A digital clinical decision support algorithm substantially reduced antibiotic prescribing in pediatric outpatient care in Rwanda, according to a non-randomized controlled trial. The study found no compromise in clinical recovery, suggesting the algorithm's effectiveness in guiding appropriate treatment.
Researchers developed a new suite of neuropsychological tests suitable for Mandarin-speaking older adults, accounting for Chinese characters and cultural nuances. The tests show high stability and strong links to novel Alzheimer's disease biomarkers.
A study by Tezpur University and University of Illinois has identified distinct metabolic patterns in blood that can distinguish gallbladder cancer cases from noncancerous conditions. The researchers detected hundreds of altered metabolites and identified markers with high diagnostic accuracy for each condition.
Researchers studied Norwegians with reported chronic health problems linked to tick bites, finding no objective evidence of persistent infections. The study suggests that physical activity and labour force participation may be more related to symptoms than tick exposure.
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Research finds a specific link between hearing loss and cognitive decline in presbycusis, a neurodegenerative disorder. The Functional-Structural Ratio (FSR) identifies reduced connections between brain areas involved in sound processing and memory, associated with worse hearing thresholds and poorer performance on memory and executive...
Researchers developed blood-based biomarkers that can support accurate dementia diagnosis in diverse populations when integrated with cognitive and neuroimaging measures. The study demonstrated that key plasma biomarkers can reliably distinguish major dementia syndromes even in complex settings.
A new review highlights the growing burden of lung cancer in never-smokers, emphasizing the need for dedicated research, screening, and clinical trials. The study argues that LCINS has distinct causes and biology requiring a different approach to diagnosis and treatment.
Researchers found Launaea nudicaulis extract improved gastric conditions, lowering acid concentration and increasing pH levels. The study suggests the plant's potential as an alternative to proton pump inhibitors for peptic ulcer treatment.
A new analysis found that wearing an Apple Watch with hypertension notifications can increase the probability of having hypertension in younger adults, while decreasing it in older adults. The study also revealed racial and ethnic disparities in cardiovascular health, highlighting the need for targeted screening and treatment.
A new review introduces a chronological and probabilistic model to explain the recurrence of autoimmune skin diseases like vitiligo. The model proposes that full disease manifestation is the outcome of genetic susceptibility and a series of environmental or internal biological hits.
A new study highlights the clinical relevance of brain functional connectome uniqueness in identifying biomarkers for major depressive disorder. Researchers found that patients with MDD displayed reduced FC uniqueness, especially in frontoparietal and sensorimotor networks.
Researchers identified four distinct brain metastasis subtypes, each with unique immune landscapes and metabolic programmes. The 'Immune-infiltrated subtype' showed high sensitivity to immunotherapy, while the 'Metabolic subtype' responded well to targeted therapies. The study paves the way for personalized treatment strategies.
A recent cohort study found that individuals diagnosed with cancer in 2020 and 2021 experienced worse short-term survival rates compared to those diagnosed between 2015 and 2019. The study suggests substantial harms associated with cancer care disruptions during the COVID-19 pandemic.
Professor Adelheid Wöhrer discussed innovative diagnostic platforms and collaborative research strategies for better understanding treatment-resistant glioblastoma. Her team is developing a novel diagnostic platform combining Virtual Raman Histology and real-time Nanopore Sequencing to enhance surgical accuracy.
Researchers discovered that ATG triggers rapid clotting and inflammation in the liver by activating a complement activation system and TGF-β pathway, leading to severe side effects. The study used human organoid models and imaging analysis to reveal the biphasic mechanism of ATG-induced liver injury.
Engineered yeast cells can mimic real cancer cells and be used to test new cancer immunotherapies much faster and cheaper than before. This new technology enables researchers to assess which CAR T variants are most promising much more quickly, leading to safer and more targeted cancer treatments.
The study validates the use of SOFA-2 in sepsis care and research, demonstrating its ability to identify clinically meaningful organ dysfunction. The findings suggest that incorporating immune markers may not improve predictive performance, highlighting the biological complexity of sepsis.
