Articles tagged with Allergic Asthma
Researchers discover a previously unknown mechanism of action for a synthetic peptide that mitigates excessive inflammatory responses in allergic asthma. The peptide inhibits a key inflammatory switch in the immune system, opening up new avenues for treating chronic inflammatory diseases.
A team of researchers has developed chimeric allergen receptors that can suppress the immune system's response to common allergens, reducing or preventing asthma symptoms in mice. The technique could eventually be used to treat a wide variety of allergies in humans.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
Johns Hopkins researchers have identified a club cell-specific role for the protein RhoA in asthma airway inflammation. The study demonstrates how RhoA can be selectively targeted to prevent asthma-related complications, and offers new details on a potential cell-specific therapeutic target.
A study in mice suggests that matcha may reduce the need to sneeze in people with nasal allergies, suppressing brainstem neuronal activation without changing major immune markers. The findings provide a potential, food-based option to complement standard care for allergic rhinitis symptoms.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
Research suggests soil microbial communities are a top predictor of childhood allergic disease rates, with certain assemblages appearing linked to better health outcomes. The study found that specific soil microbes promote health, while others negatively impact disease prevalence.
Researchers have found that early-infancy RSV infection significantly increases the risk of developing childhood asthma, especially in those with family history of allergy or asthma. Protecting newborns against RSV could substantially reduce asthma cases later in life.
A new study published in the American College of Allergy, Asthma and Immunology's annual meeting reveals a significant association between military deployment and an increased risk of developing chronic respiratory conditions. Deployed veterans were found to have a 55% higher risk of asthma compared to non-deployed peers.
A new study found that thunderstorms trigger sharp increases in asthma-related emergency department visits. Researchers analyzed 4,439 asthma-related ED visits and identified 38 thunderstorm days, with a mean of 17.91 admissions on storm days compared to 3.09 on non-storm days.
A study of 200 classrooms found that HEPA purifiers did not significantly reduce respiratory viral exposures, suggesting additional interventions are needed. Maintaining classroom humidity between 40% and 60% may help lower viral exposures and improve comfort for students and teachers.
Researchers have discovered ancestral evolutionary links of Aspergillus latus strains through genome sequencing analyses, revealing potential for reduced susceptibility to antifungal medications. The study highlights the need for improved molecular diagnostic tools to accurately identify A. latus strains and manage aspergillosis.
A new study uses preserved plants and animals from natural history museums to track pollution trends over two centuries. Researchers found significant changes in pollutant levels between specimens collected in the 19th and 20th centuries, highlighting the impact of industrial activity on human health.
Researchers explore the psychological impact of chronic illnesses on patients with asthma and allergies, finding that fear, anxiety, and social stigma can greatly interfere with treatment. The American College of Allergy, Asthma, and Immunology discusses ways clinicians can mitigate these effects and provide better care for patients.
Researchers have developed a new therapy called liver-targeted immunotherapy (LIT) that exploits the liver's natural ability to promote immune tolerance. LIT uses synthetic mannosylation to deliver allergens directly to the liver, where specialized immune cells reprogram the response from inflammation to tolerance.
Researchers found that repeated antibiotic use before age 2 is associated with a higher risk for asthma, food allergies, and hay fever later in life. The study suggests that judicious use of antibiotics in children under 2 may impact long-term health outcomes.
A recent study published in JAMA Network Open reveals that using race-neutral lung function equations can identify more Black children with reduced lung function and increase asthma diagnosis rates. This is crucial as under-diagnosis can lead to delayed treatment and long-term health issues.
Researchers have developed two therapeutic cocktails that inhibit key molecules, stopping immune cells from overreacting to allergens. The treatments reduced asthma attacks in mice by erasing the immune system's memory of asthma-causing allergens.
A global team of researchers found that patients with allergy-induced sniffles and asthma have distinct fungal colonies or mycobiomes in their noses, differing from those of healthy controls. This variation may suggest potential lines of inquiry for future treatments.
UCSF Medical Center has received the highest possible rating for maternity care, reflecting its commitment to clinical excellence and interdisciplinary collaboration. The hospital's maternal care teams include a broad array of expertise, including nurse practitioners, midwives, and obstetrician anesthesiologists.
A global survey of over 4,700 food allergy patients and families found airline travel to be a significant source of worry and anxiety. The study suggests that reasonable accommodations, such as pre-boarding and allergen-free zones, can reduce stress for travelers with food allergies.
