Articles tagged with Dengue Fever
A new survey found that 82% of U.S. adults know the best defense against mosquito-borne diseases is preventing mosquito bites and controlling mosquitoes. However, knowledge about the proper use of insect repellent remains low, with many unsure about the correct application order with sunscreen.
A new Cochrane map has identified significant gaps in dengue prevention research, with most studies lacking synthesis into reliable reviews that policymakers can use. The map highlights areas such as vaccine implementation, adult mosquito control, and environmental interventions, which require more evidence to inform effective dengue c...
EU scientists highlight the essential role of mosquito control in tackling the increase in mosquito-borne diseases in Europe. The research emphasizes the need for continued investment in research to develop sustainable, evidence-based, and integrated mosquito control strategies. A One Health approach is also recommended to improve the ...
A large dengue outbreak in Italy was analyzed to identify transmission patterns. The data show that more than half of linked transmission events involved people within 100m apart. Temperature played a role in reducing transmission, with a drop in autumn temperatures contributing to the decline.
A Phase III clinical trial is underway to develop a safe, effective, and globally accessible therapeutic for dengue. The trial, led by DNDi, involves 1,000 participants across Brazil, Malaysia, and Thailand. Monoclonal antibodies, currently the most advanced dengue treatment candidates, are being tested.
A recent study reveals that mosquitoes harbor viruses without killing them due to translational repression, allowing for efficient transmission. The virus takes a moderate approach in mosquito cells, limiting protein production to avoid overloading the host cell.
According to new research, a warming climate is making parts of California more suitable for dengue fever transmission. Nearly half of the state's population now lives in areas where conditions allow for local transmission. As temperatures rise, so does the risk of illness and potential outbreaks.
A new study maps future risk of dengue transmission in Costa Rica by analyzing climate factors and epidemiological records. The research reveals a complex interplay between seasonal weather patterns and disease transmission, highlighting the need for locally informed, seasonally adaptive strategies.
A study of over 1,000 people vaccinated with TAK-003 in Catalonia found no serious adverse events and provided new evidence on the vaccine's short-term safety in travelers. The findings suggest that the dengue vaccine has a good tolerability profile among travelers from non-endemic regions.
Dr. James Earnest's research focuses on how the immune system responds to mosquito-borne viruses, aiming to create better preventative measures for dengue and Zika infections. He is collaborating with institutions in Mexico and Uganda to study immune responses over time, shedding light on effective memory B cells and antibodies.
The Butantan-DV dengue vaccine, developed in Brazil, shows 80.5% effectiveness against severe cases over five years, with no hospitalizations in the vaccinated group. The vaccine was 65% effective in preventing symptomatic dengue during the five-year monitoring period.
Scientists have created a detailed single-cell map of asymptomatic dengue virus infections, revealing distinct immune responses that help protect individuals from the virus without symptoms. The findings could guide the development of safer and more effective dengue vaccines.
A new global standard has been established to harmonize outcomes measurement in dengue treatment trials, addressing a longstanding discrepancy that limits the comparison of evidence. The initiative aims to accelerate the development of treatments for dengue fever and improve clinical guidelines, with input from experts worldwide.
The Qdenga vaccine provided a 50% reduction in symptomatic dengue cases and 68% hospitalization rate after one dose, with protection lasting three months. The study's findings have significant implications for public health decision-making, particularly in non-endemic regions where local transmission is increasing.
Despite an increase in US cases, worry about West Nile virus remains low, with only 15% of respondents concerned about contracting the disease. The vast majority know the best defense is preventing mosquito bites and controlling mosquitoes around their homes.
A new study predicts significant increase in mosquito-borne disease risk in Brazil by 2080, with higher temperatures and changing rainfall patterns contributing to the issue. Climate action could help mitigate this risk, reducing future disease outbreaks.
A new study by researchers at Stanford University finds that warmer temperatures are driving a surge in dengue fever cases, with potential increases of up to 76% by 2050. The analysis analyzed over 1.4 million observations and found that higher temperatures were responsible for an average 18% of dengue incidence across 21 countries.
A new class of insecticide, called spatial emanators, provides protection for up to a year against mosquitoes that spread malaria, as well as dengue, West Nile, yellow fever, and Zika. The breakthrough offers lasting protection in areas where malaria is prevalent and can be used day and night without heating or electricity.
A study predicts that climate change will spread Dengue fever through Western Europe as the Asian tiger mosquito's habitat expands. Major cities like London and Paris are expected to become suitable for the mosquito, posing a significant threat to public health.
