomes, neonatal death, and NICU admission. The study also showed no increase in newborn and six-month readmissions to the NICU.
Researchers identified enhanced B-cell and T-cell responses in fully vaccinated individuals who became infected with SARS-CoV-2, generating immunological memory to prevent severe infection. Vaccine-primed memory T cells play a critical role in preventing severe COVID-19.