Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A Wayne State University team, led by Miriam Greenberg, is working on potential new targets for treating Barth syndrome, a life-threatening X-linked genetic disorder affecting mainly males. The four-year grant aims to identify specific metabolites as candidates for new treatments.
Intranasal insulin-like growth factor-1 (IGF-1) treatment reduces trigeminal pain pathway activation and oxidative stress levels in a rat model of migraine. The therapy has a unique potential to safely prevent migraine headaches through multiple novel mechanisms.
Elective egg freezing is a common method to increase pregnancy chances at a later age. Patients under 35 with normal ovarian reserve have the best chance of success, but future live births are not guaranteed. The treatment process takes 10-14 days and fees are not covered by Canadian government health insurance.
A new study suggests that when children experience discrimination, it can harm their mothers' health, particularly African American mothers. The research analyzed data from two generations of families and found a link between acute and chronic discrimination and a decline in mothers' self-rated health between ages 40 and 50.
The Wilderness Medical Society has released new clinical practice guidelines addressing critical issues in wilderness medicine, including diabetes management and spinal cord protection. The guidelines emphasize personalized care and evidence-based approaches to prevent complications and optimize patient outcomes.
This observational study analyzed nearly 30,000 patients to investigate racial/ethnic disparities in acne treatment patterns. The results suggest that differences exist in treatment and prescribing practices based on race/ethnicity, sex, and type of insurance.
Researchers developed an antibody cocktail that protects nonhuman primates against the related Sudan ebolavirus through in vitro and rodent studies. The treatment showed effectiveness in protecting against the virus, which has caused eight outbreaks and 412 deaths since 1976.
US Army scientists develop an experimental antibody cocktail that protects animals from Sudan virus, a closely related to Ebola. The treatment boosts the body's immune system to fight infection and provides protection in rhesus macaques.
A study published in Annals of Emergency Medicine found that cooling burns with running water decreases skin grafting requirements by over 40%, hospital admission by 35.8% and operating room treatment by 42.4%. Cool running water also accelerates healing, reducing scarring risk.
A new study finds that hyaluronic acid dermal filler treatment can restore a more youthful pattern of facial expressiveness. The treatment reduces facial strain and strain levels across various facial expressions, resulting in more natural-looking results.
A recent study published in BMJ Open found that zinc lozenges did not shorten the duration of common colds, contradicting previous findings. The researchers suggest further research is needed to determine optimal dosage and type of lozenges for effectiveness.
A study at the University of Calgary found that deep brain stimulation, targeting a specific region of the brain, reduced depressive symptoms in 50% of participants. Younger patients showed better improvement than older ones, with 30% experiencing complete recovery.
Research suggests that strict adherence to traditional masculine ideals can lead to more severe post-traumatic stress disorder symptoms and hinder access to effective treatment. Veterans who conform to these norms may have a harder time seeking mental health help due to societal expectations of masculinity.
A new study found that people with obesity who receive a stigma-reduction intervention, combined with standard behavioral weight loss treatment, devalue themselves less due to their weight. The Weight Bias Internalization and Stigma (BIAS) program helped participants combat negative thoughts and increase self-acceptance.
A new Danish study finds that GPs under mental strain as multimorbidity rises, leading to burnout. The research highlights the need to address working conditions and prevent healthcare inequality.
Researchers develop technique to evaluate reliability of patient risk models, which often fail to accurately predict outcomes. The method generates an unreliability score, indicating when a model's predictions are less trustworthy, helping doctors avoid ineffective or unnecessarily risky treatments.
Bone mineral density (BMD) and finite element analysis (FEA) reflect actual femur strength, making them effective surrogate markers for hip bone strength. These estimates predict hip fracture risks, potentially leading to shorter and less expensive clinical trials.
A multicenter study found that both simple and advanced computed tomography (CT) can accurately predict which stroke patients will benefit from endovascular thrombectomy. Patients with favorable imaging profiles on both CT and CT perfusion had higher odds of receiving endovascular therapy and improved functional independence rates.
A new study led by the University of Washington found improvement in trauma-related symptoms among Kenyan and Tanzanian children after receiving community-based mental health treatment. The approach, which trained laypeople as counselors, showed sustained benefits over a year after therapy.
A new study analyzing the first 1,000 participants in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) identifies key trends in the presentation and diagnosis of autism spectrum disorder. Girls with autism receive a diagnosis, on average, nearly 1.5 years later than boys, likely due to advanced language abilities.