A mobile endoscopy team performed over 500 procedures in rural hospitals across Western Cape, South Africa, revealing a high burden of treatable gastrointestinal diseases. The program substantially reduced patient travel, improving continuity of care and early cancer detection.
New diagnostic methods aim to detect RNA viruses with high sensitivity and specificity, overcoming the challenge of rapid evolutionary dynamics. The techniques include mutation-tolerant screening and precise mutation discrimination.
The American Society of Hematology released guidelines on the diagnosis of light chain (AL) amyloidosis, a rare and life-threatening disease of the bone marrow. The guidelines outline best practices for diagnosing the disorder, which typically takes about three years to diagnose.
Researchers at Waseda University have developed an integrated smart contact lens that enables real-time intraocular pressure monitoring for early glaucoma diagnosis. The device leverages parity-time symmetry for ultra-sensitive wireless detection, increasing sensitivity by a factor of 183.
Researchers successfully diagnosed and treated ten PCNSL patients using liquid biopsy, detecting hotspot MYD88 L265P mutations in circulating tumor DNA. This method offers a reliable alternative to surgical biopsies for patients with difficult-to-access lesions or frailty, enabling timely treatment initiation.
A case-control study found that even low-level air pollution in Sweden may increase the risk of developing motor neuron disease. Long-term exposure was also associated with poorer disease prognosis after diagnosis.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
Researchers have identified a new method to predict asthma exacerbations with a high degree of accuracy, analyzing data from three large asthma cohorts. The study found that the ratio between sphingolipids and steroids was the most powerful predictor of future health.
Steatotic liver disease can be precisely assessed using three-dimensional ultrafast vascular ultrasound. The technology visualizes subtle microvascular changes, enabling real-time monitoring of disease progression and therapeutic response.
Researchers have developed a web-based tool to identify people at risk of developing chronic kidney disease through subtle abnormalities in kidney function. The study shows that individuals with an eGFR below the 25th percentile had a markedly higher risk of developing kidney failure.
A new blood biomarker, brain-derived tau (BD-tau), tracks the extent of brain injury after ischemic stroke over time. It also predicts patient outcomes months to years later and detects differences associated with successful vessel reopening. BD-tau has potential applications for other neurological conditions.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.
ACCESS-AD aims to address Alzheimer's disease challenges with a coordinated framework for diagnosis, treatment and monitoring. The project combines advanced neuroimaging with digital biomarkers to support early patient identification and personalized treatment pathways.
The American College of Chest Physicians released a new clinical guideline on biologic management in severe asthma. The guideline provides evidence-based recommendations for selecting biologics for different patient populations, considering factors such as baseline oral corticosteroid use and comorbid conditions.
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
Healthcare professionals in Canada assess applicants for medical assistance in dying (MAiD) using a careful and individualized approach. They consider the patient's life circumstances, support networks, and personal preferences when determining eligibility. The assessment process is often legally and morally complex, requiring provider...
A novel deep learning model, LA-TextCNN-BiLSTM, has been developed to improve the accuracy of automatic disease classification using ICD-11 for Chinese Electronic Medical Records (EMRs). The model achieved an 83.86% accuracy rate and demonstrated robust performance in multi-label classification.
A team from Chongqing Medical University developed a model that integrates sMRI and fMRI data to predict treatment responders, achieving high accuracy rates. The dual-branch graph attention network (DBGAN) captures coordinated brain changes linked to emotion regulation and memory processing.
Researchers created an ultrathin hydrogel electrode that can track vital signals without interruption, overcoming previous dehydration, freezing, and mechanical fragility issues. The new material forms a flexible layer that can withstand extreme temperatures and retain water content over time.
A recent study published in Gut journal revealed that Streptococcus anginosus produces methionine metabolites, which significantly contribute to the development of gastric cancer. The research opens new paths for microbiota-targeted prevention strategies.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Research finds cancer cachexia-related immune cells impair T-cell negative selection, leading to irAEs. This study establishes a critical mechanism connecting cancer cachexia and irAEs, opening new avenues for targeted interventions.
A new rapid test for hepatitis C could identify more patients who can be cured if insurers increase reimbursement to cover the test's high cost. The test's point-of-care feature makes it ideal for early screening and treatment in clinics and emergency rooms.
