Research on how disease is diagnosed. Covers fetal-distress detection, faster diagnostics, redefining conditions, and bias in medical AI.
The Biggs Institute is leading a $2.5 million national, multi-site study to improve detection and diagnosis of dementia with Lewy bodies. The study will enroll 125 participants and evaluate multiple possible new tools and methods to accurately identify individuals who have accumulated abnormal alpha-synuclein in the brain.
A Chinese neurosurgical journal's study found that severe stenosis of major intracranial arteries increases the risk of cerebral infarction after revascularization surgery in moyamoya disease. Severe blockage was associated with postoperative infarctions, highlighting the importance of monitoring and mitigating this risk factor.
Researchers found that tau buildup in PSP affects brain networks involved in thinking, including the prefrontal cortex and anterior cingulate cortex. The study suggests that symptoms arise from both local tau-related damage and remote disruption of a broader cognitive network.
The Osaka Metropolitan University, K.K. DNAFORM, and INRB have developed a portable rapid diagnostic system for Ebola virus disease caused by Bundibugyo virus. The system utilizes the GenPad POCT platform and can be used near outbreak sites without power infrastructure.
Researchers are exploring innovative technologies to improve disease diagnosis and treatment. AI models have shown promise in speeding up detection and treatment discovery for rare diseases. Meanwhile, electronic noses are being developed for non-invasive cancer screening.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
A portable, airpod-size fluorescence analytical device has been designed to provide timely home molecular testing. The VPodDuo can measure fluorescent signals generated by various detection chemistry formats and detect quantities of genetic material from several pathogens and human cancer markers.
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
Incorporating structured, video-enhanced feedback into training programs halves prescribing errors by newly qualified doctors. This approach closes the performance gap between novice and experienced prescribers, demonstrates cost-effectiveness and scalability.
Researchers at Terasaki Institute develop a wireless dual-compartment biochemical monitoring platform for real-time tracking of key biomarkers in perfusion fluid and bile during normothermic machine perfusion. The study shows improved interpretation of post-transplant outcomes with combined bile and perfusate data.
A meta-analysis of individual participant data found that amyloid PET quantitation using centiloids can accurately diagnose Alzheimer's disease. The study suggests that scans in the 11-26 Centiloid range require caution, and a positivity cutoff of around 18 Centiloids is recommended.
The Association for Molecular Pathology has elected new leaders for several committees, including Genetics, Hematopathology, Infectious Diseases, Informatics, and Solid Tumors. The newly elected leaders will work together to drive the organization's mission forward.
A new study found that simple weekly electronic symptom check-ins with care teams significantly improves the quality of life for individuals undergoing treatment for advanced cancer. The benefits were notable among patient groups that historically faced barriers to care, including Black patients and those with less formal education.
Using the YEARS diagnostic algorithm is as safe as computed tomographic pulmonary angiography (CTPA) for diagnosing suspected pulmonary embolism in patients with cancer. This strategy saved 22% of patients from undergoing CTPA, highlighting its potential to streamline cancer care.
A new study published in JAMA Network Open found an alarming rise in invasive breast cancer among Asian American women over the last two decades. Breast cancer rates are rising among nearly all ethnic groups much faster than any other U.S. group, with Chinese and Vietnamese women experiencing the highest increases.
A research team has developed a bacterium that can predict the course of a disease by analyzing chemical signals in patient plasma. The bacterium responds to changes in nutrient levels and growth patterns to generate an answer, bypassing traditional machine learning algorithms.
Rates of diagnosis after emergency admission are even higher among women who are young, old, frail, or live in areas of deprivation, findings indicate. Ovarian cancer is the eighth most common female cancer worldwide, taking over 200,000 lives every year.
Researchers will study blood samples and environmental exposures over 10 years to identify genetic, environmental, and cellular factors contributing to autoimmune diseases. The goal is to develop prevention strategies and treatments by understanding the earliest biological triggers of SARDs.
A new study has identified molecular tumor characteristics that distinguish between different subtypes of diffuse large B-cell lymphoma (DLBCL). The findings suggest that tumors from high-risk patients, referred to as PG4 proteogenotype, are characterized by specific genetic mutations and protein patterns. These characteristics can hel...