Researchers have identified 107 genes that increase a person's risk of developing glaucoma, a leading cause of irreversible blindness globally. The new test uses genetic information from tens of thousands of people worldwide to accurately predict glaucoma risk using a single blood or saliva sample.
A new study suggests that an adapted form of low-intensity cognitive behavioural therapy can be effective in helping autistic adults with co-occurring depression. The intervention, called Guided Self-Help, aims to reduce depression by encouraging individuals to schedule activities that boost positive mood and become more aware of trigg...
To tackle massive wood fuel accumulations, California needs significant fuel treatments, including prescribed burns or vegetation thinning. The researchers propose solutions to overcome barriers, such as a risk-averse culture, limited finances, and complex regulations.
Research shows that older patients with untreated sleep apnea need greater medical care due to higher costs and increased health risks. The study found that Medicare beneficiaries with OSA had nearly $20,000 more in costs per year compared to those who were diagnosed and treated.
A new point-of-care diagnostic test has been developed using a biomarker called RC0497, which can differentiate infected individuals from healthy controls. The test shows promise in enabling early detection and timely treatment of this potentially deadly tick-borne disease.
A new study reveals that brain imaging can improve diagnosis and treatment of mental health disorders by identifying distinct neurobiological signatures. The research used machine learning to analyze the brains of over 1,100 children and adolescents with symptoms of depression and anxiety.
A systematic review of 422 studies found evidence of adverse effects of ageism on mental and physical health conditions, including depression and shorter life expectancy. Ageism also affects access to healthcare treatment, with denied care found in 85% of relevant studies.
A randomized clinical trial examined the effects of daily folic acid and zinc supplementation on semen quality and live births among 2,300 couples. The study found that folic acid and zinc supplementation improved semen quality and increased the chances of conception.
Researchers examined how children's psychological characteristics interact with their parents' characteristics and family dynamics to affect nutrition intervention outcomes. The study found a significant impact of strong family dynamics on improved nutritional interventions, while weak family dynamics led to minimal changes.
A new study published in JAMA Neurology suggests that early clinical treatment for concussions can significantly reduce recovery time. Athletes who received treatment within the first week of their injury recovered faster than those who delayed care, with longer recovery times reported after eight days to three weeks post-injury.
A new study shows that brief daily mindfulness training facilitates extinction of conditioned fear reactions, producing lasting reductions in threat-related arousal responses. Mindfulness appears to have a specific effect on extinction retention, which could improve treatment effects for anxiety and trauma-related disorders.
A study evaluated various commercial products to recover cotton plants from reduced dicamba and 2,4-D rates. No recovery treatments regained yields compared to untreated plots for either herbicide, with inconsistent trends from year to year.
A new study has shown that a protein therapy called rhPDGF-AB can improve the quality of scar tissue after a heart attack, leading to the formation of new blood vessels and reduced rates of dangerous heart arrhythmia. The treatment has increased survival rates in animal models and holds promise for improving patient outcomes.
The Obesity Medicine Association is launching local chapters in 12 cities/states to educate and empower healthcare providers. The chapters will provide a gathering space for clinicians to learn about the latest treatment options and share knowledge.
A Finnish study of 6.2 million people from 1996 to 2014 found that lower household income is associated with a higher risk of first psychiatric hospitalization for mental disorders. The research used national registry data to examine the relationship between household income and mental health outcomes.
A new hypothesis identifies a common link between schizophrenia and pellagra, suggesting that some people with psychosis in poorer nations may have a vitamin B3 deficiency. This could lead to better diagnosis, treatment, and potential cure of psychosis through niacin supplementation.
A recent study has provided new insights into the early development of PTSD, revealing that it proceeds along two independent tracks. The research, which tracked symptoms over 30 days after a traumatic event, suggests potential interventions to prevent its development and proposes different treatment approaches for fear-based and depre...
A new study found that gradualism, increasing project stakes step-by-step, significantly improves group coordination. The research showed that teams with gradually increasing stakes outperformed those with consistently high or low stakes.
The Hastings Center Report highlights concerns over GoFundMe's role in facilitating unproven medical treatments, which can harm donors and recipients. The report also explores the doctor burnout crisis, advocating for legal interventions to safeguard healthcare workers' safety and well-being.
A training program to support advance care planning in nursing homes is expanding to over 170 facilities across the US. The program aims to provide patients with consistent and high-quality care that aligns with their treatment preferences.