Researchers at the University of Pittsburgh have discovered a molecular pathway involving protein BLIMP1 that generates Th2 cells in response to inhaled house dust mite, driving allergic asthma. The study also found signaling molecules IL2 and IL10 are required for BLIMP1 expression, offering new therapeutic options.
A recent study by researchers at Kumamoto University found a potential link between exposure to certain everyday chemicals during pregnancy and the development of asthma in children. The study analyzed data from over 3,500 mother-child pairs and measured 24 types of phenols in urine samples collected from pregnant women.
A new study from Vanderbilt University Medical Center explores the role of antibiotics in childhood asthma development. Researchers aim to identify a critical window for intervention and develop microbiome-based therapeutics to prevent asthma onset in children exposed to antibiotics early in life.
A rare missense variant in STAT6 was found to protect against moderately severe to severe T2 high asthma. The variant reduces the capability of cells to respond to and further activate T2 inflammatory response.
Researchers at University of Leicester developed a comprehensive fungal spore calendar to help patients manage symptoms through seasonal awareness. The study found two main peaks in spore concentrations: one in the summer and smaller peak in autumn, influenced by temperature and rainfall.
A new study found that patients with asthma, allergic rhinitis, atopic dermatitis, or food allergies have a higher risk of developing EoE. Food allergy had the highest risk, with a hazard ratio of 6.31 compared to those without any of these conditions.
Prolonged exposure to incense smoke can cause headaches, respiratory dysfunction, dermatologic sensitivity, and allergic reactions in individuals with pre-existing conditions like asthma. Switching to electric or aromatic vapors, improved ventilation, and limiting burn time may help mitigate these risks.
A new video series by UC Davis aims to educate building managers on removing pollutants from indoor spaces, linked to various health issues and even economic gains. The project's three R's approach focuses on removal, reduction, and mediation of air pollution sources.
Children with asthma exposed to high levels of indoor allergens are at increased risk of developing respiratory viral infections. The study found that these allergens contribute to more severe pulmonary outcomes, including reduced lung function and increased inflammation.
Researchers found that mice lacking the G900 region exhibit reduced inflammatory response and suppressed Th2 differentiation when exposed to allergens. This discovery highlights the importance of the G900 gene enhancer in regulating immune responses and has implications for personalized treatments and asthma care.
Researchers found that iron is a regulator of energy usage by immune cells in the lungs, which can help treat asthma and other allergic diseases. Blocking or limiting iron uptake may reduce asthma severity.
Researchers have discovered a new way to inhibit immune cells that drive allergic asthma by targeting the Piezo1 protein. The study found that switching on Piezo1 channels can reduce lung inflammation and alleviate symptoms of airway hyperreactivity in mice with ILC2-dependent airway inflammation.
Researchers at the University of Cincinnati have identified a molecule that plays a role in asthma and could be targeted for treatment in the future. The study found that blocking this molecule could reduce airway constriction without affecting other key features of the disease.
A new study reveals that Respiratory Syncytial Virus (RSV) can infect nerve cells, trigger inflammation, and cause nerve damage. RSV was previously thought to only infect the respiratory tract, but this finding suggests a potential link between the virus and neurological symptoms in children.
A recent study analyzed asthma mortality rates in China and the US from 1990 to 2019, revealing substantial differences in mortality rates and risk factors. The study found that smoking was a leading risk factor for asthma mortality in China, while high body mass index (BMI) was a larger public health challenge in the US.
Researchers found that bisphenol A (BPA) inactivates microbial lipopolysaccharides (LPS), a key trigger for allergic asthma. This disruption increases susceptibility to asthma in mice, highlighting a potential link between BPA exposure and immune disorders.
The June issue of CHEST features 49 articles on clinically relevant topics, including asthma, COPD, and critical care. The journal offers web and multimedia resources to expand the reach of its research.
UCF researcher Dr. Justine Tigno-Aranjuez has discovered a new receptor that recognizes house dust mite allergens, opening up potential for broad-spectrum therapy. The finding could lead to improved treatments for common allergies, including asthma.
A new study finds that rare helper T cells called Th9 can drive allergic disease and may hold the key to precision medicine approaches for treating severe allergies. Th9 cells are activated by specific transcription factors and can produce inflammatory cytokines without antigen stimulation.
Researchers from FAU have discovered that vitamin D3 can alter the cellular inflammatory reaction in allergic asthma and alleviate symptoms. Taking vitamin D3 supplements led to less pronounced asthma symptoms and fewer allergy-inducing antibodies in children and adults.