The AKI-PURIFY survey reveals substantial variability in AKI prevention strategies and KDIGO implementation across ICUs. Despite strong evidence supporting structured preventive approaches, only one-third of respondents reported routine implementation of kidney-protective bundles.
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
A standardized on-pitch concussion assessment protocol has been developed and recommended internationally for safe player return to play in football. The protocol is informed by research evidence and expert opinion, aiming to improve diagnosis and treatment of concussions.
The NHS Clinical Entrepreneur Programme has supported the creation of 691 businesses, generating 5,184 jobs and raising over £1.27 billion in investment. The programme continues to play a critical role in retaining talent within the NHS by enabling clinicians to develop their ventures alongside their clinical careers.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
A phase III trial is investigating whether an immune-boosting drug can help keep early-stage lung cancer from coming back after surgery. Researchers aim to enroll 336 participants with stage I non-small cell lung cancer and determine if the treatment reduces recurrence.
A new blood test, Stockholm3, detected significantly more aggressive prostate cancers than the PSA test without increasing unnecessary follow-ups. The study shows that Stockholm3 identifies 90% of aggressive cancer cases, compared to 74% for PSA.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
A cohort study found that demographic, clinical, and healthcare factors influence the uptake of metabolic bariatric surgery among US adults with obesity. The study suggests improving access to this life-changing procedure through targeted policies and interventions could have a significant impact.
A study by Okayama University researchers revealed that SARS-CoV-2 antibody levels can assess infection history, symptom severity, and cognitive complications in long COVID. The findings suggest that declining S-antibody levels may indicate a greater risk of neurological complications.
Researchers describe a novel disorder caused by biallelic loss-of-function variants in the TMEM63B gene, resulting in severe lung disease. The disorder presents with early onset respiratory distress, lung abnormalities, and developmental delay but no epilepsy.
Researchers developed a simple blood-based assessment to evaluate high-density lipoprotein's (HDL) cholesterol removal capacity from blood vessel walls. The study linked low HDL function to high-risk coronary plaques, supporting the use of this method for predicting cardiovascular risk.
Researchers identified five immunomodulatory proteins in Borrelia recurrentis that prevent activation of the human complement system, allowing the pathogen to survive in the human body. These Chi proteins also convert plasminogen into active plasmin, giving Borrelia recurrentis a significant advantage in spreading after infection.
The study analyzed polygenic scores and simulated expectations to understand changes in genetic contributions to ASD and ADHD diagnoses by year of diagnosis. Findings suggest broadening diagnostic criteria as a possible explanation for increasing rates, which has significant implications for risk factors and clinical practice.
A neural network-based machine learning model accelerates diffuse optical tomography by over a million-fold, enabling real-time diagnosis. The model accurately reproduces signals even for unseen parameter combinations, with each inference taking approximately 2 milliseconds.
A recent study found that melanoma disproportionately affects Florida's senior population, with older men experiencing twice as many skin cancer-related deaths as women. The study highlights gaps in prevention and early detection, particularly among men and non-Hispanic populations.
Researchers summarize recent developments in terahertz biophotonics, highlighting its potential for overcoming technical limitations in fields like skin cancer diagnosis, wound assessment, and drug discovery. The study provides a roadmap for future research to improve the field's practical applications.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
A new set of consensus standards for classification, annotation, and quality control is being implemented for artificial intelligence applications in dry eye imaging. These standards aim to enhance consistency and multicenter collaboration in AI-assisted diagnosis.
Researchers analyzed data from over 50,000 adults who started taking aspirin and found a similar bladder cancer prevalence but lower invasive stage. Aspirin initiators received more cystoscopies, which uncovered the cancer. The study suggests that aspirin may unmask otherwise asymptomatic bladder cancer.
Researchers used an open-source AI model called Mirai to quickly identify high-risk patients and expedite their diagnostic process. This led to a significant reduction in wait times, with some women receiving biopsy results within days of having their mammograms done.