A team of physicists and cardiologists at Imperial College London have developed a model that explains the chaotic electrical signals underlying irregular heart rhythms. The model predicts which patients are unlikely to benefit from surgery and could lead to more targeted and successful treatments.
A new UK study found that nearly half of those dealing with infertility and its treatment lack access to psychological support. The survey, which received over 800 responses, also revealed a 'postcode lottery' in the funding of IVF treatments, with some areas offering more support than others.
A recent study published in JMIR Mental Health found that internet-based therapy significantly reduced depression in CVD patients, leading to improved quality of life. The treatment involved nine weeks of online cognitive behavioural therapy, with access to a nurse via the web, resulting in clinical improvements for one in five patients.
Two studies presented at RSNA 2019 used MRI and functional imaging to reveal disrupted blood-brain barriers in patients with major depressive disorder. The findings suggest a link between impaired brain connectivity and emotional regulation, potentially leading to new treatments for depression.
A new study found that preventing tooth decay from occurring is the most effective way to help avoid pain and infection. Three-year trial shows no evidence to suggest fillings are more successful than sealing or preventive techniques in treating tooth decay in primary teeth.
The December issue of SLAS Discovery features articles on new screening tools and assays for medically relevant membrane protein targets. The special issue also includes reviews and original research papers on emerging protein-lipid reconstitution methodologies.
Researchers will enroll 129 patients with upper extremity hemiparesis and limited hand movement to test contralaterally controlled functional electrical stimulation (CCFES), a new rehabilitation intervention developed by Jayme S. Knutson, PhD. The study aims to determine the optimal method for restoring hand function in stroke survivors.
Researchers integrated human and animal treatment to eliminate roundworm infections and rabies in Tanzanian villages. The study found no difference in participation rates between combined and stand-alone events.
A new study found that one-third of patients seeking treatment for buying-shopping disorder (BSD) report symptoms of online shopping addiction. Younger patients, those experiencing greater anxiety and depression, and those with more severe BSD symptoms were more likely to exhibit addictive online shopping behavior.
Primary care clinicians report that addressing patients' social needs affects their emotional wellness and clinic flow, while also increasing efficiency. Clinicians emphasize the need for tailored, patient-centered interventions to mitigate burnout, rather than relying solely on referrals.
A new biomarker blood test has identified adults with mild hypertension who are at higher risk for cardiovascular events without symptoms. The test detected slight elevations in protein biomarkers in approximately one-third of these individuals, who were more likely to experience heart attacks, strokes, or congestive heart failure.
A new diagnostic/treatment algorithm complements early guidance from the CDC for managing vaping product use associated lung injury (EVALI). The tool was developed by pulmonary and toxicology experts at the University of Rochester Medical Center and the New York State Department of Health.
Research from the University of Cambridge suggests that GP practices can effectively manage mild to moderate mental health issues, reducing stigma and waiting times. Specialist treatment remains more cost-effective in the long term, but GPs can provide just as effective care.
A new study published in Diabetes Care found that bariatric surgery significantly decreased the rate of diabetic kidney disease among severely obese teens with type 2 diabetes, compared to medical treatment alone. The five-year study also showed improvements in hyperfiltration, urinary albumin excretion, and blood pressure.
A study led by Regenstrief researcher found that the surrogate's belief in miracles was the main dimension linked to preferences for care of their loved one. Belief in miracles was associated with a preference for aggressive treatment and less acceptance of comfort-focused care plans.
Researchers analyzed data from Fitbit Flex 2 devices and phone apps to understand the impact of individual discrimination events on college students' daily lives. On average, students who experienced unfair treatment were more physically active, interacted with their phones more, and spent less time in bed.
The Zeriscope system enables veterans to virtually take their doctor with them during prolonged exposure therapy, providing real-time feedback on physical and psychological information. This innovation aims to improve treatment outcomes and reduce dropout rates for veterans with PTSD.
Researchers discovered a neural pathway for impulse control in the brain, which is associated with psychiatric disorders such as overeating, gambling, and Parkinson's disease. The study found that manipulating this circuit may lead to the development of targeted treatments for impulsivity-related issues.
Finns' risk beliefs and knowledge on indoor air health effects were surveyed, finding that a significant proportion considers minor moisture damage to pose severe health risks. Actinomycetes may be a sign of moisture damage, but its occurrence does not automatically prove harmful health effects.
A team of researchers at Yokohama National University has developed a compound that can emit light and change color under mechanical stimuli. The dye's properties were controlled by adding another chemical, resulting in high-contrast, self-recovering characteristics.