A large UK Biobank study found that poor sleep quality may bolster genetic susceptibility to asthma, potentially doubling the risk. A healthy sleep pattern was associated with a lower risk of asthma, and spotting and treating sleep disorders early on might lessen the risks.
Research published in Annals of the Rheumatic Diseases found that people with atopic diseases like asthma or eczema are at a heightened risk of developing osteoarthritis. Drugs used to dampen down allergic reactions may help lessen this risk, suggesting a potential new approach to treating the condition.
A study found that individuals with a history of atopic diseases, such as allergic asthma or rhinitis, had significantly lower rates of melanoma and skin cancer compared to non-atopic individuals. The risk of melanoma was up to 50% lower in atopic patients, and the overall risk of skin cancer was also reduced.
A new statistical analysis tool has uncovered the distribution and intermixing of Jomon hunter-gatherers and East Asian immigrant farmers in Japan. The study found that regions with higher Jomon ancestry are more prone to obesity, while those with higher East Asian ancestry are more susceptible to exacerbated asthma.
A study by researchers from the University of Tsukuba found that ELOVL6 deficiency increases ceramide levels, leading to enhanced airway inflammation and reduced treatment efficacy in patients with severe asthma. Modulating lipid composition may provide a novel approach for treating resistant asthma.
The January issue of the CHEST journal features a range of clinically relevant research on COPD, bronchiectasis, and pulmonary vascular disease. The journal's education portal offers continuing medical education (CME) credit for select articles.
A University of California Riverside study found that Salton Sea dust triggers lung neutrophil inflammation in mice, with potential implications for asthma sufferers and other terminal lake regions. The research highlights the need for further funding to understand dust-triggered inflammation and its effects on human health.
A study found that intense training schedules are associated with a heightened risk of non-allergic asthma in competitive cross-country skiers. Skiers with high-performance levels and intense training hours were more likely to develop non-allergic asthma, which was linked to airway damage caused by cold air.
The NIH has launched a clinical trial testing dupilumab, an approved treatment for moderate-to-severe asthma, in children with poorly controlled allergic asthma living in low-income urban neighborhoods. The study aims to define the activity levels of gene networks associated with asthma attacks and improve lung function.
A new study reveals that allergic asthma is a significant risk factor for human cardiovascular diseases, with certain medications affecting heart health. Researchers found that inflammatory cells play a crucial role in both conditions and that targeting them may lead to better treatment options.
A new study has found that adults with asthma are more likely to become obese later in life. The research, which included over 8,700 participants from 11 European countries and Australia, revealed that non-allergic asthma, longer disease duration, and corticosteroid treatment were associated with increased obesity risk.
Seasonal air pollution may contribute to asthma emergency department visits even in areas with generally low pollutant levels. The study used Bayesian time-stratified case-crossover models to examine associations between air pollution and asthma seasons.
Researchers found that both Gram-positive and Gram-negative bacteria induce the resorption of alveolar bone, a key component of periodontal tissue. The study suggests that positive and negative bacteria are responsible for periodontitis symptoms.
A study published in Nature Immunology identified neutrophils as a key player in the development of allergic asthma, particularly in pro-allergic environments such as excessive hygiene and air pollution. Compounds like pulmozyme may prevent disease development by destroying DNA released by neutrophils.
Researchers found that blocking IL-17A and IL-17F significantly reduces symptoms of severe allergic asthma in mice. The study suggests a new potential treatment for people with this condition, by preventing the production of pro-inflammatory molecules triggered by T-helper cells.
Researchers found that maternal e-cigarette vaping increases the risk and severity of allergic asthma in offspring, with detrimental effects partially mediated through mitochondrial function. The study highlights the need for caution when considering e-cigarettes as a safe alternative to cigarette smoking during pregnancy.
A study by Australian researchers has found that testosterone suppresses the production of immune cells that trigger allergic asthma. The finding may lead to new, targeted treatments for the disease. Women are two times more likely to develop asthma than men after puberty due to testosterone's protective effects.
Researchers found that phthalate exposure during pregnancy and breastfeeding can lead to epigenetic modifications in children, increasing the risk of developing allergic asthma. The study also showed that the effects are not limited to the child, as the offspring of exposed mothers continued to be affected even after birth.
Dasatinib, a cancer treatment, reduces inflammation and improves lung mechanics in mice with allergic asthma. The drug targets tyrosine kinases involved in asthma's signaling pathways.