PrecizionIQ is a health technology startup using high-resolution mass spectrometry and AI to detect chromosomal abnormalities in early pregnancy. The company aims to make prenatal testing more accurate, affordable, and accessible.
Prediagnostic statin use showed no association with higher survival rates, but postdiagnostic use was linked to lower all-cause and breast cancer-specific mortality among hormone receptor-positive subtypes. Statin therapy may improve survival of these patient groups.
The study found high-risk associations between alcohol use and all ten cancers examined, with risk increasing progressively as intake rose. Low-to-moderate drinking was associated with lower disease risk for type 2 diabetes, Alzheimer's disease, ischemic heart disease, and stroke.
A population-based screening trial evaluating a cell-free DNA multicancer early detection test found modest increases in diagnostic delay rates for head and neck, lung, and upper gastrointestinal cancers. These findings suggest that future trials may need to consider system-level spillover effects on healthcare resources.
Researchers found that the right ventricle is better able to withstand loss of blood perfusion and oxygen supply during cardiac arrest, leading to longer preservation of its native electrical activity. The study's findings support the use of surface ECG signals to predict neurological recovery after hospital admission.
A new simulation- and AI-based approach reduces the time and data needed for brain MRI scans, achieving a high level of accuracy with only 10% of the data required. This breakthrough could translate to a significant reduction in scan time, enabling more patients to be treated in the same amount of time.
Researchers found that impaired virtual reality path integration was closely tied to brain structure and biomarkers associated with neurodegeneration. This suggests that VR-based navigation errors may reveal hidden changes in the brain long before symptoms arise, making it a promising behavioral marker for preclinical Alzheimer's disease.
The American Cancer Society has endorsed two new types of stool tests and recommends limiting the use of blood tests for colorectal cancer screening. The guidelines aim to encourage people to get screened while improving detection rates.
A nationally representative study found a nearly 4-fold increase in type 2 diabetes prevalence among US children and adolescents between 10 to 17 years old. The substantial rise is concerning due to the disease's lifetime risk of severe complications and premature deaths.
The MAF Test predicts breast cancer prognosis and helps identify patients who may benefit from treatment. In South Korea, the test could improve survival rates for approximately 34,000 newly diagnosed breast cancer patients each year.
Researchers developed a technique that uses RNA origami to analyze sections of RNA, allowing for accurate sizing of repeat expansions in genetic disorders. The method shows promise for fast and affordable testing in clinical settings.
A new study by the University of Southampton has found that reusable catheters are just as safe for patients as single-use ones and do not increase the risk of urinary tract infections. The study followed hundreds of patients for a year and discovered that those who tested reusable catheters used 35 per cent fewer antibiotics.
A systematic review of AI models for meningioma segmentation reveals that better model architecture is the key driver of improved performance. The top models achieved high accuracy and efficiency, while future research focuses on making them more generalizable and efficient for real-world clinical settings.
A study found that PEG tube aspirate and vomitus display distinct color patterns, with the aspirate being yellow-green and the vomitus dark brown. This contrast can serve as a diagnostic clue for gastric outlet obstruction in resource-limited settings.
A team of researchers has developed a lab-grown diamond device that accurately measures radiation doses, offering improved consistency and sensitivity compared to conventional detectors. The device's compact size enables real-time measurements during treatments and environmental monitoring.
A clinical trial found that adding molecular tests on urine and stool samples did not speed up treatment initiation or reduce mortality in hospitalized patients with HIV. The study showed no significant difference in treatment initiation within 72 hours between the expanded screening group and the standard group.
Researchers at Aalto University developed a new ultrasonic needle that can collect 2-3 times more tissue than current biopsy methods, improving cancer diagnosis accuracy. The minimally invasive approach shows strong potential for broader diagnostic use, particularly in rare salivary gland tumors.
A global partnership has provided life-saving genetic testing for over 1,100 families worldwide, improving treatment options for children with congenital hyperinsulinism. The Open Hyperinsulinism Genes Project combines cutting-edge genetics expertise with funding from a charity organization to expand access to rapid genomic testing.