A team of researchers at Osaka Metropolitan University has created two models to detect and fix common labeling errors in large radiographic collections. The models achieved high accuracy rates for body-part classification and projection/orientation detection, showing promising results for improving deep-learning models in medical AI.
The 2024 report shows improved care quality and accessibility across China, with a rise in early gastrointestinal cancer detection and improved colonoscopy quality indicators. Despite progress, regional disparities persist and costly treatments for IBD remain a challenge.
Researchers found that methylene blue can reverse brain damage caused by cerebral malaria and identified a nine-gene blood signature to diagnose the disease. The study's findings offer new clues on immune processes involved in brain injury and suggest potential for early intervention and clearer treatment decisions.
Researchers describe first reported mpox transmission of clade Ib in a healthcare setting outside Africa, with Ireland's nosocomial outbreak linked to local cases. In the Democratic Republic of Congo, community transmission shifted from sexual to non-sexual routes, driven by factors like overcrowding and child malnutrition.
A study among WTC responders with chronic PTSD found measurable physical changes in their brain structure, including cortical changes and imbalance of myelinated to unmyelinated neurons. These changes were most strongly associated with re-experiencing symptoms in individuals with PTSD.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateDec 17, 2025
Public Health Alerts provide concise, data-driven information on disease outbreaks and urgent health events. The new series, launched by NEJM Evidence and CIDRAP, offers expert-reviewed reports to support public health evidence-based care.
Researchers developed an AI model that can detect coronary microvascular dysfunction using a common electrocardiogram, outperforming previous models in diagnostic tasks. The model can accurately identify a condition often missed in emergency department visits, providing a cost-effective and non-invasive way to diagnose serious heart co...
This study found that vaccination before and during COVID-19 diagnosis in pregnancy significantly lowers the risk of severe maternal illness and premature birth. The results suggest that COVID-19 vaccination plays a crucial role in protecting pregnant individuals from serious health complications associated with the virus.
A study found that only 6% of FDA-approved drugs reflect the US racial and ethnic makeup, with a decline in Black and Hispanic enrollment between 2021 and 2023. The researchers recommend setting diversity goals at preclinical stages and collecting biological samples to understand how people's bodies react to medications.
A new study found a significant rise in ADHD stimulant prescriptions in Ontario, with a 157% increase from 2015 to 2023. The study calls for better clinical guidance to ensure medications are prescribed appropriately and prevent adverse health effects.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
Scientists at Northwestern University have developed the fastest test yet for diagnosing hepatitis C virus, delivering results in just 15 minutes – up to 75% faster than current rapid tests. The highly accurate diagnostic could revolutionize HCV care by improving diagnosis and accelerating treatment uptake.
A case report describes a woman with radiation-induced cellular changes in her Pap smear that mimicked cancer recurrence. The study emphasizes the importance of recognizing these changes to prevent misdiagnosis and unnecessary medical procedures.
Researchers at Florida Atlantic University have developed a deep learning model that detects and evaluates Alzheimer's disease (AD) and frontotemporal dementia (FTD) using EEG brainwave analysis. The model achieved over 90% accuracy in distinguishing individuals with dementia from cognitively normal participants.
Researchers developed a novel magnetic biosensing technique using polydopamine-coated magnetoliposomes to monitor lectin-glycan binding. The technique provides insight into the dynamics of sugar-protein interactions and holds promise for medical diagnostics, glycoscience research, and drug discovery.
Researchers analyzed AI methods for detecting pulse rates from facial video recordings and found significant errors at elevated heart rates. The study highlights weaknesses in remote photoplethysmography (rPPG) technique under challenging conditions.
Researchers have developed a simple urine test that can effectively diagnose and stage bladder cancer using cell-free DNA fragmentation analysis. The study found that specific patterns of cfDNA fragmentation can identify muscle-invasive bladder cancer with excellent specificity and predictive value.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
Scientists at Max Planck Institute develop a novel lab-on-a-chip system using intelligent hydrogel structures to simulate spatially and temporally controlled mechanical perturbations of biological polymer networks. The system applies precise pressure forces to cellular microenvironments, enabling research into biomechanical interaction...