Europe is experiencing longer and more intense transmission seasons for mosquito-borne diseases, including West Nile virus infection and chikungunya virus disease. ECDC has warned that record-breaking outbreaks point to a 'new normal' in Europe, prompting the need for a robust response to protect public health.
The European Centre for Disease Prevention and Control (ECDC) has launched new weekly surveillance updates and public health guidance on mosquito-borne diseases, covering chikungunya, dengue, Zika, and West Nile viruses. The reports provide a comprehensive view of the evolving situation across European countries.
Researchers found that individuals with European ancestry have a higher inflammatory response to the dengue virus, which can lead to severe disease. In contrast, those with African ancestry have a lower inflammatory response, making them less susceptible to severe dengue fever. The study's findings could lead to precision medicine appr...
The review highlights the limitations of existing dengue vaccines, such as CYD-TDV and TAK-003, and the urgent need for more effective vaccines to protect millions of people. The Butantan-DV vaccine has shown promise with its single-dose regimen, but its efficacy against DENV-3 and DENV-4 is still unclear.
Researchers have identified novel mosquito repellents with high success rates from natural sources, including food and flavoring materials. The team's machine learning-based cheminformatics approach also pinpointed pyrethroid analogs up to 100 times more effective than existing industry standards.
Researchers developed a simple test that detects antibodies against four dengue virus serotypes and zika virus. The test achieved high sensitivity (87.8%) and specificity (91.4%), indicating its potential to monitor specific antibodies produced in response to exposure to the viruses.
A recent study identifies temperature and rainfall as key drivers of the global increase in dengue cases, offering actionable strategies for mitigating the disease's impact. The research found that dry season length variation is a decisive factor explaining contrasting effects of rainfall on dengue transmission.
A new retrospective study found that nearly half of patients with fever of unknown origin in sub-Saharan Africa had a detectable pathogen, including bacterial strains and hemorrhagic fever viruses. The study highlights the need for strengthened laboratory capacity to improve diagnosis and treatment.
Climate change is responsible for 19% of the current dengue burden, with a potential to spark an additional 40%-60% spike by 2050. A study found that moderating global warming would also moderate climate impacts on dengue infections.
Researchers found that natural killer T (NKT) cells influence the immune response to dengue virus, potentially reducing the severity of subsequent infections. NKT cells drive dengue-specific Th1 responses, leading to the production of protective antibodies.
A new study by the UK Centre for Ecology & Hydrology predicts high-risk towns across Europe for dengue fever outbreaks, with southern France and northern Italy being most affected. The research uses advanced high-resolution modeling to provide daily risk assessments for each area.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
Researchers identified a genetic mutation that impairs virus replication in human cells, leading to asymptomatic infections. The same mutation enhances transmission in Aedes aegypti mosquitoes, allowing the virus to spread without triggering an outbreak.
Researchers at Stowers Institute for Medical Research have identified the dengue virus genome's use of less efficient codons in its host's machinery to replicate and spread. This discovery has implications for developing novel antiviral treatments and vaccines, as well as understanding the relationship between viruses and their hosts.
A new study links dengue fever to a higher risk of depression, both short- and long-term. Researchers analyzed medical records of nearly 50,000 people who experienced dengue fever in Taiwan and found an elevated risk of depressive disorders across all timeframes.
Prof. Tomer Hertz's research will measure immune responses to polioviruses using a novel antigen array, facilitating rapid analysis in countries where polio has yet to be eradicated. The funding aims to optimize PAM – a polio antigen microarray – for safe and effective measurement of protection from polio infection.
Research found that babies born to mothers infected with dengue fever during pregnancy had lower birth weights and a higher risk of extremely low birth weight. Additionally, children whose mothers were infected had a increased risk of hospitalization from birth to age three, particularly in their second year of life.
Researchers found that insecticide paint effectively killed mosquitoes for up to a year in Cabo Verde, with good acceptance from the population. The VESTA formulation met WHO efficiency threshold requirements, making it a promising strategy for preventing vector-borne diseases.
Researchers have developed a novel approach to determine the age of mosquitoes, which could help improve pesticide strategies and reduce the spread of diseases like malaria. The method uses surface-enhanced Raman spectroscopy (SERS) to analyze biomolecules in mosquito water extract.
Researchers analyzed over 770,000 cases of chikungunya and zika in Brazil, finding a decline in spatial variations for both diseases but an increase in case numbers in 85% and 57% of clusters. High-risk areas are linked to higher temperatures, low rainfall, urbanization, and social inequality.
Researchers have identified sST2 and suPAR in the blood of dengue patients, which could accurately predict patients at risk of severe dengue. The test kits would improve patient outcomes by distinguishing between non-life-threatening cases and severe dengue, requiring hospitalization.
Researchers analyzed a World Mosquito Program trial and found that excluding transmission dynamics likely underestimates the impact of Wolbachia-infected mosquitoes. The study suggests that true efficacy may be higher than initially reported, with potential reductions in dengue fever cases ranging from 77% to 94-97%.
The digitization of Johanna Bonne-Wepster's field notes has filled significant gaps in mosquito research and tropical medicine. The collection contains valuable information on vector-borne diseases and their spread, which can inform current public health issues and future disease modeling.
A study reveals high levels of insecticide resistance among Aedes aegypti populations in Dhaka, compromising mosquito control and increasing dengue burden. Researchers recommend non-insecticidal approaches, such as Wolbachia-infected mosquitoes, to effectively manage dengue vectors.
Research from the University of Surrey and University of Birmingham finds detrimental effects of all severities of maternal dengue infections on birth outcomes, including increases in low, very low, and extremely low birth weights. Long-term consequences also include hospitalizations for children up to three years after birth.
Researchers at Trudeau Institute and Texas Biomedical Research Institute found that prior dengue infection can worsen Zika virus outcomes during pregnancy. Pregnant marmoset monkeys infected with dengue passed significantly more Zika virus to their fetuses than those without dengue, suggesting a link between the two viruses.
A new study deployed unmanned ground vehicle systems to monitor and eradicate Aedes mosquitos in Taiwanese sewers. The system detected 20.7% of inspected sewers with mosquito traces, leading to a significant reduction in adult mosquito density after intervention.
Scientists have discovered potential broad-spectrum antivirals that target multiple families of RNA viruses, which pose a significant threat to future pandemics. The new agents showed promise in preventing and mitigating viral arthritis caused by Chikungunya virus and rescuing cells from harmful effects of other viruses.
A British woman was infected with dengue while visiting family in the south of France in September 2022. The case report presents an outbreak of over 30 locally transmitted cases in France, highlighting the rapidly changing epidemiology of dengue.
A new study by Emory University researchers found that asymptomatic individuals account for a significant proportion (74%) of dengue infections in an Amazonian city. The 'super spreader' spaces, where infected people frequent, are crucial in predicting and controlling outbreaks.
A study from Sophia University used AI and remote sensing data to predict dengue fever outbreak locations. Although the model had low accuracy, it suggests that spatiotemporal prediction of disease outbreaks may be possible with improvements.
Rice University researchers have developed an innovative system to study mosquito feeding behavior using fake skin made with a 3D printer, eliminating the need for live volunteers. The system was tested on various mosquito repellents and showed promising results, suggesting it could be scaled up for future studies.
A Rutgers researcher has analyzed data from Mexico's Ministry of Health to identify dengue fever hotspots, highlighting areas where severe outbreaks occur. The study found that lower socioeconomic status increases risk of dengue fever and that DENV-2 is the deadliest serotype.
A team of experts led by LSTM has developed a globally relevant, evidence-based patient-centred set of measurements for snakebite clinical trials. The new core outcome measures aim to standardise trial methodology and support the needs of patients and clinicians worldwide.
Researchers have designed new mosquito repellents that surpass DEET's effectiveness while minimizing its drawbacks. The compounds provide human volunteers with over 95% protection from bites for at least eight hours, making them a promising alternative to traditional repellents.
Scientists at UC Riverside have discovered that volatile repellents containing ammonia and amines can be used to combat insect-borne diseases by disrupting their sense of smell and taste. The research found that these compounds can silence olfactory neurons in mosquitoes, preventing them from detecting human skin odor.
Researchers at University of California - Riverside discovered a chemical cocktail in human skin that summons disease-spreading mosquitoes. The combination of carbon dioxide plus two chemicals, 2-ketoglutaric and lactic acids, elicits a scent that attracts female Aedes aegypti mosquitoes, vectors of Zika and other viruses.
A new study finds that climate variables like temperature, rainfall, and ocean warming predict mosquito population growth in Sri Lanka for the next one to six months. The research can inform programs to limit dengue transmission, a major public health problem in the country.
Researchers found that infected mice and humans emit a specific molecule, acetophenone, which attracts mosquitoes. This altered scent allows the viruses to spread faster. A potential preventative, isotretinoin, was also tested and shown to reduce mosquito attraction.
A new machine learning-based AI tool has been developed to aid doctors in distinguishing between tropical diseases such as dengue and malaria. The tool has shown promising results in improving diagnosis accuracy.
Researchers found dengue and Zika viruses increase acetophenone production in infected hosts, making them more attractive to mosquitoes. Treatment with acne medication reduces this effect, potentially mitigating virus spread.